Experiencing Cultural Heritage Through Gamification: Mardin orphanage

This paper presents early-stage research about the role of gamification in experiencing cultural heritage strongly within the sociological context, specifically focusing on the transformation of the old orphanage located in the historical city center of Mardin. The study acknowledges the significance of the old orphanage as an architectural heritage exemplar, built of natural Mardin stone, situated within a unique historical and archaeological urban environment. However, it recognizes the challenges of preserving the building's heritage value, which necessitate surpassing the superficial restoration methods applied to adapt it into a hotel. The primary motivation of this research is to develop a method for creating a navigable and interactive virtual replica of the orphanage, centering on the processes and outcomes of transferring its heritage value. To achieve this, the paper initially outlines the documentation and analysis procedures employed, utilizing photogrammetry to capture the past and current states of the orphanage. Subsequently, participants engage with a gamified and realistic digital replica of the orphanage, involving task-based interactions and scenario-based experiences. The paper concludes by presenting preliminary results concerning participant reactions to the initial virtual model, delivered through a VR device. By raising awareness about the significance of restoring and preserving historical heritage, this study aims to positively impact the domains of tourism, education, and conservation. Furthermore, it intends to shed light on future research opportunities in the field of digital cultural heritage.International Technological Universit

Implizite Einstellungen zu Alkohol bei Patienten nach stationärer Entgiftung

Das Ziel dieser Arbeit bestand in der Erweiterung der bisher im Rah-men von gesunden Probanden erforschten Zusammenhänge impliziter Alkoholkognitionen und Trinkverhalten auf ein Studienkollektiv alko-holabhängiger Probanden mit Hilfe eines bipolaren Impliziten Assozia-tionstests (IAT). Eswurden Zusammenhänge zwischen impliziten Al-koholeinstellungen und Laborparametern, suchtanamnestischen Da-ten, expliziten Maßen der Alkoholeinstellungen, alkoholrelatierten Fragebögen und neuropsychologischen Kennwerten betrachtet.Die Labormarker CDT, γGT und MCV zeigten gemischte Resultate im Hinblick auf ihre Korrelation mit den gefundenen IAT-Effekten. So scheinen sich γGT und MCV nicht zur Bewertung impliziter Alkohol-kognitionen zu eignen, während der Labormarker CDT im Patienten-kollektiv mit dem IAT-Effekt korrelierte. Auch bei der Vorhersage des CDT konnte der IAT hier über explizite Alkoholeinstellungen hinaus zusätzliche Varianz aufklären.Es konnten Zusammenhänge zwischen erhöhten Summenscores im klinischen Alkoholismus-Fragebogen MALT und positiven impliziten Alkoholkognitionen gefunden werden. Ein gefundener quadratischer Zusammenhang zwischen Trinkmenge und IAT-Effekten bei gesunden Probanden konnte im Patientenkollek-tiv nicht repliziert werden. Es zeigte sichkein Zusammenhang zwi-schen weiteren expliziten Maßen von Alkoholkognitionen und dem IAT, was auf die Verschiedenartigkeit der zugrunde liegenden Konzep-te zurückgeführt wird. Die Ergebnisse dieser Studie unterstützen Theorien der dualen kognitiven Verarbeitung suchtbezogener Reize sowie die Theorie des Incentive Sensitization von Substanzabhängig-keit und zeigen Unterschiede zwischen impliziten Alkoholkognitionen bei Patienten im Gegensatz zu gesunden Alkoholkonsumenten auf. Es bestätigt sich erneut, dass der Alkoholabhängigkeit ein komplexes Bedingungsgefüge zugrunde liegt, in der einzelne Faktoren summativ die implizite Einstellung bezüglich des Suchtmittels Alkohol prägen

Short-term effects of transcatheter aortic valve implantation on left atrial appendage function

Background: The beneficial effects of the transcatheter aortic valve implantation (TAVI) on echocardiographic parameters including left atrial (LA) and left ventricular (LV) functions were described by previous studies. The aim of this study was to analyze the effects of TAVI on left atrial appendage (LAA) function assessed by transthoracic and transesophageal echocar­diography. Methods: Fifty-five patients with severe symptomatic aortic stenosis were included in this prospective study. LAA early and late emptying velocities, LAA filling velocity, peak early diastolic (EM), late diastolic (AM), and systolic (SM) velocities were measured with pulsed wave Doppler and tissue Doppler imaging, and E/Em ratio was calculated before and 7.1 ± 2.8 days after TAVI. A subgroup analysis was performed in accordance with the left ventricular ejection fraction (LVEF) of the patients and the severity of their LV diastolic dysfunction. Results: Although the post-procedure peaks and mean gradients of the patients decreased sig­nificantly, the LVEF increased significantly in those who had low LVEF before the procedure. The post-procedure E/Em ratio decreased significantly (p < 0.001). The post-procedural LAA mean filling velocity and EM velocity were significantly higher than the pre-procedural filling velocity (p < 0.001, p = 0.002, respectively). In the subgroup analysis, the post-procedural LAA filling velocity, early and late LAA emptying velocities, in addition to the mean velocity of the EM, AM, and SM were significantly higher than before the procedure in patients with LVEF of < 50% and E/Em ratios of > 15. Conclusions: LAA function improved soon after the TAVI procedure, especially in patients with low LVEF and marked LV diastolic dysfunction

