Analysis and application of digital spectral warping in analog and mixed-signal testing

Spectral warping is a digital signal processing transform which shifts the frequencies contained within a signal along the frequency axis. The Fourier transform coefficients of a warped signal correspond to frequency-domain 'samples' of the original signal which are unevenly spaced along the frequency axis. This property allows the technique to be efficiently used for DSP-based analog and mixed-signal testing. The analysis and application of spectral warping for test signal generation, response analysis, filter design, frequency response evaluation, etc. are discussed in this paper along with examples of the software and hardware implementation

Stimulation of reparation in a linear wound model in rats by Bischofit gel

The article is to evaluate Bischofit gel reparative activity in a linear wound model in rat

The cardio- and endothelial protective effects of ethyl methyl hydroxyl pyridine malate in modeling L-name induced nitric oxide deficiency

Currently, endothelial dysfunction is considered as a predictor of a number of pathologies, including arterial hypertension, ischemic heart disease, chronic heart failure, and is also a pathogenetic component of organ damage in diabetes, hypo estrogenic and other conditions. The purpose of the study is an experimental study of the cardio and vasoprotective effects of etoxidol under conditions of endothelial dysfunctio

Catalytic Hydrodeoxygenation of Fatty Acids for Biodiesel Production

This paper is devoted to the production of second generation biodiesel via catalytic hydrodeoxygenation of fatty acids. Pd/C catalysts with different metal loading were used. The palladium catalysts were characterized using low-temperature nitrogen physisorption and X-ray photoelectron spectroscopy. It was revealed that the most active and selective catalyst was 1%-Pd/C which allowed reaching up 97.5% of selectivity (regarding to n-heptadecane) at 100% conversion of substrate. Moreover, the chosen catalyst is more preferable according to lower metal content that leads the decrease of the process cost. The analysis of the catalysts showed that 1%-Pd/C had the highest specific surface area compared with 5%-Pd/C. Copyright © 2016 BCREC GROUP. All rights reservedReceived: 31st July 2015; Revised: 9th December 2015; Accepted: 30th December 2015How to Cite: Stepacheva, A.A., Sapunov, V.N., Sulman, E.M., Nikoshvili, L.Z., Sulman, M.G., Sidorov, A.I., Demidenko, G.N., Matveeva, V.G. (2016). Catalytic Hydrodeoxygenation of Fatty Acids for Biodiesel Production. Bulletin of Chemical Reaction Engineering & Catalysis, 11 (2): 125-132 (doi:10.9767/bcrec.11.2.538.125-132)Permalink/DOI: http://dx.doi.org/10.9767/bcrec.11.2.538.125-132Article Metrics: (click on the button below to see citations in Scopus)

«Попівська академія» як передвісник першого університету на Слобожанщині

Демиденко, Н. М. «Попівська академія» як передвісник першого університету на Слобожанщині / Надія Михайлівна Демиденко // Актуальні проблеми правової науки і державотворення в Україні в контексті правової інтеграції : матеріали ХІ Міжнародної науково-практичної конференції (18-19 травня 2018 року, м. Суми) / Сумська філія Харківського національного університету внутрішніх справ. – Суми: Видавничий дім «Ельдорадо», 2018. – С. 140-142.The article is dedicated to the cultural and educational circle led by O. Palitsyn, which operated in the second half of the 18th and early 19th centuries, and played a significant role in the spread of Western European culture in the Slobozhan region, and before the opening of the Kharkiv University, to some extent performed the role of a higher educational institution.Статья посвящена культурно-просветительскому кружку под руководством А. Палицына, который действовал во второй половине ХVIII – начале ХIХ в. и сыграл выдающуюся роль в распространении западно-европейской культуры в Слобожанщине и до открытия Харьковского университета в определенной степени выполнял роль высшего учебного заведения.Стаття присвячена культурно-просвітницькому гуртку під керівництвом О. Паліцина, який діяв у другій половині ХVIII – початку ХIХ ст. та зіграв визначну роль у поширенні західно-європейської культури на Слобожанщині і до відкриття Харківського університету у певній мірі виконував роль вищого навчального закладу

Saving health of youth concerning to physical preparation

В статті розглядається теоретичний аналіз збереження здоров’я молоді в аспекті занять різноманітними формами фізичної культури та спорту.The specific nature of the physical culture helps not only to quickly recover and to lead normal psycho-physical parameters of the body but also to form as a whole some of the psychological qualities that ensure the normal health of the person. Health is a concept containing a large number of aspects rather conditional nature since there are no permanent criteria and indicators which are universal for all people. Therefore because of some difficulties in the implementation of the most of the ideas, methods and programs that promote bringing up healthy youth these programs are needed to be revised and the formation of the principles and traditions in the field of education should be reviewed again. Issues related to the preservation of health exceeded far the medical understanding; medicine despite of the big scientific and pharmacological breakthrough can not catch up new forms of constantly progressive diseases and save and create a healthy person. In addition the doctors themselves admit that their whole aim and efforts based on this are focused only on the treatment of the disease; few people tries to "treat consciousness" individually or in a public sense. A similar situation is with the study of values, the study of which now it deals not only their particular philosophical direction - axiology, but also a number of representatives of various scientific fields - psychologists, sociologists, teachers, representatives of culture and so on, which fulfill cross - cultural studies as well as find out the place and the role of values in the life of every person, group of people of different sex and age. Issues related to the preservation of health and education of healthy people, gather together all who are not indifferent to what will be the future of the nation in order to jointly distributing spheres of influence effectively promote a healthy lifestyle (HLS). Increasingly, scientists are beginning to study the health from axiological positions, first determining the place and role of health in the hierarchical pyramid of human values, and then scientists directly determine with the steps of concerning to the formation of a healthy person.В статье рассматривается теоретический анализ сохранения здоровья молодёжи в аспекте занятий различными формами физической культуры и спорта

