Fabrication and characterization of Cu reinforced with Y-enriched particles following a novel powder metallurgy route

Dispersion strengthened copper alloys have been produced following an innovative powder metallurgy route. Copper and yttrium acetate powders have been mechanically alloyed and posteriorly thermal treated at 923 K for 3 h and 15 h under a hydrogen atmosphere in order to transform the yttrium acetate into Y2O3. Subsequently, the powders were consolidated by hot isostatic pressing. It has been concluded that the duration of the thermal treatment of the powder is a determining factor in the degree of densification of the alloy. The study of the microstructure by Scanning Electron Microscopy and Electron Backscatter Diffraction has revealed the presence of micrometer and submicrometer grains and nanometric Y-O enriched Cu particles embedded in the copper matrix, the mean grain size being smaller for the sample produced from the powder thermal treated for 15 h. Transmission Electron Microscopy investigations concluded that the nanoparticles exhibit a spherical shape with a size up to 25 nm and correspond to monoclinic Y2O3. Annealing twins have been also observed, especially in the material produced from thermal treated powder for longer. The mechanical properties have been inferred from Vickers microhardness measurements and compression tests. Below 473 K the yield strengths of the produced materials are greater than that of pure copper and above 473 K are close to them. From the study of the thermal properties of the densest material it has been found that its thermal conductivity remains nearly constant in the temperature range 300–773 K, and its value is around 85% the thermal conductivity of CuCrZr, the reference material for ITER.The present work has been supported by the Agencia Estatal de Investigación (PID2019-105325RB-C33 / AEI / 10.13039/501100011033) and by the Regional Government of Madrid through the program TECHNOFUSIÓN(III)CM (S2018/EMT-4437). The support of the Regional Government of Madrid through the multi-annual agreement with UC3M ("Excelencia para el Profesorado Universitario"- EPUC3M14) - Fifth regional research plan 2016-2020 is acknowledge

Microstructure and mechanical properties of hot rolled ODS copper

Dispersion strengthened copper alloys have been produced by following a powder metallurgy route that have consisted of milling copper and yttrium acetate powders in a planetary ball milling and subsequently sintering by hot isostatic pressing (HIP). In order to increase the degree of densification of the materials, they were subjected to a thermal treatment in vacuum and to a hot rolling process at 1173 K. The decomposition of the yttrium acetate during the thermal treatments resulted in the formation of voids, with a loss of densification that could not be satisfactorily improved with the hot rolling processing. The microstructure and the mechanical and thermal properties of the alloys were analyzed by scanning electron microscopy, electron backscattering diffraction, micro and nanohardness measurements, and compression tests and thermal conductivity measurements, both in the range 300–780 K. The best mechanical properties were obtained for the as-HIP material, with a mean grain size of 0.3 ± 0.3 μm and a yield strength value at room temperature of 520 MPa. In contrast, the material with the highest thermal conductivity for the entire range of temperature was found to be the alloy thermal treated in vacuum at 1273 K and later subjected to the hot rolling processing. The different microstructural characteristics of the alloys such as grain size, defects present in the grains and size of voids seems to be responsible of the differences on their thermal conductivity values.The present work has been supported by the Ministerio de Economía y Competitividad of Spain (ENE2015-70300-C3-2-R MINECO/FEDER) and by the Regional Government of Madrid through the program TECHNOFUSIÓN(III)CM (S2018/EMT-4437)

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Shoc2/Sur8 protein regulates neurite outgrowth

This is an openaccess article distributed under the terms of the Creative Commons Attribution License.-- et al.The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth.GL, TG and LMD were recipients of fellowships from the Ministerio de Educación y Ciencia (MEC) (to GL, TG), and Fondo de Investigaciones Sanitarias (FIS) (to LMD). LSR held a postdoctoral research contract from CIBERNED. This work was supported by FIS grant (PI10/00815) to JLO; CIBERNED to MC; SAF2008-01951, Comunidad Autónoma de Madrid (CAM) SSAL-0202-2006-01 and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) to TI; FIS grant PI12/00775 and ISCIII-RETIC (Red Temática de Investigación Cooperativa en Cáncer) RD12/0036/0027 from the Instituto de Salud Carlos III to PSG; and FIS grants (PI09/0562 and PI13/00703), ISCIIIRETIC (RD06/0020/0003 and RD12/0036/0021), and the Spanish Association Against Cancer (AECC) to JMR.Peer Reviewe

