297 research outputs found
Millimeter Wave Scattering from Neutral and Charged Water Droplets
We investigated 94GHz millimeter wave (MMW) scattering from neutral and
charged water mist produced in the laboratory with an ultrasonic atomizer.
Diffusion charging of the mist was accomplished with a negative ion generator
(NIG). We observed increased forward and backscattering of MMW from charged
mist, as compared to MMW scattering from an uncharged mist. In order to
interpret the experimental results, we developed a model based on classical
electrodynamics theory of scattering from a dielectric sphere with
diffusion-deposited mobile surface charge. In this approach, scattering and
extinction cross-sections are calculated for a charged Rayleigh particle with
effective dielectric constant consisting of the volume dielectric function of
the neutral sphere and surface dielectric function due to the oscillation of
the surface charge in the presence of applied electric field. For small
droplets with (radius smaller than 100nm), this model predicts increased MMW
scattering from charged mist, which is qualitatively consistent with the
experimental observations. The objective of this work is to develop indirect
remote sensing of radioactive gases via their charging action on atmospheric
humid air.Comment: 18 pages, 8 figure
Goodness-of-Fit Tests for Symmetric Stable Distributions -- Empirical Characteristic Function Approach
We consider goodness-of-fit tests of symmetric stable distributions based on
weighted integrals of the squared distance between the empirical characteristic
function of the standardized data and the characteristic function of the
standard symmetric stable distribution with the characteristic exponent
estimated from the data. We treat as an unknown parameter,
but for theoretical simplicity we also consider the case that is
fixed. For estimation of parameters and the standardization of data we use
maximum likelihood estimator (MLE) and an equivariant integrated squared error
estimator (EISE) which minimizes the weighted integral. We derive the
asymptotic covariance function of the characteristic function process with
parameters estimated by MLE and EISE. For the case of MLE, the eigenvalues of
the covariance function are numerically evaluated and asymptotic distribution
of the test statistic is obtained using complex integration. Simulation studies
show that the asymptotic distribution of the test statistics is very accurate.
We also present a formula of the asymptotic covariance function of the
characteristic function process with parameters estimated by an efficient
estimator for general distributions
Dense molecular gas toward W49A: A template for extragalactic starbursts?
The HCN, HCO+, and HNC molecules are commonly used as tracers of dense
star-forming gas in external galaxies, but such observations are spatially
unresolved. Reliably inferring the properties of galactic nuclei and disks
requires detailed studies of sources whose structure is spatially resolved. We
compare the spatial distributions and abundance ratios of HCN, HCO+, and HNC in
W49A, the most massive and luminous star-forming region in the Galactic disk,
based on maps of a 2' (6.6 pc) field at 14" (0.83 pc) resolution of the J=4-3
transitions of HCN, H13CN, HC15N, HCO+, H13CO+, HC18O+ and HNC. The kinematics
of the molecular gas in W49A appears complex, with a mixture of infall and
outflow motions. Both the line profiles and comparison of the main and rarer
species show that the main species are optically thick. Two 'clumps' of
infalling gas appear to be at ~40 K, compared to ~100 K at the source centre,
and may be ~10x denser than the rest of the outer cloud. Chemical modelling
suggests that the HCN/HNC ratio probes the current gas temperature, while the
HCN/HCO+ ratio and the deuterium fractionation were set during an earlier,
colder phase of evolution. The data suggest that W49A is an appropriate
analogue of an extragalactic star forming region. Our data show that the use of
HCN/HNC/HCO+ line ratios as proxies for the abundance ratios is incorrect for
W49A, suggesting the same for galactic nuclei. Our observed isotopic line
ratios such as H13CN/H13CO+ approach our modeled abundance ratios quite well in
W49A. The 4-3 lines of HCN and HCO+ are much better tracers of the dense
star-forming gas in W49A than the 1-0 lines. Our observed HCN/HNC and HCN/HCO+
ratios in W49A are inconsistent with homogeneous PDR or XDR models, indicating
that irradiation hardly affects the gas chemistry in W49A. Overall, the W49A
region appears to be a useful template for starburst galaxies.Comment: Accepted by A&A; 17 pages, 15 figure
Extended warm and dense gas towards W49A: starburst conditions in our Galaxy?
