Three-phase DC/AC power converter with power quality optimization

Introduction— The DC/AC power conversion systems currently used in multiple applications such as alternative energy sources involve power quality problems due to voltage regulations and distortions such as those caused by harmonic distortion. Objective— Develop a power converter prototype that, through a multi-objective genetic algorithm, allows optimizing the energy quality of three-phase inversion systems through the use of multilevel converters. Methodology— The prototype to be used in the power conversion is defined, the output voltage is modeled mathematically, the optimization multi-objective genetic algorithms are developed, the prototype is implemented and its operation is validated. Results— The algorithm developed and implemented in the developed prototype mitigates power quality phenomena associated with short and long duration variations such as swell, sag, undervoltage and overvoltage, avoids the presence of voltage fluctuations and presents a lower harmonic content in all 1% cases. Conclusions— The implemented prototype allows optimizing the power quality of three-phase power supply systems through the use of multilevel inverters, avoiding the presence of power quality phenomena.Introducción— Los sistemas de conversión DC/AC utilizados actualmente en múltiples aplicaciones como las fuentes alternativas de energía involucra problemas de la calidad de la energía debido regulaciones de tensión y deformaciones como las causadas por la distorsión armónica. Objetivo— Desarrollar un prototipo que a través de un algoritmo genético multiobjetivo permita optimizar la calidad de la energía de los sistemas de inversión trifásicos a través del uso de convertidores multinivel. Metodología— Se define el prototipo a utilizar en la conversión de potencia, se modela matemáticamente la tensión de salida, se desarrollan los algoritmos genéticos multiobjetivo de optimización, se implementa el prototipo y se valida su funcionamiento. Resultados— El algoritmo desarrollado e implementado en el prototipo desarrollado mitiga los fenómenos de calidad de la energía asociados a las variaciones de corta y larga duración como swell, sag, undervoltaje y overvoltaje, evita la presencia de fluctuaciones de tensión y presenta un contenido armónico menor en todos los casos del 1% Conclusiones— El prototipo implementado optimizar la calidad de la energía de los sistemas trifásicos de suministro de energía a través del uso de un inversor multinivel, evitando la presencia de fenómenos de calidad de la energía.&nbsp

Incidencia de la gestión de cobranza y recaudación del impuesto predial en la Municipalidad Distrital de Calzada, periodo 2018.

La investigación titulada “Incidencia de la gestión de cobranza y recaudación del impuesto predial en la Municipalidad Distrital de Calzada, periodo 2018”, investigación aplicada; nivel descriptivo – correlacional, con diseño no experimental; aplicando la técnica de cuestionario y análisis documental; y teniendo como población los trabajadores de la Municipalidad Distrital de Calzada, referida a la gestión de cobranza y su correlato con la recaudación del impuesto predial de la Municipalidad Distrital de Calzada, periodo 2018; se Concluye que, la gestión de cobranza incide significativamente en la recaudación del impuesto predial en la Municipalidad Distrital de Calzada, periodo 2018; la gestión de cobranza, incide significativamente en la recaudación del impuesto en predios urbanos y rústicos; se pudo establecer que los empleados encomendados en el trabajo de recaudación no realizan adecuadamente su labor, el cual repercute directamente en los resultados en función a la inscripción en el registro de contribuyentes, identificación de los contribuyentes omisos y morosos; además de una débil acción de cobranza.The research entitled "Incidence of the collection management and collection of property tax in the District Municipality of Calzada, period 2018", is an applied research with descriptive - correlational level, non-experimental design. The technique of questionnaire and documentary analysis was applied; and the population consisted of the workers of the District Municipality of Calzada, referred to the collection management and its correlation with the collection of property tax in the District Municipality of Calzada, period 2018. It is concluded that the collection management has a significant impact on the collection of property tax in the District Municipality of Calzada, period 2018; the collection management has a significant impact on the collection of the tax in urban and rustic properties. It could be established that the employees entrusted with the collection work do not perform their work properly, which has a direct impact on the results in terms of registration in the taxpayer registry, identification of defaulting and delinquent taxpayers, as well as a weak collection action

On-line method for optimal tuning of PID controllers using standard OPC interface

