71 research outputs found
SARS-CoV-2-related MIS-C: a key to the viral and genetic causes of Kawasaki disease?
- Author
- Abel L.
- Abolhassani H.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O. M.
- Al-Mulla F.
- Alkan G.
- Almuhsen S. Z.
- Alsina L.
- Anderson M. S.
- Andreakos E.
- Arditi M.
- Arkin L.
- Aydemir S.
- Aytekin C.
- Aytekin G.
- Aytekin S. E.
- Bajolle F.
- Bando S. Y.
- Bastard P.
- Bayhan G. I.
- Beland K.
- Bellos E.
- Belot A.
- Biggs C. M.
- Blanchard-Hohner G.
- Blazquez-Gamero D.
- Bloomfield M.
- Bogunovic D.
- Bolze A.
- Bondarenko A.
- Bonnet D.
- Bousfiha A. A.
- Boyarchuk O.
- Bozdemir S. E.
- Brodin P.
- Bryceson Y.
- Butte M. J.
- Casanova J. -L.
- Casari G.
- Cavalcanti A.
- Celik J. B.
- Chakravorty S.
- Cobat A.
- Colobran R.
- Condino-Neto A.
- Cooper M.
- Coskuner T.
- de Diego R. P.
- Delafontaine S.
- Demirkol Y. K.
- Drolet B. A.
- Emiroglu M.
- Erdeniz E. H.
- Fellay J.
- Flores C.
- Franco J. L.
- Gagro A.
- Gayretli Aydin Z. G.
- Gul Y.
- Gulhan B.
- Gut M.
- Haddad E.
- Haerynck F.
- Halwani R.
- Hammarstrom L.
- Hatipoglu N.
- Henrickson S. E.
- Herberg J.
- Hoste L.
- Hsieh E.
- Imai K.
- Itan Y.
- Jordan I.
- Jouanguy E.
- Kaforou M.
- Kandemir B.
- Kapakli H.
- Karbuz A.
- Kasapcopur O.
- Keles S.
- Kilic A. O.
- Klocperk A.
- Kuijpers T. W.
- Kwan M.
- Lau Y. -L.
- Lebon P.
- Lee D.
- Lei W.
- Levin M.
- Lucas C. L.
- Maglorius M.
- Mahmoudi S.
- Maniatis T.
- Mansouri D.
- Marque L.
- Menikou S.
- Meyts I.
- Milner J. D.
- Mogensen T.
- Nepesov S.
- Neves J. F.
- Notarangelo L. D.
- Novelli A.
- Novelli G.
- Okada S.
- Orbak Z.
- Ozcelik T.
- Ozkan E. A.
- Pan-Hammarstrom Q.
- Papadaki M.
- Parlakay A. O.
- Pelham S.
- Philippot Q.
- Planas-Serra L.
- Prando C.
- Puel A.
- Pujol A.
- Riviere J. G.
- Rodriguez-Gallego C.
- Rodriguez-Palmero A.
- Sancho-Shimizu V.
- Schluter A.
- Schmitt E.
- Sediva A.
- Seeleuthner Y.
- Sevketoglu E.
- Shahrooei M.
- Sobh A.
- Soler-Palacin P.
- Sozeri B.
- Stepanovskiy Y.
- Su H. C.
- Tangye S. G.
- Tayoun A. A.
- Torun S. H.
- Toubiana J.
- Tuter Oz S. K.
- Valencia-Ramos J.
- van de Beek D.
- Vatansev H.
- Volokha A.
- Yahsi A.
- Yarar V.
- Yesilbas O.
- Yildiz M.
- Yosunkaya A.
- Yuksek S. K.
- Zhang P.
- Zhang Q.
- Zhang S. -Y.
- Publication venue
- 'Rockefeller University Press'
- Publication date
- 01/01/2021
- Field of study
Epigenetic remodelling licences adult cholangiocytes for organoid formation and liver regeneration.
- Author
- A Bird
- A Natarajan
- A Raven
- Alexander Raven
- Andrea H. Brand
- AV Probst
- AW Duncan
- B Li
- B Wang
- BD Tarlow
- Berta Font-Cunill
- BJ Pepe-Mooney
- C Blanpain
- C Dorrell
- C Hall
- CY McLean
- D Serra
- D Yimlamai
- DA Kleinjan
- DM Messerschmidt
- E Li
- EM Tanaka
- Eric A. Miska
- F Antonica
- F Krueger
- Francesco Antonica
- G Ficz
- German Belenguer
- GK Michalopoulos
- GR Kafer
- Grégoire Vernaz
- H Talarmin
- H Wu
- J Font-Burgada
- J Schindelin
- Jelle van den Ameele
- JO Russell
- JP Thomson
- K Kamimoto
- KB Jensen
- KD Rasmussen
- KN Lazaridis
- L Aloia
- L Broutier
- L Planas-Paz
- L Yang
- L Zhu
- Lucía Cordero-Espinoza
- Luigi Aloia
- M Hu
- M Huch
- M Huch
- M Huch
- M Huch
- M Iurlaro
- M Okabe
- M Tahiliani
- MA Hahn
- Magdalena Zernicka-Goetz
- Meritxell Huch
- Mikel Alexander McKie
- MR Branco
- N Barker
- N Prior
- Niya Aleksieva
- OJ Marshall
- OJ Marshall
- P Stempor
- PW Hill
- PWS Hill
- R Espanol-Suner
- R Kim
- Riccardo Aiese Cigliano
- Richard L. Mort
- RL Mort
- RM Kohli
- S Chrysanthou
- S Lin
- S Picelli
- S Shin
- S Yamaguchi
- SD Sackett
- SF Boj
- SG Jin
- SJ Forbes
- SM Fouraschen
- Stuart J. Forbes
- SW Cheetham
- TY Choi
- WA Pastor
- WY Lu
- X Deng
- Y Costa
- Y Lin
- Y Reizel
- YA Medvedeva
- ZD Smith
- Publication venue
- Nat Cell Biol
- Publication date
- 01/11/2019
- Field of study
Following severe or chronic liver injury, adult ductal cells (cholangiocytes) contribute to regeneration by restoring both hepatocytes and cholangiocytes. We recently showed that ductal cells clonally expand as self-renewing liver organoids that retain their differentiation capacity into both hepatocytes and ductal cells. However, the molecular mechanisms by which adult ductal-committed cells acquire cellular plasticity, initiate organoids and regenerate the damaged tissue remain largely unknown. Here, we describe that ductal cells undergo a transient, genome-wide, remodelling of their transcriptome and epigenome during organoid initiation and in vivo following tissue damage. TET1-mediated hydroxymethylation licences differentiated ductal cells to initiate organoids and activate the regenerative programme through the transcriptional regulation of stem-cell genes and regenerative pathways including the YAP-Hippo signalling. Our results argue in favour of the remodelling of genomic methylome/hydroxymethylome landscapes as a general mechanism by which differentiated cells exit a committed state in response to tissue damage.RCUK
Cancer Research UK
ERC
H2020
Wellcome Trus
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
- Author
- Abel L.
