243 research outputs found
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Implementation and impact of pediatric antimicrobial stewardship programs: a systematic scoping review.
Background: Antibiotics are the most common medicines prescribed to children in hospitals and the community, with a high proportion of potentially inappropriate use. Antibiotic misuse increases the risk of toxicity, raises healthcare costs, and selection of resistance. The primary aim of this systematic review is to summarize the current state of evidence of the implementation and outcomes of pediatric antimicrobial stewardship programs (ASPs) globally. Methods: MEDLINE, Embase and Cochrane Library databases were systematically searched to identify studies reporting on ASP in children aged 0-18âyears and conducted in outpatient or in-hospital settings. Three investigators independently reviewed identified articles for inclusion and extracted relevant data. Results: Of the 41,916 studies screened, 113 were eligible for inclusion in this study. Most of the studies originated in the USA (52.2%), while a minority were conducted in Europe (24.7%) or Asia (17.7%). Seventy-four (65.5%) studies used a before-and-after design, and sixteen (14.1%) were randomized trials. The majority (81.4%) described in-hospital ASPs with half of interventions in mixed pediatric wards and ten (8.8%) in emergency departments. Only sixteen (14.1%) studies focused on the costs of ASPs. Almost all the studies (79.6%) showed a significant reduction in inappropriate prescriptions. Compliance after ASP implementation increased. Sixteen of the included studies quantified cost savings related to the intervention with most of the decreases due to lower rates of drug administration. Seven studies showed an increased susceptibility of the bacteria analysed with a decrease in extended spectrum beta-lactamase producers E. coli and K. pneumoniae; a reduction in the rate of P. aeruginosa carbapenem resistance subsequent to an observed reduction in the rate of antimicrobial days of therapy; and, in two studies set in outpatient setting, an increase in erythromycin-sensitive S. pyogenes following a reduction in the use of macrolides. Conclusions: Pediatric ASPs have a significant impact on the reduction of targeted and empiric antibiotic use, healthcare costs, and antimicrobial resistance in both inpatient and outpatient settings. Pediatric ASPs are now widely implemented in the USA, but considerable further adaptation is required to facilitate their uptake in Europe, Asia, Latin America and Africa
Experimental evidence of antiproton reflection by a solid surface
We report here experimental evidence of the reflection of a large fraction of
a beam of low energy antiprotons by an aluminum wall. This derives from the
analysis of a set of annihilations of antiprotons that come to rest in rarefied
helium gas after hitting the end wall of the apparatus. A Monte Carlo
simulation of the antiproton path in aluminum indicates that the observed
reflection occurs primarily via a multiple Rutherford-style scattering on Al
nuclei, at least in the energy range 1-10 keV where the phenomenon is most
visible in the analyzed data. These results contradict the common belief
according to which the interactions between matter and antimatter are dominated
by the reciprocally destructive phenomenon of annihilation.Comment: 5 pages with 5 figure
Analysis of lower limb internal kinetics and electromyography in elite race walking.
