Leptophis Ahaetulla (linnaeus, 1758) (serpentes, Colubridae): First Record For The State Of Rio Grande Do Sul, Brazil

We present the first record of Leptophis ahaetulla for the State of Rio Grande do Sul, Brazil. Between November and December 2014, and February 2015, three specimens were found, respectively: one male dead on a highway at the Parque Estadual do Espinilho, a conservation unit located at the municipality of Barra do Quaraí; and two females collected in an anthropic landscape of Salso farm at the municipality of Uruguaiana, Rio Grande do Sul, Brazil. Meristic data and coloration enables the identification of these specimens as Leptophis ahaetulla marginatus. © 2016 Check List and Authors.12

Modulation Of The Catalytic Activity Of Porphyrins By Lipid- And Surfactant-containing Nanostructures

The structural factors modulating porphyrin activity encompass pyrrole and equatorial ligands, as well as the central metal and the number and structure of their axial ligands. Of equal importance is the microenvironment provided by apoproteins, solvents and membranes. Porphyrins are often used to construct supramolecular structures with different applications. The modulation of activity of the porphyrins has been frequently achieved by mimicking nature, i.e., by the provision of different microenvironments for these molecules. The association of porphyrins to surfactant- and lipid-containing nanostructures has changed the activity of these compounds to mimic different enzymes such as SOD, cytochrome P450, peroxidases and others. In determined conditions, the reactive forms of the porphyrins are high-valence states of oxo-metal-π cations and oxo-metal produced by the reaction with peroxides and peracids. The modulation of porphyrin activity by surfactant- and lipid-containing nanostructures has also been achieved for hemeproteins, as the lipid nanostructures affect the conformation of proteins. ©2011 Sociedade Brasileira de Química.22916211633Drain, C.M., Varotto, A., Radivojevic, I., (2009) Chem. Rev., 109, p. 1630Aida, T., Inoue, S., (2000) The Porphyrin Handbook, , Kadish, K., M. Smith, K., M. Guillard R., eds.Academic Press: San Diego ch. 42Ponka, P., (1999) Am. J. Med. Sci., 318, p. 241Da Silva, D.C., De Freitas-Silva, G., Do Nascimento, E., Rebouças, J.S., Barbeira, P.J., De Carvalho, M.E., Idemori, Y.M., (2008) J. Inorg. Biochem., 102, p. 1932Bochot, C., Bartoli, J.F., Frapart, Y., Dansette, P.M., Mansuy, D., Battioni, P., (2007) J. Mol. Catal. A.: Chem., 263, p. 200Alkordi, M.H., Liu, Y.L., Larsen, R.W., Eubank, J.F., Eddaoudi, M., (2008) J. Am. Chem. Soc., 130, p. 12639Suijkerbuijk, B., Schamhart, D.J., Kooijman, H., Spek, A.L., Van Koten, G., Gebbink, R., (2010) Dalton Trans., 39, p. 6198Groves, J.T., Nemo, T.E., (1983) J. Am. Chem. Soc., 10, p. 5786Drain, C.M., Smeureanu, G., Patel, S., Gong, X.C., Garno, J.A., (2006) New. J. Chem., 30, p. 1834Wang, Y.T., Jin, W.J., (2008) Spectrochim. Acta, Part A., 70, p. 871Komatsu, T., Moritake, W., Nakagawa, A., Tsuchida, E., (2002) Chem. - Eur. J., 8, p. 5469Nagami, H., Umakoshi, H., Shimanouchi, T., Kuboi, R., (2004) Biochem. Eng. J., 21, p. 221Szoka, F., Papahadjopoulos, D., (1980) Annu. Rev. Biophys. Bioeng., 9, p. 467Atkin, R., Craig, V.S.J., Wanless, E.J., Biggs, S., (2003) Adv. Colloid Interface Sci., 