The star formation rates in starburst galaxies are orders of magnitude higher
than in local star-forming regions, and the origin of this difference is not
well understood. We use sub-mm spectral line maps to characterize the physical
conditions of the molecular gas in the luminous Galactic star-forming region
W49A and compare them with the conditions in starburst galaxies. We probe the
temperature and density structure of W49A using H_2CO and HCN line ratios over
a 2'x2' (6.6x6.6 pc) field with an angular resolution of 15" (~0.8 pc) provided
by the JCMT Spectral Legacy Survey. We analyze the rotation diagrams of lines
with multiple transitions with corrections for optical depth and beam dilution,
and estimate excitation temperatures and column densities. Comparing the
observed line intensity ratios with non-LTE radiative transfer models, our
results reveal an extended region (about 1'x1', equivalent to ~3x3 pc at the
distance of W49A) of warm (> 100 K) and dense (>10^5 cm^-3) molecular gas, with
a mass of 2x10^4 - 2x10^5 M_Sun (by applying abundances derived for other
regions of massive star-formation). These temperatures and densities in W49A
are comparable to those found in clouds near the center of the Milky Way and in
starburst galaxies. The highly excited gas is likely to be heated via shocks
from the stellar winds of embedded, O-type stars or alternatively due to UV
irradiation, or possibly a combination of these two processes. Cosmic rays,
X-ray irradiation and gas-grain collisional heating are less likely to be the
source of the heating in the case of W49A.Comment: Accepted for publication in A&A; 11 pages, 9 figure
Social networks and labour productivity in Europe: An empirical investigation
This paper uses firm-level data recorded in the AMADEUS database to
investigate the distribution of labour productivity in different European
countries. We find that the upper tail of the empirical productivity
distributions follows a decaying power-law, whose exponent is obtained
by a semi-parametric estimation technique recently developed by Clementi et al.
(2006). The emergence of "fat tails" in productivity distribution has already
been detected in Di Matteo et al. (2005) and explained by means of a model of
social network. Here we show that this model is tested on a broader sample of
countries having different patterns of social network structure. These
different social attitudes, measured using a social capital indicator, reflect
in the power-law exponent estimates, verifying in this way the existence of
linkages among firms' productivity performance and social network.Comment: LaTeX2e; 18 pages with 3 figures; Journal of Economic Interaction and
Coordination, in pres
Molecular excitation in the Interstellar Medium: recent advances in collisional, radiative and chemical processes
We review the different excitation processes in the interstellar mediumComment: Accepted in Chem. Re
Mining multi-item drug adverse effect associations in spontaneous reporting systems
<p>Abstract</p> <p>Background</p> <p>Multi-item adverse drug event (ADE) associations are associations relating multiple drugs to possibly multiple adverse events. The current standard in pharmacovigilance is bivariate association analysis, where each single drug-adverse effect combination is studied separately. The importance and difficulty in the detection of multi-item ADE associations was noted in several prominent pharmacovigilance studies. In this paper we examine the application of a well established data mining method known as association rule mining, which we tailored to the above problem, and demonstrate its value. The method was applied to the FDAs spontaneous adverse event reporting system (AERS) with minimal restrictions and expectations on its output, an experiment that has not been previously done on the scale and generality proposed in this work.</p> <p>Results</p> <p>Based on a set of 162,744 reports of suspected ADEs reported to AERS and published in the year 2008, our method identified 1167 multi-item ADE associations. A taxonomy that characterizes the associations was developed based on a representative sample. A significant number (67% of the total) of potential multi-item ADE associations identified were characterized and clinically validated by a domain expert as previously recognized ADE associations. Several potentially novel ADEs were also identified. A smaller proportion (4%) of associations were characterized and validated as known drug-drug interactions.</p> <p>Conclusions</p> <p>Our findings demonstrate that multi-item ADEs are present and can be extracted from the FDAâs adverse effect reporting system using our methodology, suggesting that our method is a valid approach for the initial identification of multi-item ADEs. The study also revealed several limitations and challenges that can be attributed to both the method and quality of data.</p
Design of Experiments for Screening
The aim of this paper is to review methods of designing screening
experiments, ranging from designs originally developed for physical experiments
to those especially tailored to experiments on numerical models. The strengths
and weaknesses of the various designs for screening variables in numerical
models are discussed. First, classes of factorial designs for experiments to
estimate main effects and interactions through a linear statistical model are
described, specifically regular and nonregular fractional factorial designs,
supersaturated designs and systematic fractional replicate designs. Generic
issues of aliasing, bias and cancellation of factorial effects are discussed.
