Dual-grating dielectric accelerators driven by a pulse-front-tilted laser

Dielectric laser-driven accelerators (DLAs) can provide high accelerating gradients in the GV/m range due to their higher breakdown thresholds than metals, which opens the way to miniaturize our next-generation particle accelerator facility. However, the electron energy gain is limited by the short interaction length between the laser pulses and the electron bunch for previously reported DLAs. This paper numerically investigates the dual-grating DLAs driven by a pulse-front-tilted (PFT) laser which extends the interaction length and boosts the electrons energy gain. The optical system to generate the PFT laser beam is also studied in detail. By two-dimensional (2D) particle-in-cell simulations we show that such a PFT laser effectively increases the energy gain by more than 100% as compared to that of a normally incident laser beam

Energy efficiency studies for dual-grating dielectric laser-driven accelerators

Dielectric laser-driven accelerators (DLAs) can provide high accelerating gradients in the GV/m range due to their having higher breakdown thresholds than metals, which opens the way for the miniaturization of the next generation of particle accelerator facilities. Two kinds of scheme, the addition of a Bragg reflector and the use of pulse-front-tilted (PFT) laser illumination, have been studied separately to improve the energy efficiency for dual-grating DLAs. The Bragg reflector enhances the accelerating gradient of the structure, while the PFT increases the effective interaction length. In this paper, we investigate numerically the advantages of using the two schemes in conjunction. Our calculations show that, for a 100-period structure with a period of 2 micrometer, such a design effectively increases the energy gain by more than 100 % when compared to employing the Bragg reflector with a normal laser, and by about 50 % when using standard structures with a PFT laser. A total energy gain of as much as 2.6 MeV can be obtained for a PFT laser beam when illuminating a 2000-period dual-grating structure with a Bragg reflector

Films and critical pedagogy in management education: A tourism studies context

This article examines and critically assesses the role of films in the practice of critical pedagogy in undergraduate management education, using tourism studies as a context. Utilising online focus groups, it aims to gain an in-depth knowledge and understanding of the role of films as an effective pedagogical medium in enhancing experiential approaches to learning. It argues that films play an important role in facilitating critical analyses of the studied phenomenon, illustrating and problematising abstract concepts and ideas, as well as in facilitating students’ ability to discern multiple and alternative discourses about management. The findings highlight the role of films in context-specific critical engagement with the studied content and in stimulating emotionality in learning development, thereby enhancing deep approaches to learning. Emotional responses, even negative ones, prove to be critical in engaging with intellectual and critical reflection after watching films. The findings yield new and empirical insights into the pedagogic use of films in management education, thereby contributing to some of the goals of critical management studies

Efficient CRISPR/Cas9 genome editing in a salmonid fish cell line using a lentivirus delivery system

The present study was funded by were funded by the Biotechnology and Biological Sciences Research Council (BB/R008612/1, BB/S004343/1 to RH and RG; grant BB/R008973/1 to SM and CD) and the Institute Strategic Programme Grants (BBS/E/D/20002172, BBS/E/D/30002275 and BBS/E/D/10002070, to RH and RG). The funders had no roles in the study design, data collection and analysis, decision to publish or preparation of the manuscript.Peer reviewedPublisher PD

Management Ideologies and Organizational Spirituality: a Typology

The topic of spirituality is gaining an increasing visibility in organization studies. It is our contention that every theory of organization is a theory of organizational spirituality. Based on Barley and Kunda’s 1992 Administrative Science Quarterly article, we discuss the evolution of management theories as spirituality theories. From such analysis, we suggest that there may be both a meaningful/liberating and an instrumental/exploitative side in the relationship between organizations and spirituality. Such a possibility is illustrated with a typology that advances four possible types of organizations regarding spirituality: the soulful organization, the holistic organization, the ascetic organization, and the professional organization. The expression of spirituality in each of these forms is discussed with the aim of contributing to a theoretically-based analysis of organizational spirituality.N/

Population-Specific Responses to Interspecific Competition in the Gut Microbiota of Two Atlantic Salmon (Salmo salar) Populations

The gut microbial community in vertebrates plays a role in nutrient digestion and absorption, development of intestine and immune systems, resistance to infection, regulation of bone mass and even host behavior and can thus impact host fitness. Atlantic salmon (Salmo salar) reintroduction efforts into Lake Ontario, Canada, have been unsuccessful, likely due to competition with non-native salmonids. In this study, we explored interspecific competition effects on the gut microbiota of two Atlantic salmon populations (LaHave and Sebago) resulting from four non-native salmonids. After 10 months of rearing in semi-natural stream tanks under six interspecific competition treatments, we characterized the gut microbiota of 178 Atlantic salmon by parallel sequencing the 16S rRNA gene. We found 3978 bacterial OTUs across all samples. Microbiota alpha diversity and abundance of 27 OTUs significantly differed between the two populations. Interspecific competition reduced relative abundance of potential beneficial bacteria (six genera of lactic acid bacteria) as well as 13 OTUs, but only in the LaHave population, indicating population-specific competition effects. The pattern of gut microbiota response to interspecific competition may reflect local adaptation of the host-microbiota interactions and can be used to select candidate populations for improved species reintroduction success

Energy efficiency studies for dual-grating dielectric laser-driven accelerators

Dielectric laser-driven accelerators (DLAs) can provide high accelerating gradients in the GV/m range due to their having higher breakdown thresholds than metals, which opens the way for the miniaturization of the next generation of particle accelerator facilities. Two kinds of scheme, the addition of a Bragg reflector and the use of pulse-front-tilted (PFT) laser illumination, have been studied separately to improve the energy efficiency for dual-grating DLAs. The Bragg reflector enhances the accelerating gradient of the structure, while the PFT increases the effective interaction length. In this paper, we investigate numerically the advantages of using the two schemes in conjunction. Our calculations show that, for a 100-period structure with a period of 2 micrometer, such a design effectively increases the energy gain by more than 100 % when compared to employing the Bragg reflector with a normal laser, and by about 50 % when using standard structures with a PFT laser. A total energy gain of as much as 2.6 MeV can be obtained for a PFT laser beam when illuminating a 2000-period dual-grating structure with a Bragg reflector.Comment: 7 pages, 4 Figures, Proceedings of EAAC2017 Conferenc

Changing patterns of cancer incidence in the early- and late-HAART periods: the Swiss HIV Cohort Study

BACKGROUND: The advent of highly active antiretroviral therapy (HAART) in 1996 led to a decrease in the incidence of Kaposi's sarcoma (KS) and non-Hodgkin's lymphoma (NHL), but not of other cancers, among people with HIV or AIDS (PWHA). It also led to marked increases in their life expectancy. METHODS: We conducted a record-linkage study between the Swiss HIV Cohort Study and nine Swiss cantonal cancer registries. In total, 9429 PWHA provided 20,615, 17,690, and 15,410 person-years in the pre-, early-, and late-HAART periods, respectively. Standardised incidence ratios in PWHA vs the general population, as well as age-standardised, and age-specific incidence rates were computed for different periods. RESULTS: Incidence of KS and NHL decreased by several fold between the pre- and early-HAART periods, and additionally declined from the early- to the late-HAART period. Incidence of cancers of the anus, liver, non-melanomatous skin, and Hodgkin's lymphoma increased in the early- compared with the pre-HAART period, but not during the late-HAART period. The incidence of all non-AIDS-defining cancers (NADCs) combined was similar in all periods, and approximately double that in the general population. CONCLUSIONS: Increases in the incidence of selected NADCs after the introduction of HAART were largely accounted for by the ageing of PWHA