Long working hours and exhaustion: A test of rumination as a mediator among mobile-flexible employees in activity-based offices

The present study examines the effect of extended work hours on experienced exhaustion in the evening in mobile-flexible employees who work in activity-flexible offices. In a seven-day diary study, it was anticipated that daily rumination is a mediator, linked to additional daily exhaustion in individuals. In a morning questionnaire, mobile-flexible employees completed daily questions about the link between extended work hours and exhaustion. Thirty-three employees completed daily questions on the extension of working hours, rumination, and exhaustion. Multilevel analyses of up to 238 daily measurements revealed that more intense extension of working hours predicted more rumination as well as exhaustion. Extended work hours and rumination both predicted more exhaustion. A test of the indirect effects showed no mediation from the extension of working hours via rumination to exhaustion. When designing mobile-flexible work models, overtime is a risk. Occupational prevention of exhaustion should promote recovery processes, especially as new work models may lead to increased rumination due to more personal responsibility of employees.El presente estudio examina el efecto de la ampliación de las horas de trabajo sobre el agotamiento experimentado por la tarde en empleados móviles-flexibles que trabajan en oficinas de actividad flexible. En un estudio de diario de siete días, se anticipó que la rumiación diaria es un mediador, vinculado al agotamiento diario adicional en los individuos. En un cuestionario matutino, los empleados con flexibilidad de actividad completaron preguntas diarias sobre la relación entre las horas de trabajo prolongadas y el agotamiento. Treinta y tres empleados completaron preguntas diarias sobre la extensión de las horas de trabajo, la rumiación y el agotamiento. Los análisis multinivel de hasta 238 mediciones diarias revelaron que una extensión más intensa de las horas de trabajo predecía más rumiación, así como agotamiento. Tanto la prolongación de la jornada laboral como la rumiación predecían un mayor agotamiento. Una prueba de los efectos indirectos no mostró ninguna mediación desde la extensión de las horas de trabajo a través de la rumiación hasta el agotamiento. Cuando se diseñan modelos de trabajo móviles y flexibles, las horas extras son un riesgo. La prevención del agotamiento en el trabajo debería promover los procesos de recuperación, especialmente porque los nuevos modelos de trabajo pueden conducir a un aumento de la rumiación debido a una mayor responsabilidad personal de los empleados

Working from home: Cognitive irritation as mediator of the link between perceived privacy and sleep problems

Since the COVID-19 pandemic began, many employees have been required to work full or part-time at home. This paper investigates the impact of perceived privacy on cognitive irritation and sleep problems among employees who worked from home during the pandemic. Additionally, we analyzed the role of cognitive irritation as a mediator between privacy and sleep problems. We created a cross-sectional questionnaire, which was completed by 293 employees who performed home-based telework in German-speaking Switzerland. A mediation analysis was then conducted using a multiple regression analysis. A test of the indirect effect showed a significant mediation path from perceived privacy via cognitive irritation to sleep problems. Hence, the negative indirect effect indicates that perceived privacy is an important job resource that may prevent sleep problems. Further research is needed regarding home-based telework and recovery strategies to prevent sleep problems

Perceived privacy in home office and musculoskeletal complaints: a test of family-work conflict, work-family conflict, and relaxation as mediators.

Many employees have had to telework all year during the COVID-19 pandemic. Even though working from home has many advantages, there are also some disadvantages worth to consider. Lack of privacy is a relevant factor when it comes to the development of severe musculoskelatal issues. This study investigated the link between perceived privacy in home office and musculoskeletal complaints (MSCs). Family-work conflict (FWC), work-family conflict (WFC), and relaxation were tested as potential mediators for the relationship between perceived privacy and MSCs. The present study's questionnaire was filled out by 287 teleworking employees. Hypotheses were tested via multiple mediation analyses examining levels of perceived privacy in home office, and its relationship on MSCs. Furthermore, the underlying effect of FWC, WFC, and MSCs were tested with a structural equation model. As assumed, lack of privacy while working at home was linked to individuals more frequently experiencing MSCs. However, the structural equation model showed no significant mediation effect. Work design efforts must address privacy while employees perform telework at home to prevent MSCs