- Abolhassani H.
- Aburto A. B.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O. M.
- Akcay N.
- Alavoine L.
- Alkan G.
- Alkhater S. A.
- Allende L. M.
- Alper Y.
- Alsina L.
- Amat K.
- Amenzoui N.
- Anderson M. S.
- Anton J.
- Aquino Y.
- Arias A. A.
- Arkin L.
- Asthana A.
- Aubart M.
- Avramenko I.
- Aydemir S.
- Aydin Z. G. G.
- Aytekin C.
- Aytekin G.
- Aytekin S. E.
- Bailey R.
- Bajolle F.
- Bando S. Y.
- Bastard P.
- Bayhan G. I.
- Beaufils C.
- Behillil S.
- Beland K.
- Belkaya S.
- Belot A.
- Bertholon F.
- Beziat V.
- Biggs C. M.
- Bigio B.
- Bilguvar K.
- Bisiaux A.
- Bizien L.
- Blanchard-Rohner G.
- Blazquez-Gamero D.
- Bloomfield M.
- Bogunovic D.
- Boisson B.
- Boisson-Dupuis S.
- Bondarenko A.
- Bonnet D.
- Borghesi A.
- Botelho-Nevers E.
- Bouiller K.
- Bousfiha A. A.
- Boyarchuk O.
- Bozdemir S. E.
- Brodin P.
- Bruneau L.
- Bryceson Y.
- Bucciol G.
- Burdet C.
- Bustamante J.
- Calcaterra V.
- Casanova J. -L.
- Casari G.
- Cavalcanti A.
- Celik J. B.
- Chahine A.
- Chan Y. -H.
- Charpentier C.
- Chen J.
- Chen S.
- Chirouze C.
- Christelle K.
- Chrousos G. P.
- Cobat A.
- Colobran R.
- Condino-Neto A.
- Conti F.
- Cooper M.
- Coskuner T.
- Couffin-Cadiergues S.
- Cyrus C.
- D'Auria E.
- Dalgard C. L.
- de Diego R. P.
- De Somer L.
- de Vera M. C.
- Dechanet A.
- DeDiego M. L.
- Delafontaine S.
- Demar M.
- Demirkol Y. K.
- Deplanque D.
- Descamps D.
- Desille-Dugast M.
- Desmarets M.
- Djossou F.
- Dong B.
- Drolet B. A.
- Duramaz B. B.
- Duval X.
- Ecobichon J. -L.
- El Zein L.
- Elnagdy M. H.
- Emiroglu M.
- Enouf V.
- Erdeniz E. H.
- Esperou H.
- Evans T.
- Fabi M.
- Feldman H. B.
- Fellay J.
- Fencl F.
- Fidouh N.
- Filippatos F.
- Flores C.
- Fouchard J.
- Freiss J.
- Fremuth J.
- Frezouls W.
- Fumado V.
- Gagneux-Brunon A.
- Gagro A.
- Garcia-Solis B.
- Gaughan C.
- Geissmann F.
- Gerardin P.
- Gervais A.
- Gissot V.
- Gonzalez-Montelongo R.
- Gul Y.
- Gulhan B.
- Gultekin S. S. K.
- Gut M.
- Haddad E.
- Haerynck F.
- Halwani R.
- Hammarstrom L.
- Hansen S. K.
- Hasan M.
- Hatipoglu N.
- Heath J.
- Hendou S.
- Henrickson S. E.
- Hernandez-Brito E.
- Hoffman I.
- Hoffmann H. -H.
- Hoste L.
- Houhou N.
- Hsieh E.
- Inigo-Campos A.
- Itan Y.
- Jabandziev P.
- Jaffre F.
- Jeulin H.
- Jordan I.
- Jouanguy E.
- Kafif O.
- Kandemir B.
- Kanik-Yuksek S.
- Kapakli H.
- Karbuz A.
- Kasapcopur O.
- Kechiche R.
- Keles S.
- Kilic A. O.
- Kilic O.
- Klocperk A.
- Laine F.
- Lau Y. -L.
- Laviolle B.
- Lazarov T.
- Le Goas C.
- Le Pen J.
- Le Voyer T.
- Lebl J.
- Lebon P.
- Lee D.
- Lefevre B.
- Legrand K.
- Lehacaut J.
- Lei W.
- Letrou S.
- Levy R.
- Libri V.
- Lifton R. P.
- Lina B.
- Liu Z.
- Lomazzi S.
- Lorenzo L.
- Lorenzo-Salazar J. M.
- Lucarelli A.
- Lucas C. L.
- Lucet J. -C.
- Luna J. M.
- Maglorius M.
- Maillot A.
- Malvy D.
- Manchon P.
- Mane S.
- Maniatis T.
- Marque L.
- Materna M.
- Medina Y. N.
- Melian A. M.
- Mentis A. -F. A.
- Mergeay-Fabre M.
- Meunier A.
- Meyts I.
- Michailidis E.
- Michos A.
- Migaud M. -C.
- Milisavljevic B.
- Milner J. D.
- Mogensen T. H.
- Moncada-Velez M.
- Montagne S.
- Moreews M.
- Morin M. -P.
- Munoz-Barrera A.
- Neehus A. -L.
- Nepesov S.
- Neves J. F.
- Ng A.
- Ng L. F. P.
- Nguyen D.
- Nicolas L.
- Notarangelo L.
- Nouroudine M.
- Novelli A.
- Novelli G.
- Ocejo-Vinals J. G.
- Ogishi M.
- Okada S.
- Orbak Z.
- Ouair H.
- Oz F. N.
- Oz S. K. T.
- Ozcelik T.
- Ozkan E. A.
- Pala F.
- Pan-Hammarstrom Q.
- Paris C.
- Parlakay A. O.
- Pato C. N.
- Pato M. T.
- Payet C.
- Paz-Artal E.
- Peel J.
- Pelham S.
- Pellier I.
- Perez-Tur J.
- Perreau P.
- Perret M.
- Pescarmona R.
- Philippot Q.
- Pino-Ramirez R. M.
- Piquard V.
- Pistone T.
- Planas A. M.
- Planas-Serra L.
- Plassart S.
- Pokorna P.
- Polat M.
- Poli C.
- Prando C.
- Puel A.
- Pujol A.
- Quintana-Murci L.
