From Public Assistance Institutions to ‘Sunshine Hotels’: Changing State perceptions about residential care for elderly people, 1939-48

This article traces the development of residential care for elderly people in the period 1939 to 1948. It begins by looking at the nature of such institutions in the period just prior to the Second World War and then discusses the complex impact of war upon such provision. Particular attention is paid to how evacuation hostels, run by local authorities and voluntary organisations, changed notions about the role of the State in the care of elderly people. The paper concludes by looking at how such changed notions were incorporated into the 1948 National Assistance Act. © 1983, Cambridge University Press. All rights reserved

Galactic structure from the Calar Alto Deep Imaging Survey (CADIS)

We used 1627 faint (15.5< R<23) stars in five fields of the Calar Alto Deep Imaging Survey (CADIS) to estimate the structure parameters of the Galaxy. The results were derived by applying two complementary methods: first by fitting the density distribution function to the measured density of stars perpendicular to the Galactic plane, and second by modelling the observed colors and apparent magnitudes of the stars in the field, using Monte Carlo simulations. The best-fitting model of the Galaxy is then determined by minimising the C-statistic, a modified chisquared. Our model includes a double exponential for the stellar disk with scaleheights h_1 and h_2 and a power law halo with exponent alpha. 24480 different parameter combinations have been simulated. Both methods yield consistent results: the best fitting parameter combination is alpha=3.0 (or alpha=2.5, if we allow for a flattening of the halo with an axial ratio of (c/a)=0.6), h_1=300 pc, h_2=900 pc, and the contribution of thick disk stars to the disk stars in the solar neighbourhood is found to be between 4 and 10%.Comment: 16 pages, 10 figures, submitted to Astronomy and Astrophysic

Novel approach to estimate tuberculosis transmission in primary care clinics in sub-Saharan Africa: protocol of a prospective study.

INTRODUCTION Tuberculosis (TB) transmission is difficult to measure, and its drivers are not well understood. The effectiveness of infection control measures at healthcare clinics and the most appropriate intervention strategies to interrupt transmission are unclear. We propose a novel approach using clinical, environmental and position-tracking data to study the risk of TB transmission at primary care clinics in TB and HIV high burden settings in sub-Saharan Africa. METHODS AND ANALYSIS We describe a novel and rapid study design to assess risk factors for airborne TB transmission at primary care clinics in high-burden settings. The study protocol combines a range of different measurements. We will collect anonymous data on the number of patients, waiting times and patient movements using video sensors. Also, we will collect acoustic sound recordings to determine the frequency and intensity of coughing. Environmental data will include indoor carbon dioxide levels (CO2 in parts per million) and relative humidity. We will also extract routinely collected clinical data from the clinic records. The number of Mycobacterium tuberculosis particles in the air will be ascertained from dried filter units using highly sensitive digital droplet PCR. We will calculate rebreathed air volume based on people density and CO2 levels and develop a mathematical model to estimate the risk of TB transmission. The mathematical model can then be used to estimate the effect of possible interventions such as separating patient flows or improving ventilation in reducing transmission. The feasibility of our approach was recently demonstrated in a pilot study in a primary care clinic in Cape Town, South Africa. ETHICS AND DISSEMINATION The study was approved by the University of Cape Town (HREC/REF no. 228/2019), the City of Cape Town (ID-8139) and the Ethics Committee of the Canton Bern (2019-02131), Switzerland. The results will be disseminated in international peer-reviewed journals

A maximum volume density estimator generalized over a proper motion-limited sample

The traditional Schmidt density estimator has been proven to be unbiased and effective in a magnitude-limited sample. Previously, efforts have been made to generalize it for populations with non-uniform density and proper motion-limited cases. This work shows that the then-good assumptions for a proper motion-limited sample are no longer sufficient to cope with modern data. Populations with larger differences in the kinematics as compared to the local standard of rest are most severely affected. We show that this systematic bias can be removed by treating the discovery fraction inseparable from the generalized maximum volume integrand. The treatment can be applied to any proper motion-limited sample with good knowledge of the kinematics. This work demonstrates the method through application to a mock catalogue of a white dwarf-only solar neighbourhood for various scenarios and compared against the traditional treatment using a survey with Pan-STARRS-like characteristics

