Affective iconic words benefit from additional sound–meaning integration in the left amygdala

Recent studies have shown that a similarity between sound and meaning of a word (i.e., iconicity) can help more readily access the meaning of that word, but the neural mechanisms underlying this beneficial role of iconicity in semantic processing remain largely unknown. In an fMRI study, we focused on the affective domain and examined whether affective iconic words (e.g., high arousal in both sound and meaning) activate additional brain regions that integrate emotional information from different domains (i.e., sound and meaning). In line with our hypothesis, affective iconic words, compared to their non‐iconic counterparts, elicited additional BOLD responses in the left amygdala known for its role in multimodal representation of emotions. Functional connectivity analyses revealed that the observed amygdalar activity was modulated by an interaction of iconic condition and activations in two hubs representative for processing sound (left superior temporal gyrus) and meaning (left inferior frontal gyrus) of words. These results provide a neural explanation for the facilitative role of iconicity in language processing and indicate that language users are sensitive to the interaction between sound and meaning aspect of words, suggesting the existence of iconicity as a general property of human language

Cross-shell excitation in two-proton knockout: Structure of 52^{52}Ca

The two-proton knockout reaction $^9$Be($^{54}$Ti,$^{52}$Ca$+ \gamma$) has been studied at 72 MeV/nucleon. Besides the strong feeding of the $^{52}$Ca ground state, the only other sizeable cross section proceeds to a 3$^-$ level at 3.9 MeV. There is no measurable direct yield to the first excited 2$^+$ state at 2.6 MeV. The results illustrate the potential of such direct reactions for exploring cross-shell proton excitations in neutron-rich nuclei and confirms the doubly-magic nature of $^{52}$Ca

The role of the g9/2 orbital in the development of collectivity in the A = 60 region: The case of 61Co

An extensive study of the level structure of 61Co has been performed following the complex 26Mg(48Ca, 2a4npg)61Co reaction at beam energies of 275, 290 and 320 MeV using Gammasphere and the Fragment Mass Analyzer (FMA). The low-spin structure is discussed within the framework of shell-model calculations using the GXPF1A effective interaction. Two quasi-rotational bands consisting of stretched-E2 transitions have been established up to spins I = 41/2 and (43/2), and excitation energies of 17 and 20 MeV, respectively. These are interpreted as signature partners built on a neutron {\nu}(g9/2)2 configuration coupled to a proton {\pi}p3/2 state, based on Cranked Shell Model (CSM) calculations and comparisons with observations in neighboring nuclei. In addition, four I = 1 bands were populated to high spin, with the yrast dipole band interpreted as a possible candidate for the shears mechanism, a process seldom observed thus far in this mass region

Water maser detections in southern candidates to post-AGB stars and Planetary Nebulae

We intended to study the incidence and characteristics of water masers in the envelopes of stars in the post-AGB and PN evolutionary stages. We have used the 64-m antenna in Parkes (Australia) to search for water maser emission at 22 GHz, towards a sample of 74 sources with IRAS colours characteristic of post-AGB stars and PNe, at declination $< -32 \deg$. In our sample, 39% of the sources are PNe or PNe candidates, and 50% are post-AGB stars or post-AGB candidates. We have detected four new water masers, all of them in optically obscured sources: three in PNe candidates (IRAS 12405-6219, IRAS 15103-5754, and IRAS 16333-4807); and one in a post-AGB candidate (IRAS 13500-6106). The PN candidate IRAS 15103-5754 has water fountain characteristics, and it could be the first PN of this class found. We confirm the tendency suggested in Paper I that the presence of water masers in the post-AGB phase is favoured in obscured sources with massive envelopes. We propose an evolutionary scenario for water masers in the post-AGB and PNe stages, in which ``water fountain'' masers could develop during post-AGB and early PN stages. Later PNe would show lower velocity maser emission, both along jets and close to the central objects, with only the central masers remaining in more evolved PNe.Comment: 11 pages, 5 figures. Accepted by Astronomy and Astrophysic

Non-linear electromagnetic response of graphene

It is shown that the massless energy spectrum of electrons and holes in graphene leads to the strongly non-linear electromagnetic response of this system. We predict that the graphene layer, irradiated by electromagnetic waves, emits radiation at higher frequency harmonics and can work as a frequency multiplier. The operating frequency of the graphene frequency multiplier can lie in a broad range from microwaves to the infrared.Comment: 5 pages, 3 figure

Cerebral effects of glucagon‐like peptide‐1 receptor blockade before and after Roux‐en‐Y gastric bypass surgery in obese women: A proof‐of‐concept resting‐state functional MRI study

