344 research outputs found

    '"Intercomprehension: a reflexive methodology in language education

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    Depuis les annĂ©es 90, la didactique de l’intercomprĂ©hension constitue une nouvelle perspective d’éducation/apprentissage aux langues, principalement en Europe, oĂč elle a Ă©tĂ© mise en Ɠuvre entre les langues appartenant Ă  une mĂȘme famille (langues romanes, scandinaves ou germaniques). Les chercheurs du projet EUROCOM ont montrĂ© que l’anglais, une des plus importantes lingua franca du monde, pouvait aussi ĂȘtre utilisĂ© comme passerelle vers n’importe quelle langue romane, y compris le français, autre importante lingua franca. Cependant, l’intercomprĂ©hension comme mĂ©thode semble quasiment inconnue dans les pays anglophones, alors qu’elle pourrait servir Ă  promouvoir l’éducation aux langues Ă©trangĂšres et au plurilinguisme dans ces pays. Ainsi, cet article prĂ©sente la didactique de l’intercomprĂ©hension, des exemples concrets d’application d’intercomprĂ©hension entre l’anglais et le français Ă  l’appui, dans le but de mettre en lumiĂšre la potentialitĂ© de cette mĂ©thode, moyen pour les apprenants de s’approprier leur bilingualitĂ© et devenir des apprenants rĂ©flexifs.Fin dagli anni ’90 la didattica dell’intercomprensione costituisce una nuova prospettiva di educazione alle lingue e di apprendimento, particolarmente in Europa, dove Ăš stata messa in atto fra lingue appartenenti ad una stessa fmaiglia (lingue romanze, scandinave, germaniche). I ricercatori del progetto EUROCOM hanno mostrato come l’inglese, una delle piĂč importanti lingue franche del mondo, possa essere usato anche come passerella verso una qualsiasi lingua romanza, compreso il francese, altra importante lingua franca. Tuttavia l’intercomprensione come metodo sembra quasi sconosciuta nei Paesi anglofoni, laddove essa potrebbe contribuire a promuovere l’educazione alle lingue straniere ad al plurilinguismo in questi Paesi. Quest’articolo presenta quindi la didattica dell’intercomprensione, sulla base di esempi concreti d’applicazione dell’intercomprensione fra inglese ed francese, allo scopo di mettere in luce la potenzialitĂ  di questo metodo, mezzo per gli allievi di appropriarsi della loro competenza bilingue e per diventare allievi riflessivi

    IFprofs: le rĂ©seau des professionnels de l’éducation en français

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    Dal 2015 l’Institut français Paris si sforza di svuluppare una rete sociale mondiale di professionisti del mondo dell’istruzione in francese, che raggruppa soprattutto insegnanti, futuri insegnanti, formatori, ricercatori, consulenti pedagogici, responsabili d’istituto e delle mediateche.Since 2015, the French Institute in Paris has been developing a social network of French-language education professionals worldwide. The network brings together in particular teachers, future teachers, teacher trainers, researchers, pedagogical counselors, as well as all those in charge of media libraries or other institutions

    APRESENTAÇÃO: QUESTIONAR OS SABERES A PARTIR DOS PERTENCIMENTOS

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    Halide Ligands to Release Strain in Cadmium Chalcogenide Nanoplatelets and Achieve High Brightness

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    International audienceZinc blende II-VI semiconductor nanoplatelets (NPLs) are defined at the atomic scale along the thickness of the nanoparticle and are initially capped with carboxylates on the top and bottom [001] facets. These ligands are exchanged on CdSe NPLs with halides that act as X-L-type ligands. These CdSe NPLs are costabilized by amines to provide colloidal stability in nonpolar solvents. The hydrogen from the amine can participate in a hydrogen bond with the lone pair electrons of surface halides. After ligand exchange, the optical features are redshifted. Thus, ligand tuning is another way, in addition to confinement, to tune the optical features of NPLs. The improved surface passivation leads to an increase in the fluorescence quantum efficiency of up to 70% in the case of bromide. However, for chloride and iodide, the surface coverage is incomplete, and thus, the fluorescence quantum efficiency is lower. This ligand exchange is associated with a decrease in stress that leads to unfolding of the NPLs, which is particularly noticeable for iodide-capped NPLs

    Emission State Structure and Linewidth Broadening Mechanisms in Type-II CdSe/CdTe Core–Crown Nanoplatelets: A Combined Theoretical–Single Nanocrystal Optical Study

