The Physiological Profile of a Blind Female Solo Ultra-Endurance Cyclist – a Novel Case Study

Ultra-endurance mountain biking (MTB) greater than 2,450 miles in 51 days with over 150,000 feet of elevation gain is a significant physiological and fear-inducing journey for anyone. This case study showcases the psychophysiology of a blind solo (i.e., single bike) rider (BSR) with history of traumatic brain injury (TBI) who achieved an unparalleled ride of the Tour Divide MTB route with 2 male guides (MG). PURPOSE: The primary purpose of this project was to observe the interplay between fatigue (acute training load, ATL), fitness (chronic training load, CTL), and form (training stress balance, TSB) as part of a performance management chart (PMC) and Training Stimulus Score™ (TSS™). METHODS: This case study was a retrospective, descriptive assessment of rider Training Peaks™ (Boulder, CO) TSS™ data, which portrays daily fluctuations between ATL (7 d avg), CTL (42 d avg), and TSB (yesterday’s CTL – yesterday’s ATL). The 3 riders continually wore a heart rate monitor and wearable wrist GPS technology (Garmin, Olathe, KS) to track metrics throughout the 51 d ride. RESULTS: BSR and MG (mean of 2 male guides) age, wt, ht, and BMI, respectively, were: 47 vs 47.5 y, 65.9 vs 77.3 kg, 1.6 vs 1.8 m, and 26.5 vs. 23.7 kg/m2. Average rider MTB metrics per day for distance, minutes, speed, and elevation gain were, respectively: 87.7±22.2 km, 7.5±2.3 hrs, 5.5±1.4 km/hr, and 957±205 m. Average daily riding heart rate, average riding peak HR, and TSS for BSR vs MG were, respectively: 138.8±5.9 vs 103.9±6.9 bpm, 161.6±27.9 vs 143.3±11.4 bpm, and 251.9±82.3 vs 302.0±95.7 TSS. BSR and MS RPE (6-20 scale) per day averages were 11-12 for overall body fatigue (i.e., all riders) and BSR was 19 for perceived “fear” vs MG remaining at 11-12 for “fear”. 51 d averages for ATL, CTL, and TSB for BSR vs MG were, respectively: 206.1±50.0 vs 216.4±48.1, 118.1±39.0 vs 117.5±32.1, and -76.6±35.0 vs -88.4±44.6. CONCLUSION: Despite greater, daily perceived “fear”, BSR (vs MG) maintained augmented PMC metrics, indicating less daily ATL, higher CTL, and better TSB. This may, in part, support BSR’s high physical ability to complete the ride despite self-reporting a greater degree of perceived “fear” each day. Ultimately, BSR’s achievements may help inform the blind and visually impaired population about accruing greater physical fitness to help offset perceptions of fear

Junctional sarcoplasmic reticulum motility in adult mouse ventricular myocytes.

Excitation-contraction (EC) coupling is the coordinated process by which an action potential triggers cardiac myocyte contraction. EC coupling is initiated in dyads where the junctional sarcoplasmic reticulum (jSR) is in tight proximity to the sarcolemma of cardiac myocytes. Existing models of EC coupling critically depend on dyad stability to ensure the fidelity and strength of EC coupling, where even small variations in ryanodine receptor channel and voltage-gated calcium channel-α 1.2 subunit separation dramatically alter EC coupling. However, dyadic motility has never been studied. Here, we developed a novel strategy to track specific jSR units in dissociated adult ventricular myocytes using photoactivatable fluorescent proteins. We found that the jSR is not static. Instead, we observed dynamic formation and dissolution of multiple dyadic junctions regulated by the microtubule-associated molecular motors kinesin-1 and dynein. Our data support a model where reproducibility of EC coupling results from the activation of a temporally averaged number of SR Ca2+ release units forming and dissolving SR-sarcolemmal junctions. These findings challenge the long-held view that the jSR is an immobile structure and provide insights into the mechanisms underlying its motility

Principles in Practice: The Advocacy and Empowerment Project

Complete Digitized Text of Chapter 8 of the book Combating Violence & Abuse of People with Disabilities: A Call to Action by Nancy M. Fitzsimons.https://cornerstone.lib.mnsu.edu/books-fitzsimons-combating-violence/1009/thumbnail.jp

Arranjo de plantas em trigo: atualização visando aumento no rendimento de grãos.

