2,592 research outputs found
Segregated water observed in a putative fish embryo cryopreservative
Development of new cryopreservation strategies has major potential in medicine and agriculture and is critical to the conservation of endangered species that currently cannot be preserved. A critical property of any potential cryopreservative solution is its ability to prevent cell-damaging ice formation during cooling and subsequent heating. This study focuses on the freezing behaviour of promising model cryoprotective solutions. We perform neutron scattering analysis, combined with computer modelling, of the water structure after quench cooling these solutions. It is found that water in this solution forms nano-clusters encapsulated by the surrounding matrix of cryoprotectant solute molecules. We posit that these small volumes inhibit ice formation, because water does not have space for the structural relaxation required to crystallize on the timescale of the cooling process
Strong Isotope Effects on Melting Dynamics and Ice Crystallisation Processes in Cryo Vitrification Solutions
The nucleation and growth of crystalline ice during cooling, and further crystallization processes during re-warming are considered to be key processes determining the success of low temperature storage of biological objects, as used in medical, agricultural and nature conservation applications. To avoid these problems a method, termed vitrification, is being developed to inhibit ice formation by use of high concentration of cryoprotectants and ultrarapid cooling, but this is only successful across a limited number of biological objects and in small volume applications. This study explores physical processes of ice crystal formation in a model cryoprotective solution used previously in trials on vitrification of complex biological systems, to improve our understanding of the process and identify limiting biophysical factors. Here we present results of neutron scattering experiments which show that even if
ice crystal formation has been suppressed during quench cooling, the water molecules, mobilised during warming, can crystallise as detectable ice. The crystallisation happens right after melting of the glass phase formed during quench cooling, whilst the sample is still transiting deep cryogenic temperatures. We also observe strong water isotope effects on ice crystallisation processes in the cryoprotectant mixture. In the neutron scattering experiment with a fully protiated water component, we observe ready crystallisation occurring just after the glass melting transition. On the contrary with a fully deuteriated water component, the process of crystallisation is either completely or substantially supressed. This behaviour might be explained by nuclear quantum effects in water. The strong isotope effect, observed here, may play an important role in development of new cryopreservation strategies
Coherent pion production in proton-deuteron collisions
Values of the proton analysing power in the
reactions at 350-360~MeV
per nucleon were obtained by using a polarised proton beam incident on a
deuterium cluster-jet target and with a polarised deuteron beam incident on a
target cell filled with polarised hydrogen. These results have a much larger
angular coverage than existing data. First measurements are also presented of
the deuteron vector analysing power and the deuteron-proton spin correlations.
Data were also obtained on the deuteron-proton spin correlation and proton
analysing power at small angles at 600~MeV per nucleon, though the angular
coverage at this energy was much more restricted even when using a deuteron
beam. By combining the extrapolated values of the spin correlations to the
forward or backward directions with published measurements of the deuteron
tensor analysing powers, the relative phases between the two non-vanishing
amplitudes were evaluated.Comment: 5 pages, 5 figure
Kaon Pair Production in Proton--Proton Collisions
The differential and total cross sections for kaon pair production in the
pp->ppK+K- reaction have been measured at three beam energies of 2.65, 2.70,
and 2.83 GeV using the ANKE magnetic spectrometer at the COSY-Juelich
accelerator. These near-threshold data are separated into pairs arising from
the decay of the phi-meson and the remainder. For the non-phi selection, the
ratio of the differential cross sections in terms of the K-p and K+p invariant
masses is strongly peaked towards low masses. This effect can be described
quantitatively by using a simple ansatz for the K-p final state interaction,
where it is seen that the data are sensitive to the magnitude of an effective
K-p scattering length. When allowance is made for a small number of phi events
where the K- rescatters from the proton, the phi region is equally well
described at all three energies. A very similar phenomenon is discovered in the
ratio of the cross sections as functions of the K-pp and K+pp invariant masses
and the identical final state interaction model is also very successful here.