The aim of this study was to analyse lower limb joint moments, powers and electromyography patterns in elite race walking. Twenty international male and female race walkers performed at their competitive pace in a laboratory setting. The collection of ground reaction forces (1000 Hz) was synchronised with two-dimensional high-speed videography (100 Hz) and electromyography of seven lower limb muscles (1000 Hz). As well as measuring key performance variables such as speed and stride length, normalised joint moments and powers were calculated. The rule in race walking which requires the knee to be extended from initial contact to midstance effectively made the knee redundant during stance with regard to energy generation. Instead, the leg functioned as a rigid lever which affected the role of the hip and ankle joints. The main contributors to energy generation were the hip extensors during late swing and early stance, and the ankle plantarflexors during late stance. The restricted functioning of the knee during stance meant that the importance of the swing leg in contributing to forward momentum was increased. The knee flexors underwent a phase of great energy absorption during the swing phase and this could increase the risk of injury to the hamstring muscles
Statistical inference of the mechanisms driving collective cell movement
Numerous biological processes, many impacting on human health, rely on collective cell
movement. We develop nine candidate models, based on advection-diffusion partial differential equations, to describe various alternative mechanisms that may drive cell movement. The parameters of these models were inferred from one-dimensional projections of laboratory observations of Dictyostelium discoideum cells by sampling from the posterior distribution using the delayed rejection adaptive Metropolis algorithm (DRAM). The best model was selected using the Widely Applicable Information Criterion (WAIC). We conclude that cell movement in our study system was driven both by a self-generated gradient in an attractant that the cells could deplete locally, and by chemical interactions between the cells
A new look at loop quantum gravity
I describe a possible perspective on the current state of loop quantum
gravity, at the light of the developments of the last years. I point out that a
theory is now available, having a well-defined background-independent
kinematics and a dynamics allowing transition amplitudes to be computed
explicitly in different regimes. I underline the fact that the dynamics can be
given in terms of a simple vertex function, largely determined by locality,
diffeomorphism invariance and local Lorentz invariance. I emphasize the
importance of approximations. I list open problems.Comment: 15 pages, 5 figure
FoxO3a as a positive prognostic marker and a therapeutic target in Tamoxifen-resistant breast cancer
Background: Resistance to endocrine treatments is a major clinical challenge in the management of estrogen receptor positive breast cancers. Although multiple mechanisms leading to endocrine resistance have been proposed, the poor outcome of this subgroup of patients demands additional studies. Methods: FoxO3a involvement in the acquisition and reversion of tamoxifen resistance was assessed in vitro in three parental ER+ breast cancer cells, MCF-7, T47D and ZR-75-1, in the deriving Tamoxifen resistant models (TamR) and in Tet-inducible TamR/FoxO3a stable cell lines, by growth curves, PLA, siRNA, RT-PCR, Western blot, Immunofluorescence, Transmission Electron Microscopy, TUNEL, cell cycle, proteomics analyses and animal models. FoxO3a clinical relevance was validated in silico by KaplanâMeier survival curves. Results: Here, we show that tamoxifen resistant breast cancer cells (TamR) express low FoxO3a levels. The hyperactive growth factors signaling, characterizing these cells, leads to FoxO3a hyper-phosphorylation and subsequent proteasomal degradation. FoxO3a re-expression by using TamR tetracycline inducible cells or by treating TamR with the anticonvulsant lamotrigine (LTG), restored the sensitivity to the antiestrogen and strongly reduced tumor mass in TamR-derived mouse xenografts. Proteomics data unveiled novel potential mediators of FoxO3a anti-proliferative and pro-apoptotic activity, while the KaplanâMeier analysis showed that FoxO3a is predictive of a positive response to tamoxifen therapy in Luminal A breast cancer patients. Conclusions: Altogether, our data indicate that FoxO3a is a key target to be exploited in endocrine-resistant tumors. In this context, LTG, being able to induce FoxO3a, might represent a valid candidate in combination therapy to prevent resistance to tamoxifen in patients at risk
Correlated pairs from the reaction
Correlated pairs emitted after the absorption of negative kaons
at rest in light nuclei and are
studied. -hyperons and deuterons are found to be preferentially
emitted in opposite directions. The invariant mass spectrum of
shows a bump whose mass is 32516 MeV/c. The bump mass (binding
energy), width and yield are reported. The appearance of a bump is discussed in
the realm of the [] clustering process in nuclei. The experiment was
performed with the FINUDA spectrometer at DANE (LNF).Comment: 13 pages, 5 figures, accepted for publication in Phys. Lett.
Flow angle from intermediate mass fragment measurements
Directed sideward flow of light charged particles and intermediate mass
fragments was measured in different symmetric reactions at bombarding energies
from 90 to 800 AMeV. The flow parameter is found to increase with the charge of
the detected fragment up to Z = 3-4 and then turns into saturation for heavier
fragments. Guided by simple simulations of an anisotropic expanding thermal
source, we show that the value at saturation can provide a good estimate of the
flow angle, , in the participant region. It is found that
depends strongly on the impact parameter. The excitation
function of reveals striking deviations from the ideal
hydrodynamical scaling. The data exhibit a steep rise of \Theta_{\flow} to a
maximum at around 250-400 AMeV, followed by a moderate decrease as the
bombarding energy increases further.Comment: 28 pages Revtex, 6 figures (ps files), to appear in Nucl.Phys.
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