- Quintin C.
- Ramaswamy S.
- Renia L.
- Rice C. M.
- Richard L.
- Rinchai D.
- Riviere J. G.
- Rodriguez-Gallego C.
- Rodriguez-Palmero A.
- Rosain J.
- Roufai L.
- Roussel L.
- Rozenberg F.
- Rubio-Rodriguez L. A.
- Salifu M.
- Sancho-Shimizu V.
- Sasek L.
- Sasia L.
- Scherbina A.
- Schluter A.
- Schmitt E.
- Sediva A.
- Seeleuthner Y.
- Sevketoglu E.
- Silverman R. H.
- Slaba K.
- Slaby O.
- Sobh A.
- Sole-Violan J.
- Soler-Palacin P.
- Sozeri B.
- Spaan A. N.
- Stepanovskiy Y.
- Su H. C.
- Talouarn E.
- Tangye S. G.
- Tanir G.
- Tardy B.
- Tatsi E. -B.
- Tayoun A. A.
- Thorball C. W.
- Thy M.
- Torun S. H.
- Toubiana J.
- Tubiana S.
- Turvey S.
- Uddin M. J.
- Uyar E.
- Valencia-Ramos J.
- Van Den Rym A. M.
- van der Werf S.
- Vatansev H.
- Vergine G.
- Vermeulen F.
- Vignali V.
- Vinh D. C.
- Visseaux B.
- Volokha A.
- von Bernuth H.
- Waucquier N.
- Weiss S. R.
- Wouters C.
- Yahsi A.
- Yarar V.
- Yatim A.
- Yazdanpanah Y.
- Yesilbas O.
- Yildiz M.
- Zatz M.
- Zawadzki P.
- Zhang P.
- Zhang Q.
- Zhang S. -Y.
- Zhang Y.
- Zuccotti G.
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C
Anti-tumour necrosis factor discontinuation in inflammatory bowel disease patients in remission: study protocol of a prospective, multicentre, randomized clinical trial
- Author
- Abad F.
- Ag?ero Tejado E.
- Aguas Peris M.
- Alba C.
- Albert M.
- Alem?n H.
- Algaba A.
- Alonso Abreu I.
- Amador M. P.
- Amat M.
- Angueira T.
- Arajol C.
- Arias-Gonz?lez L.
- Arrondo Velasco A.
- Bald?n M.
- Bard?n Garc?a B.
- Bargall? Garc?a A.
- Barreiro de Acosta M.
- Barreiro de Acosta Manuel
- Barrio Andr?s J.
- Bast?n Rey Iria
- Bastida Paz G.
- Batista L.
- Bellver Mart?nez M.
- Beltr?n Nicl?s B.
- Ben?tez J. M.
- Ber Nieto Y.
- Bermejo F.
- Bernardo D.
- Bl?zquez G?mez I.
- Bouhmidi Assakali A.
- Busquets Casals D.
- Cabriada Nu?o J. L.
- Calvet Calvo X.
- Calvo Hern?ndez M. V.
- Calvo M.
- Camps B.
- Carbajo A. Y.
- Cardona Peitx G.
- Caro-Pat?n T.
- Carri?n Bolorino S.
- Carrillo Palau M.
- Casanova M. J.
- Casellas Vald? J. A.
- Casta?o Garc?a A.
- Castro Senosiain B.
- Ceballos D.
- Cerrillo E.
- Chac?n Mart?nez S.
- Chaparro M.
- Consuelo Ca?ete Pizarro F.
- de Castro Parga M. L.
- de Francisco Garc?a R.
- de la Cruz Ram?rez M. D.
- de Miguel M.
- del Hoyo Francisco J.
- Delgado Guillena P.
- Desongles Corrales T.
- Dom?nech E.
- Donday M. G.
- Echarri Piudo A.
- Espino Paisan E.
- Espona Quer M.
- Esteve M.
- Fern?ndez Forcelledo J. L.
- Fern?ndez Pordomingo A.
- Fern?ndez-Tom? S.
- Ferreiro Iglesias R.
- Ferrer Bradley I.
- Ferrer A.
- Figueroa A.
- G?mez Delgado E.
- G?mez Irwin L.
- G?mez Pastrana B.
- Gallach Montero M.
- Garc?a Garc?a M. J.
- Garc?a Garc?a-Lezc?n C.
- Garc?a Iglesias P.
- Garc?a Ram?rez L.
- Garc?a-Bosh O.
- Garc?a-S?nchez V.
- Garre A.
- Gim?nez Poder?s T.
- Gisbert J. P.
- Gonz?lez Lama Y.
- Gracia Garc?a ?
- Gracia Garc?a B.
- Guardiola J.
- Guerra E.
- Guerra I.
- Guillot V.
- Gustmancher Saiz S.
- Guti?rrez Casbas A.
- Hern?ndez Muniesa B.
- Hern?ndez Ram?rez V.
- Hernando Verdugo M. M.
- Hernanz Chaves R.
- Herrera Justiniano J. M.
- Hinojosa del Val J.
- Ib??ez Feijoo S.
- Iborra Colomino M.
- Iglesias Flores E.
- Izquierdo Garc?a E.
- Jim?nez Garc?a N.
- L?pez de Torre Querejazu A.
- L?pez S?nchez P.
- Leo Carnerero E.
- Loizaga D?az I.
- Lucendo A. J.
- Luis Parras J.
- M?ndez-Castrill?n Rodr?guez J.
- M?nguez M.
- M?rquez Gal?n J. L.
- M?rquez Mosquera L.
- Ma?osa M.
- Maia Bosc? M.
- Mar?n Pedrosa S.
- Mar?n A.
- Mar?n-Jim?nez I.
- Marinero ?
- Mart?n Arranz E.
- Mart?n Arranz M. D.
- Mart?nez Cadilla J.
- Mart?nez S?nchez B.
- Mart?nez Sesmero J. M.
- Mart?nez C.
- Matallana V.
- Mateos Hern?ndez M. I.
- McNicholl A. G.
- Mejuto Fern?ndez R.
- Melcarne L.
- Mench?n L.
- Merino Ochoa O.
- Molas Ferrer G.
- Montoro Huguet M.
- Montserrat Torres A.
- Mora F.
- Moraleja Yudego I.
- Morales Alvarado V. J.
- Morales Mart?nez L.
- Morell A.
- Motos Garc?a C.
- Mu?oz Alonso F.
- Mu?oz Villafranca M. C.
- Mu?oz J. E.
- Mur A.
- N??ez Alonso A.
- N??ez Ortiz A.
- Nantes ?
- Navarro P.
- Navarro- Llavat M.
- Nos Mateu P.
- Nos P.
- Olivares D.