The world data on the energy dependence of the non-phi total cross section is
also reproduced, except possibly for the results closest to threshold.Comment: 12 two-column pages, 12 figures, 1 tabl
The production of K+K- pairs in proton-proton collisions at 2.83 GeV
Differential and total cross sections for the pp -> ppK+K- reaction have been
measured at a proton beam energy of 2.83 GeV using the COSY-ANKE magnetic
spectrometer. Detailed model descriptions fitted to a variety of
one-dimensional distributions permit the separation of the pp -> pp phi cross
section from that of non-phi production. The differential spectra show that
higher partial waves represent the majority of the pp -> pp phi total cross
section at an excess energy of 76 MeV, whose energy dependence would then seem
to require some s-wave phi-p enhancement near threshold. The non-phi data can
be described in terms of the combined effects of two-body final state
interactions using the same effective scattering parameters determined from
lower energy data.Comment: 12 pages, 12 figures, 3 table
Model for initiation of quality factor degradation at high accelerating fields in superconducting radio-frequency cavities
A model for the onset of the reduction in SRF cavity quality factor, the
so-called Q-drop, at high accelerating electric fields is presented. Breakdown
of the surface barrier against magnetic flux penetration at the cavity equator
is considered to be the critical event that determines the onset of Q-drop. The
worst case of triangular grooves with low field of first flux penetration Hp,
as analyzed previously by Buzdin and Daumens, [1998 Physica C 294: 257], was
adapted. This approach incorporates both the geometry of the groove and local
contamination via the Ginzburg-Landau parameter kappa, so the proposed model
allows new comparisons of one effect in relation to the other. The model
predicts equivalent reduction of Hp when either roughness or contamination were
varied alone, so smooth but dirty surfaces limit cavity performance about as
much as rough but clean surfaces do. When in combination, contamination
exacerbates the negative effects of roughness and vice-versa. To test the model
with actual data, coupons were prepared by buffered chemical polishing and
electropolishing, and stylus profilometry was used to obtain distributions of
angles. From these data, curves for surface resistance generated by simple flux
flow as a function of magnetic field were generated by integrating over the
distribution of angles for reasonable values of kappa. This showed that
combined effects of roughness and contamination indeed reduce the Q-drop onset
field by ~30%, and that that contamination contributes to Q-drop as much as
roughness. The latter point may be overlooked by SRF cavity research, since
access to the cavity interior by spectroscopy tools is very difficult, whereas
optical images have become commonplace. The model was extended to fit cavity
test data, which indicated that reduction of the superconducting gap by
contaminants may also play a role in Q-drop.Comment: 15 pages with 7 figure
Supervised Human-Guided Data Exploration
Peer reviewe
The neutron-proton charge-exchange amplitudes measured in the dp -> ppn reaction
The unpolarised differential cross section and the two deuteron tensor
analysing powers A_{xx} and A_{yy} of the pol{d}p -> (pp)n charge-exchange
reaction have been measured with the ANKE spectrometer at the COSY storage
ring. Using deuteron beams with energies 1.2, 1.6, 1.8, and 2.27 GeV, data were
obtained for small momentum transfers to a (pp) system with low excitation
energy. The results at the three lower energies are consistent with impulse
approximation predictions based upon the current knowledge of the
neutron-proton amplitudes. However, at 2.27GeV, where these amplitudes are far
more uncertain, agreement requires a reduction in the overall double-spin-flip
contribution, with an especially significant effect in the longitudinal
direction. These conclusions are supported by measurements of the
deuteron-proton spin-correlation parameters C_{x,x} and C_{y,y} that were
carried out in the pol{d}pol{p} -> (pp)n reaction at 1.2 and 2.27GeV. The
values obtained for the proton analysing power also suggest the need for a
radical re-evaluation of the neutron-proton elastic scattering amplitudes at
the higher energy. It is therefore clear that such measurements can provide a
valuable addition to the neutron-proton database in the charge-exchange region.Comment: 13 pages with 13 figure
Субсидиарное управление на железной дороге
The increase in railway speeds and the transition to unmanned transport control result in the growth of the role of operational management technologies exempt from excessive control of corporate headquarters. The objective of the work is to study the subsidiaritybased control as a new technology of controlling moving objects, and to identify borders of its efficiency. A subsidiarity-based control’s feature is that its efficiency may be revealed under certain conditions only and not always. Therefore, the application of subsidiaritybased control requires an analysis of operating conditions of vehicles. Subsidiarity-based control is an alternative to hierarchical control which is more efficient under simpler conditions. The paper reveals the essence of subsidiarity in the social and engineering field, and results of the study on application and applicability of subsidiarity-based control for the railways, its core factors are analyzed. Comparison of signal block and subsidiarity-based control systems is made, followed by description of particularities of identification of the size of blocks within subsidiarity-based control system. Additional factors of subsidiarity-based control, comprising complementarity and astatism, are described. The relationship between subsidiarity-based management and control and implementation of digital railway concept is shown.В связи сростом скоростей железнодорожного транспорта и переходом к беспилотному управлению транспортом возрастает роль технологий оперативного управления без излишнего участия внём со стороны центрального аппарата компаний. Целью работы явилось исследование субсидиарного управления как новой технологии управления подвижными объектами, определение границ его эффективности. Особенность субсидиарного управления в том, что оно эффективно не всегда, а только при определённых условиях, поэтому для его применения необходим анализ условий функционирования транспортных средств. Субсидиарное управление является альтернативой иерархическому управлению, которое эффективнее в простых условиях. Раскрывается сущность субсидиарности в социальной и технической областях. Приводятся результаты исследования применения и применимости субсидиарного управления на железной дороге, анализируются его основные факторы. Проводится сравнение сигнально-блокового управления и субсидиарного управления, показаны особенности определения размеров блоков. Описаны дополнительные факторы субсидиарного управления – комплементарность, астатизм. Продемонстрирована связь субсидиарного управления и концепции цифровой железной дороги
Quantum numbers of the state and orbital angular momentum in its decay
Angular correlations in decays, with , and , are used to measure
orbital angular momentum contributions and to determine the value of
the meson. The data correspond to an integrated luminosity of 3.0
fb of proton-proton collisions collected with the LHCb detector. This
determination, for the first time performed without assuming a value for the
orbital angular momentum, confirms the quantum numbers to be .
The is found to decay predominantly through S wave and an upper limit
of at C.L. is set on the fraction of D wave.Comment: 16 pages, 4 figure
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