103, p. 219Grassert, I., Schinkowski, K., Vollhardt, D., Oehme, G., (1998) Chirality, 10, p. 754Hait, S.K., Moulik, S.P., (2001) J. Surfactants Deterg., 4, p. 303Glick, J., Santoyo, G., Casey, P.J., (1996) J. Biol. Chem., 271, p. 2949Maldotti, A., Andreotti, L., Molinari, A., Varani, G., Cerichelli, G., Chiarini, M., (2001) Green Chem., 3, p. 42Batrakova, E.V., Kabanov, A.V., (2008) J. Controlled Release, 130, p. 98Bangham, A.D., Standish, M.M., Watkins, J.C., (1965) J. Mol. Biol., 13, p. 238Johnson, S.M., Bangham, A.D., Hill, M.W., Korn, E.D., (1971) Biochim. Biophys. Acta. Biomembr., 233, p. 820Papahadj, D., Watkins, J.C., (1967) Biochim. Biophys. Acta, Biomembr., 135, p. 639Abramson, M.B., Katzman, R., Gregor, H.P., (1964) J. Biol. Chem., 239, p. 70Hauser, H.O., (1971) Biochem. Biophys. Res. Commun., 45, p. 1049Huang, C.H., (1969) Biochemistry, 8, p. 344Saunders, L., Gammack, D., Perrin, J., (1962) J. Pharm. Pharmacol., 14, p. 567Tien, H.T., (1974) Theory and Practice, , 1th ed.Bilayer Lipid Membranes (BLM): Marcel Dekker: New YorkRazin, S., (1972) Biochim. Biophys. Acta, Biomembr., 265, p. 241Korenbrot, J.I., (1977) Annu. Rev. Physiol., 39, p. 19Batzri, S., Korn, E.D., (1973) Biochim. Biophys. Acta, Biomembr., 298, p. 1015Deamer, D., Bangham, A.D., (1976) Biochim. Biophys. Acta, Biomembr., 443, p. 629Szoka, F., Papahadjopoulos, D., (1978) Proc. Natl. Acad. Sci. U. S. A., 75, p. 4194Mishra, P.P., Bhatnagar, J., Datta, A., (2005) J. Phys. Chem. B., 109, p. 24225Pessoto, F.S., Inada, N.M., Nepomuceno, M.D., Ruggiero, A.C., Nascimento, O.R., Vercesi, A.E., Nantes, I.L., (2009) Chem. Biol. Interact., 181, p. 400Steinbeck, C.A., Hedin, N., Chmelka, B.F., (2004) Langmuir, 20, p. 10399Vanesch, J.H., Feiters, M.C., Peters, A.M., Nolte, R.J.M., (1994) J. Phys. Chem., 98, p. 5541Barber, D.C., Freitagbeeston, R.A., Whitten, D.G., (1991) J. Phys. Chem., 95, p. 4074Maiti, N.C., Mazumdar, S., Periasamy, N.J., (1998) J. Porphyrins Phthalocyanines, 2, p. 369Schmehl, R.H., Whitten, D.G., (1981) J. Phys. Chem., 85, p. 3473Perrin, M.H., (1973) J. Chem. Phys., 59, p. 2090Zhou, X.T., Ji, H.B., (2010) Chem. Eng. J., 156, p. 411Monnereau, C., Ramos, P.H., Deutman, A.B.C., Elemans, J., Nolte, R.J.M., Rowan, A.E., (2010) J. Am. Chem. Soc., 132, p. 1529Merlau, M.L., Grande, W.J., Nguyen, S.T., Hupp, J.T., (2000) J. Mol. Catal. A: Chem., 156, p. 79Anzenbacher, P., Kral, V., Jursikova, K., Gunterova, J., Kasal, A., (1997) J. Mol. Catal. A: Chem., 118, p. 63Zhao, Y.C., Xiang, Y.Z., Pu, L., Yang, M., Yu, X.Q., (2006) Appl. Catal. A, 301, p. 176Zhou, X.T., Tang, Q.H., Ji, H.B., (2009) Tetrahedron Lett., 50, p. 6601Monfared, H.H., Aghapoor, V., Ghorbanloo, M., Mayer, P., (2010) Appl. Catal. A, 372, p. 209Heijnen, J.H.M., De Bruijn, V.G., Van Den Broeke, L.J.P., Keurentjes, J.T.F., (2003) Chem. Eng. Process., 42, p. 223Santos, A.C., Luz, R.A.S., Ferreira, L.G.F., Santos-Júnior, J.R., Silva, W.C., (2010) Quim. Nova, 33, p. 539Zhou, Y.B., Ryu, E.H., Zhao, Y., Woo, L.K., (2007) Organometallics, 26, p. 358Nantes, I.L., Crespilho, F.N., Mugnol, K.C.U., Chaves, J.C.A., Luz, R.A.S., Nascimento, O.R., Pinto, S.M.S., (2010) Circular Dichroism: Theory and Spectroscopy, , Rodgers D. S., ed.Nova Science Publishers: New York ch. 8Travascio, P., Sen, D., Bennet, A.J., (2006) Can. J. Chem., 84, p. 