Orientador: João Leonardo Fernandes Pires

Obstetric and psychosocial risk factors for Australian-born and non-Australian born women and associated pregnancy and birth outcomes : a population based cohort study

Background: One in four Australians is born overseas and 47 % are either born overseas or have a parent who was. Obstetric and psychosocial risk factors for these women may differ. Method: Data from one Sydney hospital (2012–2013) of all births recorded in the ObstetriX™ database were analysed (n = 3,092). Demographics, obstetric and psychosocial risk profile, obstetric interventions and complications and selected maternal and neonatal outcomes were examined for women born in Australia and overseas. Results: Women born in Australia were younger, more likely to be primiparous (28.6 v 27.5 %), be obese (32.0 % v 21.4 %), smoke (19.7 % v 3.0 %), have an epidural (26.2 % v 20.2 %) and were less likely to have gestational diabetes mellitus (GDM) (6.8 % v 13.7 % when compared to non-Australian born women. The highest rates of GDM, Gestational Hypertension (GH) and maternal anaemia were seen in women born in China, the Philippines and Pakistan respectively. Differences were also seen in psychosocial screening between Australian and non-Australian women with Australian-born women more likely to smoke and report a mental health disorder. There was an association between having an Edinburgh Postnatal Depression Scale (EPDS) ≥ 13 and other psychosocial issues, such as thoughts of self-harm, domestic violence, childhood abuse etc. These women were also less likely to breastfeed. Women with an EPDS ≥ 13 at booking compared to women with EPDS ≤12 had a higher chance of being diagnosed with GDM (AOR 1.85 95 % CI 1.14–3.0). Conclusions: There are significant differences in obstetric and psychosocial risk profiles and maternal and neonatal outcomes between Australian-born and non-Australian born women. In particular there appears to be an association between an EPDS of ≥13 and developing GDM, which warrants further investigation

Conformational changes of calmodulin upon Ca2+ binding studied with a microfluidic mixer

A microfluidic mixer is applied to study the kinetics of calmodulin conformational changes upon Ca2+ binding. The device facilitates rapid, uniform mixing by decoupling hydrodynamic focusing from diffusive mixing and accesses time scales of tens of microseconds. The mixer is used in conjunction with multiphoton microscopy to examine the fast Ca2+-induced transitions of acrylodan-labeled calmodulin. We find that the kinetic rates of the conformational changes in two homologous globular domains differ by more than an order of magnitude. The characteristic time constants are ≈490 μs for the transitions in the C-terminal domain and ≈20 ms for those in the N-terminal domain of the protein. We discuss possible mechanisms for the two distinct events and the biological role of the stable intermediate, half-saturated calmodulin

