50 research outputs found
An Open-Source 7-Axis, Robotic Platform to Enable Dexterous Procedures within CT Scanners
This paper describes the design, manufacture, and performance of a highly
dexterous, low-profile, 7 Degree-of-Freedom (DOF) robotic arm for CT-guided
percutaneous needle biopsy. Direct CT guidance allows physicians to localize
tumours quickly; however, needle insertion is still performed by hand. This
system is mounted to a fully active gantry superior to the patient's head and
teleoperated by a radiologist. Unlike other similar robots, this robot's fully
serial-link approach uses a unique combination of belt and cable drives for
high-transparency and minimal-backlash, allowing for an expansive working area
and numerous approach angles to targets all while maintaining a small in-bore
cross-section of less than . Simulations verified the system's
expansive collision free work-space and ability to hit targets across the
entire chest, as required for lung cancer biopsy. Targeting error is on average
on a teleoperated accuracy task, illustrating the system's sufficient
accuracy to perform biopsy procedures. The system is designed for lung biopsies
due to the large working volume that is required for reaching peripheral lung
lesions, though, with its large working volume and small in-bore
cross-sectional area, the robotic system is effectively a general-purpose
CT-compatible manipulation device for percutaneous procedures. Finally, with
the considerable development time undertaken in designing a precise and
flexible-use system and with the desire to reduce the burden of other
researchers in developing algorithms for image-guided surgery, this system
provides open-access, and to the best of our knowledge, is the first
open-hardware image-guided biopsy robot of its kind.Comment: 8 pages, 9 figures, final submission to IROS 201
How Jupiters save or destroy inner Neptunes around evolved stars
In about 6 Gyr our Sun will evolve into a red giant and finally end its life as a white dwarf. This stellar metamorphosis will occur to virtually all known host stars of exoplanetary systems and is therefore crucial for their final fate. It is clear that the innermost planets will be engulfed and evaporated during the giant phase and that planets located farther out will survive. However, the destiny of planets in-between, at ~1 and 10 au, has not yet been investigated with a multiplanet tidal treatment. We here combine for the first time multiplanet interactions, stellar evolution, and tidal effects in an N-body code to study the evolution of a Neptune–Jupiter planetary system. We report that the fate of the Neptune-mass planet, located closer to the star than the Jupiter-mass planet, can be very different from the fate of a single Neptune. The simultaneous effects of gravitational interactions, mass loss, and tides can drive the planetary system toward mean motion resonances. Crossing these resonances affects particularly the eccentricity of the Neptune and thereby also its fate, which can be engulfment, collision with the Jupiter-mass planet, ejection from the system, or survival at a larger separation
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A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis.
ObjectiveEtrolizumab (rhuMAb β7, anti-β7, PRO145223) is a humanised monoclonal antibody targeting the β7 subunit of the heterodimeric integrins α4β7 and αEβ7, which are implicated in leucocyte migration and retention in ulcerative colitis (UC). This randomised phase I study evaluated the safety and pharmacology of etrolizumab in patients with moderate to severe UC.DesignIn the single ascending dose (SAD) stage, etrolizumab (0.3, 1.0, 3.0, 10 mg/kg intravenous, 3.0 mg/kg subcutaneous (SC) or placebo) was administered 4:1 (n=25) in each cohort. In the multiple dose (MD) stage, new patients received monthly etrolizumab (0.5 mg/kg SC (n=4), 1.5 mg/kg SC (n=5), 3.0 mg/kg SC (n=4), 4.0 mg/kg intravenous (n=5)) or placebo (n=5). The pharmacokinetics was studied and Mayo Clinic Score evaluated at baseline, day 29 (SAD), and days 43 and 71 (MD).ResultsIn the SAD stage, there were no dose limiting toxicities, infusion or injection site reactions. Two impaired wound healing serious adverse events occurred in two patients receiving etrolizumab. In the MD stage, there were no dose limiting toxicities, and no infusion or injection site reactions. Headache was the most common adverse event, occurring more often in etrolizumab patients. Antietrolizumab antibodies were detected in two subjects. The duration of β7 receptor full occupancy was dose related. A clinical response was observed in 12/18 patients, and clinical remission in 3/18 patients treated with etrolizumab in the MD stage, compared with 4/5 and 1/5 placebo patients, respectively.ConclusionEtrolizumab is well tolerated in moderate to severe UC. Further investigation is warranted
Observations of gas flows inside a protoplanetary gap
Gaseous giant planet formation is thought to occur in the first few million
years following stellar birth. Models predict that giant planet formation
carves a deep gap in the dust component (shallower in the gas). Infrared
observations of the disk around the young star HD142527, at ~140pc, found an
inner disk ~10AU in radius, surrounded by a particularly large gap, with a
disrupted outer disk beyond 140AU, indicative of a perturbing planetary-mass
body at ~90 AU. From radio observations, the bulk mass is molecular and lies in
the outer disk, whose continuum emission has a horseshoe morphology. The
vigorous stellar accretion rate would deplete the inner disk in less than a
year, so in order to sustain the observed accretion, matter must flow from the
outer-disk into the cavity and cross the gap. In dynamical models, the putative
protoplanets channel outer-disk material into gap-crossing bridges that feed
stellar accretion through the inner disk. Here we report observations with the
Atacama Large Millimetre Array (ALMA) that reveal diffuse CO gas inside the
gap, with denser HCO+ gas along gap-crossing filaments, and that confirm the
horseshoe morphology of the outer disk. The estimated flow rate of the gas is
in the range 7E-9 to 2E-7 Msun/yr, which is sufficient to maintain accretion
onto the star at the present rate
The detection of dust around NN Ser
Eclipse timing variations observed from the post common-envelope binary (PCEB)
NN Ser offer strong evidence in favour of circumbinary planets existing around PCEBs.