Aim: To assess the effects of Roux‐en‐Y gastric bypass surgery (RYGB)‐related changes in glucagon‐like peptide‐1 (GLP‐1) on cerebral resting‐state functioning in obese women. Materials and Methods: In nine obese females aged 40‐54 years in the fasted state, we studied the effects of RYGB and GLP‐1 on five a priori selected networks implicated in food‐ and reward‐related processes as well as environment monitoring (default mode, right frontoparietal, basal ganglia, insula/anterior cingulate and anterior cingulate/orbitofrontal networks). Results: Before surgery, GLP‐1 receptor blockade (using exendin9‐39) was associated with increased right caudate nucleus (basal ganglia network) and decreased right middle frontal (right frontoparietal network) connectivity compared with placebo. RYGB resulted in decreased right orbitofrontal (insula/anterior cingulate network) connectivity. In the default mode network, after surgery, GLP‐1 receptor blockade had a larger effect on connectivity in this region than GLP‐1 receptor blockade before RYGB (all PFWE < .05). Results remained similar after correction for changes in body weight. Default mode and right frontoparietal network connectivity changes were related to changes in body mass index and food scores after RYGB. Conclusions: These findings suggest GLP‐1 involvement in resting‐state networks related to food and reward processes and monitoring of the internal and external environment, pointing to a potential role for GLP‐1–induced changes in resting‐state connectivity in RYGB‐mediated weight loss and appetite control

Formyl Peptide Receptor as a Novel Therapeutic Target for Anxiety-Related Disorders

Formyl peptide receptors (FPR) belong to a family of sensors of the immune system that detect microbe-associated molecules and inform various cellular and sensorial mechanisms to the presence of pathogens in the host. Here we demonstrate that Fpr2/3-deficient mice show a distinct profile of behaviour characterised by reduced anxiety in the marble burying and light-dark box paradigms, increased exploratory behaviour in an open-field, together with superior performance on a novel object recognition test. Pharmacological blockade with a formyl peptide receptor antagonist, Boc2, in wild type mice reproduced most of the behavioural changes observed in the Fpr2/3(-/-) mice, including a significant improvement in novel object discrimination and reduced anxiety in a light/dark shuttle test. These effects were associated with reduced FPR signalling in the gut as shown by the significant reduction in the levels of p-p38. Collectively, these findings suggest that homeostatic FPR signalling exerts a modulatory effect on anxiety-like behaviours. These findings thus suggest that therapies targeting FPRs may be a novel approach to ameliorate behavioural abnormalities present in neuropsychiatric disorders at the cognitive-emotional interface

New neighbours: V. 35 DENIS late-M dwarfs between 10 and 30 parsecs

This paper reports updated results on our systematic mining of the DENIS database for nearby very cool M-dwarfs (M6V-M8V, 2.0<I-J<3.0, photometric distance within 30 pc), We calibrate the DENIS (M_I, I-J) colour-luminosity relationship from M dwarfs with well measured parallaxes (HIP, GCTP,...), obtaining distance errors for single dwarfs of 25%. Using proper motions measured on archive Schmidt plates for stars that meet the photometric selection criteria, we eliminate the giants by a Reduced Proper Motion cutoff, which is significantly more selective than a simple proper motion cutoff. Here we present new data for 62 red dwarf candidates selected over 5700 square degrees in the DENIS database. 26 of those originate in the 2100 square degrees analysed in Paper I, with improved parameters here, and 36 were found in 3600 additional square degrees. 25 of those are new nearby dwarfs. We determine from that sample of 62 stars a stellar density for 12.0<M_I<14.0 of 2.2(+-0.4)E-3 stars/pc^3/mag. This value is consistent with photometric luminosity functions measured from deeper and smaller-field observations, but not with the nearby star luminosity function. In addition we cross-identified the NLTT and DENIS catalogues to find 15 similar stars, in parts of the sky not yet covered by the colour-selected search.Comment: Accepted by Astronomy & astrophysics. 17 pages, 8 figure

Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation.

Brain injury elicits a systemic acute-phase response (APR), which is responsible for co-ordinating the peripheral immunological response to injury. To date, the mechanisms responsible for signalling the presence of injury or disease to selectively activate responses in distant organs were unclear. Circulating endogenous extracellular vesicles (EVs) are increased after brain injury and have the potential to carry targeted injury signals around the body. Here, we examined the potential of EVs, isolated from rats after focal inflammatory brain lesions using IL-1β, to activate a systemic APR in recipient naïve rats, as well as the behavioural consequences of EV transfer. Focal brain lesions increased EV release, and, following isolation and transfer, the EVs were sequestered by the liver where they initiated an APR. Transfer of blood-borne EVs from brain-injured animals was also enough to suppress exploratory behaviours in recipient naïve animals. EVs derived from brain endothelial cell cultures treated with IL-1β also activated an APR and altered behaviour in recipient animals. These experiments reveal that inflammation-induced circulating EVs derived from endothelial cells are able to initiate the APR to brain injury and are sufficient to generate the associated sickness behaviours, and are the first demonstration that EVs are capable of modifying behavioural responses