Inlet and airframe compatibility for a V/STOL fighter/attack aircraft with top-mounted inlets

Aerodynamic force and inlet pressure data are obtained for 9.5% force and pressure models of a V/STOL fighter/attack aircraft configuration with top mounted twin inlets. Data are presented from tests conducted in the Ames Unitary Wind Tunnels at Mach numbers of 0.6, 0.9, and 1.2 at angles of attack up to 27 deg. and angles of sideslip up to 12 deg. Trimmed aerodynamic characteristics and inlet performance are compared for three different leading edge extension (LEX) configurations. The effects of wing leading and trailing-edge flaps on the inlet are also determined. Maneuver perfromance is calculated form combined force and inlet pressure data. The largest of the three LEX sizes tested gives the best airplane maneuver performance. Wing flap deflections improved inlet recovery at all Mach numbers

Design of Rail Instrumentation for Wind Tunnel Sonic Boom Measurements and Computational-Experimental Comparisons

An innovative pressure rail concept for wind tunnel sonic boom testing of modern aircraft configurations with very low overpressures was designed with an adjoint-based solution-adapted Cartesian grid method. The computational method requires accurate free-air calculations of a test article as well as solutions modeling the influence of rail and tunnel walls. Specialized grids for accurate Euler and Navier-Stokes sonic boom computations were used on several test articles including complete aircraft models with flow-through nacelles. The computed pressure signatures are compared with recent results from the NASA 9- x 7-foot Supersonic Wind Tunnel using the advanced rail design

Predicting development of adolescent drinking behaviour from whole brain structure at 14 years of age

Adolescence is a common time for initiation of alcohol use and development of alcohol use disorders. The present study investigates neuroanatomical predictors for trajectories of future alcohol use based on a novel voxel-wise whole-brain structural equation modeling framework. In 1814 healthy adolescents of the IMAGEN sample, the Alcohol Use Disorder Identification Test (AUDIT) was acquired at three measurement occasions across five years. Based on a two-part latent growth curve model, we conducted whole-brain analyses on structural MRI data at age 14, predicting change in alcohol use score over time. Higher grey-matter volumes in the caudate nucleus and the left cerebellum at age 14 years were predictive of stronger increase in alcohol use score over 5 years. The study is the first to demonstrate the feasibility of running separate voxel-wise structural equation models thereby opening new avenues for data analysis in brain imaging

Nation and archipelago

This chapter explores John Milton's Observations upon the Articles of Peace with the Irish Rebels (1649), a 25,000-word treatise that is a touchstone text for a turning point in British and Irish history, a telling account of the tensions between colonialism and republicanism, and a tipping point in Milton's thinking around Archipelagic interdependence – the tied fates of the nations that make up the emerging British state. This multi-authored work, exemplary in its many-sided depiction of a pivotal point in the history of the three Stuart kingdoms of England, Ireland, and Scotland, depicts different national and religious communities responding to the execution of Charles I on January 30, 1649. Milton's commission was to address the “complication of interests” in Ireland in the wake of the killing of the king. His protean polemic captures the contradictions of a poet against empire countering a challenge to metropolitan government from a complex planter society

Transport and instability in driven two-dimensional magnetohydrodynamic flows

This paper concerns the generation of large scale flows in forced two-dimensional systems. A Kolmogorov flow with a sinusoidal profile in one direction (driven by a body force) is known to become unstable to a large scale flow in the perpendicular direction at a critical Reynolds number. This can occur in the presence of a beta-effect and has important implications for flows observed in geophysical and astrophysical systems. It has recently been termed ‘zonostrophic instability’ and studied in a variety of settings, both numerically and analytically. The goal of the present paper is to determine the effect of magnetic field on such instabilities using the quasi-linear approximation, in which the full fluid system is decoupled into a mean flow and waves of one scale. The waves are driven externally by a given, random body force and move on a fast time scale, while their stress on the mean flow causes this to evolve on a slow time scale. Spatial scale separation between waves and mean flow is also assumed, to allow analytical progress. The paper first discusses purely hydrodynamic transport of vorticity including zonostrophic instability, the effect of uniform background shear, and calculation of equilibrium profiles in which the effective viscosity varies spatially, through the mean flow. After brief consideration of passive scalar transport or equivalently kinematic magnetic field evolution, the paper then proceeds to study the full MHD system and to determine effective diffusivities and other transport coefficients using a mixture of analytical and numerical methods. This leads to results on the effect of magnetic field, background shear and beta-effect on zonostrophic instability and magnetically driven instabilitiesWe are grateful to the EPSRC for funding SD via a DTG research studentship

