Probing the Circumnuclear Stellar Populations of Starburst Galaxies in the Near-infrared

We employ the NASA Infrared Telescope Facility's near-infrared spectrograph SpeX at 0.8-2.4$\mu$m to investigate the spatial distribution of the stellar populations (SPs) in four well known Starburst galaxies: NGC34, NGC1614, NGC3310 and NGC7714. We use the STARLIGHT code updated with the synthetic simple stellar populations models computed by Maraston (2005, M05). Our main results are that the NIR light in the nuclear surroundings of the galaxies is dominated by young/intermediate age SPs ($t \leq 2\times10^9$yr), summing from $\sim$40\% up to 100\% of the light contribution. In the nuclear aperture of two sources (NGC1614 and NGC3310) we detected a predominant old SP component ($t > 2\times10^9$yr), while for NGC34 and NGC7714 the younger component prevails. Furthermore, we found evidence of a circumnuclear star formation ring-like structure and a secondary nucleus in NGC1614, in agreement with previous studies. We also suggest that the merger/interaction experienced by three of the galaxies studied, NGC1614, NGC3310 and NGC7714 can explain the lower metallicity values derived for the young SP component of these sources. In this scenario the fresh unprocessed metal poorer gas from the destroyed/interacting companion galaxy is driven to the centre of the galaxies and mixed with the central region gas, before star formation takes place. In order to deepen our analysis, we performed the same procedure of SP synthesis using Maraston (2011, M11) EPS models. Our results show that the newer and higher resolution M11 models tend to enhance the old/intermediate age SP contribution over the younger ages

Left atrial appendage thrombosis and persistent atrial fibrillation: Combined treatment with a totally thoracoscopic approach

Minimally invasive surgical ablation is generally contraindicated in patients with atrial fibrillation and thrombosis of the left atrial appendage. We have treated three of these patients using an innovative technique based on a bilateral video-thoracoscopic approach, performing a continuous encircling lesion at the pulmonary veins outflow with radio-frequency ablation, simultaneously excluding the left atrial appendage. The postoperative course was uneventful, without neurologic events and all patients maintained a stable sinus rhythm at 1-year follow-up. This procedure represents a new mini-invasive method to treat persistent atrial fibrillation when partial thrombosis of the left atrial appendage contraindicates other ablation techniques

A panchromatic spatially resolved study of the inner 500pc of NGC1052 -- II: Gas excitation and kinematics

We map the optical and near-infrared (NIR) emission-line flux distributions and kinematics of the inner 320$\times$535pc$^2$ of the elliptical galaxy NGC1052. The integral field spectra were obtained with the Gemini Telescope using the GMOS-IFU and NIFS instruments, with angular resolutions of 0''88 and 0''1 in the optical and NIR, respectively. We detect five kinematic components: (1 and 2) Two spatially unresolved components, being a broad line region visible in H$\alpha$, with a FWHM of $\sim$3200km s$^{-1}$ and an intermediate-broad component seen in the [OIII]$\lambda \lambda$4959,5007 doublet; (3) an extended intermediate-width component with 280<FWHM<450km s$^{-1}$ and centroid velocities up to 400km s$^{-1}$, which dominates the flux in our data, attributed either to a bipolar outflow related to the jets, rotation in an eccentric disc or a combination of a disc and large-scale gas bubbles; (4 and 5) two narrow (FWHM<150km s$^{-1}$) components, one visible in [OIII], and one visible in the other emission lines, extending beyond the field-of-view of our data, which is attributed to large-scale shocks. Our results suggest that the ionization within the observed field of view cannot be explained by a single mechanism, with photoionization being the dominant mechanism in the nucleus with a combination of shocks and photoionization responsible for the extended ionization.Comment: Accepted at MNRAS. 17 pages, 17 figure

Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population

BACKGROUND: Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in gene content and allelic polymorphism. The number of KIR loci has been reported to vary among individuals, resulting in different KIR haplotypes. In this study we report the genotypic structure of KIRs in 217 unrelated healthy Italian individuals from 22 immunogenetics laboratories, located in the northern, central and southern regions of Italy. METHODS: Two hundred and seventeen DNA samples were studied by a low resolution PCR-SSP kit designed to identify all KIR genes. RESULTS: All 17 KIR genes were observed in the population with different frequencies than other Caucasian and non-Caucasian populations; framework genes KIR3DL3, KIR3DP1, KIR2DL4 and KIR3DL2 were present in all individuals. Sixty-five different profiles were found in this Italian population study. Haplotype A remains the most prevalent and genotype 1, with a frequency of 28.5%, is the most commonly observed in the Italian population. CONCLUSION: The Italian Caucasian population shows polymorphism of the KIR gene family like other Caucasian and non-Caucasian populations. Although 64 genotypes have been observed, genotype 1 remains the most frequent as already observed in other populations. Such knowledge of the KIR gene distribution in populations is very useful in the study of associations with diseases and in selection of donors for haploidentical bone marrow transplantation

Physio-chemical characterization of three-component co-amorphous systems generated by a melt-quench method

The purpose of this work was to evaluate the possibility of creating a ternary co-amorphous system and to determine how the properties of a co-amorphous material are altered by the addition of a selected third component. Piroxicam and indomethacin form a stable co-amorphous with the Tg above room temperature. The third component added was selected based on tendency to crystallise (benzamide, caffeine) or form amorphous (acetaminophen, clotrimazole) on cooling. Generated co-amorphous systems were characterised with TGA, HSM, DSC, FTIR, and XRD. Stable ternary co-amorphous systems were successfully generated, which was confirmed using XRD, DSC and FTIR analysis. In all cases, Tg of the ternary system was lower than the Tg of the binary system, although higher than that of the individual third compound. Upon storage for 4 weeks all created ternary systems showed significantly smaller variation in Tg compared to the binary system. Stable three-component co-amorphous systems can be generated via melt quench method using either a crystalline or amorphous third component. Addition of third component can alter the Tg of co-amorphous system and in all cases created more stable co-amorphous system upon storage. Physical parameters may not be sufficient in predicting the resulting Tg, therefore knowledge of chemical interaction must be brought into equation as well

HLA-class I markers and multiple sclerosis susceptibility in the Italian population

Previous studies reported an association with multiple sclerosis (MS) of distinct HLA-class I markers, namely HLA-A*02, HLA-Cw*05 and MOG-142L. In this work, we tested the association with MS of A*02 and Cw*05 in 1273 Italian MS patients and 1075 matched controls, which were previously analyzed for MOG-142, and explored the relationship among these three markers in modulating MS risk. HLA-A*02 conferred a statistically robust MS protection (odds ratio, OR=0.61; 95% confidence intervals, CI=0.51–0.72, P<10−9), which was independent of DRB1*15 and of any other DRB1* allele and remained similar after accounting for the other two analyzed class I markers. Conversely, the protective effect we previously observed for MOG-142L was secondary to its linkage disequilibrium with A*02. Cw*05 was not associated considering the whole sample, but its presence significantly enhanced the protection in the HLA-A*02-positive group, independently of DRB1: the OR conferred by A*02 in Cw*05-positive individuals (0.22, 95% CI=0.13–0.38) was significantly lower than in Cw*05-negative individuals (0.69, 95% CI=0.58–0.83) with a significant (P=4.94 × 10−5) multiplicative interaction between the two markers. In the absence of A*02, Cw*05 behaved as a risk factor, particularly in combination with DRB1*03 (OR=3.89, P=0.0006), indicating that Cw*05 might be a marker of protective or risk haplotypes, respectively

Protein motions and dynamic effects in enzyme catalysis

The role of protein motions in promoting the chemical step of enzyme catalysed reactions remains a subject of considerable debate. Here, a unified view of the role of protein dynamics in dihydrofolate reductase catalysis is described. Recently the role of such motions has been investigated by characterising the biophysical properties of isotopically substituted enzymes through a combination of experimental and computational analyses. Together with previous work, these results suggest that dynamic coupling to the chemical coordinate is detrimental to catalysis and may have been selected against during DHFR evolution. The full catalytic power of Nature's catalysts appears to depend on finely tuning protein motions in each step of the catalytic cycle