Genetic parameters for first lactation dairy traits in the Alpine and Saanen goat breeds using a random regression test-day model

International audienceAbstractBackgroundRandom regression models (RRM) are widely used to analyze longitudinal data in genetic evaluation systems because they can better account for time-course changes in environmental effects and additive genetic values of animals by fitting the test-day (TD) specific effects. Our objective was to implement a random regression model for the evaluation of dairy production traits in French goats.ResultsThe data consisted of milk TD records from 30,186 and 32,256 first lactations of Saanen and Alpine goats. Milk yield, fat yield, protein yield, fat content and protein content were considered. Splines were used to model the environmental factors. The genetic and permanent environmental effects were modeled by the same Legendre polynomials. The goodness-of-fit and the genetic parameters derived from functions of the polynomials of orders 0 to 4 were tested. Results were also compared to those from a lactation model with total milk yield calculated over 250 days and to those of a multiple-trait model that considers performance in six periods throughout lactation as different traits. Genetic parameters were consistent between models. Models with fourth-order Legendre polynomials led to the best fit of the data. In order to reduce complexity, computing time, and interpretation, a rank reduction of the variance covariance matrix was performed using eigenvalue decomposition. With a reduction to rank 2, the first two principal components correctly summarized the genetic variability of milk yield level and persistency, with a correlation close to 0 between them.ConclusionsA random regression model was implemented in France to evaluate and select goats for yield traits and persistency, which are independent i.e. no genetic correlation between them, in first lactation

A GPS network for tropospheric tomography in the framework of the Mediterranean hydrometeorological observatory Cévennes-Vivarais (south-eastern France)

International audienceThe Mediterranean hydrometeorological observatory Cévennes-Vivarais (OHM-CV) coordinates hydrometeorological observations (radars, rain gauges, water level stations) on a regional scale in southeastern France. In the framework of OHM-CV, temporary GPS measurements have been carried out for 2 months in autumn 2002, when the heaviest rainfall are expected. These measurements increase the spatial density of the existing permanent GPS network, by adding three more receivers between the Mediterranean coast and the Cévennes-Vivarais range to monitor maritime source of water vapour flow feeding the precipitating systems over the Cévennes-Vivarais region. In addition, a local network of 18 receivers covered an area of 30 by 30 km within the field of view of the meteorological radar. These regional and local networks of permanent and temporary stations are used to monitor the precipitable water vapour (PWV) with high temporal resolution (15 min). Also, the dense local network provided data which have been inverted using tomographic techniques to obtain the 3-D field of tropospheric water vapour content. This study presents methodological tests for retrieving GPS tropospheric observations from dense networks, with the aim of assessing the uncertainties of GPS retrievals. Using optimal tropospheric GPS retrieval methods, high resolution measurements of PWV on a local scale (a few kilometres) are discussed for rain events. Finally, the results of 3-D fields of water vapour densities from GPS tomography are analysed with respect to precipitation fields derived from a meteorological radar, showing a good correlation between precipitation and water vapour depletion areas

Exploration naturaliste sous-marine des petits fonds rocheux du Cap Santa Clara au Cap Esterias, Province de l’Estuaire, Gabon: les poissons marins

Bien que située à moins de vingt kilomètres du centre de la capitale Libreville, la zone marine comprise entre le Cap Santa Clara et le Cap Esterias n’avait fait l’objet que de travaux scientifiques limités, essentiellement orientés vers les tortues marines, emblématiques des efforts de conservation du milieu marin au Gabon. Aucun véritable inventaire de la faune spécifique aux estrans et aux petits fonds rocheux n’avait été entrepris, et l’évidence d’une mission d’exploration s’imposait, renforcée par la probabilité de découvrir de nouvelles espèces, pour le Gabon, voire peut-être même pour la Science.info:eu-repo/semantics/publishedVersio

HyMeX: A 10-Year Multidisciplinary Program on the Mediterranean Water Cycle

Drobinski, P. ... et. al.-- 20 pages, 10 figures, 1 table, supplement material http://journals.ametsoc.org/doi/suppl/10.1175/BAMS-D-12-00244.1HyMeX strives to improve our understanding of the Mediterranean water cycle, its variability from the weather-scale events to the seasonal and interannual scales, and its characteristics over one decade (2010–20), with a special focus on hydrometeorological extremes and the associated social and economic vulnerability of the Mediterranean territoriesHyMeX was developed by an international group of scientists and is currently funded by a large number of agencies. It has been the beneficiary of financial contributions from CNRS; Météo-France; CNES; IRSTEA; INRA; ANR; Collectivité Territoriale de Corse; KIT; CNR; Université de Toulouse; Grenoble Universités; EUMETSAT; EUMETNET; AEMet; Université Blaise Pascal, Clermont Ferrand; Université de la Méditerranée (Aix-Marseille II); Université Montpellier 2; CETEMPS; Italian Civil Protection Department; Université Paris- Sud 11; IGN; EPFL; NASA; New Mexico Tech; IFSTTAR; Mercator Ocean; NOAA; ENEA; TU Delft; CEA; ONERA; IMEDEA; SOCIB; ETH; MeteoCat; Consorzio LAMMA; IRD; National Observatory of Athens; Ministerio de Ciencia e Innovación; CIMA; BRGM; Wageningen University and Research Center; Department of Geophysics, University of Zagreb; Institute of Oceanography and Fisheries, Split, Croatia; INGV; OGS; Maroc Météo; DHMZ; ARPA Piemonte; ARPA-SIMC Emilia-Romagna; ARPA Calabria; ARPA Friuli Venezia Giulia; ARPA Liguria; ISPRA; University of Connecticut; Università degli Studi dell'Aquila; Università di Bologna; Università degli Studi di Torino; Università degli Studi della Basilicata; Università La Sapienza di Roma; Università degli Studi di Padova; Università del Salento; Universitat de Barcelona; Universitat de les Illes Balears; Universidad de Castilla-La Mancha; Universidad Complutense de Madrid; MeteoSwiss; and DLR. It also received support from the European Community's Seventh Framework Programme (e.g., PERSEUS, CLIM-RUN)Peer reviewe

Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection

Background: Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene. Objectives: This study sought to test the association between the rs9349379 genotype and SCAD. Methods: Results from case control studies from France, United Kingdom, United States, and Australia were analyzed to test the association with SCAD risk, including age at first event, pregnancy-associated SCAD (P-SCAD), and recurrent SCAD. Results: The previously reported risk allele for FMD (rs9349379-A) was associated with a higher risk of SCAD in all studies. In a meta-analysis of 1,055 SCAD patients and 7,190 controls, the odds ratio (OR) was 1.67 (95% confidence interval [CI]: 1.50 to 1.86) per copy of rs9349379-A. In a subset of 491 SCAD patients, the OR estimate was found to be higher for the association with SCAD in patients without FMD (OR: 1.89; 95% CI: 1.53 to 2.33) than in SCAD cases with FMD (OR: 1.60; 95% CI: 1.28 to 1.99). There was no effect of genotype on age at first event, P-SCAD, or recurrence. Conclusions: The first genetic risk factor for SCAD was identified in the largest study conducted to date for this condition. This genetic link may contribute to the clinical overlap between SCAD and FMD

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Tourisme d’observation et éléphants de forêt (Loxodonta cyclotis) au Campement de Nyonié, Gabon

Central African ecosystems are home to a rich biodiversity, including the endangered forest elephant (Loxodonta cyclotis). Ecotourism is a growing industry in the region, but it can have a negative impact on elephant populations. This study investigates the relationship between ecotourism and forest elephants at the "Campement de Nyonié" in Gabon, a tourist site located outside of protected areas. Data was collected through direct observations of elephants on foot and in off-road vehicle. Results showed that elephants are present in a large and continuous area around the camp. Their activity is concentrated in the south, near the Wonga-Wongué Presidential Reserve, and in the west, near the coast. Elephants live in matriarchal groups, led by older females. The results suggest that tourist activity at the "Campement de Nyonié" does not drive elephants away. On the contrary, it could even contribute to their conservation by raising public awareness and generating revenue for environmental protection. The study highlights the importance of cooperation between tourism stakeholders and authorities to balance biodiversity conservation and economic development. Keywords: Sighting tourism, Loxodonta cyclotis, spatial distribution, social structuring, Campement de NyoniéLes écosystèmes d'Afrique centrale abritent une importante biodiversité, dont l'éléphant de forêt (Loxodonta cyclotis), une espèce menacée. Le tourisme d'observation de la faune est une activité en plein essor dans la sous-région, mais il peut avoir un impact négatif sur les populations d'éléphants. Une étude a été menée au Campement de Nyonié, au Gabon, un site touristique situé en dehors des aires protégées. Les données ont été collectées par observations directes des éléphants à pied et en voiture tout-terrain. Les résultats montrent que les éléphants sont présents dans une zone large et continue autour du Campement de Nyonié. Leur activité se concentre au sud, près de la Réserve présidentielle de Wonga-Wongué et à l'ouest, près de la côte. Les éléphants vivent en groupes matriarcaux, dirigés par des femelles âgées. Les résultats suggèrent que l'activité touristique du Campement de Nyonié n'éloigne pas les éléphants. Au contraire, elle pourrait même contribuer à leur conservation en favorisant la sensibilisation du public et en générant des revenus pour la protection de l'environnement. Les résultats de cette étude soulignent l'importance de la coopération entre les acteurs du tourisme et les autorités pour concilier la conservation de la biodiversité et le développement économique. Mots clés: Tourisme d’observation, Loxodonta cyclotis, distribution spatiale, structuration sociale, Campement de Nyoni

Paradoxical State Anxiety and Working Memory in a Patient with Acute Stroke

International audienc

JDS_ARNAL_SUPPLEMENTARY_MATERIAL_TABLE S1

 SUPPLEMENTARY MATERIAL TABLE S1: Position and percentages of variance explained by segments of 10 adjacent SNPs explaining more than 1% of variance</p