Alterations in Homologous Recombination-Related Genes and Distinct Platinum Response in Metastatic Triple-Negative Breast Cancers: A Subgroup Analysis of the ProfiLER-01 Trial

International audienc

Chapitre 9. Le point de vue des praticiens en aménagement

Les statistiques le montrent, plusieurs familles montréalaises, par choix ou par obligation, quittent la ville chaque année pour s’établir dans les municipalités voisines. En effet, les chiffres et la cartographie présentés par Gill (chapitre 1) font bien ressortir l’exode des quartiers centraux au profit de secteurs suburbains, caractérisés par une plus faible densité et l’abondance d’habitations unifamiliales. Quoique Montréal présente un solde positif de ménages familiaux accueillis annuel..

Application of the person-centered care to manage responsive behaviors in clients with major neurocognitive disorders : a qualitative single case study

Objectives: Our study aimed to describe “how” and “why” the person-centered care (PCC) approach was applied within a long-term care (LTC) community to manage responsive behaviors (RBs) in individuals with major neurocognitive disorders.Methods: A descriptive holistic single case study design was employed in the context of an LTC community in Quebec, using semi-structured interviews and non-participatory observations of experienced care providers working with clients with RBs, photographing the physical environ-ment, and accessing documents available on the LTC community’s public website. A thematic content analysis was used for data analysis.Results: The findings generated insight into the importance of considering multiple components of the LTC community to apply the PCC approach for managing RBs, including a) creating a homelike environment, b) developing a therapeutic relationship with clients, c) engaging clients in mean-ingful activities, and d) empowering care providers by offering essential resources.Conclusions: Applying and implementing the PCC approach within an LTC community to manage clients’ RBs is a long-term multi-dimensional process that requires a solid foundation.Clinical implications: These findings highlight the importance of considering multiple factors relevant to persons, environments, and meaningful activities to apply the PCC approach within LTC communities to manage RBs

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

International audienceTo investigate whether Src, JAK2 and phosphatidylinositol 3-kinase (PI3K) pathways are involved in the proliferation of human colonic tumour cells induced by glycine-extended gastrin (G-gly), the precursor of the mature amidated gastrin and to elucidate the molecular interaction between these three kinases in response to this peptide

Vivre en famille au cœur de la ville

La réinvention de l'habitat familial par le développement de la ville-satellite, de la cité-jardin ou de la banlieue a suscité - suscite encore - beaucoup d'enthousiasme. Or, les effets pervers de la prolifération de ces formes urbaines, notamment par la disqualification des quartiers anciens et des espaces publics et la dépendance à l'automobile, sont de plus en plus évidents. Aujourd'hui, le défi de mieux arrimer la vie en famille et la ville reste entier. Il passe par la transformation des milieux aménagés dans les dernières décennies, certes, mais surtout par la réhabilitation des quartiers délaissés du cœur de la ville. Ce livre ne fait pas que revisiter les arguments mettant en opposition ville et banlieue, il vise aussi à rendre intelligible une réalité complexe et nuancée : celle de la diversité des quartiers, des familles et des perspectives d'intervention. Il ne s'agit pas ici de favoriser une forme d'habitat au détriment d'une autre, mais d'envisager l'environnement urbain comme un ensemble d'espaces complémentaires et, à leur manière, profitables

Aerosol and ozone changes as forcing for climate evolution between 1850 and 2100

International audienceGlobal aerosol and ozone distributions and their associated radiative forcings were simulated between 1850 and 2100 following a recent historical emission dataset and under the representative concentration pathways (RCP) for the future. These simulations were used in an Earth System Model to account for the changes in both radiatively and chemically active compounds, when simulating the climate evolution. The past negative stratospheric ozone trends result in a negative climate forcing culminating at −0.15 W m−2 in the 1990s. In the meantime, the tropospheric ozone burden increase generates a positive climate forcing peaking at 0.41 W m−2. The future evolution of ozone strongly depends on the RCP scenario considered. In RCP4.5 and RCP6.0, the evolution of both stratospheric and tropospheric ozone generate relatively weak radiative forcing changes until 2060-2070 followed by a relative 30 % decrease in radiative forcing by 2100. In contrast, RCP8.5 and RCP2.6 model projections exhibit strongly different ozone radiative forcing trajectories. In the RCP2.6 scenario, both effects (stratospheric ozone, a negative forcing, and tropospheric ozone, a positive forcing) decline towards 1950s values while they both get stronger in the RCP8.5 scenario. Over the twentieth century, the evolution of the total aerosol burden is characterized by a strong increase after World War II until the middle of the 1980s followed by a stabilization during the last decade due to the strong decrease in sulfates in OECD countries since the 1970s. The cooling effects reach their maximal values in 1980, with −0.34 and −0.28 W m−2 respectively for direct and indirect total radiative forcings. According to the RCP scenarios, the aerosol content, after peaking around 2010, is projected to decline strongly and monotonically during the twenty-first century for the RCP8.5, 4.5 and 2.6 scenarios. While for RCP6.0 the decline occurs later, after peaking around 2050. As a consequence the relative importance of the total cooling effect of aerosols becomes weaker throughout the twenty-first century compared with the positive forcing of greenhouse gases. Nevertheless, both surface ozone and aerosol content show very different regional features depending on the future scenario considered. Hence, in 2050, surface ozone changes vary between −12 and +12 ppbv over Asia depending on the RCP projection, whereas the regional direct aerosol radiative forcing can locally exceed −3 W m−2

Upregulated Apelin Signaling in Pancreatic Cancer Activates Oncogenic Signaling Pathways to Promote Tumor Development

International audienceDespite decades of effort in understanding pancreatic ductal adenocarcinoma (PDAC), there is still a lack of innovative targeted therapies for this devastating disease. Herein, we report the expression of apelin and its receptor, APJ, in human pancreatic adenocarcinoma and its protumoral function. Apelin and APJ protein expression in tumor tissues from patients with PDAC and their spatiotemporal pattern of expression in engineered mouse models of PDAC were investigated by immunohistochemistry. Apelin signaling function in tumor cells was characterized in pancreatic tumor cell lines by Western blot as well as proliferation, migration assays and in murine orthotopic xenograft experiments. In premalignant lesions, apelin was expressed in epithelial lesions whereas APJ was found in isolated cells tightly attached to premalignant lesions. However, in the invasive stage, apelin and APJ were co-expressed by tumor cells. In human tumor cells, apelin induced a long-lasting activation of PI3K/Akt, upregulated β-catenin and the oncogenes c-myc and cyclin D1 and promoted proliferation, migration and glucose uptake. Apelin receptor blockades reduced cancer cell proliferation along with a reduction in pancreatic tumor burden. These findings identify the apelin signaling pathway as a new actor for PDAC development and a novel therapeutic target for this incurable disease