Electromiograph Parameters in Thedysfunctional Patient with Open Bite

INTRODUCTION: Open bite is an occlusal problem that appears in 0.5% of the population, and is more frequent in women. There is correlation between open bite and dysfunctional syndrome with TMJ disorders. AIM OF THE STUDY: We attempted to analyze muscular parameters in patients with open bite treated with an occlusal splint by EMG recordings. MATERIAL AND METHODS: Myotronics K6 electromiograph can provide information in the following situations: maximum force bite, lateral and protrusion movements, with and without an occlusal splint. RESULTS: In maximum force bite with the occlusal splint more activity was found in the elevator muscles with a lack of dygastric activity. There was less EMG activity in protrusive and lateral movements with occlusal splint. CONCLUSION: With better support between the dental arches (occlusal splint) more activity was obtained in the elevators when biting, and when interferences were eliminated activity in the contralateral muscles was reduced

Lab-on-a-chip platforms based on highly sensitive nanophotonic Si biosensors for single nucleotide DNA testing

In order to solve the drawbacks of sensitivity and portability in optical biosensors we have developed ultrasensitive and miniaturized photonic silicon sensors able to be integrated in a "lab-on-a-chip" microsystem platform. The sensors are integrated Mach-Zehnder interferometers based on TIR optical waveguides (Si/SiO2/Si3N4) of micro/nanodimensions. We have applied this biosensor for DNA testing and for detection of single nucleotide polymorphisms at BRCA-1 gene, involved in breast cancer development, without target labeling. The oligonucleotide probe is immobilized by covalent attachment to the sensor surface through silanization procedures. The hybridization was performed for different DNA target concentrations showing a lowest detection limit at 10 pM. Additionally, we have detected the hybridization of different concentrations of DNA target with two mismatching bases corresponding to a mutation of the BRCA-1 gene. Following the way of the lab-on-a-chip microsystem, integration with the microfluidics has been achieved by using a novel fabrication method of 3-D embedded microchannels using the polymer SU-8 as structural material. The optofluidic chip shows good performances for biosensing

Design review of a compact and low cost elementary radiating cell for satellite broadcasting automotive receiving arrays

This communication presents a review of the developments carried out towards the electromagnetic modeling, design and practical implementation of the basic building block of a planar antenna for the reception of Ku-band satellite broadcasting services from user terminals on board automotive platforms. The antenna is conceived as a low profile phased array with fully electronic beam steering and polarization tracking capabilities. This phased array is intended to address the market of low cost consumer applications, which imposes stringent structural and performance-to-price ratio requirements. As will be shown next, these demanding requirements are going to drive the design of the array basic building block: the so-called Elementary Radiating Cell (ERC)

A Hybrid Approach to Parallel Pattern Discovery in C++

Funding: EU Horizon 2020 project, TeamPlay, grant number 779882, and UK EPSRC Discovery, grant number EP/P020631/1.Parallel pattern libraries offer a strong combination of abstraction and performance. However, discovering places in sequential code where parallel patterns should be introduced is still highly non-trivial, often requiring expert manual analysis and profiling. We present a hybrid discovery technique to detect instances of parallel patterns in sequential code. This employs both static and dynamic trace-based analysis, together with hotspot detection. We evaluate our pattern discovery mechanism on a number of representative benchmarks. We evaluate the performance of the resulting parallelised benchmarks on a 24-core parallel machine.Postprin

Precision determination of the dpi -> NN transition strength at threshold

An unusual but effective way to determine at threshold the dpi -> NN transition strength is to exploit the hadronic ground-state broadening in pionic deuterium, accessible by x-ray spectroscopy. The broadening is dominated by the true absorption channel dpi- -> nn, which is related to s-wave pion production pp -> dpi+ by charge symmetry and detailed balance. Using the exotic atom circumvents the problem of Coulomb corrections to the cross section as necessary in the production experiments. Our dedicated measurement finds (1171+23/-49) meV for the broadening yielding (252+5/-11) \mub.Comment: 4 pages, 2 figures, 1 tabl

PrevenBox: Evaluation of concomitant use of preventive medications with OnabotulinumtoxinA in migraine

