Fear of exercise and health-related quality of life in patients with an implantable cardioverter defibrillator

Several studies have reported improved survival rates thanks to the use of an implantable cardioverter defibrillator (ICD) in the treatment of patients with life-threatening arrhythmia. However, the effects of the ICD on health-related quality of life (HR-QoL) of these patients are not clear. The aim of this study is to describe HR-QoL and fear of exercise in ICD patients. Eighty-nine ICD patients from the University Hospital in Groningen, the Netherlands, participated in this study. HR-QoL was measured using the Rand-36 and the Quality of Life After Myocardial Infarction Dutch language version questionnaires. Fear of exercise was measured using the Tampa Scale for Kinesiophobia, Dutch version and the Fear Avoidance Beliefs Questionnaire, Dutch version. Association between outcome variables was analysed by linear regression analyses. Study results show that the HR-QoL of patients with ICDs in our study population is significantly worse than that of normal healthy people. Furthermore, fear of exercise is negatively associated with HR-QoL corrected for sex, age and number of years living with an ICD. After implantation of the ICD, patients with a clear fear of exercise should be identified and interventions should be considered in order to increase their HR-QoL

Low-voltage Ge avalanche photodetector for highly sensitive 10Gb/s Si photonic receivers

We demonstrate low-voltage germanium waveguide avalanche photodetectors (APD) with gain-bandwidth product of 88GHz. A 7.1dB sensitivity improvement is demonstrated for an APD wire-bonded to a 10Gb/s CMOS transimpedance amplifier, at -6.2V APD bias

8x14Gb/s ring WDM modulator array with integrated tungsten heaters and Ge monitor photodetectors

An 8x14Gb/s wavelength-division multiplexed Si ring modulator array is presented with uniform channel performance. Tungsten heaters and Ge monitor photodetectors at the ring modulator drop ports are co-integrated to track and control the modulation quality

FabR regulates Salmonella biofilm formation via its direct target FabB

Background: Biofilm formation is an important survival strategy of Salmonella in all environments. By mutant screening, we showed a knock-out mutant of fabR, encoding a repressor of unsaturated fatty acid biosynthesis (UFA), to have impaired biofilm formation. In order to unravel how this regulator impinges on Salmonella biofilm formation, we aimed at elucidating the S. Typhimurium FabR regulon. Hereto, we applied a combinatorial high-throughput approach, combining ChIP-chip with transcriptomics. Results: All the previously identified E. coli FabR transcriptional target genes (fabA, fabB and yqfA) were shown to be direct S. Typhimurium FabR targets as well. As we found a fabB overexpressing strain to partly mimic the biofilm defect of the fabR mutant, the effect of FabR on biofilms can be attributed at least partly to FabB, which plays a key role in UFA biosynthesis. Additionally, ChIP-chip identified a number of novel direct FabR targets (the intergenic regions between hpaR/hpaG and ddg/ydfZ) and yet putative direct targets (i.a. genes involved in tRNA metabolism, ribosome synthesis and translation). Next to UFA biosynthesis, a number of these direct targets and other indirect targets identified by transcriptomics (e.g. ribosomal genes, ompA, ompC, ompX, osmB, osmC, sseI), could possibly contribute to the effect of FabR on biofilm formation. Conclusion: Overall, our results point at the importance of FabR and UFA biosynthesis in Salmonella biofilm formation and their role as potential targets for biofilm inhibitory strategies

Ionospheric response to the 2009 sudden stratospheric warming over the equatorial, low, and middle latitudes in the South American sector

The present study investigates the ionospheric total electron content (TEC) and F-layer response in the Southern Hemisphere equatorial, low, and middle latitudes due to major sudden stratospheric warming (SSW) event, which took place during January-February 2009 in the Northern Hemisphere. In this study, using 17 ground-based dual frequency GPS stations and two ionosonde stations spanning latitudes from 2.8°N to 53.8°S, longitudes from 36.7°W to 67.8°W over the South American sector, it is observed that the ionosphere was significantly disturbed by the SSW event from the equator to the midlatitudes. During day of year 26 and 27 at 14:00 UT, the TEC was two times larger than that observed during average quiet days. The vertical TEC at all 17 GPS and two ionosonde stations shows significant deviations lasting for several days after the SSW temperature peak. Using one GPS station located at Rio Grande (53.8°S, 67.8°W, midlatitude South America sector), it is reported for the first time that the midlatitude in the Southern Hemisphere was disturbed by the SSW event in the Northern Hemisphere.Fil: Fagundes, P. R.. Universidade do Vale do Paraíba; BrasilFil: Goncharenko, L. P.. Massachusetts Institute of Technology; Estados UnidosFil: De Abreu, A. J.. Universidade do Vale do Paraíba; BrasilFil: Venkatesh, K.. Universidade do Vale do Paraíba; BrasilFil: Pezzopane, M.. Istituto Nazionale Di Geofisica E Vulcanologia; ItaliaFil: De Jesus, R.. Universidade do Vale do Paraíba; BrasilFil: Gende, Mauricio Alfredo. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coster, A. J.. Massachusetts Institute of Technology; Estados UnidosFil: Pillat, V. G.. Universidade do Vale do Paraíba; Brasi