What factors influence training opportunities for older workers? Three factorial surveys exploring the attitudes of HR professionals

The core research questions addressed in this paper are: what factors influence HR professionals in deciding whether to approve training proposals for older workers? What kind of training are they more likely to recommend for older employees and in which organizational contexts? We administered three factorial surveys to 66 HR professionals in Italy. Participants made specific training decisions based on profiles of hypothetical older workers. Multilevel analyses indicated that access to training decreases strongly with age, while highly-skilled older employees with low absenteeism rates are more likely to enjoy training opportunities. In addition, older workers displaying positive performance are more likely to receive training than older workers who perform poorly, suggesting that training late in working life may serve as a reward for good performance rather than as a means of enhancing productivity. The older the HR professional evaluating training proposals, the higher the probability that older workers will be recommended for training. keywords: training; older workers; HR professionals; factorial survey; multilevel model

GSK-3 as potential target for therapeutic intervention in cancer

The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of GSK-3 has been implicated in many human pathologies including: bipolar depression, Alzheimer's disease, Parkinson's disease, cancer, non-insulin-dependent diabetes mellitus (NIDDM) and others. In some cases, suppression of GSK-3 activity by phosphorylation by Akt and other kinases has been associated with cancer progression. In these cases, GSK-3 has tumor suppressor functions. In other cases, GSK-3 has been associated with tumor progression by stabilizing components of the beta-catenin complex. In these situations, GSK-3 has oncogenic properties. While many inhibitors to GSK-3 have been developed, their use remains controversial because of the ambiguous role of GSK-3 in cancer development. In this review, we will focus on the diverse roles that GSK-3 plays in various human cancers, in particular in solid tumors. Recently, GSK-3 has also been implicated in the generation of cancer stem cells in various cell types. We will also discuss how this pivotal kinase interacts with multiple signaling pathways such as: PI3K/PTEN/Akt/mTORC1, Ras/Raf/MEK/ERK, Wnt/beta-catenin, Hedgehog, Notch and others

High Glucose-Mediated Oxidative Stress Impairs Cell Migration

Deficient wound healing in diabetic patients is very frequent, but the cellular and molecular causes are poorly defined. In this study, we evaluate the hypothesis that high glucose concentrations inhibit cell migration. Using CHO.K1 cells, NIH-3T3 fibroblasts, mouse embryonic fibroblasts and primary skin fibroblasts from control and diabetic rats cultured in 5 mM D-glucose (low glucose, LG), 25 mM D-glucose (high glucose, HG) or 25 mM L-glucose medium (osmotic control - OC), we analyzed the migration speed, protrusion stability, cell polarity, adhesion maturation and the activity of the small Rho GTPase Rac1. We also analyzed the effects of reactive oxygen species by incubating cells with the antioxidant N-Acetyl-Cysteine (NAC). We observed that HG conditions inhibited cell migration when compared to LG or OC. This inhibition resulted from impaired cell polarity, protrusion destabilization and inhibition of adhesion maturation. Conversely, Rac1 activity, which promotes protrusion and blocks adhesion maturation, was increased in HG conditions, thus providing a mechanistic basis for the HG phenotype. Most of the HG effects were partially or completely rescued by treatment with NAC. These findings demonstrate that HG impairs cell migration due to an increase in oxidative stress that causes polarity loss, deficient adhesion and protrusion. These alterations arise, in large part, from increased Rac1 activity and may contribute to the poor wound healing observed in diabetic patients

Metabolic regulation by p53

We are increasingly aware that cellular metabolism plays a vital role in diseases such as cancer, and that p53 is an important regulator of metabolic pathways. By transcriptional activation and other means, p53 is able to contribute to the regulation of glycolysis, oxidative phosphorylation, glutaminolysis, insulin sensitivity, nucleotide biosynthesis, mitochondrial integrity, fatty acid oxidation, antioxidant response, autophagy and mTOR signalling. The ability to positively and negatively regulate many of these pathways, combined with feedback signalling from these pathways to p53, demonstrates the reciprocal and flexible nature of the regulation, facilitating a diverse range of responses to metabolic stress. Intriguingly, metabolic stress triggers primarily an adaptive (rather than pro-apoptotic) p53 response, and p53 is emerging as an important regulator of metabolic homeostasis. A better understanding of how p53 coordinates metabolic adaptation will facilitate the identification of novel therapeutic targets and will also illuminate the wider role of p53 in human biology