Second, group screening experiments are considered including factorial group
screening and sequential bifurcation. Third, random sampling plans are
discussed including Latin hypercube sampling and sampling plans to estimate
elementary effects. Fourth, a variety of modelling methods commonly employed
with screening designs are briefly described. Finally, a novel study
demonstrates six screening methods on two frequently-used exemplars, and their
performances are compared
Estimation of a suitable Schmidt number range in diesel sprays at high injection pressure
The aim of this paper is to estimate a suitable range for the Schmidt number value in non-evaporative diesel sprays. For this purpose, mass distribution data obtained from X-ray absorption experiments existing in literature and a theoretical derivation for spray microscopic characteristics have been combined. Firstly, a procedure based on Gaussian concentration profiles has been proposed in order to interpret X-ray absorption results and relate them to physical parameters as local concentration or spray density. After this, information about FWHM (Full Width at Half Maximum) values has allowed to estimate spray angle in the tested conditions by the definition of Gaussian profiles for the mass radial distribution inside the spray. Following, a theoretical model dependent on momentum flux and Schmidt number has been used to simulate local mass concentration evolution along the spray axis and compare it with the values obtained from the experiments. The combination of the experimental and the theoretical data has allowed to estimate a suitable range for the Schmidt number value in such conditions as those existing in diesel sprays. © 2011 Elsevier Masson SAS. All rights reserved.This work was sponsored by "Vicerrectorado de Investigacion, Desarrollo e Innovacion" of the "Universitat Politecnica de Valencia" in the frame of the project "Estudio numeric de la cavitacion en toberas de inyeccion Diesel mediante Grid Computing (Cavigrid) Reference No 2597.Salvador Rubio, FJ.; Ruiz Rosales, S.; Gimeno, J.; De La Morena Borja, J. (2011). Estimation of a suitable Schmidt number range in diesel sprays at high injection pressure. International Journal of Thermal Sciences. 50(9):1790-1798. doi:10.1016/j.ijthermalsci.2011.03.030S1790179850
Positive predictive value of automated database records for diabetic ketoacidosis (DKA) in children and youth exposed to antipsychotic drugs or control medications: a tennessee medicaid study
<p>Abstract</p> <p>Background</p> <p>Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of treatment with some atypical antipsychotic drugs in children and <b>youth</b>. Because drug-associated DKA is rare, large automated health outcomes databases may be a valuable data source for conducting pharmacoepidemiologic studies of DKA associated with exposure to individual antipsychotic drugs. However, no validated computer case definition of DKA exists. We sought to assess the positive predictive value (PPV) of a computer case definition to detect incident cases of DKA, using automated records of Tennessee Medicaid as the data source and medical record confirmation as a "gold standard."</p> <p>Methods</p> <p>The computer case definition of DKA was developed from a retrospective cohort study of antipsychotic-related type 2 diabetes mellitus (1996-2007) in Tennessee Medicaid enrollees, aged 6-24 years. Thirty potential cases with any DKA diagnosis (ICD-9 250.1, ICD-10 E1x.1) were identified from inpatient encounter claims. Medical records were reviewed to determine if they met the clinical definition of DKA.</p> <p>Results</p> <p>Of 30 potential cases, 27 (90%) were successfully abstracted and adjudicated. Of these, 24 cases were confirmed by medical record review (PPV 88.9%, 95% CI 71.9 to 96.1%). Three non-confirmed cases presented acutely with severe hyperglycemia, but had no evidence of acidosis.</p> <p>Conclusions</p> <p>Diabetic ketoacidosis in children and youth can be identified in a computerized Medicaid database using our case definition, which could be useful for automated database studies in which drug-associated DKA is the outcome of interest.</p
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