Absolute measurement of the nitrogen fluorescence yield in air between 300 and 430 nm

The nitrogen fluorescence induced in air is used to detect ultra-high energy cosmic rays and to measure their energy. The precise knowledge of the absolute fluorescence yield is the key quantity to improve the accuracy on the cosmic ray energy. The total yield has been measured in dry air using a 90Sr source and a [300-430 nm] filter. The fluorescence yield in air is 4.23 $\pm$ 0.20 photons per meter when normalized to 760 mmHg, 15 degrees C and with an electron energy of 0.85 MeV. This result is consistent with previous experiments made at various energies, but with an accuracy improved by a factor of about 3. For the first time, the absolute continuous spectrum of nitrogen excited by 90Sr electrons has also been measured with a spectrometer. Details of this experiment are given in one of the author's PhD thesis [32].Comment: accepted for publication in NIM

A Preliminary Look at the Physics Reach of a Solar Neutrino TPC: Time-Independent Two Neutrino Oscillations

This paper will discuss the physics reach of a solar neutrino TPC containing many tons of He4 under high pressure. Particular attention is given to the LMA and SMA solutions, which are allowed by current data, and which are characterized by a lack of time-dependent phenomena (either summer-winter or day-night asymmetries). In this case, the physics of neutrino masses and mixing is all contained in the energy dependence of the electron neutrino survival probability, (or in its reciprocal, the electron neutrino disappearance probability).Comment: 19 pages, 12 figure

Progress on a spherical TPC for low energy neutrino detection

The new concept of the spherical TPC aims at relatively large target masses with low threshold and background, keeping an extremely simple and robust operation. Such a device would open the way to detect the neutrino-nucleus interaction, which, although a standard process, remains undetected due to the low energy of the neutrino-induced nuclear recoils. The progress in the development of the fist 1 m$^3$ prototype at Saclay is presented. Other physics goals of such a device could include supernova detection, low energy neutrino oscillations and study of non-standard properties of the neutrino, among others.Comment: 3 pages, talk given at the 9th Workshop on Topics in Astroparticle and Underground Physics, Zaragoza, September 10-1

10,000 Standard Solar Models: a Monte Carlo Simulation

We have evolved 10,000 solar models using 21 input parameters that are randomly drawn for each model from separate probability distributions for every parameter. We use the results of these models to determine the theoretical uncertainties in the predicted surface helium abundance, the profile of the sound speed versus radius, the profile of the density versus radius, the depth of the solar convective zone, the eight principal solar neutrino fluxes, and the fractions of nuclear reactions that occur in the CNO cycle or in the three branches of the p-p chains. We also determine the correlation coefficients of the neutrino fluxes for use in analysis of solar neutrino oscillations. Our calculations include the most accurate available input parameters, including radiative opacity, equation of state, and nuclear cross sections. We incorporate both the recently determined heavy element abundances recommended by Asplund, Grevesse & Sauval (2005) and the older (higher) heavy element abundances recommended by Grevesse & Sauval (1998). We present best-estimates of many characteristics of the standard solar model for both sets of recommended heavy element compositions.Comment: ** John N. Bahcall passed away on August 17, 2005. Manuscript has 60 pages including 10 figure

Insulin-Like Growth Factor-1 but Not Insulin Predicts Cognitive Decline in Huntington's Disease

BACKGROUND: Huntington\u27s disease (HD) is one of several neurodegenerative disorders that have been associated with metabolic alterations. Changes in Insulin Growth Factor 1 (IGF-1) and/or insulin input to the brain may underlie or contribute to the progress of neurodegenerative processes. Here, we investigated the association over time between changes in plasma levels of IGF-1 and insulin and the cognitive decline in HD patients. METHODS: We conducted a multicentric cohort study in 156 patients with genetically documented HD aged from 22 to 80 years. Among them, 146 patients were assessed at least twice with a follow-up of 3.5 ± 1.8 years. We assessed their cognitive decline using the Unified Huntington\u27s Disease Rating Scale, and their IGF-1 and insulin plasmatic levels, at baseline and once a year during the follow-up. Associations were evaluated using a mixed-effect linear model. RESULTS: In the cross-sectional analysis at baseline, higher levels of IGF-1 and insulin were associated with lower cognitive scores and thus with a higher degree of cognitive impairment. In the longitudinal analysis, the decrease of all cognitive scores, except the Stroop interference, was associated with the IGF-1 level over time but not of insulin. CONCLUSIONS: IGF-1 levels, unlike insulin, predict the decline of cognitive function in HD

Effectiveness of anti-psychotics and related drugs in the Huntington French-speaking group cohort.