Relationship of DAG1 and SERPINA5 Sperm Proteins With Bull Fertility

Study Description: Semen from 22 dairy bulls was used to evaluate the presence, localization, and quantification of DAG1 and SERPINA5 on sperm. Sperm motility parameters and viability was also evaluated for semen from each bull. Semen from 19 out of the 22 dairy bulls was used for in vitro embryo production (two Low-SCR and one High-SCR were not available for in vitro embryo production). Bulls were classified based on their sire conception rates (SCR) values as High-SCR (SCR \u3e 1.0) or Low-SCR fertility (SCR \u3c -4.0). Low fertility bulls were subdivided based on their blastocyst rate (BL) as High-BL (Low-SCR/High-BL BL ≥ 31%) or Low-BL (Low-SCR/Low-BL BL ≤ 26%), and High-SCR bulls were not subdivided. The GLM procedure in SAS was used with bull as a fixed effect to determine if variance was greater between bulls compared to within bull. Correlations were determined among DAG1 and SERPINA5 concentrations, percentage of tail labeled for SERPINA5, SCR, sperm total motility, progressive motility, and viability, and in vitro embryo produced cleavage rate (CL) and BL. The GLIMMIX procedure of SAS was used to evaluate the relationship of bull field fertility (High- and Low-SCR), and field and in vitro fertility (High-SCR, Low-SCR/High-BL, Low-SCR/Low-BL) classifications with sperm total (TMOT) and progressive (PROG) motility, viability, CL, BL, DAG1 and SERPINA5 relative concentration, and proportion of sperm tail labeled for SERPINA5. Both SERPINA5 and DAG1 were localized on the sperm head; however, SERPINA5 was also localized on the sperm tail. There was greater variance in concentration among bulls compared to within bull for both DAG1 (P \u3c 0.01; 69.4 vs 49.1, respectively) and SERPINA5 (P \u3c 0.01; 325.8 vs 285.4, respectively). There was a positive correlation between concentration of DAG1 and SERPINA5 (P = 0.01; r = 0.54). Concentrations of SERPINA5 were also correlated with CL (P = 0.04; r = 0.48), and percentage of sperm tail labeled for SERPINA5 was correlated with viability (P = 0.05; r = 0.44) and tended to be correlated with CL (P = 0.10; r = 0.39). There was no relationship between SCR or BL rate classifications and DAG1 (P ≥ 0.66), SERPINA5 (P ≥ 0.54), or percentage of sperm tail labeled for SERPINA5 (P ≥ 0.48)

The Perceived Size and Shape of Objects in Peripheral Vision

Little is known about how we perceive the size and shape of objects in far peripheral vision. Observations made during an artistic study of visual space suggest that objects appear smaller and compressed in the periphery compared with central vision. To test this, we conducted three experiments. In Experiment 1, we asked participants to draw how a set of peripheral discs appeared when viewed peripherally without time or eye movement constraints. In Experiment 2, we used the method of constant stimuli to measure when a briefly presented peripheral stimulus appeared bigger or smaller compared with a central fixated one. In Experiment 3, we measured how accurate participants were in discriminating shapes presented briefly in the periphery. In Experiment 1, the peripheral discs were reported as appearing significantly smaller than the central disc, and as having an elliptical or polygonal contour. In Experiment 2, participants judged the size of peripheral discs as being significantly smaller when compared with the central disc across most of the peripheral field, and in Experiment 3, participants were quite accurate in reporting the shape of the peripheral object, except in the far periphery. Our results show that objects in the visual periphery are perceived as diminished in size when presented for long and brief exposures, suggesting diminution is an intrinsic feature of the structure of the visual space. Shape distortions, however, are reported only with longer exposures

Using the community psychology competencies to address sexual assault on a college campus

Sexual assault on college campuses is a national issue, with a recent report from the White House estimating that 20% of women will experience a sexual assault during college.  Students at Wichita State University formed a campus organization to bring visibility to both community psychology and address this important problem.  The Community Psychology Association is comprised of both graduate and undergraduate students, and members utilized three community psychology competencies: ecological perspectives, information dissemination/building public awareness, and community organizing and community advocacy in their work to improve resources and campus support for this issue.  Community Psychology Association members utilized focus groups with campus students, faculty, and staff to facilitate discussions on sexual assault, campus safety, and university and administrative accountability.  Content analysis revealed multiple themes that were used to generate a larger campus discussion and promote change in campus policies. As a result of these activities, major changes occurred at Wichita State, including data driven programming for interventions regarding sexual assault, changes in leadership in the offices of Title IX and Student Affairs, support for a CDC grant, and overall increased organizational awareness for sexual assault survivors.  This study highlights the importance of applying community psychology principles and concepts to research and action to ultimately have a positive and tangible impact on the local community