Optimal estimation of drift and diffusion coefficients in the presence of static localization error

No abstract available

Large Scale Structure Formation with Global Topological Defects. A new Formalism and its implementation by numerical simulations

We investigate cosmological structure formation seeded by topological defects which may form during a phase transition in the early universe. First we derive a partially new, local and gauge invariant system of perturbation equations to treat microwave background and dark matter fluctuations induced by topological defects or any other type of seeds. We then show that this system is well suited for numerical analysis of structure formation by applying it to seeds induced by fluctuations of a global scalar field. Our numerical results are complementary to previous investigations since we use substantially different methods. The resulting microwave background fluctuations are compatible with older simulations. We also obtain a scale invariant spectrum of fluctuations with about the same amplitude. However, our dark matter results yield a smaller bias parameter compatible with $b\sim 2$ on a scale of $20 Mpc$ in contrast to previous work which yielded to large bias factors. Our conclusions are thus more positive. According to the aspects analyzed in this work, global topological defect induced fluctuations yield viable scenarios of structure formation and do better than standard CDM on large scales.Comment: uuencoded, compressed tar-file containing the text in LaTeX and 12 Postscript Figures, 41 page

Charged Kaon K \to 3 pi CP Violating Asymmetries at NLO in CHPT

We give the first full next-to-leading order analytical results in Chiral Perturbation Theory for the charged Kaon K \to 3 pi slope g and decay rates CP-violating asymmetries. We have included the dominant Final State Interactions at NLO analytically and discussed the importance of the unknown counterterms. We find that the uncertainty due to them is reasonable just for \Delta g_C, i.e. the asymmetry in the K^+ \to pi^+ pi^+ pi^- slope g; we get \Delta g_C = -(2.4 +- 1.2) 10^{-5}. The rest of the asymmetries are very sensitive to the unknown counterterms. In particular, the decay rate asymmetries can change even sign. One can use this large sentivity to get valuable information on those counterterms and on Im(G_8) coupling --very important for the CP-violating parameter epsilon'_K-- from the eventual measurement of these asymmetries. We also provide the one-loop O(e^2 p^2) electroweak octet contributions for the neutral and charged Kaon K \to 3 pi decays.Comment: 43+2 pages, 2 figures. Version accepted in JHEP. Small changes in the final numerics of CP asymmetries due to change in input valu

The relation between the column density structures and the magnetic field orientation in the Vela C molecular complex

We statistically evaluated the relative orientation between gas column density structures, inferred from Herschel submillimetre observations, and the magnetic field projected on the plane of sky, inferred from polarized thermal emission of Galactic dust observed by the Balloon-borne Large-Aperture Submillimetre Telescope for Polarimetry (BLASTPol) at 250, 350, and 500 μm, towards the Vela C molecular complex. First, we find very good agreement between the polarization orientations in the three wavelength-bands, suggesting that, at the considered common angular resolution of 3.0 that corresponds to a physical scale of approximately 0.61 pc, the inferred magnetic field orientation is not significantly affected by temperature or dust grain alignment effects. Second, we find that the relative orientation between gas column density structures and the magnetic field changes progressively with increasing gas column density, from mostly parallel or having no preferred orientation at low column densities to mostly perpendicular at the highest column densities. This observation is in agreement with previous studies by the Planck collaboration towards more nearby molecular clouds. Finally, we find a correspondence between (a) the trends in relative orientation between the column density structures and the projected magnetic field; and (b) the shape of the column density probability distribution functions (PDFs). In the sub-regions of Vela C dominated by one clear filamentary structure, or "ridges", where the high-column density tails of the PDFs are flatter, we find a sharp transition from preferentially parallel or having no preferred relative orientation at low column densities to preferentially perpendicular at highest column densities. In the sub-regions of Vela C dominated by several filamentary structures with multiple orientations, or "nests", where the maximum values of the column density are smaller than in the ridge-like sub-regions and the high-column density tails of the PDFs are steeper, such a transition is also present, but it is clearly less sharp than in the ridge-like sub-regions. Both of these results suggest that the magnetic field is dynamically important for the formation of density structures in this region