Introduction− The controlled PID is the most widely used mathematical algorithm as a regulatory control strategy in industrial environments. The applications are varied; however, its answer depends on the proper calculation of its three parameters: the proportional, the derivative, and the integral. Analytical tuning and experimental methods solve the problem, but new tuning possibilities are now enabled within the digital and process integration context. Objective− Automatically and remotely obtain the optimal parameters of the PID controller, taking advantage of an online connection via the OPC communication protocol to analyze the transient response of the system. Methodology− The study is carried out in three main phases; it begins with a PD3 SMAR thermal process with connection via OPC; in this phase, the mathematical model of the process is built analytically based on fundamental laws. In the second phase, using an analytical tuning method, the PID control architecture is created on which the online experimentation is carried out. In the third phase, the genetic algorithms for automatic tuning are implemented, extracting performance measures from the PID controller through the transient response of the process and optimally determining the values for the proportional, derivative, and integral parameters. Results− The automatic tuning method was tested with two properly instrumented industrial processes. The potential for application can be seen due to its good result and because it does not require specific mathematical knowledge compared to conventional tuning methods. Conclusions− The automatic tuning method can be used remotely to calculate the optimal parameters of a PID controller. The parameters are calculated from the transient response and the definition of design criteria adaptable to any need for control, response, and process

Theoretical approximation in obtaining a model of quality management for the training with a productive approach

La globalización actual, propiciando entornos más productivos y competitivos, requiere recurso humano calificado para afrontar los retos del desarrollo, con la Educación Superior, como actor importante en la formación de profesionales competentes, con conocimientos, criterios técnicos, actitud, habilidades y valores, eficacia, eficiencia y competitividad. Se realiza entonces, una revisión teórica, en la búsqueda de un Modelo de Calidad, para mejorar la gestión en productividad y competitividad profesional, en entornos productivos, reseñando conceptos como Calidad, Modelos de Gestión, Calidad en la Educación, en la Formación Profesional y de Ingenieros, para aproximar una propuesta de construcción de este modeloCurrent globalization, favouring more productive and competitive, environments requires qualified human resources to meet the challenges of development, with higher education, as an important actor in the training of competent professionals, with knowledge, technical criteria, attitude, skills and values, effectiveness, efficiency and competitiveness. Is performed then, a review theoretical, in the search of a model of quality, to improve the management in productivity and competitiveness professional, in environments productive, outlining concepts as quality, models of management, quality in it education, in it training professional and of engineers, for approach a proposed of construction of this mode

Introducción a los análisis espaciales con énfasis en modelos de nicho ecológico

En 2016 implementamos un sistema de seminarios de enseñanza, en formato de videos libres y accesibles desde internet, con la finalidad de dar a conocer de forma sencilla y en castellano, las bases conceptuales y aplicaciones de los modelos de nicho ecológico en estudios de ecología, conservación biológica, epidemiología y agrobiodviersidad, así como su implementación para el diseño de políticas públicas de los recursos naturales. Cada seminario fue desarrollado por uno o varios expertos discutiendo conceptos, métodos y diferentes herramientas disponibles para elaborar modelos de distribución de especies. Este manuscrito reúne los resúmenes de cada uno de los seminarios en línea, dando referencias clave para cada tema y el enlace al video correspondiente. Los videos están disponibles de forma libre en YouTube o en formato .mp4 bajo solicitud

Mitochondrial genome sequencing of marine leukaemias reveals cancer contagion between clam species in the Seas of Southern Europe

