3,582 research outputs found
Liver disease in chelated transfusion-dependent thalassemics: the role of iron overload and chronic hepatitis C.
Abstract
Iron overload and hepatitis virus C infection cause liver fibrosis in thalassemics. In a monocentric retrospective analysis of liver disease in a cohort of 191 transfusion-dependent thalassemics, in 126 patients who had undergone liver biopsy (mean age 17.2 years; 58 hepatitis virus C-RNA positive and 68 hepatitis virus C-RNA negative) the liver iron concentration (median 2.4 mg/gr dry liver weight) was closely related to serum ferritin levels (R = 0.58; p<0.0001). Male gender (OR 4.12) and serum hepatitis virus C-RNA positivity (OR 11.04) were independent risk factors for advanced liver fibrosis. The majority of hepatitis virus C-RNA negative patients with low iron load did not develop liver fibrosis, while hepatitis virus C-RNA positive patients infected with genotype 1 or 4 and iron overload more frequently developed advanced fibrosis. Hepatitis virus C infection is the main risk factor for liver fibrosis in transfusion-dependent thalassemics. Adequate chelation therapy usually prevents the development of liver fibrosis in thalassemics free of hepatitis virus C-infection and reduces the risk of developing severe fibrosis in thalassemics with chronic hepatitis C
Stochastic Cellular Automata Model for Stock Market Dynamics
In the present work we introduce a stochastic cellular automata model in
order to simulate the dynamics of the stock market. A direct percolation method
is used to create a hierarchy of clusters of active traders on a two
dimensional grid. Active traders are characterised by the decision to buy,
(+1), or sell, (-1), a stock at a certain discrete time step. The remaining
cells are inactive,(0). The trading dynamics is then determined by the
stochastic interaction between traders belonging to the same cluster. Most of
the stylized aspects of the financial market time series are reproduced by the
model.Comment: 17 pages and 7 figure
GW170104: Observation of a 50-Solar-Mass Binary Black Hole Coalescence at Redshift 0.2
We describe the observation of GW170104, a gravitational-wave signal produced by the coalescence of a pair of stellar-mass black holes. The signal was measured on January 4, 2017 at 10 11:58.6 UTC by the twin advanced detectors of the Laser Interferometer Gravitational-Wave Observatory during their second observing run, with a network signal-to-noise ratio of 13 and a false alarm rate less than 1 in 70 000 years. The inferred component black hole masses are 31.2-6.0+8.4M\u27 and 19.4-5.9+5.3M (at the 90% credible level). The black hole spins are best constrained through measurement of the effective inspiral spin parameter, a mass-weighted combination of the spin components perpendicular to the orbital plane, ĂâĄeff=-0.12-0.30+0.21. This result implies that spin configurations with both component spins positively aligned with the orbital angular momentum are disfavored. The source luminosity distance is 880-390+450 Mpc corresponding to a redshift of z=0.18-0.07+0.08. We constrain the magnitude of modifications to the gravitational-wave dispersion relation and perform null tests of general relativity. Assuming that gravitons are dispersed in vacuum like massive particles, we bound the graviton mass to mgĂąâ°Â€7.7Ăâ10-23 eV/c2. In all cases, we find that GW170104 is consistent with general relativity
Nomenclature for renal replacement therapy and blood purification techniques in critically ill patients: practical applications
This article reports the conclusions of the second part of a consensus expert conference on the nomenclature of renal replacement therapy (RRT) techniques currently utilized to manage acute kidney injury and other organ dysfunction syndromes in critically ill patients. A multidisciplinary approach was taken to achieve harmonization of definitions, components, techniques, and operations of the extracorporeal therapies. The article describes the RRT techniques in detail with the relevant technology, procedures, and phases of treatment and key aspects of volume management/fluid balance in critically ill patients. In addition, the article describes recent developments in other extracorporeal therapies, including therapeutic plasma exchange, multiple organ support therapy, liver support, lung support, and blood purification in sepsis. This is a consensus report on nomenclature harmonization in extracorporeal blood purification therapies, such as hemofiltration, plasma exchange, multiple organ support therapies, and blood purification in sepsis
Search for Gamma Ray Bursts with the Argo-YBJ Detector in Scaler Mode
We report on the search for Gamma Ray Bursts (GRBs) in the energy range 1-100
GeV in coincidence with the prompt emission detected by satellites using the
Astrophysical Radiation with Ground-based Observatory at YangBaJing (ARGO-YBJ)
air shower detector. Thanks to its mountain location (Yangbajing, Tibet, P.R.
China, 4300 m a.s.l.), active surface (about 6700 m**2 of Resistive Plate
Chambers), and large field of view (about 2 sr, limited only by the atmospheric
absorption), the ARGO-YBJ air shower detector is particularly suitable for the
detection of unpredictable and short duration events such as GRBs. The search
is carried out using the "single particle technique", i.e. counting all the
particles hitting the detector without measurement of the energy and arrival
direction of the primary gamma rays.
Between 2004 December 17 and 2009 April 7, 81 GRBs detected by satellites
occurred within the field of view of ARGO-YBJ (zenith angle < 45 deg). It was
possible to examine 62 of these for >1 GeV counterpart in the ARGO-YBJ data
finding no statistically significant emission. With a lack of detected spectra
in this energy range fluence upper limits are profitable, especially when the
redshift is known and the correction for the extragalactic absorption can be
considered. The obtained fluence upper limits reach values as low as 10**{-5}
erg cm**{-2} in the 1-100 GeV energy region.
