Performance and the City: Constructing Urban Identities in Contemporary London

The relationship between spectators, performers and spaces is investigated in a critical perspective which aims at further developing the concept of the city as a performance place where precarious urban identities are dynamically and temporarily shaped and reshaped. Even if this essay takes into due account the seminal studies of Barthes (1971), H. Lefebvre (1974), and urban theorists such as Reyner Banham and Kevin Lynch who conceived of the city as a ‘legible’ text, at the same time it argues that textuality and performativity must be perceived as intertwined cultural practices that work together to shape the body of phenomenal, intellectual, psychic, and social encounters that frame a subject’s experience of the city. London 2012 Olympic Games, and in particular the stunning Opening Ceremony directed by Danny Boyle, for which visitors and overseas spectators were invited to transform themselves into a global theatrical audience, can be used as a privileged viewpoint from which to analyse the different ways of perceiving, but also being looked at and performing oneself, in and through spaces which tend at modifying, or at interrogating or destabilizing one’s traditional identity

Letteratura e mondo digitale

This essay discusses literature’s persistent diffidence against electronic productions, wrongly perceived as on the verge of erasing the print world of the literary. At the same time, the essay shows how deep the digital world’s fascination over a literary mind may be, and in how many ways the ‘established’ field of human knowledge may be significantly enriched by opening paths of communications where no boundaries are constructed, so that the free circulation among all of them is made possible without endangering the identity of the electronic and literary worlds. Rather, the perspectives belonging to these two worlds may give major contributions not only to the creation and study of electronic /new media literature, but also to the exploration and understanding of the full implications of what the transition/transformation/translation from page to screen may signify. The complexities of the processes involved are illustrated through the analyses of theories and critical thinking, as well as the study of written and visual materials.L’articolo discute la persistente diffidenza da parte della letteratura verso le produzioni elettroniche, erroneamente percepite come se fossero sul punto di cancellare il mondo della stampa. Nello stesso tempo, l’articolo mostra sia quanto possa essere profonda la fascinazione esercitata dal mondo digitale su una mente letteraria, sia in quanti e quali modi il campo ‘costituito’ della conoscenza umana possa essere arricchito dall’apertura di percorsi di comunicazione non delimitati da confini. In questo modo la libera circolazione tra di essi può avvenire senza che l’identità del mondo elettronico e quella del mondo letterario vengano minacciate. Piuttosto, i due mondi insieme possono fornire un importante contributo non solo alla creazione e analisi della letteratura dei nuovi media, ma anche all’esplorazione e comprensione delle implicazioni di cosa possa significare la transizione/trasformazione/traduzione da pagina a schermo. Le complessità dei processi coinvolti vengono illustrate attraverso l’analisi delle teorie e del pensiero critico, e attraverso lo studio di testi a stampa e visuali

How public ambulance arrivals impact on Emergency Department workload and resource use

Objectives: To examine patient's characteristics associated with ED arrival mode, and to determine EMS impact on ED clinical resource use, workload and crowding. Methods: This is a retrospective study of patients seen at Sant'Andrea Hospital ED. Comparison focused on visit characteristics, and on resource use. Results: The use of EMS ambulance confirms association to older age, higher rate of hospital admission, longer length of stay, and severity of injury. Moreover our data show that ambulance referred patients are triaged into a higher acuity category and have a greater intensive care unit admission. Conclusion: Ambulance arrivals have a significant impact on ED resource use, workload and crowding

Brown Tumour in a Patient with Secondary Hyperparathyroidism Resistant to Medical Therapy: Case Report on Successful Treatment after Subtotal Parathyroidectomy

Brown tumour represents a serious complication of hyperparathyroidism. Differential diagnosis, based on histological examination, is only presumptive and clinical, radiological and laboratory data are necessary for definitive diagnosis. Here we describe a case of a brown tumour localised in the maxilla due to secondary hyperparathyroidism in a young women with chronic renal failure. Hemodialysis and pharmacological treatment were unsuccessful in controlling secondary hyperparathyroidism making it necessary to proceed with a subtotal parathyroidectomy. The proper timing of the parathyroidectomy and its favourable effect on regression of the brown tumor made it possible to avoid a potentially disfiguring surgical removal of the brown tumor

Renal function and physical fitness after 12-mo supervised training in kidney transplant recipients

To evaluate the effect of a 12-mo supervised aerobic and resistance training, on renal function and exercise capacity compared to usual care recommendations

Successful recovery of associated interstitial nephritis and focal segmental glomerulosclerosis in patients with HCV and HIV treated with sofosbuvir and daclatasvir and revision of literature

In this report, we describe the coexistence of two rare and debated complications of hepatitis C virus (HCV) infection: interstitial nephritis, with associated focal glomerulosclerosis, and autoimmune hepatitis, in a 55-year-old HIV/HCV-coinfected woman. The patient was treated for the immune-mediated manifestations with mycophenolate mofetil, which she continued for 9 years, as symptoms relapsed at every attempt to discontinue immunosuppression. The patient finally cleared HCV infection thanks to new direct-acting agents and could discontinue immunosuppressive therapy maintaining stable conditions and laboratory parameters after 24-weeks follow-up

Dysbiosis and zonulin upregulation alter gut epithelial and vascular barriers in patients with ankylosing spondylitis

