The Shifted Coupled Cluster Method: A New Approach to Hamiltonian Lattice Gauge Theories

It is shown how to adapt the non-perturbative coupled cluster method of many-body theory so that it may be successfully applied to Hamiltonian lattice $SU(N)$ gauge theories. The procedure involves first writing the wavefunctions for the vacuum and excited states in terms of linked clusters of gauge invariant excitations of the strong coupling vacuum. The fundamental approximation scheme then consists of i) a truncation of the infinite set of clusters in the wavefunctions according to their geometric {\em size}, with all larger clusters appearing in the Schr\"odinger equations simply discarded, ii) an expansion of the truncated wavefunctions in terms of the remaining clusters rearranged, or ``shifted'', to describe gauge invariant {\em fluctuations} about their vacuum expectation values. The resulting non-linear truncated Schr\"odinger equations are then solved self-consistently and exactly. Results are presented for the case of $SU(2)$ in $d=3$ space-time dimensions.Comment: 13 pages + 5 postscript figures, plain Late

Promoting good academic practice through the curriculum and project work

This paper outlines a University wide initiative introduced at City University London, the underlying aim of which is to develop good academic practice skills amongst students and discourage them from undertaking plagiarism or other forms of academic misconduct. The initiative is organised under three projects, which are being undertaken by a set of eight Educational Development Associates (EDAs) - existing academics acting as ‘change agents’ within their Schools. The paper focuses on the first project that EDAs undertook, that being the Learning Activity Project. This involved EDAs working with staff within their Schools to develop new, formative, programme-specific learning activities, to be undertaken by all students in the first term of their studies, and with the aim of providing students with practice in the study skills that they need to demonstrate in subsequent assessments of that programme. After reviewing relevant literature on academic conduct issues, the main body of the paper provides three case studies, each of which details the development of a learning activity in one of the Schools of the University. These learning activities share a common element, in that they are all delivered using a piece of software called OLIVIA. However, for purposes of this paper, each case study details specific aspects of the relevant learning activity, such that readers are provided with a broad perspective of the experiences of implementation of the project through the lenses of different Schools. The last section of the paper details the evaluative mechanism that is being used for the initiative as a whole

Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion

Type 2 immunity, which involves coordinated regulation of innate and adaptive immune responses, can protect against helminth parasite infection, but may lead to allergy and asthma after inappropriate activation. We demonstrate that il25−/− mice display inefficient Nippostrongylus brasiliensis expulsion and delayed cytokine production by T helper 2 cells. We further establish a key role for interleukin (IL)-25 in regulating a novel population of IL-4–, IL-5–, IL-13–producing non–B/non–T (NBNT), c-kit+, FcɛR1− cells during helminth infection. A deficit in this population in il25−/− mice correlates with inefficient N. brasiliensis expulsion. In contrast, administration of recombinant IL-25 in vivo induces the appearance of NBNT, c-kit+, FcɛR1− cells and leads to rapid worm expulsion that is T and B cell independent, but type 2 cytokine dependent. We demonstrate that these IL-25–regulated cells appear rapidly in the draining lymph nodes, implicating them as a source of type 2 cytokines during initiation of worm expulsion

Stabilities of nanohydrated thymine radical cations: insights from multiphoton ionization experiments and ab initio calculations

Multi-photon ionization experiments have been carried out on thymine-water clusters in the gas phase. Metastable H2O loss from T+(H2O)n was observed at n ≥ 3 only. Ab initio quantum-chemical calculations of a large range of optimized T+(H2O)n conformers have been performed up to n = 4, enabling binding energies of water to be derived. These decrease smoothly with n, consistent with the general trend of increasing metastable H2O loss in the experimental data. The lowest-energy conformers of T+(H2O)3 and T+(H2O)4 feature intermolecular bonding via charge-dipole interactions, in contrast with the purely hydrogen-bonded neutrals. We found no evidence for a closed hydration shell at n = 4, also contrasting with studies of neutral clusters

Discrete kink dynamics in hydrogen-bonded chains I: The one-component model

We study topological solitary waves (kinks and antikinks) in a nonlinear one-dimensional Klein-Gordon chain with the on-site potential of a double-Morse type. This chain is used to describe the collective proton dynamics in quasi-one-dimensional networks of hydrogen bonds, where the on-site potential plays role of the proton potential in the hydrogen bond. The system supports a rich variety of stationary kink solutions with different symmetry properties. We study the stability and bifurcation structure of all these stationary kink states. An exactly solvable model with a piecewise ``parabola-constant'' approximation of the double-Morse potential is suggested and studied analytically. The dependence of the Peierls-Nabarro potential on the system parameters is studied. Discrete travelling-wave solutions of a narrow permanent profile are shown to exist, depending on the anharmonicity of the Morse potential and the cooperativity of the hydrogen bond (the coupling constant of the interaction between nearest-neighbor protons).Comment: 12 pages, 20 figure