Progressive Transmission of Large Archaeological Models

Entrepreneurship motivation plays important role in developing new business organization. This research addresses to test variable influence entrepreneurship among students in East Java.  It refers to the theory of planned behavior  modified by Segel et. al (2004)  that uses three dependent variables, they are perceived feasibility or self afficacy (SE), risk tolerence (TR) and net desirability of self employment (NDSE) to explain entreprenuership motivation.To test this assertions, sample used are 854 students from 10 universities in Surabaya, Malang and Jember. Then, hypothesis both partial and simultanious  variables, SE,TR and NDSE have positive relation to entrepreneurship motivation (MB) tested by regression and correlation analysis. As a result,  findings support hypotesis and have significant implication for the way in which we conceptualize entrepreneurship motivation

Elusa. From Nabatean Trading Post to Late Antique Desert Metropolis: Results of the 2015−2020 Seasons

In Roman to late Byzantine times, Elusa (Hebrew: Haluza, Arabic: al-Khalasa) was the most important settlement in the Negev region and its only proper city. Identified in 1838 by E. Robinson, it was subsequently visited by numerous researchers. The most important investigations took place in the form of surveys and excavations from the 1970s until 2001, during which, among other things, the only theatre in the region and the city’s cathedral were uncovered. However, despite several research projects, very basic information on the city and its genesis, history and structure has been lacking until now. Since 2015, this has been the focus of an international cooperation project that is investigating these fundamental questions using a multi-method approach. The focus here is also on the role of the city in the region, as it appears as an economic, administrative, cultural and religious centre. Particular emphasis is placed on the city’s flourishing in light of its precarious natural location within the Negev Desert. The article reflects the combined findings of remote sensing, archaeological survey, geophysical prospection, targeted excavations, geochemical soil sampling and extensive find material analyses and thus provides an unprecedented insight into the character and development of ancient Elusa.In Roman to late Byzantine times, Elusa (Hebrew: Haluza, Arabic: al-Khalasa) was the most important settlement in the Negev region and its only proper city. Identified in 1838 by E. Robinson, it was subsequently visited by numerous researchers. The most important investigations took place in the form of surveys and excavations from the 1970s until 2001, during which, among other things, the only theatre in the region and the city’s cathedral were uncovered. However, despite several research projects, very basic information on the city and its genesis, history and structure has been lacking until now. Since 2015, this has been the focus of an international cooperation project that is investigating these fundamental questions using a multi-method approach. The focus here is also on the role of the city in the region, as it appears as an economic, administrative, cultural and religious centre. Particular emphasis is placed on the city’s flourishing in light of its precarious natural location within the Negev Desert. The article reflects the combined findings of remote sensing, archaeological survey, geophysical prospection, targeted excavations, geochemical soil sampling and extensive find material analyses and thus provides an unprecedented insight into the character and development of ancient Elusa

Targeting the innate repair receptor axis via erythropoietin or pyroglutamate helix B surface peptide attenuates hemolytic-uremic syndrome in mice

Hemolytic-uremic syndrome (HUS) can occur as a systemic complication of infections with Shiga toxin (Stx)-producing Escherichia coli and is characterized by microangiopathic hemolytic anemia and acute kidney injury. Hitherto, therapy has been limited to organ-supportive strategies. Erythropoietin (EPO) stimulates erythropoiesis and is approved for the treatment of certain forms of anemia, but not for HUS-associated hemolytic anemia. EPO and its non-hematopoietic analog pyroglutamate helix B surface peptide (pHBSP) have been shown to mediate tissue protection via an innate repair receptor (IRR) that is pharmacologically distinct from the erythropoiesis-mediating receptor (EPO-R). Here, we investigated the changes in endogenous EPO levels in patients with HUS and in piglets and mice subjected to preclinical HUS models. We found that endogenous EPO was elevated in plasma of humans, piglets, and mice with HUS, regardless of species and degree of anemia, suggesting that EPO signaling plays a role in HUS pathology. Therefore, we aimed to examine the therapeutic potential of EPO and pHBSP in mice with Stx-induced HUS. Administration of EPO or pHBSP improved 7-day survival and attenuated renal oxidative stress but did not significantly reduce renal dysfunction and injury in the employed model. pHBSP, but not EPO, attenuated renal nitrosative stress and reduced tubular dedifferentiation. In conclusion, targeting the EPO-R/IRR axis reduced mortality and renal oxidative stress in murine HUS without occurrence of thromboembolic complications or other adverse side effects. We therefore suggest that repurposing EPO for the treatment of patients with hemolytic anemia in HUS should be systematically investigated in future clinical trials