If real, these planets may be accompanied by a disc of dust. We here present the ALMA
detection of flux at 1.3 mm from NN Ser, which is likely due to thermal emission from
a dust disc of mass ∼ 0.8±0.2 M⊕. We performed simulations of the history of NN Ser
to determine possible origins of this dust, and conclude that the most likely origin is, in
fact, common-envelope material which was not expelled from the system and instead
formed a circumbinary disc. These discs have been predicted by theory but previously
remained undetected. While the presence of this dust does not prove the existence of
planets around NN Ser, it adds credibility to the possibility of planets forming from
common-envelope material in a ‘second-generation’ scenario
Exoplanet imaging data challenge: benchmarking the various image processing methods for exoplanet detection
The Exoplanet Imaging Data Challenge is a community-wide effort meant to offer a platform for a fair and common comparison of image processing methods designed for exoplanet direct detection. For this purpose, it gathers on a dedicated repository (Zenodo), data from several high-contrast ground-based instruments worldwide in which we injected synthetic planetary signals. The data challenge is hosted on the CodaLab competition platform, where participants can upload their results. The specifications of the data challenge are published on our website https://exoplanet-imaging-challenge.github.io/. The first phase, launched on the 1st of September 2019 and closed on the 1st of October 2020, consisted in detecting point sources in two types of common data-set in the field of high-contrast imaging: data taken in pupil-tracking mode at one wavelength (subchallenge 1, also referred to as ADI) and multispectral data taken in pupil-tracking mode (subchallenge 2, also referred to as ADI+mSDI). In this paper, we describe the approach, organisational lessons-learnt and current limitations of the data challenge, as well as preliminary results of the participants’ submissions for this first phase. In the future, we plan to provide permanent access to the standard library of data sets and metrics, in order to guide the validation and support the publications of innovative image processing algorithms dedicated to high-contrast imaging of planetary systems
The Seventh Data Release of the Sloan Digital Sky Survey
This paper describes the Seventh Data Release of the Sloan Digital Sky Survey
(SDSS), marking the completion of the original goals of the SDSS and the end of
the phase known as SDSS-II. It includes 11663 deg^2 of imaging data, with most
of the roughly 2000 deg^2 increment over the previous data release lying in
regions of low Galactic latitude. The catalog contains five-band photometry for
357 million distinct objects. The survey also includes repeat photometry over
250 deg^2 along the Celestial Equator in the Southern Galactic Cap. A
coaddition of these data goes roughly two magnitudes fainter than the main
survey. The spectroscopy is now complete over a contiguous area of 7500 deg^2
in the Northern Galactic Cap, closing the gap that was present in previous data
releases. There are over 1.6 million spectra in total, including 930,000
galaxies, 120,000 quasars, and 460,000 stars. The data release includes
improved stellar photometry at low Galactic latitude. The astrometry has all
been recalibrated with the second version of the USNO CCD Astrograph Catalog
(UCAC-2), reducing the rms statistical errors at the bright end to 45
milli-arcseconds per coordinate. A systematic error in bright galaxy photometr
is less severe than previously reported for the majority of galaxies. Finally,
we describe a series of improvements to the spectroscopic reductions, including
better flat-fielding and improved wavelength calibration at the blue end,
better processing of objects with extremely strong narrow emission lines, and
an improved determination of stellar metallicities. (Abridged)Comment: 20 pages, 10 embedded figures. Accepted to ApJS after minor
correction