Correction to: Bioaerosol sampling of patients with suspected pulmonary tuberculosis: a study protocol

An amendment to this paper has been published and can be accessed via the original articl

The Subdwarf Luminosity Function

Using data from the Sloan Digital Sky Survey Early Data Release and SuperCOSMOS Sky Survey scans of POSS-I plates we identify a sample of 2600 subdwarfs using reduced proper motion methods and strict selection criteria. This forms one of the largest and most reliable samples of candidate subdwarfs known, and enables us to determine accurate luminosity functions along many different lines of sight. We derive the subdwarf luminosity function with unprecedented accuracy to M_V <= 12.5, finding good agreement with recent local estimates but discrepancy with results for the more distant spheroid. This provides further evidence that the inner and outer parts of the stellar halo cannot be described by a single density distribution. We also find that the form of the inner spheroid density profile within heliocentric distances of 2.5 kpc is closely matched by a power law with an index of -3.15 +/- 0.3.Comment: 21 pages, 29 figures (Figs 4,6,7,11 are low res versions.) Published in MNRAS: minor explanatory additions to text, new subsection (5.2) on reddening, reference adde

The stellar halo of the Galaxy

Stellar halos may hold some of the best preserved fossils of the formation history of galaxies. They are a natural product of the merging processes that probably take place during the assembly of a galaxy, and hence may well be the most ubiquitous component of galaxies, independently of their Hubble type. This review focuses on our current understanding of the spatial structure, the kinematics and chemistry of halo stars in the Milky Way. In recent years, we have experienced a change in paradigm thanks to the discovery of large amounts of substructure, especially in the outer halo. I discuss the implications of the currently available observational constraints and fold them into several possible formation scenarios. Unraveling the formation of the Galactic halo will be possible in the near future through a combination of large wide field photometric and spectroscopic surveys, and especially in the era of Gaia.Comment: 46 pages, 16 figures. References updated and some minor changes. Full-resolution version available at http://www.astro.rug.nl/~ahelmi/stellar-halo-review.pd

Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has been hampered by limited sample sizes. We sought to address this obstacle by applying a centralized analysis pipeline to a SCZ cohort of 21,094 cases and 20,227 controls. A global enrichment of CNV burden was observed in cases (OR=1.11, P=5.7×10−15), which persisted after excluding loci implicated in previous studies (OR=1.07, P=1.7 ×10−6). CNV burden was enriched for genes associated with synaptic function (OR = 1.68, P = 2.8 ×10−11) and neurobehavioral phenotypes in mouse (OR = 1.18, P= 7.3 ×10−5). Genome-wide significant evidence was obtained for eight loci, including 1q21.1, 2p16.3 (NRXN1), 3q29, 7q11.2, 15q13.3, distal 16p11.2, proximal 16p11.2 and 22q11.2. Suggestive support was found for eight additional candidate susceptibility and protective loci, which consisted predominantly of CNVs mediated by non-allelic homologous recombination

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

Transcriptomic imputation approaches combine eQTL reference panels with large-scale genotype data in order to test associations between disease and gene expression. These genic associations could elucidate signals in complex genome-wide association study (GWAS) loci and may disentangle the role of different tissues in disease development. We used the largest eQTL reference panel for the dorso-lateral prefrontal cortex (DLPFC) to create a set of gene expression predictors and demonstrate their utility. We applied DLPFC and 12 GTEx-brain predictors to 40,299 schizophrenia cases and 65,264 matched controls for a large transcriptomic imputation study of schizophrenia. We identified 413 genic associations across 13 brain regions. Stepwise conditioning identified 67 non-MHC genes, of which 14 did not fall within previous GWAS loci. We identified 36 significantly enriched pathways, including hexosaminidase-A deficiency, and multiple porphyric disorder pathways. We investigated developmental expression patterns among the 67 non-MHC genes and identified specific groups of pre- and postnatal expression