Background: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. Methods: Ileal biopsies were obtained from 50 HLA-B27+ patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry. Serum levels of lipopolysaccharide (LPS), LPS-binding protein (LPS-BP), intestinal fatty acid-BP (iFABP) and zonulin were assayed by ELISA. Monocyte immunological functions were studied in in vitro experiments. In addition the effects of antibiotics on tight junctions in human leukocyte antigen (HLA)-B27 transgenic (TG) rats were assessed. Results: Adherent and invasive bacteria were observed in the gut of patients with AS with the bacterial scores significantly correlated with gut inflammation. Impairment of the gut vascular barrier (GVB) was also present in AS, accompanied by significant upregulation of zonulin, and associated with high serum levels of LPS, LPS-BP, iFABP and zonulin. In in vitro studies zonulin altered endothelial tight junctions while its epithelial release was modulated by isolated AS ileal bacteria. AS circulating monocytes displayed an anergic phenotype partially restored by ex vivo stimulation with LPS+sCD14 and their stimulation with recombinant zonulin induced a clear M2 phenotype. Antibiotics restored tight junction function in HLA-B27 TG rats. Conclusions: Bacterial ileitis, increased zonulin expression and damaged intestinal mucosal barrier and GVB, characterises the gut of patients with AS and are associated with increased blood levels of zonulin, and bacterial products. Bacterial products and zonulin influence monocyte behaviour

Ca2+-activated K+ channels modulate microglia affecting motor neuron survivalin hSOD1G93A mice

Recent studies described a critical role for microglia in amyotrophic lateral sclerosis (ALS), where these CNS-resident immune cells participate in the establishment of an inflammatory microenvironment that contributes to motor neuron degeneration. Understanding the mechanisms leading to microglia activation in ALS could help to identify specific molecular pathways which could be targeted to reduce or delay motor neuron degeneration and muscle paralysis in patients. The intermediate-conductance calcium-activated potassium channel KCa3.1 has been reported to modulate the "pro-inflammatory" phenotype of microglia in different pathological conditions. We here investigated the effects of blocking KCa3.1 activity in the hSOD1G93AALS mouse model, which recapitulates many features of the human disease. We report that treatment of hSOD1G93A mice with a selective KCa3.1 inhibitor, 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole (TRAM-34), attenuates the "pro-inflammatory" phenotype of microglia in the spinal cord, reduces motor neuron death, delays onset of muscle weakness, and increases survival. Specifically, inhibition of KCa3.1 channels slowed muscle denervation, decreased the expression of the fetal acetylcholine receptor γ subunit and reduced neuromuscular junction damage. Taken together, these results demonstrate a key role for KCa3.1 in driving a pro-inflammatory microglia phenotype in ALS

The Mini AGN at the Center of the Elliptical Galaxy NGC 4552 with HST

The complex phenomenology shown by the UV-bright, variable spike first detected with the Hubble Space Telescope (HST) at the center of the otherwise normal galaxy NGC 4552 is further investigated with both HST imaging (FOC) and spectroscopy (FOS). HST/FOC images taken in 1991, 1993, and 1996 in the near UV have been analyzed in a homogeneous fashion, showing that the central spike has brightened by a factor ~4.5 between 1991 and 1993, and has decreased its luminosity by a factor ~2.0 between 1993 and 1996. FOS spectroscopy extending from the near UV to the red side of the optical spectrum reveals a strong UV continuum over the spectrum of the underlying galaxy, along with several emission lines in both the UV and the optical ranges. In spite of the low luminosity of the UV continuum of the spike (~3*10^5 Lsolar), the spike is definitely placed among AGNs by current diagnostics based on the emission line intensity ratios, being just on the borderline between Seyferts and LINERs. Line profiles are very broad, and both permitted and forbidden lines are best modelled with a combination of broad and narrow components, with FWHM of ~3000 km s^-1 and ~700 km s^-1, respectively. This evidence argues for the variable central spike being produced by a modest accretion event onto a central massive black hole (BH), with the accreted material having possibly being stripped from a a star in a close fly by with the BH. The 1996 broad Halpha luminosity of this mini-AGN is ~5.6*10^37 erg s^-1, about a factor of two less than that of the nucleus of NGC 4395, heretofore considered to be the faintest known AGN.Comment: 40 pages, LaTeX, with 12 PostScript figures. Accepted for publication in the Astrophysical Journa

Recent results and perspectives on cosmology and fundamental physics from microwave surveys

Recent cosmic microwave background data in temperature and polarization have reached high precision in estimating all the parameters that describe the current so-called standard cosmological model. Recent results about the integrated Sachs-Wolfe effect from cosmic microwave background anisotropies, galaxy surveys, and their cross-correlations are presented. Looking at fine signatures in the cosmic microwave background, such as the lack of power at low multipoles, the primordial power spectrum and the bounds on non-Gaussianities, complemented by galaxy surveys, we discuss inflationary physics and the generation of primordial perturbations in the early Universe. Three important topics in particle physics, the bounds on neutrinos masses and parameters, on thermal axion mass and on the neutron lifetime derived from cosmological data are reviewed, with attention to the comparison with laboratory experiment results. Recent results from cosmic polarization rotation analyses aimed at testing the Einstein equivalence principle are presented. Finally, we discuss the perspectives of next radio facilities for the improvement of the analysis of future cosmic microwave background spectral distortion experiments.Comment: 27 pages, 9 figures. Review Article. International Journal of Modern Physics D, in press. [Will appear also on the proceedings of the Fourteenth Marcel Grossmann Meeting University of Rome "La Sapienza" - Rome, July 12-18, 2015 (http://www.icra.it/mg/mg14/), eds. Robert T. Jantzen, Kjell Rosquist, Remo Ruffini. World Scientific, Singapore