Local stability properties of complex, species-rich soil food webs with functional block structure

Publication history: Accepted - 14 October 2021; Published online - 3 November 2021.Ecologists have long debated the properties that confer stability to complex, species-rich ecological networks. Species-level soil food webs are large and structured networks of central importance to ecosystem functioning. Here, we conducted an analysis of the stability properties of an up-to-date set of theoretical soil food web models that account both for realistic levels of species richness and the most recent views on the topological structure (who is connected to whom) of these food webs. The stability of the network was best explained by two factors: strong correlations between interaction strengths and the blocked, nonrandom trophic structure of the web. These two factors could stabilize our model food webs even at the high levels of species richness that are typically found in soil, and that would make random systems very unstable. Also, the stability of our soil food webs is well-approximated by the cascade model. This result suggests that stability could emerge from the hierarchical structure of the functional organization of the web. Our study shows that under the assumption of equilibrium and small perturbations, theoretical soil food webs possess a topological structure that allows them to be complex yet more locally stable than their random counterpart. In particular, results strongly support the general hypothesis that the stability of rich and complex soil food webs is mostly driven by correlations in interaction strength and the organization of the soil food web into functional groups. The implication is that in real-world food web, any force disrupting the functional structure and distribution pattern of interaction strengths (i.e., energy fluxes) of the soil food webs will destabilize the dynamics of the system, leading to species extinction and major changes in the relative abundances of species.TC was supported by the project SENSE (Structure and Ecological Niche in the Soil Environment; EC FP7 –631399 –SENSE). TC and FdC were also supported by the NERC Grant Controls on the stability of soils and their functioning under land use and climate change (NE/M017036/1) as was RDB (NE/M017028/1). MÖ was supported by the European Regional Development Fund [Centre of Excellence EcolChange]

Pulmonary Function and Blood DNA Methylation: A Multiancestry Epigenome-Wide Association Meta-Analysis

Rationale: Methylation integrates factors present at birth and modifiable across the lifespan that can influence pulmonary function. Studies are limited in scope and replication. Objectives: To conduct large-scale epigenome-wide meta-analyses of blood DNA methylation and pulmonary function. Methods: Twelve cohorts analyzed associations of methylation at cytosine-phosphate-guanine probes (CpGs), using Illumina 450K or EPIC/850K arrays, with FEV1, FVC, and FEV1/FVC. We performed multiancestry epigenome-wide meta-analyses (total of 17,503 individuals; 14,761 European, 2,549 African, and 193 Hispanic/Latino ancestries) and interpreted results using integrative epigenomics. Measurements and Main Results: We identified 1,267 CpGs (1,042 genes) differentially methylated (false discovery rate, \u3c0.025) in relation to FEV1, FVC, or FEV1/FVC, including 1,240 novel and 73 also related to chronic obstructive pulmonary disease (1,787 cases). We found 294 CpGs unique to European or African ancestry and 395 CpGs unique to never or ever smokers. The majority of significant CpGs correlated with nearby gene expression in blood. Findings were enriched in key regulatory elements for gene function, including accessible chromatin elements, in both blood and lung. Sixty-nine implicated genes are targets of investigational or approved drugs. One example novel gene highlighted by integrative epigenomic and druggable target analysis is TNFRSF4. Mendelian randomization and colocalization analyses suggest that epigenome-wide association study signals capture causal regulatory genomic loci. Conclusions: We identified numerous novel loci differentially methylated in relation to pulmonary function; few were detected in large genome-wide association studies. Integrative analyses highlight functional relevance and potential therapeutic targets. This comprehensive discovery of potentially modifiable, novel lung function loci expands knowledge gained from genetic studies, providing insights into lung pathogenesis