- Ollero Pena V.
- on behalf of the Exit study group of Geteccu
- Orobitg J.
- Ortega L.
- Ortiz de Z?rate J.
- P?rez Mart?nez I.
- Pallar?s Manrique H.
- Pan?s J.
- Paradela Carreiro A.
- Peral Ballester L.
- Pereira Bueno S.
- Pi?ero P?rez C.
- Pineda Mari?o J. R.
- Planas Giner A.
- Plaza Santos M. R.
- Ponferrada D?az ?
- Poza Card?n J.
- Prieto Vicente V.
- Puchades L.
- Ramos L?pez L.
- Redondo S.
- Riestra Men?ndez S.
- Rivero Tirado M.
- Rodr?guez Guti?rrez C.
- Rodr?guez Lago I.
- Rodr?guez E.
- Romero Izquierdo S.
- Rubio Iturria S.
- Ruiz Antor?n M. B.
- Ruiz A.
- S?nchez G?mez E.
- S?nchez Ulayar A.
- S?nchez C.
- Salazar L. F.
- Sampedro Gonz?lez M. J.
- Sangrador C.
- Serra K.
- Spicakova K.
- Su?rez Ferrer C.
- Talavera Fabuel A.
- Taxonera C.
- Tordera M.
- Torrella Cort?s E.
- Tosca J.
- Trigo Salado C.
- Uriarte Estefan?a F.
- V?zquez Mor?n J. M.
- Van Domselaar M.
- Ventura L?pez P.
- Vera M.
- Vicu?a Arregui M.
- Villoria Ferrer A.
- Virg?s Aller T.
- Y??ez Feria D.
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Background:
Patients with inflammatory bowel disease who achieve remission with anti-tumour necrosis factor (anti-TNF) drugs may have treatment withdrawn due to safety concerns and cost considerations, but there is a lack of prospective, controlled data investigating this strategy. The primary study aim is to compare the rates of clinical remission at 1?year in patients who discontinue anti-TNF treatment versus those who continue treatment.
Methods:
This is an ongoing, prospective, double-blind, multicentre, randomized, placebo-controlled study in patients with Crohn?s disease or ulcerative colitis who have achieved clinical remission for ?6?months with an anti-TNF treatment and an immunosuppressant. Patients are being randomized 1:1 to discontinue anti-TNF therapy or continue therapy. Randomization stratifies patients by the type of inflammatory bowel disease and drug (infliximab versus adalimumab) at study inclusion. The primary endpoint of the study is sustained clinical remission at 1?year. Other endpoints include endoscopic and radiological activity, patient-reported outcomes (quality of life, work productivity), safety and predictive factors for relapse. The required sample size is 194 patients. In addition to the main analysis (discontinuation versus continuation), subanalyses will include stratification by type of inflammatory bowel disease, phenotype and previous treatment. Biological samples will be obtained to identify factors predictive of relapse after treatment withdrawal.
Results:
Enrolment began in 2016, and the study is expected to end in 2020.
Conclusions:
This study will contribute prospective, controlled data on outcomes and predictors of relapse in patients with inflammatory bowel disease after withdrawal of anti-TNF agents following achievement of clinical remission.
Clinical trial reference number:
EudraCT 2015-001410-1
Spread of a SARS-CoV-2 variant through Europe in the summer of 2020.
- Author
- Aguilera A.
- Aguirre-Quiñonero A.
- Alberdi M.B.
- Alberola-Enguidanos J.
- Albert E.
- Algarate S.
- Almela-Ferrer M.R.
- Althaus C.L.
- Alvarez-Argüelles M.E.
- Antuori-Torres A.
- Aranzamendi-Zaldumbide M.
- Argüello H.
- Azcona-Gutiérrez J.M.
- Barbeito-Castiñeiras G.
- Benito R.
- Bloom J.D.
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Following its emergence in late 2019, the spread of SARS-CoV-21,2 has been tracked by phylogenetic analysis of viral genome sequences in unprecedented detail3–5. Although the virus spread globally in early 2020 before borders closed, intercontinental travel has since been greatly reduced. However, travel within Europe resumed in the summer of 2020. Here we report on a SARS-CoV-2 variant, 20E (EU1), that was identified in Spain in early summer 2020 and subsequently spread across Europe. We find no evidence that this variant has increased transmissibility, but instead demonstrate how rising incidence in Spain, resumption of travel, and lack of effective screening and containment may explain the variant’s success. Despite travel restrictions, we estimate that 20E (EU1) was introduced hundreds of times to European countries by summertime travellers, which is likely to have undermined local efforts to minimize infection with SARS-CoV-2. Our results illustrate how a variant can rapidly become dominant even in the absence of a substantial transmission advantage in favourable epidemiological settings. Genomic surveillance is critical for understanding how travel can affect transmission of SARS-CoV-2, and thus for informing future containment strategies as travel resumes. © 2021, The Author(s), under exclusive licence to Springer Nature Limited
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
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- van Blokland I.
- van Heel D. A.
- Vecchia M.
- Veerapen K.
- Venn L. D.
- Venturelli S.
- Vergori A.
- Verma A.
- Verma S. S.
- Verzuri A.
- Villalonga J. M.
- Vincenti A.
- Voide C.
- Von Frenckell C.
- von Hohenstaufen K. A.
- Vonk J. M.
- Vulesevic N. R. B.
- Wain L. V.
- Walker S.
- Walters R. K.
- Wang J.
- Wang X.
- Wanying Z.
- Warmerdam R.
- Weiss S. T.
- Wicks S. J.
- Willer C.
- Williams A. T.
- Wilson D. J.
- Wilson J. F.
- Wolford B.
- Wolford B.
- Woolley A. E.
- Wright J.
- Wyllie D. H.
- Xue X.
- Yadav A.
- Yassen A. M.
- Zanella I.
- Zeberg H.
- Zguro K.
- Zhang M.
- Zhao J. H.
- Zhou W.
- Zhou W.
- Zlatopolsky M.
- Zollner B. W. S.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2021
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component. Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci (eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene), including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.
- Author
- Ab Majid MA
- Ab Rahman AS
- Ab Rahman R
- Abayasinghe C
- Abbott T
- Abdullah NH
- Abdur-Rahman L
- Abeloos J
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- Abidin UN
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- Zoulamoglou M
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- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Autoantibodies against type I IFNs in patients with life-threatening COVID-19
- Author
- Abad Capa Jorge
- Abel L.
- Abela L.
- Abelb L.
- Abelc L.
- Abers M.S.
- Agra J.J.C.
- Aguilera-Albesa S.
- Aiuti A.
- Akcan O.M.
- Al-Mulla F.
- Alarcon M.G.
