1,919 research outputs found

    A Model for Process Oriented Risk Managenent

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    REDD+ politics in the media : A case study from Vietnam

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    Special Issue: Shifting global development discourses - Implications for forests and livelihoods ( Vol. 19, Supplement 1, December 2017)Reducing emissions from deforestation and degradation (REDD+) is an international effort to create financial value for the carbon stored in forests, offering incentives for developing countries to reduce emissions from land uses. Vietnam is engaged in the international REDD+ debate and is a partner to numerous multi- and bilateral agreements. Different actors have diverse interests in the REDD+ agenda, and in Vietnam, even though an authoritarian state, different views exist on what REDD+ should achieve. Through the analysis of media articles this study intends to understand how public debates on REDD+ are framed in the Vietnamese policy domain and how actors use the media to promote their interests. Reporting about a diversity of actors and interests, in particular related to expressions of equity concerns in media frames could reflect a growing inclusive political space. Our findings show that while state actors dominate REDD+ media frames, some limited space is present for non-state actors’ interests, but equity issue discussed still reflect predominantly state mediated concerns. However, caution is still required due to the limitations these findings come with.Peer reviewe

    Physiology and physical chemistry of bile acids

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    Bile acids (BAs) are facial amphiphiles synthesized in the body of all vertebrates. They undergo the enterohepatic circulation: they are produced in the liver, stored in the gallbladder, released in the intestine, taken into the bloodstream and lastly re-absorbed in the liver. During this pathway, BAs are modified in their molecular structure by the action of enzymes and bacteria. Such transformations allow them to acquire the chemical–physical properties needed for fulling several activities including metabolic regulation, antimicrobial functions and solubilization of lipids in digestion. The versatility of BAs in the physiological functions has inspired their use in many bioapplications, making them important tools for active molecule delivery, metabolic disease treatments and emulsification processes in food and drug industries. Moreover, moving over the borders of the biological field, BAs have been largely investigated as building blocks for the construction of supramolecular aggregates having peculiar structural, mechanical, chemical and optical properties. The review starts with a biological analysis of the BAs functions before progressively switching to a general overview of BAs in pharmacology and medicine applications. Lastly the focus moves to the BAs use in material science

    Usual and unusual suspects : What network analysis can tell us about climate policy integration

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    Key messages Understanding adaptation-mitigation linkages helps identify co-benefits and reduce negative interactions between the two climate change domains. Barriers include working in institutional siloes and lack of information: adaptation actors are not well-informed about mitigation actions and vice-versa. Policy network analysis sheds light on adaptation-mitigation actor interactions and what can be done to improve them. It reveals both the usual and unusual suspects who can foster linkages between the two domains. This InfoBrief summarizes the findings of a climate change policy network analysis conducted in Peru and published in the journal Climate Policy (Locatelli et al. 2020)

    How institutions and beliefs affect environmental discourse: Evidence from an eight-country survey on REDD+

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    This paper investigates the adoption of discourses on Reducing Emissions from Deforestation and forest Degradation (REDD +) across different national contexts. It draws on institutional theories to develop and test a number of hypotheses on the role of shared beliefs and politico-economic institutions in determining the discursive choices of policy actors. The results show that win win ecological modernization discourse, embraced by powerful government agencies and international actors, dominates national REDD + policy arenas. This discourse is challenged primarily by a minority reformist civic environmentalist discourse put forward primarily by domestic NGOs. We find evidence that countries with a less democratic political system and large-scale primary sector investments facilitate the adoption of reconciliatory ecological modernization discourse, which may not directly challenge the drivers of deforestation. Policy actors who believe in and are engaged in market-based approaches to REDD + are much more likely to adopt ecological modernization discourses, compared to policy actors who work on community development and livelihoods issues.Peer reviewe

    Spider surgical system versus multiport laparoscopic surgery. Performance comparison on a surgical simulator

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    BACKGROUND: The rising interest towards minimally invasive surgery has led to the introduction of laparo-endoscopic single site (LESS) surgery as the natural evolution of conventional multiport laparoscopy. However, this new surgical approach is hampered with peculiar technical difficulties. The SPIDER surgical system has been developed in the attempt to overcome some of these challenges. Our study aimed to compare standard laparoscopy and SPIDER technical performance on a surgical simulator, using standardized tasks from the Fundamentals of Laparoscopic Surgery (FLS). METHODS: Twenty participants were divided into two groups based on their surgical laparoscopic experience: 10 PGY1 residents were included in the inexperienced group and 10 laparoscopists in the experienced group. Participants performed the FLS pegboard transfers task and pattern cutting task on a laparoscopic box trainer. Objective task scores and subjective questionnaire rating scales were used to compare conventional laparoscopy and SPIDER surgical system. RESULTS: Both groups performed significantly better in the FLS scores on the standard laparoscopic simulator compared to the SPIDER. Inexperienced group: Task 1 scores (median 252.5 vs. 228.5; p = 0.007); Task 2 scores (median 270.5 vs. 219.0; p = 0.005). Experienced group: Task 1 scores (median 411.5 vs. 309.5; p = 0.005); Task 2 scores (median 418.0 vs. 331.5; p = 0.007). Same aspects were highlighted for the subjective evaluations, except for the inexperienced surgeons who found both devices equivalent in terms of ease of use only in the peg transfer task. CONCLUSIONS: Even though the SPIDER is an innovative and promising device, our study proved that it is more challenging than conventional laparoscopy in a population with different degrees of surgical experience. We presume that a possible way to overcome such challenges could be the development of tailored training programs through simulation methods. This may represent an effective way to deliver training, achieve mastery and skills and prepare surgeons for their future clinical experience

    Hippocampal neuroplasticity and inflammation: relevance for multiple sclerosis

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    Cognitive impairment is very frequent during multiple sclerosis (MS), involving approximately 40–70% of the patients, with a profound impact on patient's life. It is now established that among the various central nervous system (CNS) structures involved during the course of MS, the hippocampus is particularly sensitive to the detrimental effects of neuroinflammation. Different studies demonstrated hippocampal involvement during MS, in association with depression and cognitive impairment, such as verbal and visuo-spatial memory deficits, even during the earlier phases of the disease. These cognitive alterations could represent the visible consequences of a hidden synaptic impairment. Indeed, neuronal and immune functions are intertwined and the immune system is able to modulate the efficacy of synaptic transmission and the induction of the main forms of synaptic plasticity, such as long term potentiation (LTP). Hippocampal synaptic plasticity has been studied during the last decades as the physiological basis of human learning and memory and its disruption can be associated with behavioral and cognitive abnormalities. The aim of the present work is to review the available evidence about the presence of hippocampal synaptic plasticity alterations in experimental models of MS, specifically during the course of experimental autoimmune encephalomyelitis (EAE) and to discuss their relevance with regard to human MS. Indeed, the failure of synapses to express plasticity during neuroinflammation could potentially lead to a progressive failure of the brain plastic reserve, possibly contributing to disability progression and cognitive impairment during MS
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