Shoc2/Sur8 Protein Regulates Neurite Outgrowth

The Shoc2 protein has been implicated in the positive regulation of the Ras-ERK pathway by increasing the functional binding interaction between Ras and Raf, leading to increased ERK activity. Here we found that Shoc2 overexpression induced sustained ERK phosphorylation, notably in the case of EGF stimulation, and Shoc2 knockdown inhibited ERK activation. We demonstrate that ectopic overexpression of human Shoc2 in PC12 cells significantly promotes neurite extension in the presence of EGF, a stimulus that induces proliferation rather than differentiation in these cells. Finally, Shoc2 depletion reduces both NGF-induced neurite outgrowth and ERK activation in PC12 cells. Our data indicate that Shoc2 is essential to modulate the Ras-ERK signaling outcome in cell differentiation processes involved in neurite outgrowth.This work was supported by FIS grant (PI10/00815) to JLO; CIBERNED to MC; SAF2008-01951, Comunidad Autónoma de Madrid (CAM) S-SAL-0202-2006-01 and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED) to TI; FIS grant PI12/00775 and ISCIII-RETIC (Red Temática de Investigación Cooperativa en Cáncer) RD12/0036/0027 from the Instituto de Salud Carlos III to PSG; and FIS grants (PI09/0562 and PI13/00703), ISCIII-RETIC (RD06/0020/0003 and RD12/0036/0021), and the Spanish Association Against Cancer (AECC) to JMR. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.S

Multicenter study of lumen-apposing metal stents with or without pigtail in endoscopic ultrasound-guided biliary drainage for malignant obstruction - BAMPI TRIAL: an open-label, randomized controlled trial protocol

Background It is unclear whether the insertion of an axis-orienting double-pigtail plastic stent (DPS) through biliary lumen-apposing meal stent (LAMS) in EUS-guided choledochoduodenostomy (CDS) improves the stent patency. The aim of this study is to determine whether this technical variant offers a clinical benefit in EUS-guided biliary drainage (BD) for the management of distal malignant biliary obstruction. Methods/design This is a multicenter open-label, randomized controlled trial with two parallel groups. Eighty-four patients with malignant biliary obstruction will undergo EUS-BD (CDS type) using LAMS in 7 tertiary hospitals in Spain and will be randomized to the LAMS and LAMS plus DPS groups. The primary endpoint is the rate of recurrent biliary obstruction, as a stent dysfunction parameter, detected during follow-up. Secondary endpoints: technical and clinical success (reduction in bilirubin > 50% within 14 days of stent placement), safety, and others (number of reinterventions, time to biliary obstruction, prognostic factors, survival rate). Discussion The BAMPI trial has been designed to determine whether the addition of a coaxial axis-orienting DPS through LAMS is superior to LAMS alone to prevent stent dysfunction

Evaluación de competencias procedimentales a través de videos y checklist

La seguridad del paciente es objetivo de la OMS. Debe determinar la calidad asistencial y la formación grado/posgrado. En el aprendizaje en competencias procedimentales el alumnado debe de ser capaz de reproducir lo aprendido en espacios controlados en el contacto con las personas enfermas. Se presenta el material audiovisual y la validación de "checklist" por expertos, con el objetivo de reducir los errores provocados por los potenciales límites de la memoria y la atención sanitaria. Específicamente a partir de vídeos disponibles en RUA, se ha realizado simulación clínica. Para evaluar las habilidades adquiridas se han usado checklist con los criterios imprescindibles para llevar a cabo buenas prácticas profesionales. Para el estudio de la fiabilidad, cada grupo ha tenido dos observadores evaluando al alumnado. Se ha calculado el nivel de acuerdo interobservador a través del coeficiente kappa >0.80. Como resultados se presentan, videos y checklist. El alumnado participante ha sido informado del procedimiento, su no participación, no afectará a la calificación final. Podríamos concluir, de forma preliminar diciendo que, la utilización de material audiovisual facilita el autoaprendizaje y evaluar las competencias de forma individual, permite al alumnado reconocer lo aprendido antes de la incorporación a la práctica real con pacientes

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Effect of Y, La, and Yb simultaneous doping on the thermal conductivity and thermoelectric performances of CaMnO3 ceramics

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