PURPOSE: Huntington's disease is a rare condition. Patients are commonly treated with antipsychotics and tetrabenazine. The evidence of their effect on disease progression is limited and no comparative study between these drugs has been conducted. We therefore compared the effectiveness of antipsychotics on disease progression. METHODS: 956 patients from the Huntington French Speaking Group were followed for up to 8 years between 2002 and 2010. The effectiveness of treatments was assessed using Unified Huntington's Disease Rating Scale (UHDRS) scores and then compared using a mixed model adjusted on a multiple propensity score. RESULTS: 63% of patients were treated with antipsychotics during the survey period. The most commonly prescribed medications were dibenzodiazepines (38%), risperidone (13%), tetrabenazine (12%) and benzamides (12%). There was no difference between treatments on the motor and behavioural declines observed, after taking the patient profiles at the start of the drug prescription into account. In contrast, the functional decline was lower in the dibenzodiazepine group than the other antipsychotic groups (Total Functional Capacity: 0.41 ± 0.17 units per year vs. risperidone and 0.54 ± 0.19 vs. tetrabenazine, both p<0.05). Benzamides were less effective than other antipsychotics on cognitive evolution (Stroop interference, Stroop color and Literal fluency: p<0.05). CONCLUSIONS: Antipsychotics are widely used to treat patients with Huntington's disease. Although differences in motor or behavioural profiles between patients according to the antipsychotics used were small, there were differences in drug effectiveness on the evolution of functional and cognitive scores

The EUSO simulation and analysis framework

ESAF is the simulation and analysis software framework developed for the EUSO experiment. ESAF's scope is the whole process of data simulations and data-analysis, from the primary particle interaction in atmosphere to the reconstruction of the event. Based on the ROOT package and designed using Object Oriented technology, ESAF is organized in two main programs: the full montecarlo simulation and the reconstruction framework. The former includes all the relevant physical contributions, shower development in atmosphere, light transport to the detector pupil and detector response, while the latter comprises basic data cleaning, track direction, shower profile and energy reconstruction algorithms. Here we describe the software architecture and its main features

Requirements and simulation study of the performance of EUSO as external payload on board the International Space Station

The "Extreme Universe Space Observatory - EUSO" has been conceived as the first Space mission devoted to the investigation of Ultra High Energy Cosmic Ray, using the Earth's atmosphere as a giant detector. The scientific objectives of the experiment are to observe the UHECR spectrum above the GZK energy, with an improvement of one order of magnitude in the statistics of collected events with respect to the existing experiments, in such a way to study the source distribution in a full sky survey, as well as to open the channel (set a confidence limit) on the neutrino astronomy in this energy range. Supposed to be accommodated as external payload on board the International Space Station, EUSO phase A study has been positively completed in July 2004. Nowadays, due to funding problems of the Space Agencies involved in the project, EUSO is currently on hold. Nevertheless, as result of an end-to-end simulation approach, we summarize here the expected scientific performance coming out from the phase A, as well as the expected improvements in the technical performance of the EUSO Instrument to be achieved during Phase B, in order to fulfil the scientific objectives posed as goal of the experiment

Search for charginos in e+e- interactions at sqrt(s) = 189 GeV

An update of the searches for charginos and gravitinos is presented, based on a data sample corresponding to the 158 pb^{-1} recorded by the DELPHI detector in 1998, at a centre-of-mass energy of 189 GeV. No evidence for a signal was found. The lower mass limits are 4-5 GeV/c^2 higher than those obtained at a centre-of-mass energy of 183 GeV. The (\mu,M_2) MSSM domain excluded by combining the chargino searches with neutralino searches at the Z resonance implies a limit on the mass of the lightest neutralino which, for a heavy sneutrino, is constrained to be above 31.0 GeV/c^2 for tan(beta) \geq 1.Comment: 22 pages, 8 figure

Search for composite and exotic fermions at LEP 2

A search for unstable heavy fermions with the DELPHI detector at LEP is reported. Sequential and non-canonical leptons, as well as excited leptons and quarks, are considered. The data analysed correspond to an integrated luminosity of about 48 pb^{-1} at an e^+e^- centre-of-mass energy of 183 GeV and about 20 pb^{-1} equally shared between the centre-of-mass energies of 172 GeV and 161 GeV. The search for pair-produced new leptons establishes 95% confidence level mass limits in the region between 70 GeV/c^2 and 90 GeV/c^2, depending on the channel. The search for singly produced excited leptons and quarks establishes upper limits on the ratio of the coupling of the excited fermio