115 research outputs found
Classifying post-traumatic stress disorder using the magnetoencephalographic connectome and machine learning
Given the subjective nature of conventional diagnostic methods for post-traumatic stress disorder (PTSD), an objectively measurable biomarker is highly desirable; especially to clinicians and researchers. Macroscopic neural circuits measured using magnetoencephalography (MEG) has previously been shown to be indicative of the PTSD phenotype and severity. In the present study, we employed a machine learning-based classification framework using MEG neural synchrony to distinguish combat-related PTSD from trauma-exposed controls. Support vector machine (SVM) was used as the core classification algorithm. A recursive random forest feature selection step was directly incorporated in the nested SVM cross validation process (CV-SVM-rRF-FS) for identifying the most important features for PTSD classification. For the five frequency bands tested, the CV-SVM-rRF-FS analysis selected the minimum numbers of edges per frequency that could serve as a PTSD signature and be used as the basis for SVM modelling. Many of the selected edges have been reported previously to be core in PTSD pathophysiology, with frequency-specific patterns also observed. Furthermore, the independent partial least squares discriminant analysis suggested low bias in the machine learning process. The final SVM models built with selected features showed excellent PTSD classification performance (area-under-curve value up to 0.9). Testament to its robustness when distinguishing individuals from a heavily traumatised control group, these developments for a classification model for PTSD also provide a comprehensive machine learning-based computational framework for classifying other mental health challenges using MEG connectome profiles
Addressing the Language Binding Problem With Dynamic Functional Connectivity During Meaningful Spoken Language Comprehension
During speech, how does the brain integrate information processed on different timescales and in separate brain areas so we can understand what is said? This is the language binding problem. Dynamic functional connectivity (brief periods of synchronization in the phase of EEG oscillations) may provide some answers. Here we investigate time and frequency characteristics of oscillatory power and phase synchrony (dynamic functional connectivity) during speech comprehension. Twenty adults listened to meaningful English sentences and non-sensical âJabberwockyâ sentences in which pseudo-words replaced all content words, while EEG was recorded. Results showed greater oscillatory power and global connectivity strength (mean phase lag index) in the gamma frequency range (30â80 Hz) for English compared to Jabberwocky. Increased power and connectivity relative to baseline was also seen in the theta frequency range (4â7 Hz), but was similar for English and Jabberwocky. High-frequency gamma oscillations may reflect a mechanism by which the brain transfers and integrates linguistic information so we can extract meaning and understand what is said. Slower frequency theta oscillations may support domain-general processing of the rhythmic features of speech. Our findings suggest that constructing a meaningful representation of speech involves dynamic interactions among distributed brain regions that communicate through frequency-specific functional networks
Evidence that smooth pursuit velocity, not eye position, modulates alpha and beta oscillations in human middle temporal cortex
Suppression of 5â25 Hz oscillations have been observed in MT1 during pursuit eye move- ments, suggesting oscillations that play a role in oculomotor control and/or the integration of extrareti- nal signals during pursuit. The amplitude of these rhythms appears to covary with head-centered eye position, but an alternative is that they depend on a velocity signal that lags the movement of the eyes. To investigate, we explored how alpha and beta amplitude changes related to ongoing eye move- ment depended on pursuit at different eccentricities. The results revealed largely identical patterns of modulation in the alpha and beta amplitude, irrespective of the eccentricity at which the pursuit eye movement was performed. The signals we measured therefore do not depend on head-centered posi- tion. A second experiment was designed to investigate whether the alpha and beta oscillations depended on the direction of pursuit, as opposed to just speed. We found no evidence that alpha or beta oscillations depended on direction, but there was a significant effect of eye speed on the magni- tude of the beta suppression. This suggests distinct functional roles for alpha and beta suppression in pursuit behavior
Atypical functional connectivity during unfamiliar music listening in children with autism
Background: Atypical processing of unfamiliar, but less so familiar, stimuli has been
described in Autism Spectrum Disorder (ASD), in particular in relation to face processing.
We examined the construct of familiarity in ASD using familiar and unfamiliar songs,
to investigate the link between familiarity and autism symptoms, such as repetitive
behavior.
Methods: Forty-eight children, 24 with ASD (21 males, mean age = 9.96 years ± 1.54)
and 24 typically developing (TD) controls (21 males, mean age = 10.17 ± 1.90)
completed a music familiarity task using individually identified familiar compared to
unfamiliar songs, while magnetoencephalography (MEG) was recorded. Each song
was presented for 30 s. We used both amplitude envelope correlation (AEC) and the
weighted phase lag index (wPLI) to assess functional connectivity between specific
regions of interest (ROI) and non-ROI parcels, as well as at the whole brain level,
to understand what is preserved and what is impaired in familiar music listening in
this population.
