Examining the feasibility of acceptance and commitment therapy self-help for problematic pornography viewing: Results from a pilot open trial

This pilot study evaluated the feasibility of an acceptance and commitment therapy (ACT) self-help program for problematic pornography viewing (PV). A sample of 19 adults seeking help for problematic PV was recruited in an open trial. Participants reported adequate program acceptability, although only 45% of those completing post-assessment read at least half of the self-help book. Significant improvements on problematic PV and cognitive fusion were found over the 8-week intervention period, with effects sustaining at 8-week follow-up. Participants who read more improved more on PV problems and psychological inflexibility. Overall, an ACT self-help approach appears feasible and potentially efficacious for PV

Chemical differentiation in regions of high-mass star formation I. CS, dust and N2H^+ in southern sources

Aims. Our goals are to compare the CS, N2H+ and dust distributions in a representative sample of high-mass star forming dense cores and to determine the physical and chemical properties of these cores. Methods. We compare the results of CS(5-4) and 1.2 mm continuum mapping of twelve dense cores from the southern hemisphere presented in this work, in combination with our previous N2H+(1-0) and CS(2-1) data. We use numerical modeling of molecular excitation to estimate physical parameters of the cores. Results. Most of the maps have several emission peaks (clumps). We derive basic physical parameters of the clumps and estimate CS and N2H+ abundances. Masses calculated from LVG densities are higher than CS virial masses and masses derived from continuum data, implying small-scale clumpiness of the cores. For most of the objects, the CS and continuum peaks are close to the IRAS point source positions. The CS(5-4) intensities correlate with continuum fluxes per beam in all cases, but only in five cases with the N2H+(1-0) intensities. The study of spatial variations of molecular integrated intensity ratios to continuum fluxes reveals that I(N2H+)/F{1.2} ratios drop towards the CS peaks for most of the sources, which can be due to a N2H+ abundance decrease. For CS(5-4), the I(CS)/F{1.2} ratios show no clear trends with distance from the CS peaks, while for CS(2-1) such ratios drop towards these peaks. Possible explanations of these results are considered. The analysis of normalized velocity differences between CS and N2H+ lines has not revealed indications of systematic motions towards CS peaks.Comment: 13 pages, 5 figures, accepted by Astronomy and Astrophysic

Stress-induced c-Fos expression is differentially modulated by dexamethasone, diazepam and imipramine

Immobilization stress upregulates c-Fos expression in several CNS areas. Repeated stress or the use of drugs can modulate stress-induced c-Fos expression. Here, we investigated in 40 different areas of the rat brain the effects of dexamethasone (SDX, a synthetic glucocorticoid), diazepam (SBDZ, a benzodiazepine), and imipramine (IMI, an antidepressant) on the c-Fos expression induced by restraint stress. Wistar rats were divided into four groups and submitted to 20 days of daily injection of saline (three first groups) or imipramine, 15 mg/kg, i.p. On day 21, animals were submitted to injections of saline (somatosensory, SS), SDX (1 mg/kg, i.p.), SBDZ (5 mg/kg, i.p.), or IMI (15 mg/kg, i.p.) before being submitted to restraint. Immediately after stress, the animals were perfused and their brains processed with immunohistochemistry for c-Fos (Ab-5 Oncogene Science). Dexamethasone reduced stress- induced c-Fos expression in SS cortex, hippocampus, paraventricular nucleus of the hypothalamus (PVH), and locus coeruleus (LC), whereas diazepam reduced c-Fos staining in the SS cortex, hippocampus, bed nucleus of stria terminalis, septal area, and hypothalamus (preoptic area and supramammillary nucleus). Chronic administration of imipramine decreased staining in the hippocampus, PVH, and LC, while increasing it in the nucleus raphe pallidus. We conclude that dexamethasone, diazepam and imipramine differentially modulate stress-induced Fos expression. the present study provides an important comparative background that may help in the further understanding of the effects of these compounds and on the brain activation as well as on the behavioral, neuroendocrine, and autonomic responses to stress.UFRRJ, Dept Physiol Sci, BR-23890000 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Physiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, BrazilWeb of Scienc

Dendritic Cells in Chronic Mycobacterial Granulomas Restrict Local Anti-Bacterial T Cell Response in a Murine Model

Background: Mycobacterium-induced granulomas are the interface between bacteria and host immune response. During acute infection dendritic cells (DCs) are critical for mycobacterial dissemination and activation of protective T cells. However, their role during chronic infection in the granuloma is poorly understood. Methodology/Principal Findings: We report that an inflammatory subset of murine DCs are present in granulomas induced by Mycobacteria bovis strain Bacillus Calmette-guerin (BCG), and both their location in granulomas and costimulatory molecule expression changes throughout infection. By flow cytometric analysis, we found that CD11c + cells in chronic granulomas had lower expression of MHCII and co-stimulatory molecules CD40, CD80 and CD86, and higher expression of inhibitory molecules PD-L1 and PD-L2 compared to CD11c + cells from acute granulomas. As a consequence of their phenotype, CD11c + cells from chronic lesions were unable to support the reactivation of newly-recruited, antigen 85Bspecific CD4 + IFNc + T cells or induce an IFNc response from naïve T cells in vivo and ex vivo. The mechanism of this inhibition involves the PD-1:PD-L signaling pathway, as ex vivo blockade of PD-L1 and PD-L2 restored the ability of isolated CD11c + cells from chronic lesions to stimulate a protective IFNc T cell response. Conclusions/Significance: Our data suggest that DCs in chronic lesions may facilitate latent infection by down-regulating protective T cell responses, ultimately acting as a shield that promotes mycobacterium survival. This DC shield may explai

Re-cycling paradigms: cell cycle regulation in adult hippocampal neurogenesis and implications for depression

Since adult neurogenesis became a widely accepted phenomenon, much effort has been put in trying to understand the mechanisms involved in its regulation. In addition, the pathophysiology of several neuropsychiatric disorders, such as depression, has been associated with imbalances in adult hippocampal neurogenesis. These imbalances may ultimately reflect alterations at the cell cycle level, as a common mechanism through which intrinsic and extrinsic stimuli interact with the neurogenic niche properties. Thus, the comprehension of these regulatory mechanisms has become of major importance to disclose novel therapeutic targets. In this review, we first present a comprehensive view on the cell cycle components and mechanisms that were identified in the context of the homeostatic adult hippocampal neurogenic niche. Then, we focus on recent work regarding the cell cycle changes and signaling pathways that are responsible for the neurogenesis imbalances observed in neuropathological conditions, with a particular emphasis on depression

On the Origin of Scanning: The Impact of Location on Internet-Wide Scans

Fast IPv4 scanning has enabled researchers to answer a wealth of security and networking questions. Yet, despite widespread use, there has been little validation of the methodology’s accuracy, including whether a single scan provides sufficient coverage. In this paper, we analyze how scan origin affects the results of Internet-wide scans by completing three HTTP, HTTPS, and SSH scans from seven geographically and topologically diverse networks. We find that individual origins miss an average 1.6–8.4% of HTTP, 1.5–4.6% of HTTPS, and 8.3–18.2% of SSH hosts. We analyze why origins see different hosts, and show how permanent and temporary blocking, packet loss, geographic biases, and transient outages affect scan results. We discuss the implications for scanning and provide recommendations for future studies

A Genome-Scale DNA Repair RNAi Screen Identifies SPG48 as a Novel Gene Associated with Hereditary Spastic Paraplegia

We have identified a novel gene in a genome-wide, double-strand break DNA repair RNAi screen and show that is involved in the neurological disease hereditary spastic paraplegia