Astrochemical confirmation of the rapid evolution of massive YSOs and explanation for the inferred ages of hot cores

Aims. To understand the roles of infall and protostellar evolution on the envelopes of massive young stellar objects (YSOs). Methods. The chemical evolution of gas and dust is traced, including infall and realistic source evolution. The temperatures are determined self-consistently. Both ad/desorption of ices using recent laboratory temperature-programmed-desorption measurements are included. Results. The observed water abundance jump near 100 K is reproduced by an evaporation front which moves outward as the luminosity increases. Ion-molecule reactions produce water below 100 K. The age of the source is constrained to t \~ 8 +/- 4 x 10^4 yrs since YSO formation. It is shown that the chemical age-dating of hot cores at ~ few x 10^3 - 10^4 yr and the disappearance of hot cores on a timescale of ~ 10^5 yr is a natural consequence of infall in a dynamic envelope and protostellar evolution. Dynamical structures of ~ 350AU such as disks should contain most of the complex second generation species. The assumed order of desorption kinetics does not affect these results.Comment: Accepted by A&A Letters; 4 pages, 5 figure

Cultural Resources Survey of the Leander Rehabilitation Center, Williamson County, Texas

In August-September 1996, personnel from Prewitt and Associates, Inc., conducted a cultural resources survey of ca. 725 acres of the former Leander Rehabilitation Center. The project area lies adjacent to U.S. Highway 183 and FM 620 in southern Williamson County, Texas. The survey resulted in additional documentation of one previously recorded prehistoric archeological site (41 WM452), the identification and recording of four historic archeological sites (41WM892, 41WM893, 41WM896, and 41WM897), and reconnaissance-level documentation of 45 historic buildings and structures. Site 41WM452 is an extensive upland lithic scatter and lithic procurement site which lacks subsurface deposits, features, and datable materials. Site 41WM892 is a wood-chopper camp that contains a number of rock alignments and limited artifact deposits dating to the first decade of the twentieth century. Site 41WM893 is a remnant of a railroad spur used during the 1937-1941 construction of Marshall Ford Dam (now Mansfield Dam). Site 41WM896 contains a small number of features and sparse artifact deposits associated with the 1937-1945 Rhodes farmstead. Site 41WM897 is an isolated historic well with unknown associations. None of these archeological sites contains important information, and it is recommended that they be considered not eligible for listing in the National Register of Historic Places or for designation as State Archeological Landmarks. The 45 buildings and structures, at 36 locations, are associated with the former State Dairy and Hog Farm. This farm was established in 1942, expanded after 1945, and reached its peak years of production as a hog farm between 1950 and the late 1960s, Created to serve the needs of the State Board of Control and the State Hospital, the facility is significant for its success in food production for eleemosynary institutions in Austin and throughout Texas, as well as for its role in the application of modern psychiatric treatment based on the therapeutic value of manual labor. Among the surveyed resources are dwellings, an office and warehouse building, a dormitory, a variety of agricultural buildings and structures, and infrastructural elements, all built between 1943 and 1955. Twenty-one of the 45 surveyed resources are recommended as being eligible for listing in the National Register of Historic Places under Criteria A and C as Contributing resources in a historic district and for designation as State Archeological Landmarks

Reflections on Tiles (in Self-Assembly)

We define the Reflexive Tile Assembly Model (RTAM), which is obtained from the abstract Tile Assembly Model (aTAM) by allowing tiles to reflect across their horizontal and/or vertical axes. We show that the class of directed temperature-1 RTAM systems is not computationally universal, which is conjectured but unproven for the aTAM, and like the aTAM, the RTAM is computationally universal at temperature 2. We then show that at temperature 1, when starting from a single tile seed, the RTAM is capable of assembling n x n squares for n odd using only n tile types, but incapable of assembling n x n squares for n even. Moreover, we show that n is a lower bound on the number of tile types needed to assemble n x n squares for n odd in the temperature-1 RTAM. The conjectured lower bound for temperature-1 aTAM systems is 2n-1. Finally, we give preliminary results toward the classification of which finite connected shapes in Z^2 can be assembled (strictly or weakly) by a singly seeded (i.e. seed of size 1) RTAM system, including a complete classification of which finite connected shapes be strictly assembled by a "mismatch-free" singly seeded RTAM system.Comment: New results which classify the types of shapes which can self-assemble in the RTAM have been adde