20 Pág.Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the transfer of living cancer cells. In marine bivalves, leukaemia-like transmissible cancers, called hemic neoplasia (HN), have demonstrated the ability to infect individuals from different species. We performed whole-genome sequencing in eight warty venus clams that were diagnosed with HN, from two sampling points located more than 1000 nautical miles away in the Atlantic Ocean and the Mediterranean Sea Coasts of Spain. Mitochondrial genome sequencing analysis from neoplastic animals revealed the coexistence of haplotypes from two different clam species. Phylogenies estimated from mitochondrial and nuclear markers confirmed this leukaemia originated in striped venus clams and later transmitted to clams of the species warty venus, in which it survives as a contagious cancer. The analysis of mitochondrial and nuclear gene sequences supports all studied tumours belong to a single neoplastic lineage that spreads in the Seas of Southern Europe.We thank the Galicia Supercomputing Centre (CESGA) for the availability of informatic resources. JMCT, SR, SD, and JT are supported by European Research Council (ERC) Starting Grant 716,290 SCUBA CANCERS. ALB is supported by MINECO PhD fellowship BES-2016-078166. DG-S is supported by postdoctoral contract ED481B/2018/091 from Xunta de Galicia. DP is supported by ERC grant ERC-617457-PHYLOCANCER and by Spanish Ministry of Economy and Competitiveness (MINECO) grant PID2019-106247GB-I00. This research was partially funded by the European Union’s Horizon 2020 research and innovation programme under grant agreement 730984, ASSEMBLE Plus project. CESAM got financial support from FCT/MEC (UIDP/50017/2020, UIDB/50017/2020).Peer reviewe

CIGB-300, a synthetic peptide-based drug that targets the CK2 phosphoaceptor domain. Translational and clinical research

CK2 represents an oncology target scientifically validated. However, clinical research with inhibitors of the CK2-mediated phosphorylation event is still insufficient to recognize it as a clinically validated target. CIGB-300, an investigational peptide-based drug that targets the phosphoaceptor site, binds to a CK2 substrate array in vitro but mainly to B23/nucleophosmin in vivo. The CIGB-300 proapoptotic effect is preceded by its nucleolar localization, inhibition of the CK2-mediated phosphorylation on B23/nucleophosmin and nucleolar disassembly. Importantly, CIGB-300 shifted a protein array linked to apoptosis, ribosome biogenesis, cell proliferation, glycolisis, and cell motility in proteomic studies which helped to understand its mechanism of action. In the clinical ground, CIGB-300 has proved to be safe and well tolerated in a First-in-Human trial in women with cervical malignancies who also experienced signs of clinical benefit. In a second Phase 1 clinical trial in women with cervical cancer stage IB2/II, the MTD and DLT have been also identified in the clinical setting. Interestingly, in cervical tumors the B23/nucleophosmin protein levels were significantly reduced after CIGB-300 treatment at the nucleus compartment. In addition, expanded use of CIGB-300 in case studies has evidenced antitumor activity when administered as compassional option. Collectively, our data outline important clues on translational and clinical research from this novel peptide-based drug reinforcing its perspectives to treat cancer and paving the way to validate CK2 as a promising target in oncology.Fil: Perea, Silvio E.. Center for Genetic Engineering and Biotechnology; CubaFil: Baladron, Idania. Center for Genetic Engineering and Biotechnology; CubaFil: Garcia, Yanelda. Center for Genetic Engineering and Biotechnology; CubaFil: Perera, Yasser. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Adlin. Center for Genetic Engineering and Biotechnology; CubaFil: Soriano, Jorge L.. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Batista, Noyde. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Palau, Aley. Center for Genetic Engineering and Biotechnology; Cuba. General Hospital ‘‘Hermanos Ameijeiras’; CubaFil: Hernández, Ignacio. Center for Genetic Engineering and Biotechnology; CubaFil: Farina, Hernán Gabriel. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Idrian. Center for Genetic Engineering and Biotechnology; CubaFil: Gonzalez, Lidia. Center for Genetic Engineering and Biotechnology; CubaFil: Gil, Jeovanis. Center for Genetic Engineering and Biotechnology; CubaFil: Rodriguez, Arielis. Center for Genetic Engineering and Biotechnology; CubaFil: Solares, Margarita. Center for Genetic Engineering and Biotechnology; CubaFil: Santana, Agueda. Center for Genetic Engineering and Biotechnology; CubaFil: Cruz, Marisol. Center for Genetic Engineering and Biotechnology; CubaFil: Lopez, Matilde. Center for Genetic Engineering and Biotechnology; CubaFil: Valenzuela, Carmen. Center for Genetic Engineering and Biotechnology; CubaFil: Reyes, Osvaldo. Center for Genetic Engineering and Biotechnology; CubaFil: López Saura, Pedro A.. Center for Genetic Engineering and Biotechnology; CubaFil: González, Carlos A.. Center for Genetic Engineering and Biotechnology; CubaFil: Diaz, Alina. Center for Genetic Engineering and Biotechnology; CubaFil: Castellanos, Lila. Center for Genetic Engineering and Biotechnology; CubaFil: Sanchez, Aniel. Center for Genetic Engineering and Biotechnology; CubaFil: Betancourt, Lazaro. Center for Genetic Engineering and Biotechnology; CubaFil: Besada, Vladimir. Center for Genetic Engineering and Biotechnology; CubaFil: González, Luis J.. Center for Genetic Engineering and Biotechnology; CubaFil: Garay, Hilda. Center for Genetic Engineering and Biotechnology; CubaFil: Gómez, Roberto. Center for Genetic Engineering and Biotechnology; CubaFil: Gomez, Daniel Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes; ArgentinaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Perrin, Phillipe. No especifíca;Fil: Renualt, Jean Yves. No especifíca;Fil: Sigman, Hugo. No especifíca;Fil: Herrera, Luis. Center for Genetic Engineering and Biotechnology; CubaFil: Acevedo, Boris. Center for Genetic Engineering and Biotechnology; Cub

