Jornada lectiva, aprendizajes y vida cotidiana del alumnado de Educación Secundaria Postobligatoria

El artículo se deriva del proyecto coordinado I+D+i RESORTES centrado en el estudio de los tiempos sociales y su incidencia en la construcción cotidiana de la condición juvenil. Este trabajo tiene como objetivo analizar, a través de las respuestas a cuestionarios específicos, las valoraciones de profesorado y alumnado de Educación Secundaria Postobligatoria sobre la organización e incidencia de varias unidades del tiempo escolar (horarios, jornada lectiva) en el rendimiento y competencias académicas, necesidades psicobiológicas y realización de actividades relacionales. Los resultados presentan una visión optimista, pero desvelan inconsistencias y cuestionamientos en el análisis pormenorizado atendiendo, fundamentalmente, a la experiencia profesionalThis article reports on a coordinated Research, Development and Innovation project (RESORTES) that explored the social use of time and its influence on the daily construction of youth identity. A specific questionnaire was employed to analyze post-compulsory secondary school students’ and teachers’ evaluations of the organization of school time (the school day and its scheduling) and its impact on achievement and academic competencies, psycho-biological needs, and participation in relational activities. The results invite an overall optimistic interpretation while, at the same time, the detailed analysis reveals inconsistencies and raises questions, especially related to the professional experienceS

High-Throughput System for the Early Quantification of Major Architectural Traits in Olive Breeding Trials Using UAV Images and OBIA Techniques

The need for the olive farm modernization have encouraged the research of more efficient crop management strategies through cross-breeding programs to release new olive cultivars more suitable for mechanization and use in intensive orchards, with high quality production and resistance to biotic and abiotic stresses. The advancement of breeding programs are hampered by the lack of efficient phenotyping methods to quickly and accurately acquire crop traits such as morphological attributes (tree vigor and vegetative growth habits), which are key to identify desirable genotypes as early as possible. In this context, an UAV-based high-throughput system for olive breeding program applications was developed to extract tree traits in large-scale phenotyping studies under field conditions. The system consisted of UAV-flight configurations, in terms of flight altitude and image overlaps, and a novel, automatic, and accurate object-based image analysis (OBIA) algorithm based on point clouds, which was evaluated in two experimental trials in the framework of a table olive breeding program, with the aim to determine the earliest date for suitable quantifying of tree architectural traits. Two training systems (intensive and hedgerow) were evaluated at two very early stages of tree growth: 15 and 27 months after planting. Digital Terrain Models (DTMs) were automatically and accurately generated by the algorithm as well as every olive tree identified, independently of the training system and tree age. The architectural traits, specially tree height and crown area, were estimated with high accuracy in the second flight campaign, i.e. 27 months after planting. Differences in the quality of 3D crown reconstruction were found for the growth patterns derived from each training system. These key phenotyping traits could be used in several olive breeding programs, as well as to address some agronomical goals. In addition, this system is cost and time optimized, so that requested architectural traits could be provided in the same day as UAV flights. This high-throughput system may solve the actual bottleneck of plant phenotyping of "linking genotype and phenotype," considered a major challenge for crop research in the 21st century, and bring forward the crucial time of decision making for breeders

Network-based analysis reveals differences in plant assembly between the native and the invaded ranges

Associated with the introduction of alien species in a new area, interactions with other native species within the recipient community occur, reshaping the original community and resulting in a unique assemblage. Yet, the differences in community assemblage between native and invaded ranges remain unclear. Mediterranean grasslands provide an excellent scenario to study community assembly following transcontinental naturalisation of plant species. Here, we compared the community resemblance of plant communities in Mediterranean grasslands from both the native (Spain) and invaded (Chile) ranges. We used a novel approach, based on network analysis applied to co-occurrence analysis in plant communities, allowing us to study the co-existence of native and alien species in central Chile. This useful methodology is presented as a step forward in invasion ecology studies and conservation strategies. We found that community structure differed between the native and the invaded range, with alien species displaying a higher number of connections and, therefore, acting as keystones to sustain the structure within the invaded community. Alien species acting like keystones within the Chilean grassland communities might exacerbate the threat posed by biological invasions for the native biodiversity assets. Controlling the spread of the alien species identified here as keystones should help managing potential invasion in surrounding areas. Network analyses is a free, easy-to-implement and straightforward visual tool that can be widely used to reveal shifts in native communities and elucidate the role of multiple invaders into communitie

