Collisional dark matter density profiles around supermassive black holes

We solve the spherically symmetric time dependent relativistic Euler equations on a Schwarzschild background space-time for a perfect fluid, where the perfect fluid models the dark matter and the space-time background is that of a non-rotating supermassive black hole. We consider the fluid obeys an ideal gas equation of state as a simple model of dark matter with pressure. Assuming out of equilibrium initial conditions we search for late-time attractor type of solutions, which we found to show a constant accretion rate for the non-zero pressure case, that is, the pressure itself suffices to produce stationary accretion regimes. We then analyze the resulting density profile of such late-time solutions with the function $A/r^{\kappa}$. For different values of the adiabatic index we find different slopes of the density profile, and we study such profile in two regions: a region one near the black hole, located from the horizon up to 50$M$ and a region two from $\sim 800M$ up to $\sim 1500M$, which for a black hole of $10^{9}M_{\odot}$ corresponds to $\sim 0.1$pc. The profile depends on the adiabatic index or equivalently on the pressure of the fluid and our findings are as follows: in the near region the density profile shows values of $\kappa <1.5$ and in the limit of the pressure-less case $\kappa \rightarrow 1.5$; on the other hand, in region two, the value of $\kappa<0.3$ in all the cases we studied. If these results are to be applied to the dark matter problem, the conclusion is that, in the limit of pressure-less gas the density profile is cuspy only near the black hole and approaches a non-cuspy profile at bigger scales within 1pc. These results show on the one hand that pressure suffices to provide flat density profiles of dark matter and on the other hand show that the presence of a central black hole does not distort the density profile of dark matter at scales of 0.1pc.Comment: 7 pages, 8 eps figures, accepted for publication in MNRA

Transformation of glucocorticoid and progesterone receptors to the DNA-binding state

This brief review explores some recent observations relating to the structure of untransformed glucocorticoid and progesterone receptors and the mechanism by which the receptors are transformed to the DNA-binding state. In their molybdate-stabilized, untransformed state, progesterone and glucocorticoid receptors exist as a heteromeric 8-9S complex containing one unit of steroid binding phosphoprotein and one or two units of the 90 kD heat shock protein hsp90. When the receptors are transformed, the steroid-binding protein dissociates from hsp90. In cytosol preparations, temperature-mediated dissociation proceeds much more rapidly in the presence of hormone. The dissociated receptor binds to DNA with high affinity, regardless of whether it is in the hormone-bound or the hormone-free state. These observations raise the possibility that the primary, and perhaps the only, role for the hormone is to promote dissociation of the receptor-hsp90 complex. Molybdate, vanadate, and tungstate inhibit receptor transformation to the DNA-binding form, an effect that appears to reflect the ability of these transition metal oxyanions to stabilize the complex between the steroid receptor and hsp90. By promoting the formation of disulfide bonds, hydrogen peroxide also stabilizes the glucocorticoid receptor-hsp90 complex and prevents receptor transformation. A small, heat-stable factor present in all cytosol preparations inhibits receptor transformation, and, when the factor is removed, glucocorticoid receptors are rapidly transformed. This ubiquitous factor has the physical properties of a metal anion, and it is proposed that molybdate and vanadate affect steroid receptor complexes by interacting with a metal anion-binding site that is normally occupied by this endogenous receptor-stabilizing factor.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38448/1/240350105_ftp.pd

Panel. Family Beyond Fiction

The Bundren Family in Space: Adapting As I Lay Dying for the Stage / Tyler Mercer and Chris Dieman, Live Source Theater Group; Elizabeth Cornell, Fordham University“The Family of Man”: William Faulkner and U. S. Public Diplomacy in Postwar Japan / Yuko Yamamoto, Chiba UniversityThe Family of Man, a photographic exhibition curated by Edward Steichen, toured worldwide between 1955 and 1962; William Faulkner traveled to Latin America, Asia, and Europe as a cultural ambassador between 1954 and 1961. Faulkner arrived in Tokyo, Japan, on August 1, 1955 and starred in the documentary film, Impressions of Japan (1955), created by the United States Information Service (USIS). Commissioned by the USIS, The Family of Man opened in Tokyo on March 21, 1956. My paper considers the film and the exhibition, both successful USIS-sponsored activities in Japan, within the context of U. S. public diplomacy in Japan around the year 1955, especially in relation to the Atoms for Peace campaign. What emerges from situating the film and the exhibition in this context is that, in the postwar Cold War era, Faulkner himself became an official spokesperson for “the Family of Man.”Coming of Age with John Williams’ Music in The Reivers / Mariana Sonntag WhitmerBefore delighting audiences with his well-known music for the Harry Potter, Star Wars, and Indiana Jones franchises, John Williams wrote music for small (mostly TV) projects and low-level dramas. The opportunity to compose the music for the filmic interpretation of Faulkner’s The Reivers in 1969 proved to be career-changing. My presentation examines how Williams musically enhances our understanding of Lucius McCaslin’s experiences as they lead him to a new level of maturity. Interwoven amongst a fabric of American musical idioms, distinct sets of musical materials guide the audience through Lucius’ internal musings as he struggles with the enticement of disobedience. Even the popular songs heard throughout the film point to the careful consideration accorded the film’s musical accompaniment, as it enhances our understanding of the narrative. Ultimately, it was Faulkner’s novel that stimulated Williams to craft this important score which launched his musical career

Potential scope and impact of a transboundary model of nurse practitioners in aged care\ud \ud

Aged care is a growing issue in Australia and other countries. There are significant barriers to meeting the health needs of this population. Current services have gaps between care and lack communication and integration between care providers. Research was conducted in the Australian Capital Territory to investigate the potential role of the aged care nurse practitioner in health service delivery in aged care settings. A multimethod case study design was utilised, with three student nurse practitioners (SNP) providing care to aged care clients across three sectors of health service delivery (residential aged care facilities, general medical practices and acute care). Data collection consisted of in-depth interviews and journal entries of the SNP, as well as focus groups and surveys of multidisciplinary staff and patients over the age of 65 years in the settings frequented by the SNP. The aged care SNP were found to cross professional and organisational boundaries, cross intra- as well as interorganisational boundaries and to contribute to more seamless patient care as members of a multidisciplinary aged care team. The aged care nurse practitioner role consequently has the potential to function in a networked rather than a hierarchical manner, and this could be a key element in addressing gaps in care across care locales and between disciplines.\ud \u