Besides this individual search for a higher energy counterpart, a statistical
study of the stack of all the GRBs both in time and in phase was made, looking
for a common feature in the GRB high energy emission. No significant signal has
been detected.Comment: accepted for publication in Ap
Prospects for the measurement of muon-neutrino disappearance at the FNAL-Booster
Neutrino physics is nowadays receiving more and more attention as a possible
source of information for the long-standing problem of new physics beyond the
Standard Model. The recent measurement of the mixing angle in the
standard mixing oscillation scenario encourages us to pursue the still missing
results on leptonic CP violation and absolute neutrino masses. However,
puzzling measurements exist that deserve an exhaustive evaluation. The NESSiE
Collaboration has been setup to undertake conclusive experiments to clarify the
muon-neutrino disappearance measurements at small , which will be able to
put severe constraints to models with more than the three-standard neutrinos,
or even to robustly measure the presence of a new kind of neutrino oscillation
for the first time. To this aim the use of the current FNAL-Booster neutrino
beam for a Short-Baseline experiment has been carefully evaluated. This
proposal refers to the use of magnetic spectrometers at two different sites,
Near and Far. Their positions have been extensively studied, together with the
possible performances of two OPERA-like spectrometers. The proposal is
constrained by availability of existing hardware and a time-schedule compatible
with the CERN project for a new more performant neutrino beam, which will
nicely extend the physics results achievable at the Booster. The possible FNAL
experiment will allow to clarify the current disappearance tension
with appearance and disappearance at the eV mass scale. Instead, a new
CERN neutrino beam would allow a further span in the parameter space together
with a refined control of systematics and, more relevant, the measurement of
the antineutrino sector, by upgrading the spectrometer with detectors currently
under R&D study.Comment: 76 pages, 52 figure
The detection of neutrino interactions in the emulsion/lead target of the OPERA experiment
The OPERA neutrino detector in the underground Gran Sasso Laboratory (LNGS)
was designed to perform the first detection of neutrino oscillations in
appearance mode through the study of oscillations. The
apparatus consists of an emulsion/lead target complemented by electronic
detectors and it is placed in the high energy long-baseline CERN to LNGS beam
(CNGS) 730 km away from the neutrino source. Runs with CNGS neutrinos were
successfully carried out in 2007 and 2008 with the detector fully operational
with its related facilities for the emulsion handling and analysis. After a
brief description of the beam and of the experimental setup we report on the
collection, reconstruction and analysis procedures of first samples of neutrino
interaction events
Bi-allelic JAM2 Variants Lead to Early-Onset Recessive Primary Familial Brain Calcification.
Primary familial brain calcification (PFBC) is a rare neurodegenerative disorder characterized by a combination of neurological, psychiatric, and cognitive decline associated with calcium deposition on brain imaging. To date, mutations in five genes have been linked to PFBC. However, more than 50% of individuals affected by PFBC have no molecular diagnosis. We report four unrelated families presenting with initial learning difficulties and seizures and later psychiatric symptoms, cerebellar ataxia, extrapyramidal signs, and extensive calcifications on brain imaging. Through a combination of homozygosity mapping and exome sequencing, we mapped this phenotype to chromosome 21q21.3 and identified bi-allelic variants in JAM2. JAM2 encodes for the junctional-adhesion-molecule-2, a key tight-junction protein in blood-brain-barrier permeability. We show that JAM2 variants lead to reduction of JAM2 mRNA expression and absence of JAM2 protein in patient's fibroblasts, consistent with a loss-of-function mechanism. We show that the human phenotype is replicated in the jam2 complete knockout mouse (jam2 KO). Furthermore, neuropathology of jam2 KO mouse showed prominent vacuolation in the cerebral cortex, thalamus, and cerebellum and particularly widespread vacuolation in the midbrain with reactive astrogliosis and neuronal density reduction. The regions of the human brain affected on neuroimaging are similar to the affected brain areas in the myorg PFBC null mouse. Along with JAM3 and OCLN, JAM2 is the third tight-junction gene in which bi-allelic variants are associated with brain calcification, suggesting that defective cell-to-cell adhesion and dysfunction of the movement of solutes through the paracellular spaces in the neurovascular unit is a key mechanism in CNS calcification
First events from the CNGS neutrino beam detected in the OPERA experiment
The OPERA neutrino detector at the underground Gran Sasso Laboratory (LNGS)
was designed to perform the first detection of neutrino oscillations in
appearance mode, through the study of nu_mu to nu_tau oscillations. The
apparatus consists of a lead/emulsion-film target complemented by electronic
detectors. It is placed in the high-energy, long-baseline CERN to LNGS beam
(CNGS) 730 km away from the neutrino source. In August 2006 a first run with
CNGS neutrinos was successfully conducted. A first sample of neutrino events
was collected, statistically consistent with the integrated beam intensity.
After a brief description of the beam and of the various sub-detectors, we
report on the achievement of this milestone, presenting the first data and some
analysis results.Comment: Submitted to the New Journal of Physic
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