Análisis del orden de entrada en el sistema de franquicia español

Desde las perspectivas de marketing, dirección estratégica y organización industrial se ha analizado la sostenibilidad de las ventajas competitivas (Barney, 1991; Hamel y Prahalad, 1994; Carpenter y Nakamoto, 1994; Kalyanaram et al., 1995; Covin et al., 1999). Así, la teoría del orden de entrada explica que aquellas empresas que entran antes en un mercado obtienen ventajas frente a las siguientes entrantes (Michael, 2003). Por tanto, esta investigación, centrada en el sector de la franquicia, analiza la influencia del momento de entrada en los resultados empresariales.From marketing, strategic management and industrial organization perspectives, it has been analyzed the sustainability of competitive advantages (Barney, 1991; Hamel and Prahalad, 1994; Carpenter and Nakamoto, 1994; Kalyanaram et al., 1995; Covin et al., 1999). The first-mover advantage explains that those firms that entry before in the market gain more advantages than the followers (Michael, 2003). Therefore, this research, focused on the franchised distribution system, analyzes the influence of the timing of entry on profitability

The diet of the first Europeans from Atapuerca

Hominin dietary specialization is crucial to understanding the evolutionary changes of craniofacial biomechanics and the interaction of food processing methods’ effects on teeth. However, the diet-related dental wear processes of the earliest European hominins remain unknown because most of the academic attention has focused on Neandertals. Non-occlusal dental microwear provides direct evidence of the effect of chewed food particles on tooth enamel surfaces and reflects dietary signals over time. Here, we report for the first time the direct effect of dietary abrasiveness as evidenced by the buccal microwear patterns on the teeth of the Sima del Elefante-TE9 and Gran Dolina-TD6 Atapuerca hominins (1.2–0.8 million years ago − Myr) as compared with other Lower and Middle Pleistocene populations. A unique buccal microwear pattern that is found in Homo antecessor (0.96–0.8 Myr), a well-known cannibal species, indicates dietary practices that are consistent with the consumption of hard and brittle foods. Our findings confirm that the oldest European inhabitants ingested more mechanically-demanding diets than later populations because they were confronted with harsh, fluctuating environmental conditions. Furthermore, the influence of grit-laden food suggests that a high-quality meat diet from butchering processes could have fueled evolutionary changes in brain size.This work was supported by the research grants, from the Dirección General de Investigación of Ministerio Ciencia y Tecnología (Spain), numbers CGL2007-60802/BTE, CGL2011-22999, CGL2012-38434-C03-01/02/03 and CGL2014-52611-C2-1-P, as well as by the grant 2009SGR884 Group of Study on the Evolution of Hominins and other Primates and grant 2014SGR900 Group of Analyses on Socio-Ecological Processes, Cultural Changes and Population Dynamics during Prehistory (GAPS) and CERCA Programme of the Generalitat de Catalunya

Two-Centered Magical Charge Orbits

We determine the two-centered generic charge orbits of magical N = 2 and maximal N = 8 supergravity theories in four dimensions. These orbits are classified by seven U-duality invariant polynomials, which group together into four invariants under the horizontal symmetry group SL(2,R). These latter are expected to disentangle different physical properties of the two-centered black-hole system. The invariant with the lowest degree in charges is the symplectic product (Q1,Q2), known to control the mutual non-locality of the two centers.Comment: 1+17 pages, 1 Table; v2: Eq. (3.23) corrected; v3: various refinements in text and formulae, caption of Table 1 expanded, Footnote and Refs. added. To appear on JHE