- Alavoine L.
- Albert M.L.
- Alcover A.
- Aldave J.C.
- Algera A.G.
- Alkan G.
- Allardet-Servent J.
- Allende L.M.
- Alsina L.
- Alvarez J.T.
- Alyanakian M.A.
- Amador-Borrero B.
- Amat K.K.A.
- Amoura Z.
- Anderson M.S.
- Andrejak C.
- Angoulvant F.
- Antolí A.
- Arias A.A.
- Arias A.A.
- Arquero M.F.
- Arranz M.J.
- Arslan S.
- Aschard H.
- Assant S.
- Astrom K.
- Auguet T.
- Aytekin S.E.
- Azot A.
- Bachelet D.
- Bajolle F.
- Baldolli A.
- Ballester M.
- Bansal N.
- Barrett K.S.
- Barrou B.
- Basmaci R.
- Bastard P.
- Bax D.
- Behillil S.
- Behillil S.
- Bellani G.
- Belot A.
- Belota A.
- Beluze M.
- Benkerrou D.
- Bettini L.R.
- Beudel M.
- Beurton A.
- Bhavsar K.
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- Bigio B.
- Bilbao A.
- Bilguvar K.
- Biondi A.
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- Blanch G.R.
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- Blanco I.
- Blandinières A.
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- Soler-Palacín P.
- Soler-Palacín P.
- Solis B.G.
- Solé-Violán J.
- Sottini A.
- Spaan A.N.
- Spaan A.N.
- Stack M.
- Stepanovskiy Y.
- Stijnis C.S.
- Stilma W.
- Stoclin A.
- Su H.C.
- Sua H.C.
- Sánchez-Ramón S.
- Taccone F.
- Tagherset L.
- Tandjaoui-Lambiotte Y.
- Tandjaoui-Lambiottea Y.
- Tangy F.
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- Taupin J.L.
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- Tellier M.C.
- Terrier B.
- Terrier B.
- Terrier O.
- Terzian Z.
- Teunissen C.
- Thoral P.
- Thumerelle C.
- Thy M.
- Timsit J.F.
- Tomasoni G.
- Tores F.
- Toubert A.
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- Treoux T.
- Trouillet-Assant S.
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- Troya J.
- Tsang J.S.
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- Tual C.
- Tubiana S.
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- Tucci A.
- Turvey S.
- Téoulé F.
- Uddin F.
- Uddin M.J.
- Ungeheuer M.N.
- Universitat Autònoma de Barcelona
- Ursini M.V.
- Ursini M.V.
- Uzunhan Y.
- Vabres P.
- Valencia-Ramos J.
- Valsecchi M.G.
- van Agtmael M.
- van Baarle F.
- van de Beek D.
- van de Beek D.
- van de Beek D.
- van Den Rym A.M.
- van der Poll T.
- van der Valk M.
- van der Werf S.
- van der Werf S.
- van Mourik N.
- van Vugt M.
- Vandernoot I.
- Vanel N.
- Vasse M.
- Vatansev H.
- Vazquez S.E.
- Veelo D.
- Veislinger A.
- Viel S.
- Vignali V.
- Vilain C.
- Vilaire M.E.
- Vincent A.
- Vinh D.C.
- Vinh D.C.
- Visseaux B.
- Visseaux B.
- Vlaar A.P.J.
- Vladikine N.
- Vogt G.
- Voiriot G.
- von Bernuth H.
- Vuotto F.
- Vélez-Santamaria V.
- Wang Q.
- Washington N.
- Wiedemann A.
- Woollett M.
- Wouters D.
- Yang R.
- Yasar K.K.
- Yazdanpanah Y.
- Yazdanpanah Y.
- Yosunkaya A.
- Young B.E.
- Yucel F.
- Zannad F.
- Zarhrate M.
- Zatz M.
- Zawadzki P.
- Zhang P.
- Zhang Q.
- Zhang S.Y.
- Zhang Y.
- Zwinderman A.H.
- Íñigo-Campos A.
- Publication venue
- 'American Association for the Advancement of Science (AAAS)'
- Publication date
- 01/01/2020
- Field of study
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men
SARS-CoV-2 susceptibility and COVID-19 disease severity are associated with genetic variants affecting gene expression in a variety of tissues
- Author
- Aarno Palotie
- Abdolmajid Hosseini
- Abdulaziz AlMalik
- Abdulraheem Alshareef
- Achille Iolascon
- Adam S. Butterworth
- Afshar Etemadi Aleagha
- Agnese Verzuri
- Agostino Ognibene
- Agostino Riva
- Ahmadreza Niavarani
- Ahna Girshick
- Aida Fiz-Lopez
- Alba Parra Martınez
- Albandary M. Alowayn
- Albert Tenesa
- Albert V. Smith
- Alessandra Guarnaccia
- Alessandra Renieri
- Alessandra Stella
- Alessandra Vergori
- Alessandro Pancrazzi
- Alessia Giorli
- Alex Serra-Llovich
- Alex Soriano
- Alex Stuckey
- Alexander Labkowsky
- Alexander T. Williams
- Alexander W. Charney
- Alexandra Aksentijevich
- Alexandre Belisle
- Ali Amirsavadkouhi
- Ali Sobh
- Alice Donati
- Alicia de Felipe Mimbrera
- Alicia R. Martin
- Alireza Adamsara
- Altaf Ali
- Amal Al Mutairi
- Amin K. Khattab
- Amr M. Yassen
- Amr Samir
- Amy Trankiem
- Anastasia Lucas
- Andre G. Uitterlinden
- Andrea Antinori
- Andrea Cossarizza
- Andrea Ganna
- Andrea Ganna
- Andrea Martın-Nalda
- Andrea Tommasi
- Andres Metspalu
- Andrew Beck
- Andrew P. Boughton
- Anil P. S. Ori
- Ann E. Woolley
- Anna Canaccini
- Anna Carreras
- Anna Dominguez-Mayoral
- Anna L. Guyatt
- Anna M. Planas
- Anna Maria Pinto
- Annarita Giliberti
- Anne E. Justice
- Anne Kallaste
- Anne Marie O’Connell
- Anne Richmond
- Anne Richmond
- Anne-Sophie Sauvage
- Annique Claringbould
- Anoud Albader
- Antonella D’Arminio Monforte
- Antonella Vincenti
- Antonio Di Biagio
- Antonio Perrella Francesco Bianchi