Results: Increased wPLI synchronization for familiar vs. unfamiliar music was found
for typically developing children in the gamma frequency. There were no significant
differences within the ASD group for this comparison. During the processing of unfamiliar
music, we demonstrated left lateralized increased theta and beta band connectivity in
children with ASD compared to controls. An interaction effect found greater alpha band
connectivity in the TD group compared to ASD to unfamiliar music only, anchored in
the left insula.Conclusion: Our results revealed atypical processing of unfamiliar songs in children
with ASD, consistent with previous studies in other modalities reporting that processing
novelty is a challenge for ASD. Relatively typical processing of familiar stimuli may
represent a strength and may be of interest to strength-based intervention planning.info:eu-repo/semantics/publishedVersio
The Acquisition of Human B Cell Memory in Response to Plasmodium Falciparum Malaria
Immunity to Plasmodium falciparum (Pf), the most deadly agent of malaria, is only acquired after years of repeated infections and appears to wane rapidly without ongoing exposure. Antibodies (Abs) are central to malaria immunity, yet little is known about the Bâcell biology that underlies Pfâspecific humoral immunity. To address this gap in our knowledge we carried out a yearâlong prospective study of the acquisition and maintenance of longâlived plasma cells (LLPCs) and memory B cells (MBCs) in 225 individuals aged two to twentyâfive years in Mali, in an area of intense seasonal transmission. Using protein microarrays containing approximately 25% of the Pf proteome we determined that Pfâspecific Abs were acquired only gradually, in a stepwise fashion over years of Pf exposure. Pfâspecific Ab levels were significantly boosted each year during the transmission season but the majority of these Abs were short lived and were lost over the subsequent six month period of no transmission. Thus, we observed only a small incremental increase in stable Ab levels each year, presumably reflecting the slow acquisition LLPCs. The acquisition Pfâspecific MBCs mirrored the slow stepâwise acquisition of LLPCs. This slow acquisition of Pfâspecific LLPCs and MBCs was in sharp contrast to that of tetanus toxoid (TT)âspecific LLPCs and MBCs that were vi vi rapidly acquired and stably maintained following a single vaccination in individuals in this cohort. In addition to the development of normal MBCs we observed an expansion of atypical MBCs that are phenotypically similar to hyporesponsive FCRL4+ cells described in HIVâinfected individuals. Atypical MBC expansion correlated with cumulative exposure to Pf, and with persistent asymptomatic Pfâinfection in children, suggesting that the parasite may play a role in driving the expansion of atypical MBCs. Collectively, these observations provide a rare glimpse into the process of the acquisition of human B cell memory in response to infection and provide evidence for a selective deficit in the generation of Pfâspecific LLPCs and MBCs during malaria. Future studies will address the mechanisms underlying the slow acquisition of LLPCs and MBCs and the generation and function of atypical MBCs
The Atacama Cosmology Telescope: Cross Correlation with Planck maps
We present the temperature power spectrum of the Cosmic Microwave Background
obtained by cross-correlating maps from the Atacama Cosmology Telescope (ACT)
at 148 and 218 GHz with maps from the Planck satellite at 143 and 217 GHz, in
two overlapping regions covering 592 square degrees. We find excellent
agreement between the two datasets at both frequencies, quantified using the
variance of the residuals between the ACT power spectra and the ACTxPlanck
cross-spectra. We use these cross-correlations to calibrate the ACT data at 148
and 218 GHz, to 0.7% and 2% precision respectively. We find no evidence for
anisotropy in the calibration parameter. We compare the Planck 353 GHz power
spectrum with the measured amplitudes of dust and cosmic infrared background
(CIB) of ACT data at 148 and 218 GHz. We also compare planet and point source
measurements from the two experiments.Comment: 9 pages, 8 figure
Cosmological Constraints from the SDSS maxBCG Cluster Catalog
We use the abundance and weak lensing mass measurements of the SDSS maxBCG
cluster catalog to simultaneously constrain cosmology and the richness--mass
relation of the clusters. Assuming a flat \LambdaCDM cosmology, we find
\sigma_8(\Omega_m/0.25)^{0.41} = 0.832\pm 0.033 after marginalization over all
systematics. In common with previous studies, our error budget is dominated by
systematic uncertainties, the primary two being the absolute mass scale of the
weak lensing masses of the maxBCG clusters, and uncertainty in the scatter of
the richness--mass relation. Our constraints are fully consistent with the WMAP
five-year data, and in a joint analysis we find \sigma_8=0.807\pm 0.020 and
\Omega_m=0.265\pm 0.016, an improvement of nearly a factor of two relative to
WMAP5 alone. Our results are also in excellent agreement with and comparable in
precision to the latest cosmological constraints from X-ray cluster abundances.