Gene therapy with mesenchymal stem cells expressing IFN-ß ameliorates neuroinflammation in experimental models of multiple sclerosis

[Background and Purpose]: Recombinant IFN‐ß is one of the first‐line treatments in multiple sclerosis (MS), despite its lack of efficacy in some patients. In this context, mesenchymal stem cells (MSCs) represent a promising therapeutic alternative due to their immunomodulatory properties and multipotency. Moreover, by taking advantage of their pathotropism, these cells can be genetically modified to be used as carriers for delivering or secreting therapeutic drugs into injured tissues. Here, we report the therapeutic effect of systemic delivery of adipose‐derived MSCs (AdMSCs), transduced with the IFN‐β gene, into mice with experimental autoimmune encephalomyelitis (EAE).[Experimental Approach]: Relapsing–remitting and chronic progressive EAE were induced in mice. Cells were injected i.v. Disease severity, inflammation and tissue damage were assessed clinically, by flow cytometry of spleens and histopathological evaluation of the CNS respectively.[Key Results]: Genetic engineering did not modify the biological characteristics of these AdMSCs (morphology, growth rate, immunophenotype and multipotency). Furthermore, the transduction of IFN‐ß to AdMSCs maintained and, in some cases, enhanced the functional properties of AdMSCs by ameliorating the symptoms of MS in EAE models and by decreasing indications of peripheral and central neuro‐inflammation.[Conclusion and Implications]: Gene therapy was found to be more effective than cell therapy in ameliorating several clinical parameters in both EAE models, presumably due to the continuous expression of IFN‐β. Furthermore, it has significant advantages over AdMSC therapy, and also over systemic IFN‐ß treatment, by providing long‐term expression of the cytokine at therapeutic concentrations and reducing the frequency of injections, while minimizing dose‐limiting side effects.This work was supported by Fondo de Investigaciones Sanitarias ISCIII (Spain) and Fondo Europeo de Desarrollo Regional (FEDER) from the European Union through the research grants PI12/01097 and PI15/00963 and ISCIII Red de Terapia Celular TerCel RD12/0019/0006 to F.M., by the Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía‐FEDER/Fondo de Cohesion Europeo (FSE) de Andalucía through the research grants P09‐CTS‐04532, PI‐57069 and PAIDI‐Bio‐326 to F.M. and PI‐0160/2012 to K.B. M.J.P.‐M. has been supported by grants from Red Temática de Investigación Cooperativa Red Española de Esclerosis Múltiple REEM (RD07/0060 and RD12/0032). B.O. is financed by a contract from Excelent Project CTS‐7670/11 from Consejería de Economía, Innovación, Ciencia y Empleo (Junta de Andalucía)

The First Galaxy Cluster Discovered by the VISTA Variables in the Vía Láctea Survey