Competing Patterns of Signaling Activity in Dictyostelium discoideum

Quantitative experiments are described on spatio-temporal patterns of coherent chemical signaling activity in populations of {\it Dictyostelium discoideum} amoebae. We observe competition between spontaneously firing centers and rotating spiral waves that depends strongly on the overall cell density. At low densities, no complete spirals appear and chemotactic aggregation is driven by periodic concentric waves, whereas at high densities the firing centers seen at early times nucleate and are apparently entrained by spiral waves whose cores ultimately serve as aggregation centers. Possible mechanisms for these observations are discussed.Comment: 10 pages, RevTeX, 4 ps figures, accepted in PR

Stereo Photogrammetry Measurements of the Position and Attitude of a Nozzle-Plume/Shock-Wave Interaction Model in the NASA Ames 9- by 7-Ft Supersonic Wind Tunnel

Stereo photogrammetry was used to measure the position and attitude of a slender body of revolution during nozzle-plume/shock-wave interaction tests in the NASA Ames 9- by 7-Ft Supersonic Wind Tunnel. The model support system was designed to allow the model to be placed at many locations in the test section relative to a pressure rail on one sidewall. It included a streamwise traverse as well as a thin blade that offset the model axis from the sting axis. With these features the support system was more flexible than usual resulting in higher-than-usual uncertainty in the position and attitude of the model. Also contributing to this uncertainty were the absence of a balance, so corrections for sting deflections could not be applied, and the wings-vertical orientation of the model, which precluded using a gravity-based accelerometer to measure pitch angle. Therefore, stereo photogrammetry was chosen to provide independent measures of the model position and orientation. This paper describes the photogrammetry system and presents selected results from the test

Computational and Experimental Study of Plume and Shock Interaction Effects on Sonic Boom in the NASA Ames 9x7 Supersonic Wind Tunnel

A wind tunnel test was performed in the NASA Ames 9x7 Supersonic Wind Tunnel focusing on the shock waves traveling through and interacting with an exhaust nozzle plume. This experimental study was conducted to develop and validate the CFD capability required to accurately include nozzle flow with impinging shock effects on near field and groundpropagated sonic boom signatures. The model was made to be generic, and included a simple nozzle shape, two different aft decks, and a few generic horizontal tails. High pressure air was pumped through a nozzle at various nozzle pressure ratios (NPR) to represent the engine plume in flight. The three different aft body representations each created a different shock wave signature that passed through the plume. An aft deck configuration, where part of the aircraft shields the nozzle plume, was also tested. Retroreflective Background-Oriented Schlieren (RBOS) was used to obtain schlieren images of the flow field around the model and behind the model. This study compares wind tunnel data and numerical simulations conducted by the NASA Tetrahedral Unstructured Software System CFD code, USM3D

Temporal dystrophic remodeling within the intrinsic cardiac nervous system of the streptozotocin-induced diabetic rat model

INTRODUCTION: The pathogenesis of heart failure (HF) in diabetic individuals, called “diabetic cardiomyopathy”, is only partially understood. Alterations in the cardiac autonomic nervous system due to oxidative stress have been implicated. The intrinsic cardiac nervous system (ICNS) is an important regulatory pathway of cardiac autonomic function, however, little is known about the alterations that occur in the ICNS in diabetes. We sought to characterize morphologic changes and the role of oxidative stress within the ICNS of diabetic hearts. Cultured ICNS neuronal cells from the hearts of 3- and 6-month old type 1 diabetic streptozotocin (STZ)-induced diabetic Sprague-Dawley rats and age-matched controls were examined. Confocal microscopy analysis for protein gene product 9.5 (PGP 9.5) and amino acid adducts of (E)-4-hydroxy-2-nonenal (4-HNE) using immunofluorescence was undertaken. Cell morphology was then analyzed in a blinded fashion for features of neuronal dystrophy and the presence of 4-HNE adducts. RESULTS: At 3-months, diabetic ICNS neuronal cells exhibited 30% more neurite swellings per area (p = 0.01), and had a higher proportion with dystrophic appearance (88.1% vs. 50.5%; p = <0.0001), as compared to control neurons. At 6-months, diabetic ICNS neurons exhibited more features of dystrophy as compared to controls (74.3% vs. 62.2%; p = 0.0448), with 50% more neurite branching (p = 0.0015) and 50% less neurite outgrowth (p = <0.001). Analysis of 4-HNE adducts in ICNS neurons of 6-month diabetic rats demonstrated twice the amount of reactive oxygen species (ROS) as compared to controls (p = <0.001). CONCLUSION: Neuronal dystrophy occurs in the ICNS neurons of STZ-induced diabetic rats, and accumulates temporally within the disease process. In addition, findings implicate an increase in ROS within the neuronal processes of ICNS neurons of diabetic rats suggesting an association between oxidative stress and the development of dystrophy in cardiac autonomic neurons