The remarkable consistency among these results demonstrates that cluster
abundance constraints are not only tight but also robust, and highlight the
power of optically-selected cluster samples to produce precision constraints on
cosmological parameters.Comment: comments welcom
High resolution CMB power spectrum from the complete ACBAR data set
In this paper, we present results from the complete set of cosmic microwave
background (CMB) radiation temperature anisotropy observations made with the
Arcminute Cosmology Bolometer Array Receiver (ACBAR) operating at 150 GHz. We
include new data from the final 2005 observing season, expanding the number of
detector-hours by 210% and the sky coverage by 490% over that used for the
previous ACBAR release. As a result, the band-power uncertainties have been
reduced by more than a factor of two on angular scales encompassing the third
to fifth acoustic peaks as well as the damping tail of the CMB power spectrum.
The calibration uncertainty has been reduced from 6% to 2.1% in temperature
through a direct comparison of the CMB anisotropy measured by ACBAR with that
of the dipole-calibrated WMAP5 experiment. The measured power spectrum is
consistent with a spatially flat, LambdaCDM cosmological model. We include the
effects of weak lensing in the power spectrum model computations and find that
this significantly improves the fits of the models to the combined ACBAR+WMAP5
power spectrum. The preferred strength of the lensing is consistent with
theoretical expectations. On fine angular scales, there is weak evidence (1.1
sigma) for excess power above the level expected from primary anisotropies. We
expect any excess power to be dominated by the combination of emission from
dusty protogalaxies and the Sunyaev-Zel'dovich effect (SZE). However, the
excess observed by ACBAR is significantly smaller than the excess power at ell
> 2000 reported by the CBI experiment operating at 30 GHz. Therefore, while it
is unlikely that the CBI excess has a primordial origin; the combined ACBAR and
CBI results are consistent with the source of the CBI excess being either the
SZE or radio source contamination.Comment: Submitted to ApJ; Changed to apply a WMAP5-based calibration. The
cosmological parameter estimation has been updated to include WMAP
Evidence for dark energy from the cosmic microwave background alone using the Atacama Cosmology Telescope lensing measurements
For the first time, measurements of the cosmic microwave background radiation
(CMB) alone favor cosmologies with dark energy over models without dark
energy at a 3.2-sigma level. We demonstrate this by combining the CMB lensing
deflection power spectrum from the Atacama Cosmology Telescope with temperature
and polarization power spectra from the Wilkinson Microwave Anisotropy Probe.
The lensing data break the geometric degeneracy of different cosmological
models with similar CMB temperature power spectra. Our CMB-only measurement of
the dark energy density confirms other measurements from
supernovae, galaxy clusters and baryon acoustic oscillations, and demonstrates
the power of CMB lensing as a new cosmological tool.Comment: 4 pages, 3 figures; replaced with version accepted by Physical Review
Letters, added sentence on models with non-standard primordial power spectr
Detection of the Power Spectrum of Cosmic Microwave Background Lensing by the Atacama Cosmology Telescope
We report the first detection of the gravitational lensing of the cosmic
microwave background through a measurement of the four-point correlation
function in the temperature maps made by the Atacama Cosmology Telescope. We
verify our detection by calculating the levels of potential contaminants and
performing a number of null tests. The resulting convergence power spectrum at
2-degree angular scales measures the amplitude of matter density fluctuations
on comoving length scales of around 100 Mpc at redshifts around 0.5 to 3. The
measured amplitude of the signal agrees with Lambda Cold Dark Matter cosmology
predictions. Since the amplitude of the convergence power spectrum scales as
the square of the amplitude of the density fluctuations, the 4-sigma detection
of the lensing signal measures the amplitude of density fluctuations to 12%.Comment: 4 pages, 4 figures, replaced title and author list with version
accepted by Physical Review Letters. Likelihood code can be downloaded from
http://bccp.lbl.gov/~sudeep/ACTLensLike.htm
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