“La devoción de la cruz”: entre la crueldad humana y la clemencia divina

La presencia de la violencia en el teatro de Calderón ha sido observada ya por numerosos investigadores, a pesar de lo cual dicha violencia no ha sido explicada siempre de manera satisfactoria. A la luz de las ideas de Séneca, San Agustín, Santo Tomás de Aquino y San Bernardo de Claraval, en el presente ensayo se analizan las diferentes manifestaciones de violencia y crueldad en “La devoción de la cruz”, una de las primeras obras de Calderón, y que ha sido criticada, a su vez, por quienes no entienden o no simpatizan con la cultura del Barroco español. En contra de la violencia y de la crueldad que se observan en esta obra, Calderón propone como remedio la clemencia, la cual fue considerada como un vicio por Séneca, mientras que San Agustín, Santo Tomás, San Bernardo y los autores más destacados del Siglo de Oro la vieron como una virtud cristiana que debía tenerse en cuenta en la administración de justicia

Evaluación del comportamiento a la fatiga de másticos bituminosos reforzados con poliolefinas a través de una metodología basada en energía disipada

Polymers are known to improve the fatigue resistance of sphalt mastics. However, undesirable results can be obtained if the polymer is not successfully integrated into the bitumen binder. The goal of this work is to evaluate the effect of the addition of three selected polyolefins on their mastic’s fatigue performance. Low and high density polyethylenes (LDPE and HDPE) and polypropylene (PP) were chosen and used at the concentration of 4 wt.%. A dissipated energy approach was used in order to analyze the fatigue resistance, at 25 ºC, of the three composites studied. Dynamic time sweeps at and above the linear viscoelastic threshold were carried out. Based on that, the results demonstrated a better improvement when the LDPE was considered. For that binder, fluorescence optical microscopy observations at 25 ºC provided morphological evidence of a more homogeneous bitumen-polymer distribution which could be behind the improved fatigue behavior.El uso de polímeros mejora la resistencia a la fatiga de los másticos asfálticos. Sin embargo, se pueden obtener resultados no esperados si el polímero no se integra eficientemente en el ligante bituminoso. El objetivo de este trabajo es evaluar el efecto de la adición de 3 poliolefinas sobre el comportamiento a la fatiga. Se seleccionaron polietilenos de baja y alta densidad (PEBD y PEAD) y polipropileno (PP) que se usaron al 4 % en peso. Se empleó una metodología basada en la energía disipada, a 25 ºC. Se realizaron ensayos dinámicos de barrido de tiempo en el límite y por encima del intervalo de viscoelasticidad lineal, que demostraron un mejor comportamiento para el mástico que contenía PEBD. Para él, se observó a través de microscopía óptica de fluorescencia que la distribución de polímero en el betún era mucho más homogénea, y éste podría ser el motivo del comportamiento mejorado

Long-time behavior of an angiogenesis model with flux at the tumor boundary

This paper deals with a nonlinear system of partial differential equations modeling a simplified tumor-induced angiogenesis taking into account only the interplay between tumor angiogenic factors and endothelial cells. Considered model assumes a nonlinear flux at the tumor boundary and a nonlinear chemotactic response. It is proved that the choice of some key parameters influences the long-time behaviour of the system. More precisely, we show the convergence of solutions to different semi-trivial stationary states for different range of parameters.Comment: 17 page

The impact of man on the morphodynamics of the Huelva coast (SW Spain)

The Huelva coast is composed by large sandy beaches and spits, only interrupted by the presence of the estuarine mouths of the Guadiana, Piedras, Tinto-Odiel and Guadalquivir which are in an advanced state of sediment infilling. The morphology and processes of the Huelva coast are mainly linked to tidal regime, wave action, coastal-drift currents, fluvial dynamics, climatic change and anthropogenic activity. In the last five decades anthropogenic activity has modified the natural dynamics by the construction of jetties, docks, harbour and coastal developments. The main consequences have been the interruption of the sedimentary bypassing caused by an active west-to-east littoral drift, the modification of the tidal regime, the wave refraction-diffraction scheme and the intensification of the littoral erosive processes. All these effects will increase with the slow sea-level rise, close to 0.6 cm per year, which will induce a higher efficacy of the erosional events. A future retreat of about 10-15 m of the coastline is estimated.La costa de Huelva esta constituida por extensas playas y flechas litorales, interrumpidas por la presencia de grandes estuarios (Guadiana, Piedras, Tinto-Odiel y Guadalquivir) en un estado avanzado de colmatación. La morfología y los procesos de la costa se deben principalmente a una serie de factores: régimen mareal, olas, corrientes de deriva, dinámica fluvial, cambio climático y la actividad antrópica. En las últimas cinco décadas la actividad antrópica ha modificado la dinámica natural debido a la construcción de espigones, escolleras, puertos y urbanizaciones. Las principales consecuencias de esta actividad han sido la interrupción del trasvase de sedimentos del Este hacia el Oeste por la corriente de deriva litoral, la alteración del régimen mareal, la modificación de los procesos de refracción-difracción de olas y la intensificación de los procesos erosivos. Todos estos efectos se verán incrementados con el paulatino ascenso del nivel del mar en el Golfo de Cádiz, del orden de 0,6 cm anuales, repercutiendo en una mayor eficacia de los eventos erosivos. Se estima una pérdida del orden de 10-15 m en el perfil de las playas