The Impact of |Delta I|=5/2 Transitions in K-> pi pi Decays

We consider the impact of isospin violation on the analysis of K-> pi pi decays. We scrutinize, in particular, the phenomenological role played by the additional weak amplitude, of |Delta I|=5/2 in character, incurred by the presence of isospin violation. We show that Watson's theorem is appropriate in O(m_d-m_u), so that the inferred pi-pi phase shift at sqrt{s}=m_K determines the strong phase difference between the I=0 and I=2 amplitudes in K-> pi pi decay. We find the magnitude of the |Delta I|=5/2 amplitude thus implied by the empirical branching ratios to be larger than expected from estimates of isospin-violating strong and electromagnetic effects. We effect a new determination of the octet and 27-plet coupling constants with strong-interaction isospin violation and with electromagnetic effects, as computed by Cirigliano, Donoghue, and Golowich, and find that we are unable to resolve the difficulty. Exploring the role of |Delta I|=5/2 transitions in the CP-violating observable epsilon'/epsilon, we determine that the presence of a |Delta I|=5/2 amplitude impacts the empirical determination of omega, the ratio of the real parts of the |Delta I|=3/2 to |Delta I|=1/2 amplitudes, and that it generates a decrease in the estimation of epsilon'/epsilon.Comment: 29 pages, 1 ps fig, refs. added, to appear in Phys. Rev.

Genetic, abiotic and social influences on sex differentiation in cichlid fishes and the evolution of sequential hermaphroditism

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73799/1/j.1467-2979.2005.00184.x.pd

Alignments in the odd-proton actinides 237Np and 241Am

High spin states in 237Np and 241Am have been studied with the "unsafe" Coulomb excitation technique. In each nucleus, signature partner rotational bands built on the [523]5/2- and [642]5/2+ orbitals of respective h9/2 and i13/2 parentage have been delineated. An additional pair of bands based on the [521]3/2- (f7/2) state was also observed in 241Am. New information on the even-even 236Pu and 242Cm transfer products is also presented. From the present data, the role of i13/2 protons in generating angular momentum in the even-even nuclei of the region is documented. A satisfactory description of the evolution of the rotational sequences with spin is achieved within the framework of the cranked shell model. Nevertheless, when combined with information on odd-neutron nuclei available from elsewhere, the data highlight significant shortcomings of the available theoretical predictions

The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism

Although multiple reports show that defective genetic networks underlie the aetiology of autism, few have translated into pharmacotherapeutic opportunities. Since drugs compete with endogenous small molecules for protein binding, many successful drugs target large gene families with multiple drug binding sites. Here we search for defective gene family interaction networks (GFINs) in 6,742 patients with the ASDs relative to 12,544 neurologically normal controls, to find potentially druggable genetic targets. We find significant enrichment of structural defects (P≤2.40E-09, 1.8-fold enrichment) in the metabotropic glutamate receptor (GRM) GFIN, previously observed to impact attention deficit hyperactivity disorder (ADHD) and schizophrenia. Also, the MXD-MYC-MAX network of genes, previously implicated in cancer, is significantly enriched (P≤3.83E-23, 2.5-fold enrichment), as is the calmodulin 1 (CALM1) gene interaction network (P≤4.16E-04, 14.4-fold enrichment), which regulates voltage-independent calcium-activated action potentials at the neuronal synapse. We find that multiple defective gene family interactions underlie autism, presenting new translational opportunities to explore for therapeutic interventions

The Atacama Cosmology Telescope: A Catalog of >4000 Sunyaev–Zel’dovich Galaxy Clusters

We present a catalog of 4195 optically confirmed Sunyaev–Zel'dovich (SZ) selected galaxy clusters detected with signal-to-noise ratio >4 in 13,211 deg2 of sky surveyed by the Atacama Cosmology Telescope (ACT). Cluster candidates were selected by applying a multifrequency matched filter to 98 and 150 GHz maps constructed from ACT observations obtained from 2008 to 2018 and confirmed using deep, wide-area optical surveys. The clusters span the redshift range 0.04 1 clusters, and a total of 868 systems are new discoveries. Assuming an SZ signal versus mass-scaling relation calibrated from X-ray observations, the sample has a 90% completeness mass limit of M500c > 3.8 × 1014 M⊙, evaluated at z = 0.5, for clusters detected at signal-to-noise ratio >5 in maps filtered at an angular scale of 2farcm4. The survey has a large overlap with deep optical weak-lensing surveys that are being used to calibrate the SZ signal mass-scaling relation, such as the Dark Energy Survey (4566 deg2), the Hyper Suprime-Cam Subaru Strategic Program (469 deg2), and the Kilo Degree Survey (825 deg2). We highlight some noteworthy objects in the sample, including potentially projected systems, clusters with strong lensing features, clusters with active central galaxies or star formation, and systems of multiple clusters that may be physically associated. The cluster catalog will be a useful resource for future cosmological analyses and studying the evolution of the intracluster medium and galaxies in massive clusters over the past 10 Gyr