P114 Background: OnabotulinumtoxinA is an effective, tolerable and safepreventive treatment for chronic migraine (CM). Other than a reduc-tion in headache frequency or disability, in CM the withdrawal ofconcomitant preventive medication indicates treatment effectivenessand quality of life improvement. Objective: To characterize the change in the use of oral preventivemedication after treatment with OnabotulinumtoxinA in patientswith migraine. Methods: This is a multicentre study. We consecutively included pa-tients with migraine (ICHD-3) that were on preventive treatment withOnabotulinumtoxinA. We retrospectively collected demographic data, diagnosis of migraine, frequency and intensity changes, number ofcycle and OnabotulinumtoxinA dose. In addition, we listed the initialand current preventive treatment (number of drugs and group) andthe number and cycle of medications withdrawn. We performed aunivariate and logistic regression analysis. Results: We included 542 patients: 87.6% women, mean age 47.6 ±11.7 years. A 89.3% had chronic migraine and 10.8% had high fre-quency episodic migraine. The mean reduction in frequency aftertreatment was 13.4±8.2 headache days/month. At baseline, a 91.3%took other preventives and during treatment with Onabotulinumtox-inA a 58.6% withdrew at least one drug, 25.8% stopped completelyall oral preventive drugs. Factors associated with withdrawal were:being male, having >50% response in frequency and intensity, thenumber of infiltrations and a shorter chronification period until thefirst OnabotulinumtoxinA administration (p <0.05). The multivariateanalysis showed that a better response in intensity (OR:1.8 [1.4-2.2], p<0.001), a greater number of infiltrations (OR:1.1 [1.0-1.2], p<0.001)and a shorter chronification period (OR:0.994 [0.992-0.997], p<0.001)were predictors of withdrawal. The ROC curve, showed that 6 Onabo-tulinumtoxinA cycles was the cut-off point that better predicted oralpreventive medication withdrawal (p <0.001). Conclusions: Treatment with OnabotulinumtoxinA reduces the use ofother preventive medications for migraine. The highest probability ofwithdrawal occurs after 6 cycles of treatment

Parental Smoking Modifies the Relation between Genetic Variation in Tumor Necrosis Factor-α (TNF) and Childhood Asthma

BACKGROUND: Polymorphisms in the proinflammatory cytokine genes tumor necrosis factor-α (TNF) and lymphotoxin-α (LTA, also called TNF-β) have been associated with asthma and atopy in some studies. Parental smoking is a consistent risk factor for childhood asthma. Secondhand smoke and ozone both stimulate TNF production. OBJECTIVES: Our goal was to investigate whether genetic variation in TNF and LTA is associated with asthma and atopy and whether the association is modified by parental smoking in a Mexican population with high ozone exposure. METHODS: We genotyped six tagging single nucleotide polymorphisms (SNPs) in TNF and LTA, including functional variants, in 596 nuclear families consisting of asthmatics 4–17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests. RESULTS: The A allele of the TNF-308 SNP was associated with increased risk of asthma [relative risk (RR) = 1.54; 95% confidence interval (CI), 1.04–2.28], especially among children of non-smoking parents (RR = 2.06; 95% CI, 1.19–3.55; p for interaction = 0.09). Similarly, the A allele of the TNF-238 SNP was associated with increased asthma risk among children of nonsmoking parents (RR = 2.21; 95% CI, 1.14–4.30; p for interaction = 0.01). LTA SNPs were not associated with asthma. Haplotype analyses reflected the single SNP findings in magnitude and direction. TNF and LTA SNPs were not associated with the degree of atopy. CONCLUSIONS: Our results suggest that genetic variation in TNF may contribute to childhood asthma and that associations may be modified by parental smoking

Operational flexibility options in power plants with integrated post-combustion capture

Flexibility in power plants with amine based carbon dioxide (CO2) capture is widely recognised as a way of improving power plant revenues. Despite the prior art, its value as a way to improve power plant revenues is still unclear. Most studies are based on simplifying assumptions about the capabilities of power plants to operate at part load and to regenerate additional solvent after interim storage of solvent. This work addresses this gap by examining the operational flexibility of supercritical coal power plants with amine based CO2 capture, using a rigorous fully integrated model. The part-load performance with capture and with additional solvent regeneration, of two coal-fired supercritical power plant configurations designed for base load operation with capture, and with the ability to fully bypass capture, is reported. With advanced integration options configuration, including boiler sliding pressure control, uncontrolled steam extraction with a floating crossover pressure, constant stripper pressure operation and compressor inlet guide vanes, a significant reduction of the electricity output penalty at part load is observed. For instance at 50% fuel input and 90% capture, the electricity output penalty reduces from 458 kWh/tCO2 (with conventional integration options) to 345 kWh/tCO2 (with advanced integration options), compared to a reduction from 361 kWh/tCO2 to 342 kWh/tCO2 at 100% fuel input and 90% capture. However, advanced integration options allow for additional solvent regeneration to a lower magnitude than conventional integration options. The latter can maintain CO2 flow export within 10% of maximum flow across 30–78% of MCR (maximum continuous rating). For this configuration, one hour of interim solvent storage at 100% MCR is evaluated to be optimally regenerated in 4 h at 55% MCR, and 3 h at 30% MCR, providing rigorously validated useful guidelines for the increasing number of techno-economic studies on power plant flexibility, and CO2 flow profiles for further studies on integrated CO2 networks