Development of a metric of aquatic invertebrates for volunteers (MAIV): a simple and friendly biotic metric to assess ecological quality of streams

Citizen science activities, involving local people in volunteer-supported and sustainable monitoring programs, are common. In this context, the objective of the present work was to develop a simple Metric of Aquatic Invertebrates for Volunteers (MAIV), including a user-friendly tool that can be easily accessed by volunteers, and to evaluate the e ciency of a volunteer monitoring program following an audit procedure. To obtain MAIV values, macroinvertebrate communities were reduced to 18 surrogate taxa, which represented an acceptable compromise between simplicity, e ciency, and reproducibility of the data, compared to the regular Water Framework Directive monitoring. When compared to results obtained with the National Classification System of Portugal, MAIV accurately detected moderate, poor, and bad ecological status. Thus, MAIV can be used by volunteers as a complement to the o cial monitoring program, as well as a prospective early warning tool for local problems related to ecological quality. Volunteers were students supervised by their teachers. Results obtained by volunteers were compared to results obtained by experts on macroinvertebrate identification to measure the e ciency of the procedure, by counting gains and losses on sorting, and identification. Characteristics of groups of volunteers (age and school level) did not influence significantly the e ciency of the procedure, and generally results of volunteers and experts matched.info:eu-repo/semantics/publishedVersio

Prevalence of bucco-dental pathologies in patients

Introduction: Oral diseases in psychiatric patients are usually a result of bad oral hygiene and psychopharmaceutical side-effects. Objective: The aim of this study was to detect the most prevalent oral lesions in patients hospitalized in a psychiatric institution in Caracas, Venezuela with the confirmed diagnosis of psychiatric illness. Methods: A transversal study consisted of 65 hospitalized patients with psychiatric disorders out of whom 50 were males and 15 females. Patients were aged from 19 to 80 years, mean age 50.2 years. Data on oral lesions were obtained within history and clinical examination of the oral cavity. Other medical data were collected from medical documentation. Statistical analysis was performed by SPSS version 17.0. Results: 56.92% of patients had caries in at least one tooth, 29.23% presented gingivitis and 56.92% periodontal disease. In relation to Temporomandibular joint, 36.92% presented articular sounds and 10.76% muscular pain. Between the most prevalent parafunctional habits were found cigarette habit, bruxism, onychophagia and cheek bite. Conclusion: Results imply that psychiatric patients are more frequently involved with oral lesions than healthy persons. It is necessary to organize specific preventive and educational oral health programmes with these patients, in a multidisciplinary group

Structure-activity relationships based on 3D-QSAR CoMFA/CoMSIA and design of aryloxypropanol-amine agonists with selectivity for the human β3-adrenergic receptor and anti-obesity and anti-diabetic profiles

Indexación: Scopus.Acknowledgments: This work was supported by FONDECYT No. 11130701. We would also like to thank fDoTr CthLeafbr efeora vthaeil afrbeilei tayvoafiltahbeilsitoyf towfa trheer seoqfutwireadret orecqaulciureladt etothcealAcuDla(thet ttph:e/ A/dDt c(lhatbt.pw:/e/dbstc.cloabm.w/seobfst.wcoamre/-stoofotlws aarned-tools and http://teqip.jdvu.ac.in/QSAR_Tools/). SDG. Conflicts of Interest: The authors declare no conflict of interest. Conflicts of Interest: The authors declare no conflict of interest.The wide tissue distribution of the adrenergic β3 receptor makes it a potential target for the treatment of multiple pathologies such as diabetes, obesity, depression, overactive bladder (OAB), and cancer. Currently, there is only one drug on the market, mirabegron, approved for the treatment of OAB. In the present study, we have carried out an extensive structure-activity relationship analysis of a series of 41 aryloxypropanolamine compounds based on three-dimensional quantitative structure-activity relationship (3D-QSAR) techniques. This is the first combined comparative molecular field analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA) study in a series of selective aryloxypropanolamines displaying anti-diabetes and anti-obesity pharmacological profiles. The best CoMFA and CoMSIA models presented values of r2 ncv = 0.993 and 0.984 and values of r2 test = 0.865 and 0.918, respectively. The results obtained were subjected to extensive external validation (q2, r2, r2 m, etc.) and a final series of compounds was designed and their biological activity was predicted (best pEC50 = 8.561). © 2018 by the authors.https://www.mdpi.com/1420-3049/23/5/119

Reversible collapse of insoluble monolayers

II Encuentro sobre nanociencia y nanotecnología de investigadores y tecnólogos de la Universidad de Córdoba. NANOUC

Colapso reversible de monocapas insolubles. Influencia de la línea de tensión de los dominios

II Encuentro sobre nanociencia y nanotecnología de investigadores y tecnólogos de la Universidad de Córdoba. NANOUC