Dark Matter in the Galaxy Cluster CL J1226+3332 at Z=0.89

We present a weak-lensing analysis of the galaxy cluster CL J1226+3332 at z=0.89 using Hubble Space Telescope Advanced Camera for Surveys images. The cluster is the hottest (>10 keV), most X-ray luminous system at z>0.6 known to date. The relaxed X-ray morphology, as well as its high temperature, is unusual at such a high redshift. Our mass reconstruction shows that on a large scale the dark matter distribution is consistent with a relaxed system with no significant substructures. However, on a small scale the cluster core is resolved into two mass clumps highly correlated with the cluster galaxy distribution. The dominant mass clump lies close to the brightest cluster galaxy whereas the other less massive clump is located ~40" (~310 kpc) to the southwest. Although this secondary mass clump does not show an excess in the X-ray surface brightness, the gas temperature of the region is much higher (12~18 keV) than those of the rest. We propose a scenario in which the less massive system has already passed through the main cluster and the X-ray gas has been stripped during this passage. The elongation of the X-ray peak toward the southwestern mass clump is also supportive of this possibility. We measure significant tangential shears out to the field boundary (~1.5 Mpc), which are well described by an Navarro-Frenk-White profile with a concentration parameter of c200=2.7+-0.3 and a scale length of rs=78"+-19" (~600 kpc) with chi^2/d.o.f=1.11. Within the spherical volume r200=1.6 Mpc, the total mass of the cluster becomes M(r<r200)=(1.4+-0.2) x 10^15 solar mass. Our weak-lensing analysis confirms that CL1226+3332 is indeed the most massive cluster known to date at z>0.6.Comment: Accepted for publication in Ap

Temporal dynamics of trematode intermediate snail host environmental DNA in small water body habitats

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Sensory Electrical Stimulation Improves Foot Placement during Targeted Stepping Post-Stroke

Proper foot placement is vital for maintaining balance during walking, requiring the integration of multiple sensory signals with motor commands. Disruption of brain structures post-stroke likely alters the processing of sensory information by motor centers, interfering with precision control of foot placement and walking function for stroke survivors. In this study, we examined whether somatosensory stimulation, which improves functional movements of the paretic hand, could be used to improve foot placement of the paretic limb. Foot placement was evaluated before, during, and after application of somatosensory electrical stimulation to the paretic foot during a targeted stepping task. Starting from standing, twelve chronic stroke participants initiated movement with the non-paretic limb and stepped to one of five target locations projected onto the floor with distances normalized to the paretic stride length. Targeting error and lower extremity kinematics were used to assess changes in foot placement and limb control due to somatosensory stimulation. Significant reductions in placement error in the medial–lateral direction (p = 0.008) were observed during the stimulation and post-stimulation blocks. Seven participants, presenting with a hip circumduction walking pattern, had reductions (p = 0.008) in the magnitude and duration of hip abduction during swing with somatosensory stimulation. Reductions in circumduction correlated with both functional and clinical measures, with larger improvements observed in participants with greater impairment. The results of this study suggest that somatosensory stimulation of the paretic foot applied during movement can improve the precision control of foot placement

Mass Cytometry Defines Virus-Specific CD4 + T Cells in Influenza Vaccination

The antiviral response to influenza virus is complex and multifaceted, involving many immune cell subsets. There is an urgent need to understand the role of CD4+ T cells, which orchestrate an effective antiviral response, to improve vaccine design strategies. In this study, we analyzed PBMCs from human participants immunized with influenza vaccine, using high-dimensional single-cell proteomic immune profiling by mass cytometry. Data were analyzed using a novel clustering algorithm, denoised ragged pruning, to define possible influenza virus-specific clusters of CD4+ T cells. Denoised ragged pruning identified six clusters of cells. Among these, one cluster (Cluster 3) was found to increase in abundance following stimulation with influenza virus peptide ex vivo. A separate cluster (Cluster 4) was found to expand in abundance between days 0 and 7 postvaccination, indicating that it is vaccine responsive. We examined the expression profiles of all six clusters to characterize their lineage, functionality, and possible role in the response to influenza vaccine. Clusters 3 and 4 consisted of effector memory cells, with high CD154 expression. Cluster 3 expressed cytokines like IL-2, IFN-γ, and TNF-α, whereas Cluster 4 expressed IL-17. Interestingly, some participants had low abundance of Clusters 3 and 4, whereas others had higher abundance of one of these clusters compared with the other. Taken together, we present an approach for identifying novel influenza virus-reactive CD4+ T cell subsets, a method that could help advance understanding of the immune response to influenza, predict responsiveness to vaccines, and aid in better vaccine design

Case Series of a Knowledge Translation Intervention to Increase Upper Limb Exercise in Stroke Rehabilitation