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    Type-II heterostructures are key elementary components in optoelectronic, photovoltaic, and quantum devices. The staggered band alignment of materials leads to the stabilization of indirect excitons (IXs), i.e., correlated electron–hole pairs experiencing spatial separation with novel properties, boosting optical gain and promoting strategies for the design of information storage, charge separation, or qubit manipulation devices. Planar colloidal CdSe/CdTe core–crown type-II nested structures, grown as nanoplatelets (NPLs), are the focus of the present work. By combining low temperature single NPL measurements and electronic structure calculations, we gain insights into the mechanisms impacting the emission properties. We are able to probe the sensitivity of the elementary excitations (IXs, trions) with respect to the appropriate structural parameter (core size). Neutral IXs, with binding energies reaching 50 meV, are shown to dominate the highly structured single NPL emission. The large broadening linewidth that persists at the single NPL level clearly results from strong exciton–LO phonon coupling (Eph = 21 meV) whose strength is poorly influenced by trapped charges. The spectral jumps (≈10 meV) in the photoluminescence recorded as a function of time are explained by the fluctuations in the IX electrostatic environment considering fractional variations (≈0.2 e) of the noncompensated charge defects

    Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

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    Abstract Cardiac ischaemia-reperfusion (I/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Hence, AOX represents a natural rescue mechanism from respiratory stress. This study aimed to determine how respiratory restoration through xenotopically expressed AOX affects the re-perfused post-ischaemic mouse heart. As expected, AOX supports ETC function and attenuates the ROS load in post-anoxic heart mitochondria. However, post-ischaemic cardiac remodelling over 3 and 9 weeks was not improved. AOX blunted transcript levels of factors known to be up-regulated upon I/R such as the atrial natriuretic peptide (Anp) whilst expression of pro-fibrotic and pro-apoptotic transcripts were increased. Ex vivo analysis revealed contractile failure at nine but not 3 weeks after ischaemia whilst label-free quantitative proteomics identified an increase in proteins promoting adverse extracellular matrix remodelling. Together, this indicates an essential role for ETC-derived signals during cardiac adaptive remodelling and identified ROS as a possible effector.Peer reviewe

    Respiratory chain signalling is essential for adaptive remodelling following cardiac ischaemia

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    Abstract Cardiac ischaemia-reperfusion (I/R) injury has been attributed to stress signals arising from an impaired mitochondrial electron transport chain (ETC), which include redox imbalance, metabolic stalling and excessive production of reactive oxygen species (ROS). The alternative oxidase (AOX) is a respiratory enzyme, absent in mammals, that accepts electrons from a reduced quinone pool to reduce oxygen to water, thereby restoring electron flux when impaired and, in the process, blunting ROS production. Hence, AOX represents a natural rescue mechanism from respiratory stress. This study aimed to determine how respiratory restoration through xenotopically expressed AOX affects the re-perfused post-ischaemic mouse heart. As expected, AOX supports ETC function and attenuates the ROS load in post-anoxic heart mitochondria. However, post-ischaemic cardiac remodelling over 3 and 9 weeks was not improved. AOX blunted transcript levels of factors known to be up-regulated upon I/R such as the atrial natriuretic peptide (Anp) whilst expression of pro-fibrotic and pro-apoptotic transcripts were increased. Ex vivo analysis revealed contractile failure at nine but not 3 weeks after ischaemia whilst label-free quantitative proteomics identified an increase in proteins promoting adverse extracellular matrix remodelling. Together, this indicates an essential role for ETC-derived signals during cardiac adaptive remodelling and identified ROS as a possible effector.Peer reviewe

    Rapidly measured indicators of recreational water quality and swimming-associated illness at marine beaches: a prospective cohort study

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    <p>Abstract</p> <p>Introduction</p> <p>In the United States and elsewhere, recreational water quality is monitored for fecal indicator bacteria to help prevent swimming-associated illnesses. Standard methods to measure these bacteria take at least 24 hours to obtain results. Molecular approaches such as quantitative polymerase chain reaction (qPCR) can estimate these bacteria faster, in under 3 hours. Previously, we demonstrated that measurements of the fecal indicator bacteria <it>Enterococcus </it>using qPCR were associated with gastrointestinal (GI) illness among swimmers at freshwater beaches. In this paper, we report on results from three marine beach sites.</p> <p>Methods</p> <p>We interviewed beach-goers and collected water samples at marine beaches affected by treated sewage discharges in Mississippi in 2005, and Rhode Island and Alabama in 2007. Ten to twelve days later, we obtained information about gastrointestinal, respiratory, eye, ear and skin symptoms by telephone. We tested water samples for fecal indicator organisms using qPCR and other methods.</p> <p>Results</p> <p>We enrolled 6,350 beach-goers. The occurrence of GI illness among swimmers was associated with a log<sub>10</sub>-increase in exposure to qPCR-determined estimates of fecal indicator organisms in the genus <it>Enterococcus </it>(AOR = 2.6, 95% CI 1.3-5.1) and order <it>Bacteroidales </it>(AOR = 1.9, 95% CI 1.3-2.9). Estimates of organisms related to <it>Clostridium perfringens </it>and a subgroup of organisms in the genus <it>Bacteroides </it>were also determined by qPCR in 2007, as was F+ coliphage, but relationships between these indicators and illness were not statistically significant.</p> <p>Conclusions</p> <p>This study provides the first evidence of a relationship between gastrointestinal illness and estimates of fecal indicator organisms determined by qPCR at marine beaches.</p
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