Case-Control Analysis of the Impact of Anemia on Quality of Life in Patients with Cancer: A Qca Study Analysis

The impact of anemia on the quality of life (QoL) in cancer patients has been studied previously; however, the cut-off point used to define anemia differed among studies, thus providing inconsistent results. Therefore, we analysed the clinical impact of anemia on QoL using the same cut-off point for hemoglobin level to define anemia as that used in ESMO clinical practice guidelines. This post-hoc analysis aimed to determine the impact of anemia on QoL in cancer patients through the European Organization for Research and Treatment of Cancer Quality of life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. We found that cancer patients with anemia had significantly worse QoL in clinical terms. In addition, anemic patients had more pronounced symptoms than those in non-anemic patients. Anemia is a common condition in cancer patients and is associated with a wide variety of symptoms that impair quality of life (QoL). However, exactly how anemia affects QoL in cancer patients is unclear because of the inconsistencies in its definition in previous reports. We aimed to examine the clinical impact of anemia on the QoL of cancer patients using specific questionnaires. We performed a post-hoc analysis of a multicenter, prospective, case-control study. We included patients with cancer with (cases) or without (controls) anemia. Participants completed the European Organization for Research and Treatment of Cancer Quality of Life questionnaire version 3.0 (EORTC QLQ-C30) and Euro QoL 5-dimension 3-level (EQ-5D-3L) questionnaire. Statistically significant and clinically relevant differences in the global health status were examined. From 2015 to 2018, 365 patients were included (90 cases and 275 controls). We found minimally important differences in global health status according to the EORTC QLQ-C30 questionnaire (case vs. controls: 45.6 vs. 58%, respectively; mean difference: -12.4, p < 0.001). Regarding symptoms, cancer patients with anemia had more pronounced symptoms in six out of nine scales in comparison with those without anemia. In conclusion, cancer patients with anemia had a worse QoL both clinically and statistically

Measurement of the cosmic ray spectrum above 4×10184{\times}10^{18} eV using inclined events detected with the Pierre Auger Observatory

A measurement of the cosmic-ray spectrum for energies exceeding $4{\times}10^{18}$ eV is presented, which is based on the analysis of showers with zenith angles greater than $60^{\circ}$ detected with the Pierre Auger Observatory between 1 January 2004 and 31 December 2013. The measured spectrum confirms a flux suppression at the highest energies. Above $5.3{\times}10^{18}$ eV, the "ankle", the flux can be described by a power law $E^{-\gamma}$ with index $\gamma=2.70 \pm 0.02 \,\text{(stat)} \pm 0.1\,\text{(sys)}$ followed by a smooth suppression region. For the energy ($E_\text{s}$) at which the spectral flux has fallen to one-half of its extrapolated value in the absence of suppression, we find $E_\text{s}=(5.12\pm0.25\,\text{(stat)}^{+1.0}_{-1.2}\,\text{(sys)}){\times}10^{19}$ eV.Comment: Replaced with published version. Added journal reference and DO