Tailoring of corticosteroids in COPD management

This literature review updates the reader on the new studies regarding steroid therapy over the last year in stable COPD and in exacerbations. In stable COPD, we critique the 2011 update and 2013 revision of the GOLD guidelines, discuss why combining inhaled corticosteroids (ICS) with long-acting beta-agonists (LABA) (ICS/LABA) is preferable over LABA alone and review the literature for intraclass differences, finding that the evidence does not clearly support superiority of any particular ICS/LABA. We also address other comparisons against ICS/LABA, including triple therapy. We briefly review which type of inhaler should be chosen. For exacerbations, we report the REDUCE trial findings favouring a 5-day course of systemic steroids, and other trials addressing which steroid and route to use, including in an intensive care setting. Lastly, the future lies in new anti-inflammatories and re-phenotyping the heterogeneous amalgamation of COPD. A Spanish guideline recommends distinguishing steroid-responsive eosinophilic exacerbators from other phenotypes

Driver Perceptions of V2V and V2I for Autonomous Vehicles: A Study of Technology Acceptance Factors

We acknowledge that an earlier version of this material was presented in a conference at the International Conference on Information Society (i-Society 2023), held on 24th to 26th October 2023, Dublin, Ireland.This study will examine user acceptance towards the latest autonomous vehicle technologies with a focus on vehicle-to-vehicle (V2V) and vehicle-to infrastructure (V2I) technologies. An online survey was utilised to collect 203 responses (from a diverse group of people with about 35 master students). This research will predominantly utilise a quantitative research approach to study consumer views on autonomous vehicle technologies and will be conducted amongst professional and nonprofessional drivers. The technology acceptance model (TAM) by Davis represents the underlying research model of this study updated to include significant factors. Hypothesis testing is performed for three scenarios (AV, V2V, and V2I) using multiple regression analysis and ANOVA test in SPSS version 20. However, the outcomes of this study revealed that V2V exhibited the most considerable and statistically significant positive impact on the driver, as evidenced by the variables compatibility (COP) and perceived ease of use (PEOU). Besides, the study also conducted on V2I demonstrated that the most significant positive influence was observed by attitude towards using (ATU) and driver context (DC), which relates to the existing literature on pervasive computing. Furthermore, it was found that PEOU and DC variables exhibited a strong positive impact on autonomous vehicles (AV), with statistical significance

New particle-hole symmetries and the extended interacting boson model

We describe shape coexistence and intruder many-particle-hole (mp-nh)excitations in the extended interacting boson model EIBM and EIBM-2,combining both the particle-hole and the charge degree of freedom.Besides the concept of I-spin multiplets and subsequently $SU(4)$ multiplets, we touch upon the existence of particle-hole mixed symmetry states. We furthermore describe regular and intrudermany-particle-hole excitations in one nucleus on an equal footing, creating (annihilating) particle-hole pairs using the K-spin operatorand studying possible mixing between these states. As a limiting case,we treat the coupling of two IBM-1 Hamiltonians, each decribing the regular and intruder excitations respectively, in particular lookingat the $U(5)$-$SU(3)$ dynamical symmetry coupling. We apply such coupling scheme to the Po isotopes

Shape coexistence in atomic nuclei and its spectroscopic fingerprints

In the present discussion we concentrate on shape coexistence asobtained within a deformed single-particle field as well as startingfrom the spherical shell-model, incorporating deformationeffects via the residual proton-neutron quadrupole interaction. Wediscuss in particular the appearance of shape coexisting phenomena inthe Pb region. In a second part then, we present a number ofexperimental fingerprints that allow to recognize the appearance ofshape coexisting phenomena or of shape mixing through the use ofselective experiments (e.g. band structure, spectroscopic factors,static moments, E0 properties and alpha-decay)