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Laboratuvardan Kliniğe Transplantasyon Pratiği

Transplantasyon; Temel Tıbbi Bilimler, Moleküler Tıp, Genetik ve İmmünolojiden klinik uygulamalardan destek alan multidisipliner bir tıp dalıdır. Temel bilimlerdeki başarılı çalışmaların kliniğe uygulanması, klinikte karşılaşılan sorunların da, oluşturulan deneysel hayvan modellerinde irdelenmesi, elde edilen bilgilerin klinik uygulamalara aktarılması; diğer deyişle tecrübelerin “Translational” özellikli olması günümüz transplantasyon çalışmalarında bir gerekliliktir. İmmün sistemin bileşenlerinin ve reaksiyonlarının iyi bilinmesi, hücreler arası ilişkilerde greftin reddi ya da kabul edilmesinin şartlarını doğru anlamak ve uygun laboratuvar yöntemleri ile klinik durumun aydınlatılması transplantasyonda stratejik önemdedir. Bu nedenle, klinik transplantasyon çalışmaları yapanlar temel bilimler bilgileri ile de donanımlı olmalıdırlar. Multidisipliner bir dal olma bilinci ile yapılan klinik transplantasyon çalışmalarında başarı yakalanmaktadır. Laboratuvardan Kliniğe Transplantasyon kitabımızda tüm yönleri ile transplantasyonun organizmaya etkileri ve bunların klinik sonuçlarını, çalışmalarımızın ışığında sunmayı ve tartışmayı hedefledik. Editör: Prof.Dr. Mesut İzzet TİTİZ Yardımcı Editör: Doç.Dr. Pınar AT

KRONİK LENFOSİTİK LÖSEMİ’DE ZAP-70’İN PROGNOSTİK ÖNEMİ

KLL, klinik seyri degisken bir hastalıktır. Kötü klinik seyir gösterecek hastaları önceden belirlemek çok önemlidir. Klinik evreleme sistemleri, erken evrede tanı konmus hastalardan daha sonra hangilerinin hızlı seyredecegini belirlemede yetersizdir. Çalısmamızda, ZAP-70 ifadelenmesinin KLL hastalarındaki diger prognostik belirteçlerle iliskisini ve tedavisiz izlem süresine etkisini göstermeyi amaçladık. Standart morfolojik ve immünfenotipik ölçütlerle tanı konulmus olan 52 KLL hastası çalısmaya alındı. ZAP-70 ve CD38 ifadelenmesini akım sitometrik yöntemle degerlendirdik. 47 hastada FISH’le 13q delesyonu, 11q delesyonu, p53 delesyonu ve trizomi 12 çalısıldı. 52 hastanın 32’sinde (% 61,5) ZAP-70 ifadelenmesi % 20’nin altındayken, 20’sinde (% 38,5) ZAP-70 ifadelenmesi % 20’nin üzerindeydi. ZAP-70 pozitif olan hastalarda, ZAP-70 negatif hastalara göre klinik evre daha ileriydi (p= 0,02) ve Hb düzeyleri anlamlı olarak düsüktü (p= 0,02) ve LKS anlamlı olarak daha kısaydı (p= 0,04). ZAP-70 ifadelenmesi ile CD38 ( >% 30) ve sitogenetik anormallikler arasında anlamlı iliski saptanmadı. ZAP-70 pozitif olan hastalarda tedavi gereksinimi ZAP-70 negatif gruptan anlamlı derecede fazlaydı (p= 0,02). CD38 ifadelenmesi ve FISH anormallikleriyle tedavi gereksinimi arasında anlamlı iliski olmadıgı gözlendi (p> 0,05). Çok degiskenli analizde, ZAP-70’in tedavi gereksinimi üzerine bagımsız degisken oldugu gözlendi (p= 0,03). Sonuç olarak ZAP-70 pozitif hastaların tedavi gereksinimlerinin fazla oldugunu saptadık. Akım sitometrik olarak ZAP-70 ifadelenmesinin tanı anında saptanması, KLL hastalarının hangilerinin tedavi gereksinimi olacagının önceden belirlenmesinde çok degerlidir