- Anu Tamm
- Anurag Verma
- Archie Campbell
- Archie Campbell
- Arianna Emiliozzi
- Arianna Gabrieli
- Aris Baras
- Arthur Timothy D
- Asher Haug Baltzell
- Ashish Yadav
- Athanasios Kousathanas
- Attia A. S. Mohamed
- Aubrey Annis
- Augusto Rendon
- Avromie Karp
- Bader Alghamdi
- Bahareh Sharififard
- Bandar A. Suliman
- Barbara Rossetti
- Bari Britvan
- Bartlomiej P. Przychodzen
- Beatriz Cortes
- Beatriz Dietl
- Ben M. Brumpton
- Benjamin M. Neale
- Benoit Misset
- Bernard Lambermont
- Bhavi Trivedi
- Binglan Li
- Biswarup Ghosh
- Bjørn Olav Asvold
- Bluma Brenner
- Brett L. Collins
- Brooke Rhead
- Brooke Wolford
- Brooke Wolford
- Brooke Wolford Sebastian Zo¨ llner
- Bruno Frediani
- Carlo Rivolta
- Carlos Domingo
- Carlota Dobano
- Carmelo Piscopo
- Carmen Marciano
- Carolina Medina-Gomez
- Caroline Cusick
- Caroline Hayward
- Caroline Hayward
- Caterina Lo Rizzo
- Catherine A. Ball
- Catherine E. Bee
- Catherine John
- Cathy Voide
- Cesira Nencioni
- Charlotte Guzman
- Chiara Barbieri
- Chiara Batini
- Chiara Fallerini
- Chiara Gabbi
- Chiara Spertilli
- Chloe Fawns-Ritchie
- Chloe Fawns-Ritchie
- Chris C. A. Spencer
- Chris Tselios
- Christelle Meuris
- Christian Von Frenckell
- Christine Stevens
- Christine Stevens
- Christopher A. Odhams
- Christopher J. Griffiths
- Christopher J. O’Donnell
- Christopher R. Gignoux
- Christos Polymeropoulos
- Chureerat Phokaew
- Claire Churchhouse
- Claudia Suardi
- Claudio Ferri
- Clive Hoggart
- Cotton Seed
- CRiPSI
- Cristen Willer
- Cristina Mussini
- D'Antonio Matteo
- D'Antonio-Chronowska Agnieszka
- Daiana Aguero
- Dan Mason
- Daniel Auld
- Daniel E. Kaufmann
- Daniel I. Chasman
- Daniel J. Wilson
- Daniel King
- Daniel M. Jordan
- Daniel Rader
- Daniel Rhodes
- Daniela Francisci
- Danielle Henry
- Danilo Tacconi
- Danny Park
- Darin Adra
- Dave J. Carey
- David A. van Heel
- David Bennett
- David Bernardo
- David Dalmau
- David H. Wyllie
- David J. Porteous
- David J. Porteous
- David R. Morrison
- David Torrents
- Davide Grassi
- Davide Romani
- Deema AlZahrani
- Derrick W. Crook
- Dhryata Kamdar
- Diana Alaverdian
- Diego Ripamonti
- Dionysios Neofytos
- Doaa Shahin
- Domenico A. Coviello
- Dona Baraka
- Donatella Acquilini
- Dorota Pasko
- Douglas M. Shaw
- Duncan Emma
- Duncan S. Palmer
- Ebrahim S. Mahmoud
- Ebtehal Alsolm
- Eco (E. J. C. ) de geus
- Edoardo Conticini
- Edward J. Hollox
- Edward Laane
- Eimear E. Kenny
- Elena Andreucci
- Elena Bargagli
- Elena Desanctis
- Elena Jimenez-Xarrie
- Elena Muino
- Eliecer Coto
- Elisa Arribas
- Elisa Benetti
- Elisa Frullanti
- Elisabetta Menatti
- Elisabetta Schiaroli
- Elizabeth G. Atkinson
- Elizabeth W. Karlson
- Eman Barhoush
- Emanuele Catena
- Emanuele Di Angelantonio
- Emma F. Perez
- Emma L. Adams
- Ene Reimann
- Enrico Martinelli
- Eric E. Schadt
- Erik Solligard
- Erwin Schurr
- Esteban Lopera
- Esther Gonzalez-Villa
- Eugenia Quiros-Roldan
- Eurie L. Hong
- F. Kyle Satterstrom
- Fabio Lena
- Faisal Almalki
- Fatimah Alqubaishi
- Fawz Al Harthi
- Federica Gaia Miraglia
- Federico Anedda
- Federico Franchi
- Ferdinando Giannattasio
- FHoGID RegCOVID
- Filippo Aucella
- Filippo Biscarini
- FinnGen
- Floriana Valentino
- Francesca Andretta
- Francesca Fava
- Francesca Gatti
- Francesca Mari
- Francesca Montagnani
- Francesco Castelli
- Francesco Paciosi
- Francesco Paciosi
- Francesco Raimondi
- Francesco Vladimiro Segala
- Francisca Ruiz-Jaen
- Francisco Lozano
- Franco Maggiolo
- Frazer
- Frederic Frippiat
- G. Mark Lathrop
- Gabriella Coiro
- Gabriella Doddato
- Gabriella Maria Squeo
- Gavin Band
- Geetha Chittoor
- Gemma Castano-Vinyals
- Gemma Serrano-Heras
- Genes &
- Genevieve Roberts
- Genni Spargi
- Georgia Chan
- Giada Beligni
- Gian Piero Caldarelli
- Gianfranco Parati
- Gilles Darcis
- Gillian M. Belbin
- Gina Peloso
- Giordano Botta`
- Girish N. Nadkarni
- Gita A. Pathak
- Gita A. Pathak
- Giulianini Franco
- Giuseppe Fiorentino
- Giuseppe Merla
- Giusy Tiseo
- Gloria Pessina
- Goncalo R. Abecasis
- Gopal Sarma
- Guillaume Butler-Laporte
- Guillaume ButlerLaporte
- Guillermo M. Albaiceta
- Hadeel AlBardis
- Hakon Hakonarson
- Hakon Hakonarson
- Hamed Abdollahi
- Hani Al-Afghani
- Hannah Polikowski
- Hanteera S. Moahmed
- Harendra Guturu
- Health Research Team
- Helene Alavere
- Hengameh Ansari Tadi
- Hilary C. Martin
- Hilary Finucane
- Howard D. Sesso
- Hugo Zeberg
- Hung-Hsin Chen
- Huy Nguyen
- Ilaria Meloni
- Ilaria Rancan
- Iman Almohammed
- Immacolata Andolfo
- Inge Ringmets
- Irene Salib
- Irene van Blokland
- Isabella Zanella
- Israel Fernandez-Cadenas
- Ivan Galvan-Femenia
- J. Brent Richards
- J. Brent Richards
- J. Michael Gaziano
- Jaana Pesukova
- Jack A. Kosmicki
- Jacob Armstrong