Quantum Creation of an Open Inflationary Universe

We discuss a dramatic difference between the description of the quantum creation of an open universe using the Hartle-Hawking wave function and the tunneling wave function. Recently Hawking and Turok have found that the Hartle-Hawking wave function leads to a universe with Omega = 0.01, which is much smaller that the observed value of Omega > 0.3. Galaxies in such a universe would be about $10^{10^8}$ light years away from each other, so the universe would be practically structureless. We will argue that the Hartle-Hawking wave function does not describe the probability of the universe creation. If one uses the tunneling wave function for the description of creation of the universe, then in most inflationary models the universe should have Omega = 1, which agrees with the standard expectation that inflation makes the universe flat. The same result can be obtained in the theory of a self-reproducing inflationary universe, independently of the issue of initial conditions. However, there exist two classes of models where Omega may take any value, from Omega > 1 to Omega << 1.Comment: 23 pages, 4 figures. New materials are added. In particular, we show that boundary terms do not help to solve the problem of unacceptably small Omega in the new model proposed by Hawking and Turok in hep-th/9803156. A possibility to solve the cosmological constant problem in this model using the tunneling wave function is discusse

Development of three triplex real-time reverse transcription PCR assays for the qualitative molecular typing of the nine serotypes of African horse sickness virus

Blood samples collected as part of routine diagnostic investigations from South African horses with clinical signs suggestive of African horse sickness (AHS) were subjected to analysis with an AHS virus (AHSV) group specific reverse transcription quantitative polymerase chain reaction (AHSV RT-qPCR) assay and virus isolation (VI) with subsequent serotyping by plaque inhibition (PI) assays using AHSV serotype-specific antisera. Blood samples that tested positive by AHSV RT-qPCR were then selected for analysis using AHSV type specific RT-qPCR (AHSV TS RT-qPCR) assays. The TS RT-qPCR assays were evaluated using both historic stocks of the South African reference strains of each of the 9 AHSV serotypes, as well as recently derived stocks of these same viruses. Of the 503 horse blood samples tested, 156 were positive by both AHSV RT-qPCR and VI assays, whereas 135 samples that were VI negative were positive by AHSV RT-qPCR assay. The virus isolates made from the various blood samples included all 9 AHSV serotypes, and there was 100% agreement between the results of conventional serotyping of individual virus isolates by PI assay and AHSV TS RT-qPCR typing results. Results of the current study confirm that the AHSV TS RT-qPCR assays for the identification of individual AHSV serotypes are applicable and practicable and therefore are potentially highly useful and appropriate for virus typing in AHS outbreak situations in endemic or sporadic incursion areas, which can be crucial in determining appropriate and timely vaccination and control strategies.Racing South Africa (Pty) Ltd, the Mary Slack and Daughters Foundation and Thoroughbred Racing Trust of South Africa.http://www.elsevier.com/locate/jviromet2016-10-31hb2016Equine Research CentreVeterinary Tropical Disease

Striatal mRNA expression patterns underlying peak dose L-DOPA-induced dyskinesia in the 6-OHDA hemiparkinsonian rat

L-DOPA is the primary pharmacological treatment for relief of the motor symptoms of Parkinson’s disease (PD). With prolonged treatment (⩾5 years) the majority of patients will develop abnormal involuntary movements as a result of L-DOPA treatment, known as L-DOPA-induced dyskinesia. Understanding the underlying mechanisms of dyskinesia is a crucial step toward developing treatments for this debilitating side effect. We used the 6-hydroxydopamine (6-OHDA) rat model of PD treated with a three-week dosing regimen of L-DOPA plus the dopa decarboxylase inhibitor benserazide (4 mg/kg and 7.5 mg/kg s.c., respectively) to induce dyskinesia in 50% of individuals. We then used RNA-seq to investigate the differences in mRNA expression in the striatum of dyskinetic animals, non-dyskinetic animals, and untreated parkinsonian controls at the peak of dyskinesia expression, 60 min after L-DOPA administration. Overall, 255 genes were differentially expressed; with significant differences in mRNA expression observed between all three groups. In dyskinetic animals 129 genes were more highly expressed and 14 less highly expressed when compared with non-dyskinetic and untreated parkinsonian controls. In L-DOPA treated animals 42 genes were more highly expressed and 95 less highly expressed when compared with untreated parkinsonian controls. Gene set cluster analysis revealed an increase in expression of genes associated with the cytoskeleton and phosphoproteins in dyskinetic animals compared with non-dyskinetic animals, which is consistent with recent studies documenting an increase in synapses in dyskinetic animals. These genes may be potential targets for drugs to ameliorate L-DOPA-induced dyskinesia or as an adjunct treatment to prevent their occurrence

Modification of forests by people means only 40% of remaining forests have high ecosystem integrity

Many global environmental agendas, including halting biodiversity loss, reversing land degradation, and limiting climate change, depend upon retaining forests with high ecological integrity, yet the scale and degree of forest modification remain poorly quantified and mapped. By integrating data on observed and inferred human pressures and an index of lost connectivity, we generate a globally consistent, continuous index of forest condition as determined by the degree of anthropogenic modification. Globally, only 17.4 million km2 of forest (40.5%) has high landscape-level integrity (mostly found in Canada, Russia, the Amazon, Central Africa, and New Guinea) and only 27% of this area is found in nationally designated protected areas. Of the forest inside protected areas, only 56% has high landscape-level integrity. Ambitious policies that prioritize the retention of forest integrity, especially in the most intact areas, are now urgently needed alongside current efforts aimed at halting deforestation and restoring the integrity of forests globally