We report the first confirmed detection of the galaxy cluster VVV-J144321-611754 at very low latitudes (l = 315.°836, b = -1.°650) located in the tile d015 of the VISTA Variables in the Vía Láctea (VVV) survey. We defined the region of 30 ×30 arcmin 2 centered in the brightest galaxy finding 25 galaxies. For these objects, extinction-corrected median colors of (H-K s ) = 0.34 ± 0.05 mag, (J-H) = 0.57 ± 0.08 mag, and (J-K s ) = 0.87 ± 0.06 mag; R 1/2 = 1.59 ± 0.″16; C = 3.01 ± 0.08; and Sérsic index n = 4.63 ± 0.39 were estimated. They were visually confirmed showing characteristics of early-type galaxies in the near-IR images. An automatic clustering analysis performed in the whole tile found that the concentration of galaxies VVV-J144321-611754 is a real, compact concentration of early-type galaxies. Assuming a typical galaxy cluster with low X-ray luminosity, the photometric redshift of the brightest galaxy is z = 0.196 ± 0.025. Follow-up near-IR spectroscopy with FLAMINGOS-2 at the Gemini-South telescope revealed that the two brighter cluster galaxies have typical spectra of early-type galaxies and the estimated redshift for the brightest galaxy VVV-J144321.06-611753.9 is z = 0.234 ± 0.022 and that for VVV-J144319.02-611746.1 is z = 0.232 ± 0.019. Finally, these galaxies clearly follow the cluster red sequence in the rest-frame near-IR color-magnitude diagram with a slope similar to a galaxy cluster at a redshift of 0.2. These results are consistent with the presence of a bona fide galaxy cluster beyond the Milky Way disk.Fil: Baravalle, Laura Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Nilo Castellón, José Luis. Universidad de La Serena; ChileFil: Alonso, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Díaz Tello, J.. Pontificia Universidad Católica de Chile; Chile. Universidad Nacional Autónoma de México; MéxicoFil: Damke, G.. Universidad de La Serena; ChileFil: Valotto, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Cuevas Larenas, H.. Universidad de La Serena; ChileFil: Sánchez, Bruno Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Ríos, M. de los. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Minniti, D.. Universidad Andrés Bello; ChileFil: Domínguez, M.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Gurovich, Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Barbá, R.. Universidad de La Serena; ChileFil: Soto, M.. Universidad de Atacama; ChileFil: Castro, F. Milla. Universidad de La Serena; Chil

Hydroxychloroquine efficacy and safety in preventing SARS-CoV-2 infection and COVID-19 disease severity during pregnancy (COVID-Preg) : A structured summary of a study protocol for a randomised placebo controlled trial

Objectives: The primary objectives of the study are: 1. To assess the effect of hydroxychloroquine (HCQ) in reducing SARS-CoV-2 viral shedding by PCR in infected pregnant women with mild symptoms. 2. To assess the efficacy of HCQ to prevent SARS-CoV-2 infection in pregnant women in contact with an infected or suspected case. 3. To evaluate the effect of HCQ in preventing the development of the COVID-19 disease in asymptomatic SARS-CoV-2-infected pregnant women. The secondary objectives are: 1. To determine the effect of HCQ on the clinical course and duration of the COVID-19 disease in SARS-CoV-2-infected pregnant women. 2. To determine the impact of HCQ on the risk of hospitalization and mortality of SARS-CoV-2-infected pregnant women. 3. To assess the safety and tolerability of HCQ in pregnant women. 4. To describe the clinical presentation of SARS-CoV-2 infection during pregnancy. 5. To describe the effects of maternal SARS-CoV-2 infection on pregnancy and perinatal outcomes by treatment group. 6. To determine the risk of vertical transmission (intra-utero and intra-partum) of SARS-CoV-2. Trial design: Randomized double-blind placebo-controlled two-arm multicentre clinical trial to evaluate the safety and efficacy of HCQ to prevent and/or minimize SARS-CoV-2 infection during pregnancy. Participants will be randomized to receive a 14-day oral treatment course of HCQ or placebo, ratio 1:1. Participants: Study population: pregnant women undergoing routine prenatal follow up or attending emergency units at the participating hospitals who report either symptoms/signs suggestive of COVID-19 disease or close contact with a suspected or confirmed COVID-19 case. Inclusion criteria Women will be invited to participate in the trial and sign an informed consent if they meet the following inclusion criteria. •Presenting with fever (≥37.5°C) and/or one mild symptom suggestive of COVID-19 disease (cough, dyspnoea, chills, odynophagia, diarrhoea, muscle pain, anosmia, dysgeusia, headache) OR being contact*of a SARS-CoV-2 confirmed or suspected case in the past 14 days •More than 12 weeks of gestation (dated by ultrasonography) •Agreement to deliver in the study hospitals Exclusion criteria •Known hypersensitivity to HCQ or other 4-amonoquinoline compounds •History of retinopathy of any aetiology •Concomitant use of digoxin, cyclosporine, cimetidine •Known liver disease •Clinical history of cardiac pathology including known long QT syndrome •Unable to cooperate with the requirements of the study •Participating in other intervention studies •Delivery onset (characterized by painful uterine contractions and variable changes of the cervix, including some degree of effacement and slower progression of dilatation up to 5 cm for first and subsequent labours) The study participants will be stratified by clinical presentation and SARS-CoV-2 PCR results. Assignment of participants to study groups will be as follows: •SARS-CoV-2-PCR confirmed, infected pregnant women: a. symptomatic (n=100) b. asymptomatic (n=100) •SARS-CoV-2 PCR negative pregnant women in contact*with a SARS-CoV-2-infected confirmed or suspected case (n=514).*The ECDC definition of close contact will be followed. The trial will be conducted in five hospitals in Spain: Hospital Clínic of Barcelona, Hospital Sant Joan de Déu and Hospital de la Santa Creu i Sant Pau, in Barcelona, and HM Puerta del Sur and Hospital Universitario de Torrejón, in Madrid. Intervention and comparator: Participants will be randomized to HCQ (400 mg/day for three days, followed by 200 mg/day for 11 days) or placebo (2 tablets for three days, followed by one tablet for 11 days). Main outcomes: The primary outcome is the number of PCR-confirmed infected pregnant women assessed from collected nasopharyngeal and oropharyngeal swabs at day 21 after treatment start (one week after treatment is completed). Randomisation: Allocation of participants to study arms will be done centrally by the trial's Sponsor (the Barcelona Institute for Global Health, ISGlobal) by block randomization. This method will ensure balanced allocation to both arms. The electronic CRF will automatically assign a study number to each participant, depending on her study group and recruitment site. Each number will be related to a treatment number, which assigns them to one of the study arms. Blinding (masking): Participants, caregivers, investigators and those assessing the outcomes will be blinded to group assignment. Study tablets (HCQ and placebo) will be identically packaged in small opaque bottles. Numbers to be randomised (sample size): This study requires 200 SARS-CoV-2 infected and 514 contact pregnant women, randomised 1:1 with 100 and 227 respectively in each study arm. Trial Status: Protocol version 1.0, from May 8th, 2020. Recruitment is ongoing (first patient recruited the 19th May 2020 and recruitment end anticipated by December 2020). Trial registration: EudraCT number: 2020-001587-29, registered 2 April 2020. Clinicaltrials.gov identifier: NCT04410562, retrospectively registered 1 June 2020. Full protocol: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol

Original Article Lack of Association of GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 Polymorphisms for Susceptibility and Outcome in Brazilian Prostate Cancer Patients (benign prostatic hyperplasia / genetic inheritance / outcome / prostate cancer / risk factors

Abstract. The polymorphic inheritance of human drug-metabolizing enzymes, such as those encoded by the GST and CYP systems, has been implicated in both cancer risk and prognostic. In an effort to increase our understanding of the interaction between potential environmental exposure, lifestyle, and genetic factors in the predisposition and response to radiotherapy of prostate cancer patients, we examined GSTT1, GSTM1, GSTO1, GSTP1 and CYP1A1 genotypes in a Brazilian population. We studied 125 prostate cancer patients and 100 benign prostatic hyperplasia patients paired for ethnic and lifestyle characteristics. Lifetime occupational history, dietary patterns, cigarette-smoking, and other anamnestic data were obtained through interviews. Outcome was evaluated in 42 stage ≤ T2a patients presenting a Gleason score ≤ 6, PSA ≤ 10 ng/ml, treated with radiotherapy and followed up for 12 to 34 months (15 ± 8 months). None of the studied polymorphisms was found associated to prostate cancer risk either considered separately or in combination, in uni-or multivariate regression logistic analysis. Also, there was no association between genotypes and possible clinical factors of risk or any parameter of tumour aggressiveness at diagnosis or during follow-up. Patients' response to radiotherapy treatment was not associated to any genotype. In conclusion, our data suggest that GST and CYP1A1 genotypes are not associated with the susceptibility to prostate cancer or its outcome in the Brazilian population