- Jacqueline I. Goldstein
- Jahad Alghamdi
- Jaime Masjuan
- James B. Meigs
- James F. Wilson
- Jara Carcel-Marquez
- Jean-Baptiste Giot
- Jehad K. Albakri
- Jehan J. El-Jawhari
- Jekaterina Tabri
- Jennifer Below
- Jennifer E. Huffman
- Jennifer R. Harris
- Jessica Jacques
- Jiannis Ragoussis
- Jing Hua Zhao
- Jiongming Wang
- Joan Marti-Fabregas
- Joan Montaner Villalonga
- JoAnn E. Manson
- Joel Starkopf
- John Danesh
- John Wright
- Jonathan Afilalo
- Jonathan Grip
- Jonathan Shortt
- Jonathon LeFaive
- Jordan W. Smoller
- Jordi Perez-Tur
- Josep L. Bedini
- Josep Maria Mercader
- Josep Mercader
- Joseph B. Leader
- Joseph B. McCormick
- Joseph D. Buxbaum
- Joseph R. Glessner
- Joseph T. Glessner
- Jouke Jan Hottenga
- Juan Gomez
- Judith Garcia-Aymerich
- Judith. M. Vonk
- Judy H. Cho
- Juha Karjalainen
- Julie E. Buring
- Julie E. Horowitz
- Julien Guiot
- Julien Guntz
- Junghyun Jung
- Justine K. Rudkin
- Kai Kisand
- Kamal Okasha
- Karen A. Hunt
- Kari North
- Karolina Chwialkowska
- Katherine Keller
- Kathleen C. Barnes
- Kathrin Aprile von Hohenstaufen
- Kati Donner
- Kati Hensen
- Kati Kristiansson
- Katia Capitani
- Katja Kivinen
- Keith Noto
- Kelly A
- Kelly Cho
- Kenton D’Mellow
- Kevin W. Li
- Konrad J. Karczewski
- Kristi Lall
- Kristi Niblo
- Kristian Hveem
- Kristin Rand
- Kristin Tsuo
- Kristina Zguro
- Kristjan Metsalu
- Kristy Crooks
- Kumar Veerapen
- Kumardeep Chaudhary
- Kyle Gettler
- Laetitia Laurent
- Laia Llucia-Carol
- Laila Al-Awdah
- Lara Lloret Iglesias
- Lara Tang
- Laura Bergantini
- Laura D. Venn
- Laura Di Sarno
- Laura G. Sloofman
- Laura M. Huckins
- Lauro Sumoy
- Leen Abu Safieh
- Leonardo Croci
- Leonardo Marquez
- Lia Crotti
- Liam L. Hiester
- Lili Milani
- Lill-Iren S. Trogstad
- Lindo Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambul
- Lindokuhle Nkambule
- Lindokuhle Nkambule
- Lorenzo Salerni
- Louis Petitjean
- Louise V. Wain
- Loukas Moutsianas
- Luca Cantarini
- Luca Guidelli
- Luca Masucci
- Lude Franke Marike Boezen
- Luisa Tavecchia
- Luong Ruiz
- M. Arfan Ikram
- Maarja Lepamets
- Madeleine Durand
- Madonna M. Eltoukhy
- Maha Albeladi
- Mahmoud Abdel-Aziz
- Mairo Puusepp
- Malak Abedalthagafi
- Manal Alaamery
- Manolis Kogevinas
- Mansour Almutairi
- Manuel A. R. Ferreira
- Marc Afilalo
- Marcela Morris
- Marco Castori
- Marco Falcone
- Marco Feri
- Marco Gori
- Marco Mandala`
- Marco Rizzi
- Marco Tanfoni
- Marco Vecchia
- Margherita Baldassarri
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari E. K. Niemi
- Mari Kaunisto
- Maria Antonietta Mazzei
- Maria Antonietta Mencarelli
- Maria Bandini
- Maria J. Arranz
- Maria Lorubbio
- Maria Palmieri
- Maria Teresa La Rovere
- Marie Coignet
- Marie Thys
- Mario Capasso
- Mario Tumbarello
- Mario Umberto Mondelli
- Marissa Zyndorf.
- Mark Daly
- Mark J. Caulfield
- Markus Perola
- Marta Corridi
- Marta Garcıa-Clemente
- Marta GuindoMartinez
- Marta L. DeDiego
- Martin D. Tobin
- Marwa H. Elnagdy
- Mary Ann Belli
- Mary K. Balaconis
- Marylyn D. Ritchie
- Masahiro Kanai
- Masahiro Kanai
- Masahiro Kanai
- Massimiliano Fabbiani
- Massimo Carella
- Massimo Di Pietro
- Massimo Girardis
- Massimo Mangino
- Massimo Vaghi
- Mathieu Quinodoz
- Matsui Hiroko
- Matteo Bassetti
- Matteo Della Monica
- Matteo Siano
- Matthew C. Gass
- Matthew Solomonson
- Matthew Solomonson
- Matti Pirinen
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Mattia Cordioli
- Maureen Oliveira
- Maurizio Bussotti
- Maurizio Sanarico
- Maurizio Sanguinetti
- May Alrashed
- Meike Bartels
- Melania Degli Antoni
- Menachem Zlatopolsky
- Meriem Bouab
- Miao Zhang
- Michael Gaddis
- Michael Hultstro¨ m
- Michael N. Cantor
- Michael Peruggia
- Michael Preuss
- Michae¨ l Chasse´
- Michel (M. G. ) Nivard
- Michel Georges
- Michel Moutschen
- Michelle Daya
- Mihael H. Polymeropoulos
- Miklos Lipcsey
- Milos Pavlovic
- Mirella Bruttini
- Miriam Lucia Carriero
- Miriana D’Alessandro
- Mirjam Lista
- Mohamed A. F. Hegazy
- Mohamed R. El-shanshory
- Mohamed S. Abd Elghafar
- Mohamed S. Torky
- Mohammad S. Fawzy
- Mohammed A. Eid
- Mona Sawaji
- Moneera Alswailm
- Monica Poscente
- Monnat Pongpanich
- Monpat Chamnanphon
- Morteza Saeedi
- Nadia Harerimana
- Nardin Rezk Branka Vulesevic
- Natalia Blay
- Natalia Cullell
- Nathalie Brassard
- Nathan Berkowitz
- Nathan Cheng
- Nattiya Hirankarn
- Navya Shilpa Josyula
- Nguyen Jennifer P
- Nicholas Rafaels
- Nick Shrine
- Nicola Picchiotti
- Nicolas Arning
- Nicolas Tardif
- Nicole Soranzo
- Nikolas Baya
- Nils Koelling
- Noam D. Beckmann
- Noemie Boillat
- Noemie Suh
- Nofar Kimchi
- Noor Mamlouk
- Nora Aljawini
- Nouf AlDhawi
- Nour Albesher
- Noura S. Abul-Husn
- Olav Rooyackers
- Olivier Malaise
