A brief review of the effect of wildfires on rockfall occurrence

Wildfires and rockfalls are among the major hazards in forested mountainous regions across Europe. Understanding processes and conditions that lead to rockfalls during and after a wildfire in different geological contexts is, therefore, of great relevance. The increase of rockfalls associated with the occurrence of wildfires is connected to several factors, not only in the detached area but also in the propagation and affected area. Wildfires cause changes in the mechanical properties of rocks and discontinuities as well as the loss of protective capacity from vegetation, complemented by the effect induced by firefighting activities and by extreme temperatures that may deteriorate the installed protective measures. After the occurrence of a wildfire, there is an increase in the frequency and intensity of rockfalls in the burned area, causing a major impact of rockfalls on road networks and inhabited areas. Additionally, the rockfall risk perception is usually increased due to the removal of vegetation by wildfires, exposing both rock blocks and the rock mass. In this review, the main factors that influence the occurrence of rockfalls after a wildfire are briefly reviewed

A global customer experience management architecture

Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. A. Cuadra-Sanchez, M. Cutanda-Rodriguez, I. Perez-Mateos, A. Aurelius, K. Brunnstrom, J. Laulajainen, M. Varela, and J. E. López de Vergara, "A global customer experience management architecture", in Future Network and Mobile Summit, 2012, 1-8The quality of experience (QoE) is one of the main research lines in ITC industry, which seeks to manage quality as perceived by users. This document analyzes and describes requirements of a QoE driven management system architecture, which has been designed in the Celtic IPNQSIS project. The architecture is grouped into different levels: Data acquisition level, Monitoring level and Control Level. Each level comprises a specific set of capacities, such as Data collector, or Traffic Monitor amongst others. The architecture described in this paper constitutes the guidelines of the IPNQSIS project in terms of a QoE ecosystem that will settle the basis of global customer experience management architecture.This work is carried out in the framework of the Celtic and EUREKA initiative IPNQSIS (IP Network Monitoring for Quality of Service Intelligent Support) and has been partially funded by CDTI under Spanish PRINCE (PRoducto INdustrial para la gestión de la Calidad de Experiencia) project, meanwhile the Swedish part of the project is co funded by VINNOVA and the work of Finnish partners has been partially funded by Tekes

Different profiles of immune reconstitution in children and adults with HIV-infection after highly active antiretroviral therapy

BACKGROUND: Recent advances in characterizing the immune recovery of HIV-1-infected people have highlighted the importance of the thymus for peripheral T-cell diversity and function. The aim of this study was to investigate differences in immune reconstitution profiles after highly active antiretroviral therapy (HAART) between HIV-children and adults. METHODS: HIV patients were grouped according to their previous clinical and immunological status: 9 HIV-Reconstituting-adults (HIV-Rec-adults) and 10 HIV-Reconstituting-children (HIV-Rec-children) on HAART with viral load (VL) ≤400 copies/ml and CD4(+ )≥500 cells/μL at least during 6 months before the study and CD4(+ )≤300 cells/μL anytime before. Fifteen healthy-adults and 20 healthy-children (control subjects) were used to calculate Z-score values to unify value scales between children and adults to make them comparable. RESULTS: HIV-Rec-children had higher T-cell receptor excision circles (TREC) and lower interleukin (IL)-7 levels than HIV-Rec-adults (p < 0.05). When we analyzed Z-score values, HIV-Rec-children had higher TREC Z-score levels (p = 0.03) than HIV-Rec-adults but similar IL-7 Z-score levels. Regarding T-cell subsets, HIV-Rec-children had higher naïve CD4(+ )(CD4(+)CD45RA (hi+)CD27(+)), naïve CD8(+ )(CD8(+)CD45RA (hi+)CD27(+)), and memory CD8(+ )(CD8(+)CD45RO(+)) cells/μl than HIV-Rec-adults, but similar memory CD4(+ )(CD4(+)CD45RO(+)) counts. HIV-Rec-children had lower naïve CD8(+ )Z-score values than HIV-Rec-adults (p = 0.05). CONCLUSION: Our data suggest that HIV-Rec-children had better thymic function than HIV-Rec-adults and this fact affects the peripheral T-cell subsets. Thus, T-cell recovery after HAART in HIV-Rec-adults could be the consequence of antigen-independent peripheral T-cell expansion while in HIV-Rec-children thymic output could play a predominant role in immune reconstitution