613Omodeo-Sale, F., Monti, D., Olliaro, P., Taramelli, D.P., (2001) Biochem. Pharmacol., 61, p. 999Ishigure, S., Mitsui, T., Ito, S., Kondo, Y., Kawabe, S., Kondo Dewa M, T., Mino, H., Nango, M., (2010) Langmuir, 26, p. 7774Umakoshi, H., Morimoto, K., Ohama, Y., Nagami, H., Shimanouchi, T., Kuboi, R., (2008) Langmuir, 24, p. 4451Prieto, T., Marcon, R.O., Prado, F.M., Caires, A.C.F., Di Mascio, P., Brochsztain, S., Nascimento, O.R., Nantes, I.L., (2006) J. Phys.Chem., 8, p. 1963Mugnol, K.C.U., Ando, R.A., Nagayasu, R.Y., Faljoni-Alario, A., Brochsztain, S., Santos, P.S., Nascimento, R.O., Nantes, I.L., (2008) Biophys. J., 94, p. 4066Nagatomo, H., Matsushita, Y., Sugamoto, K., Matsui, T., (2003) Tetrahedron: Asymmetry, 14, p. 2339Cantonetti, V., Monti, D., Venanzi, M., Bombelli, C., Ceccacci, F., Mancini, G., (2004) Tetrahedron: Asymmetry, 15, p. 1969Hiraka, K., Kanehisa, M., Tamai, M., Asayama, S., Nagaoka, S., Oyaizu, K., Yuasa, M., Kawakami, H., (2008) Colloids Surf. B, 67, p. 54Yuasa, M., Oyaizu, K., Horiuchi, A., Ogata, A., Hatsugai, T., Yamaguchi, A., Kawakami, H., (2004) Mol. Pharm., 1, p. 387Aron, J., Baldwin, D.A., Marques, H.M., Pratt, J.M., Adams, P.A., (1986) J. Inorg. Biochem., 27, p. 227Wang, J.S., Vanwart, H.E., (1989) J. Phys. Chem., 93, p. 7925Munro, O.Q., Marques, H.M., (1996) Inorg. Chem., 35, p. 3752Prieto, T., Nascimento, O.R., Tersariol, I.L.S., Faljoni-Alario, A., Nantes, I.L., (2004) J. Phys. Chem. B, 108, p. 11124Prieto, T., Nantes, I.L., Nascimento, O.R., (2004) Prog. Colloid Polym. Sci., 128, p. 1Makarska, M., Radzki, S., Legendziewicz, J., (2002) J. Alloys Compd., 341, p. 233Riposati, A., Prieto, T., Shida, C.S., Nantes, I.L., Nascimento, O.R., (2006) J. Inorg. Biochem., 100, p. 226Claiborne, A., Fridovich, I., (1979) J. Biol. Chem., 254, p. 4245Hiner, A.N.P., Ruiz, J.H., Lopez, J.N.R., Canovas, F.G., Brisset, N.C., Smith, A.T., Arnao, M.B., Acosta, M., (2002) J. Biol. Chem., 277, p. 26879Primus, J.L., Grunenwald, S., Hagedoorn, P.L., Albrecht-Gary, A.M., Mandon, D., Veeger, C.T., (2002) J. Am. Chem. Soc., 124, p. 1214Demontellano, P.R.O., (1992) Annu. Rev. Pharmacol. Toxicol., 32, p. 89Savenkova, M.I., Kuo, J.M., De Montellano, P.R.O., (1998) Biochemistry, 37, p. 10828Smith, A.T., Veitch, N.C., (1998) Curr. Opin. Chem. Biol., 2, p. 269Prieto, T., Mugnol, K.C.U., Araujo, J.C., Sousa, F.L., Soares, V.A., Cilento, G., Nantes, I.L., (2007) Catalysis and Photochemistry in Heterogeneous Media, , Nantes I. L.Brochesztain, S. eds.Research Signpost: Kerala ch. 1Zucchi, M.R., Nascimento, O.R., Faljoni-Alario, A., Prieto, T., Nantes, I.L., (2003) Biochem. J., 370, p. 671Kinnunen, P.K.J., (1992) Chem. Phys. Lipids, 63, p. 251Kawai, C., Prado, F.M., Nunes, G.L.C., Di Mascio, P., Carmona-Ribeiro, A.M., Nantes, I.L., (2005) J. Biol. Chem., 280, p. 34709Araujo, J.C., Prieto, T., Prado, F.M., Trindade, F.J., Nunes, G.L.C., Dos Santos, J.G., Di Masco, P., Nantes, I.L., (2007) J. Nanosci. Nanotechnol., 7, p. 3643Estevam, M.L., Nascimento, O.R., Baptista, M.S., Di Mascio, P., Prado, F.M., Faljoni-Alario, A., Zucchi, M.D., Nantes, I.L., (2004) J. Biol. Chem., 279, p. 39214Kawai, C., Nantes, I.L., Baptista, M.D.S., (2010) FEBS J., 277, p. 224Nantes, I.L., Faljoni-Alario, A., Vercesi, A.E., Santos, K.E., Bechara, E.J.H., (1998) Free Radic. Biol. Med., 25, p. 54

Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

One of the challenges of nanotechnology is to improve the efficacy of treatments for diseases, in order to reduce morbidity and mortality rates. Following this line of study, we made a nanoparticle formulation with a small size, uniform surfaces, and a satisfactory encapsulation coefficient as a target for colorectal cancer cells. The results of binding and uptake prove that using the target system with folic acid works: Using this system, cytotoxicity and cell death are increased when compared to using free oxaliplatin. The data show that the system maximized the efficiency of oxaliplatin in modulating tumor progression, increasing apoptosis and decreasing resistance to the drug. Thus, for the first time, our findings suggest that PLGA-PEG-FA increases the antitumor effectiveness of oxaliplatin by functioning as a facilitator of drug delivery in colorectal cancer.Radiolog

Characterization of topoisomerase II α and minichromosome maintenance protein 2 expression in anal carcinoma

The present study aimed to ascertain the significance of topoisomerase II alpha (TOP2A) and minichromosome maintenance protein (MCM) 2 expression in anal carcinoma. A total of 75 anal lesions were retrieved from the files of the Department of Pathology of Barretos Cancer Hospital (Barretos, Brazil) in order to verify the human papillomavirus (HPV) statuses of these lesions and characterize the immunohistochemical expression levels of TOP2A and MCM2 in anal carcinoma, as these are important markers for cervical HPV-induced lesions; their expression was also compared with respect to p16 and Ki-67. The vast majority of the cases tested positive for HPV16 (84%); 1 case tested positive for both HPV16 and HPV18. Positive HPV16 status was more frequent in early stages than in advanced stages (P=0.008). Positive immunohistochemical reactivity for MCM2 and TOP2A protein was observed in 71.6 and 100% of cases, respectively. Positive reactivity for p16 was significantly associated (P=0.001) with histological grade, and was more commonly expressed in squamous cell carcinoma than adenocarcinomas. HPV16 was strongly associated with positive p16 protein expression (76.6%). However, the high expression of Ki-67 combined with the high expression of p16 was predominantly observed in Stage III-IV cases. MCM2, TOP2A, p16 and Ki-67 exhibited intense positive staining in the anal lesions, indicating that these markers were significantly and constantly expressed in anal carcinoma.info:eu-repo/semantics/publishedVersio

Single Spin Asymmetry ANA_N in Polarized Proton-Proton Elastic Scattering at s=200\sqrt{s}=200 GeV

We report a high precision measurement of the transverse single spin asymmetry $A_N$ at the center of mass energy $\sqrt{s}=200$ GeV in elastic proton-proton scattering by the STAR experiment at RHIC. The $A_N$ was measured in the four-momentum transfer squared $t$ range $0.003 \leqslant |t| \leqslant 0.035$ \GeVcSq, the region of a significant interference between the electromagnetic and hadronic scattering amplitudes. The measured values of $A_N$ and its $t$-dependence are consistent with a vanishing hadronic spin-flip amplitude, thus providing strong constraints on the ratio of the single spin-flip to the non-flip amplitudes. Since the hadronic amplitude is dominated by the Pomeron amplitude at this $\sqrt{s}$, we conclude that this measurement addresses the question about the presence of a hadronic spin flip due to the Pomeron exchange in polarized proton-proton elastic scattering.Comment: 12 pages, 6 figure

Evolution of the differential transverse momentum correlation function with centrality in Au+Au collisions at sNN=200\sqrt{s_{NN}} = 200 GeV

We present first measurements of the evolution of the differential transverse momentum correlation function, {\it C}, with collision centrality in Au+Au interactions at $\sqrt{s_{NN}} = 200$ GeV. {\it C} exhibits a strong dependence on collision centrality that is qualitatively similar to that of number correlations previously reported. We use the observed longitudinal broadening of the near-side peak of {\it C} with increasing centrality to estimate the ratio of the shear viscosity to entropy density, $\eta/s$, of the matter formed in central Au+Au interactions. We obtain an upper limit estimate of $\eta/s$ that suggests that the produced medium has a small viscosity per unit entropy.Comment: 7 pages, 4 figures, STAR paper published in Phys. Lett.