- Olumide Adeleye
- Opass Putchareon
- Oreste De Vivo
- P-PredictUs SeroCOVID
- Pajaree Chariyavilaskul
- Paloma de la Cal-Sabater
- Paloma Menendez-Valladares
- Pamela Raggi
- Paola Bergomi
- Paola Petrocelli
- Paolo Cameli
- Paolo Di Domenico
- Paolo Piacentini
- Part Peterson
- Pascale Huynen
- Patrick Deelen
- Patrick Turley
- Patrizia Zucchi
- Pattama Torvorapanit
- Paul H. Lee
- Paul M. Ridker
- Paul Naaber
- Paul O’Reilly
- Paul R. H. J. Timmers
- Pauline Lanting
- Per Magnus
- Pere Soler
- Petty E. Lauren
- Phil Tsao
- Philippe Le´ onard
- Pier Giorgio Scotton
- Pierpaolo Parravicini
- Pierre Lepage
- Pierre-Yves Bochud
- Pietro Pinoli
- Pimpayao Sodsai
- Pintip Suchartlikitwong
- Prabhu Arumugam
- Qin Qin Huang
- Rachel G. Liao
- Rafael de Cid
- Raffaele Bruno
- Raffaele Scala
- Raghavendran Partha
- Rahul Gupta
- Raili Allos
- Rana Hasanato
- Rasoul Aliannejad
- Ravaglia Sabrina
- Raymond K. Walters
- Reedik Magi
- Renato Polimanti
- Renzo Scaggiante
- Riccardo Colombo
- Richard C. Trembath
- Richard H. Scott
- Richard J. Packer
- Rita Perna
- Roaa T. Halawani
- Robert C. Free
- Robert C. Green
- Robert Frithiof
- Robert P. Sebra
- Robert Warmerdam
- Roberta Russo
- Roger Colobran
- Ron Do
- Rosangela Artuso
- Rossella Tita
- Rui Li
- Ruth J. F. Loos
- Ryan C. Thompson
- Sabine Claassen
- Sabino Scolletta
- Sabrina Ravaglia
- Saeideh Ahmadi
- Salam Massadeh
- Saleh Alqahtani
- Sam Bryant
- Sam Bryant
- Sam Choi
- Sameer Chavan
- Sameera AlJohani
- Sami Koskelainen
- Samira Azarzar
- Samuli Ripatti
- Sandra P. Smieszek
- Sandro Mancarella
- Sandro Panese
- Sanni Ruotsalainen
- Sara Alotaibi
- Sara Amitrano
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sara Pigazzini
- Sarah Alkwai
- Sarah Finer
- Sarah G. Earle
- Sauro Luchi
- Saverio Giuseppe Parisi
- Scott T. Weiss
- Sebastian Garcıa Madrona
- Semira Gonseth Nussle
- Serafina Valente
- Serena Ludovisi
- Serghei Mangul
- Sergio Daga
- Seyed Behrooz Mohseni Moghaddam
- Shang-Kuan Lin
- Shannon McCurdy
- Shawn N. Murphy
- Shawneequa Callier
- Shea J. Andrews
- Shea J. Andrews
- Shea J. Andrews
- Shefali S. Verma
- Shona M. Kerr
- Silvia Baroni
- Silvia Cappelli
- Silvia Rojo
- Simona Dei
- Simona Marcantonio
- Simona Sarzi-Braga
- Simone Furini
- Slayton J. Underwood
- Sophie Venturelli
- Souad Rahmouni
- Spencer Knight
- Stefania Mantovani
- Stefano Baratti
- Stefano Busani
- Stefano Ceri
- Stefano Rusconi
- Stephanie Bibert
- Stephen J. Wicks
- Steven Ascolillo
- Ste´ phanie Gofflot
- Stuart C. Sealfon
- Susan Walker
- Susanna Croci
- Susanna Guerrini
- Tala Abdullah
- Tamer A. Elhadidy
- Tess Levy
- Thanyawee Puthanakit
- Thitima B. Suttichet
- Tim D. Spector
- Tiziana Bachetti
- Tom Fowler
- Tomas Segura
- Tomislav Maricic
- Tomoko Nakanishi
- Tomoko Nakanishi
- Tonu Esko
- Tooraj Mirshahi
- Tormod Rogne
- Triin Laisk
- Tullio Trotta
- Valentina Anemoli
- Vasilios Polymeropoulos
- Veronica Rico
- Veronica Robles
- Ve´ronique Erard
- Victor Moreno
- Vincent Mooser
- Vincenzo Forgetta
- Vincenzo Forgetta
- Voraphoj Nilaratanakul
- Vorasuk Shotelersuk
- Walaa A. Felemban
- Walaa M. El-Lawaty
- Walid T. Khafaga
- Wanna Chetruengchai
- Watsamon Jantarabenjakul
- Wei Zhou
- Wei Zhou
- Wenhan Lu
- Werner Albrich
- Xavier Farre
- Xiao Chang
- Xiao Chang
- Xiaoqing Xue
- Xueyang Wang
- Yan V. Sun
- Yaseen M. Arabi
- Yasmine Belhaj
- Yasser M. El-Sherbiny
- Yen-Chen Anne Feng
- Yuk-Lam Ho
- Yuki Bradford
- Yunsung Lee
- Yuval Itan
- Yves Beguin
- Zaman Afrasiabi
- Zeinab Naderpour
- Zhu Wanying
- Ziab Z. Alahmadey
- Øyvind Helgeland
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2022
- Field of study
Variability in SARS-CoV-2 susceptibility and COVID-19 disease severity between individuals is partly due to
genetic factors. Here, we identify 4 genomic loci with suggestive associations for SARS-CoV-2 susceptibility
and 19 for COVID-19 disease severity. Four of these 23 loci likely have an ethnicity-specific component.
Genome-wide association study (GWAS) signals in 11 loci colocalize with expression quantitative trait loci
(eQTLs) associated with the expression of 20 genes in 62 tissues/cell types (range: 1:43 tissues/gene),
including lung, brain, heart, muscle, and skin as well as the digestive system and immune system. We perform
genetic fine mapping to compute 99% credible SNP sets, which identify 10 GWAS loci that have eight or fewer
SNPs in the credible set, including three loci with one single likely causal SNP. Our study suggests that the
diverse symptoms and disease severity of COVID-19 observed between individuals is associated with variants across the genome, affecting gene expression levels in a wide variety of tissue types
- …