Influence of UV radiation from a massive YSO on the chemistry of its envelope

We have studied the influence of far ultraviolet (UV) radiation from a massive young stellar object (YSO) on the chemistry of its own envelope by extending the models of Doty et al. (2002) to include a central source of UV radiation. The models are applied to the massive star-forming region AFGL 2591 for different inner UV field strengths. Depth-dependent abundance profiles for several molecules are presented and discussed. We predict enhanced column densities for more than 30 species, especially radicals and ions. Comparison between observations and models is improved with a moderate UV field incident on the inner envelope, corresponding to an enhancement factor G0~10-100 at 200 AU from the star with an optical depth tau~15-17. Subtle differences are found compared with traditional models of Photon Dominated Regions (PDRs) because of the higher temperatures and higher gas-phase H2O abundance caused by evaporation of ices in the inner region. In particular, the CN/HCN ratio is not a sensitive tracer of the inner UV field, in contrast with the situation for normal PDRs: for low UV fields, the extra CN reacts with H2 in the inner dense and warm region and produces more HCN. It is found that the CH+ abundance is strongly enhanced and grows steadily with increasing UV field. High-J lines of molecules like CN and HCN are most sensitive to the inner dense region where UV radiation plays a role. Thus, even though the total column density affected by UV photons is small, comparison of high-J and low-J lines can selectively trace and distinguish the inner UV field from the outer one. In addition, future Herschel-HIFI observations of hydrides can sensitively probe the inner UV field.Comment: Accepted for publication in A&A. 13 pages, 10 figure

The effect of a strong external radiation field on protostellar envelopes in Orion

We discuss the effects of an enhanced interstellar radiation field (ISRF) on the observables of protostellar cores in the Orion cloud region. Dust radiative transfer is used to constrain the envelope physical structure by reproducing SCUBA 850 micron emission. Previously reported 13CO, C17O and H2CO line observations are reproduced through detailed Monte Carlo line radiative transfer models. It is found that the 13CO line emission is marginally optically thick and sensitive to the physical conditions in the outer envelope. An increased temperature in this region is needed in order to reproduce the 13CO line strengths and it is suggested to be caused by a strong heating from the exterior, corresponding to an ISRF in Orion 10^3 times stronger than the "standard" ISRF. The typical temperatures in the outer envelope are higher than the desorption temperature for CO. The C17O emission is less sensitive to this increased temperature but rather traces the bulk envelope material. The data are only fit by a model where CO is depleted, except in the inner and outermost regions where the temperature increases above 30-40 K. The fact that the temperatures do not drop below approximately 25 K in any of the envelopes whereas a significant fraction of CO is frozen-out suggest that the interstellar radiation field has changed through the evolution of the cores. The H2CO lines are successfully reproduced in the model of an increased ISRF with constant abundances of 3-5x10^{-10}.Comment: 11 pages, 10 figures. Accepted for publication in A&

Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment.

Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE. Therefore, a better understanding of the signals controlling migration of neutrophils as well as evaluating the role of these cells in demyelination is important to define cellular components that contribute to disease in MS patients. In this study, we examined the functional role of the chemokine CXCL1 in contributing to neuroinflammation and demyelination in EAE. Using transgenic mice in which expression of CXCL1 is under the control of a tetracycline-inducible promoter active within glial fibrillary acidic protein-positive cells, we have shown that sustained CXCL1 expression within the CNS increased the severity of clinical and histologic disease that was independent of an increase in the frequency of encephalitogenic Th1 and Th17 cells. Rather, disease was associated with enhanced recruitment of CD11b+ Ly6G+ neutrophils into the spinal cord. Targeting neutrophils resulted in a reduction in demyelination arguing for a role for these cells in myelin damage. Collectively, these findings emphasize that CXCL1-mediated attraction of neutrophils into the CNS augments demyelination suggesting that this signaling pathway may offer new targets for therapeutic intervention

Bounding the dimensions of rational cohomology groups

Let $k$ be an algebraically closed field of characteristic $p > 0$, and let $G$ be a simple simply-connected algebraic group over $k$ that is defined and split over the prime field $\mathbb{F}_p$. In this paper we investigate situations where the dimension of a rational cohomology group for $G$ can be bounded by a constant times the dimension of the coefficient module. We then demonstrate how our results can be applied to obtain effective bounds on the first cohomology of the symmetric group. We also show how, for finite Chevalley groups, our methods permit significant improvements over previous estimates for the dimensions of second cohomology groups.Comment: 13 page

The Power of Duples (in Self-Assembly): It's Not So Hip To Be Square

In this paper we define the Dupled abstract Tile Assembly Model (DaTAM), which is a slight extension to the abstract Tile Assembly Model (aTAM) that allows for not only the standard square tiles, but also "duple" tiles which are rectangles pre-formed by the joining of two square tiles. We show that the addition of duples allows for powerful behaviors of self-assembling systems at temperature 1, meaning systems which exclude the requirement of cooperative binding by tiles (i.e., the requirement that a tile must be able to bind to at least 2 tiles in an existing assembly if it is to attach). Cooperative binding is conjectured to be required in the standard aTAM for Turing universal computation and the efficient self-assembly of shapes, but we show that in the DaTAM these behaviors can in fact be exhibited at temperature 1. We then show that the DaTAM doesn't provide asymptotic improvements over the aTAM in its ability to efficiently build thin rectangles. Finally, we present a series of results which prove that the temperature-2 aTAM and temperature-1 DaTAM have mutually exclusive powers. That is, each is able to self-assemble shapes that the other can't, and each has systems which cannot be simulated by the other. Beyond being of purely theoretical interest, these results have practical motivation as duples have already proven to be useful in laboratory implementations of DNA-based tiles