NUP98 is fused to HOXA9 in a variant complex t(7;11;13;17) in a patient with AML-M2

The t(7;11)(p15;p15.4) has been reported to fuse the NUP98 gene (11p15), a component of the nuclear pore complex, with the class-1 homeobox gene HOXA9 at 7p15. This translocation has been associated with myeloid leukemias, predominantly acute myeloid leukemia (AML) M2 subtype with trilineage myelodysplastic features, and with a poor prognosis. The derived fusion protein retains the FG repeat motif of NUP98 N-terminus and the homeodomain shared by the HOX genes, acting as an oncogenic transcription factor critical for leukemogenesis. We report here a new complex t(7;11)-variant, i.e., t(7;11;13;17)(p15;p15;p?;p1?2) in a patient with AML-M2 and poor prognosis. The NUP98-HOXA9 fusion transcript was detected by RT-PCR, suggesting its role in the malignant transformation as it has been postulated for other t(7;11)-associated leukemias. No other fusion transcripts involving the NUP98 or HOXA9 genes were present, although other mechanisms involving several genes on chromosomes 13 and 17 may also be involved. To our knowledge, this is the first t(7;11) variant involving NUP98 described in hematological malignancies

Radial Distribution of Near-UV Flux in Disc Galaxies in the range 0<z<1

(Abridged) The goal of this paper is to quantify the changes on the SF distribution within the disc galaxies in the last ~8 Gyr. We use as a proxy for the SF radial profile the Near-UV surface brightness distributions, allowing suitably for extinction. We compare the effective radii (R_eff) and concentration of the flux distribution in the rest-frame Near-UV for a sample of 270 galaxies in the range 0<z<1. This radial distribution is compared to that measured in the rest-frame B-band, which traces older stellar populations. The analysis is performed using deep, high resolution, multi-band images from GALEX, SDSS, and HST/ACS - GOODS-South. The relation R_eff(NUV)- M* suffers a moderate change between z~1 and z~0: at a fixed stellar mass of 1E10 M_sun, galaxies increase their effective radii by a factor 1.18+/-0.06. Median profiles in NUV show signs of truncation at R~R_eff, and median colour profiles (NUV-B) show a minimum (a "bluest" point) also around R~1-1.5 R_eff. The distributions of NUV flux are more compact at z~1 than nowadays, in terms of the fraction of flux enclosed in a specific radius (in kpc). Our results indicate that the SF surface density has decreased dramatically in discs since z~1, and this decline has been more intense in the central parts (<~R_eff) of the galaxies. In addition, our data suggest that the bulges/pseudo-bulges have grown in surface brightness with regard to the discs since z~1.Comment: 26 pages, 21 figures, accepted for publication in Astronomy & Astrophysics on March 21s

Integral Field Spectroscopy of a sample of nearby galaxies. I. Sample, Observations and Data Reduction

Aims: Integral Field Spectroscopy (IFS) is a powerful approach for the study of nearby galaxies since it enables a detailed analysis of their resolved physical properties. Here we present the sample of nearby galaxies selected to exploit the two dimensional information provided by the IFS. Methods: We observed a sample of 48 galaxies from the Local Universe with the PPAK Integral Field Spectroscopy unit (IFU), of the PMAS spectrograph, mounted at the 3.5m telescope at Calar Alto Observatory (Almeria, Spain). Two different setups were used during these studies (low -V300- and medium -V600- resolution mode) covering a spectral range of around 3700-7000 Angs. We developed a full automatic pipeline for the data reduction, that includes an analysis of the quality of the final data products. We applied a decoupling method to obtain the ionised gas and stellar content of these galaxies, and to derive the main physical properties of the galaxies. To asses the accuracy in the measurements of the different parameters, we performed a set of simulations to derive the expected relative errors obtained with these data. In addition, we extracted two aperture, central and integrated spectra, from the datacubes. The main properties of the stellar populations and ionised gas of these galaxies and an estimate of their relative errors are derived from those spectra, as well as from the whole datacubes. Results: The comparison of the central spectrum extracted from the datacubes and the SDSS spectrum for those galaxies in common shows a good agreement between the derived values from both samples. We find differences in the properties of galaxies when comparing a central and an integrated spectra, showing the effects of the extracted aperture in the interpretation of the data. Finally, we present two dimensional maps of some of the main properties derived with the decoupling procedure.Comment: 17 pages, 20 figures, accepted for publication in A&

Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry

Spanish Myeloma Group (GEM) and Grupo Castellano-Leones de Gammapatias Monoclonales, cooperative study groups: et al.Multiple myeloma remains largely incurable. However, a few patients experience more than 10 years of relapsefree survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with a complete response, since some patients revert to having a profile of monoclonal gammopathy of undetermined significance. We compared the distribution of multiple compartments of lymphocytes and dendritic cells in the bone marrow and peripheral blood of multiple myeloma patients with long-term disease control (n=28), patients with newly diagnosed monoclonal gammopathy of undetermined significance (n=23), patients with symptomatic multiple myeloma (n=23), and age-matched healthy adults (n=10). Similarly to the patients with monoclonal gammopathy of undetermined significance and symptomatic multiple myeloma, patients with long-term disease control showed an expansion of cytotoxic CD8 + T cells and natural killer cells. However, the numbers of bone marrow T-regulatory cells were lower in patients with long-term disease control than in those with symptomatic multiple myeloma. It is noteworthy that B cells were depleted in patients with monoclonal gammopathy of undetermined significance and in those with symptomatic multiple myeloma, but recovered in both the bone marrow and peripheral blood of patients with long-term disease control, due to an increase in normal bone marrow B-cell precursors and plasma cells, as well as pre-germinal center peripheral blood B cells. The number of bone marrow dendritic cells and tissue macrophages differed significantly between patients with long-term disease control and those with symptomatic multiple myeloma, with a trend to cell count recovering in the former group of patients towards levels similar to those found in healthy adults. In summary, our results indicate that multiple myeloma patients with long-term disease control have a constellation of unique immune changes favoring both immune cytotoxicity and recovery of B-cell production and homing, suggesting improved immune surveillance.This work was supported by the Cooperative Research Thematic Network (RTICCs; RD06/0020/0006 and G03/136), Instituto de Salud Carlos III/ Subdirección General de Investigación Sanitaria (FIS: PI060339; 06/1354; 02/0905; 01/0089/01-02; PS09/01897/01370) and Consejeria de Educacion (GR37) and Consejería de Sanidad, Junta de Castilla y León, Valladolid, Spain (557/A/10). The authors also thank the Fundación Carolina-BBVA for supporting and promoting the exchange of medical researchers from Latin America to Spain.Peer Reviewe

Primary care randomized clinical trial: manual therapy effectiveness in comparison with TENS in patients with neck pain

This study investigated effectiveness of manual therapy (MT) with transcutaneous electrical nerve stimulation (TENS) to reduce pain intensity in patients with mechanical neck disorder (MND). A randomized multi-centered controlled clinical trial was performed in 12 Primary Care Physiotherapy Units in Madrid Region. Ninety patients were included with diagnoses of subacute or chronic MND without neurological damage, 47 patients received MT and 43 TENS. The primary outcome was pain intensity measured in millimeters using the Visual Analogue Scale (VAS). Also disability, quality of life, adverse effects and sociodemographic and prognosis variables were measured. Three evaluations were performed (before, when the procedure ?nished and six months after). Seventy-one patients (79%) completed the follow-up measurement at six months. In more than half of the treated patients the procedure had a clinically relevant ?short term? result after having ended the intervention, when either MT or TENS was used. The success rate decreased to one-third of the patients 6 months after the intervention. No differences can be found in the reduction of pain, in the decrease of disability nor in the quality of life between both therapies. Both analyzed physiotherapy techniques produce a short-term pain reduction that is clinically relevant.Ministerio de SanidadInstituto de Salud Carlos II