Background and Purpose. Current approaches to upper limb rehabilitation are not sufficient to drive neural reorganization and maximize recovery after stroke. To address this evidence-practice gap, a knowledge translation intervention using the Behaviour Change Wheel was developed. The intervention involves collaboratively working with stroke therapy teams to change their practice and increase therapy intensity by therapists prescribing supplementary self-directed arm exercise. The purposes of this case series are: (1) to provide an illustrative example of how a research-informed process changed clinical practice and (2) to report on staff members’ and patients’ perceptions of the utility of the developed intervention. Case Descriptions. A participatory action research approach was used in 3 stroke rehabilitation units in the United Kingdom. The intervention aimed to change 4 therapist-level behaviors: (1) screening patients for suitability for supplementary self-directed arm exercise, (2) provision of exercises, (3) involving family and caregivers in assisting with exercises, and (4) monitoring and progressing exercises. Data on changes in practice were collected by therapy teams using a bespoke audit tool. Utility of the intervention was explored in qualitative interviews with patients and staff. Outcomes. Components of the intervention were successfully embedded in 2 of the 3 stroke units. At these sites, almost all admitted patients were screened for suitability for supplementary self-directed exercise. Exercises were provided to 77%, 70%, and 88% of suitable patients across the 3 sites. Involving family and care givers and monitoring and progressing exercises were not performed consistently. Conclusions. This case report is an example of how a rigorous research-informed knowledge translation process resulted in practice change. Research is needed to demonstrate that these changes can translate into increased intensity of upper limb exercise and affect patient outcome

Mock galaxy redshift catalogues from simulations: implications for Pan-STARRS1

We describe a method for constructing mock galaxy catalogues which are well suited for use in conjunction with large photometric surveys. We use the semi-analytic galaxy formation model of Bower et al. implemented in the Millennium simulation. We apply our method to the specific case of the surveys soon to commence with PS1, the first of 4 telescopes planned for the Pan-STARRS system. PS1 has 5 photometric bands (grizy), and will carry out an all-sky 3pi survey and a medium deep survey (MDS) over 84 sq.deg. We calculate the expected magnitude limits for extended sources in the two surveys. We find that, after 3 years, the 3pi survey will have detected over 10^8 galaxies in all 5 bands, 10 million of which will lie at redshift z>0.9, while the MDS will have detected over 10^7 galaxies with 0.5 million lying at z>2. These numbers at least double if detection in the shallowest band, y is not required. We then evaluate the accuracy of photometric redshifts estimated using an off-the-shelf photo-z code. With the grizy bands alone it is possible to achieve an accuracy in the 3pi survey of Delta z/(1+z)~0.06 for 0.25<z<0.8, which could be reduced by about 15% using near infrared photometry from the UKIDDS survey, but would increase by about 25% for the deeper sample without the y band photometry. For the MDS an accuracy of Delta z/(1+z)~0.05 is achievable for 0.02<z<1.5 using grizy. A dramatic improvement in accuracy is possible by selecting only red galaxies. In this case, Delta z/(1+z)~0.02-0.04 is achievable for ~100 million galaxies at 0.4<z<1.1 in the 3pi survey and for 30 million galaxies in the MDS at 0.4<z<2. We investigate the effect of using photo-z in the estimate of the baryonic acoustic oscillation scale. We find that PS1 will achieve a similar accuracy in this estimate as a spectroscopic survey of 20 million galaxies.Comment: 23 pages, 18 figures, accepted by MNRA

The Millennium Galaxy Catalogue: 16 < B_MGC < 24 galaxy counts and the calibration of the local galaxy luminosity function

The Millennium Galaxy Catalogue (MGC) is a 37.5 deg^2, medium-deep, B-band imaging survey along the celestial equator, taken with the Wide Field Camera on the Isaac Newton Telescope. The survey region is contained within the regions of both the Two Degree Field Galaxy Redshift Survey (2dFGRS) and the Sloan Digital Sky Survey Early Data Release (SDSS-EDR). The survey has a uniform isophotal detection limit of 26 mag arcsec^-2 and it provides a robust, well-defined catalogue of stars and galaxies in the range 16 <= B_MGC < 24 mag. Here we describe the survey strategy, the photometric and astrometric calibration, source detection and analysis, and present the galaxy number counts that connect the bright and faint galaxy populations within a single survey. We argue that these counts represent the state of the art and use them to constrain the normalizations (phi*) of a number of recent estimates of the local galaxy luminosity function. We find that the 2dFGRS, SDSS Commissioning Data (CD), ESO Slice Project, Century Survey, Durham/UKST, Mt Stromlo/APM, SSRS2, and NOG luminosity functions require a revision of their published phi* values by factors of 1.05 +/- 0.05, 0.76 +/- 0.10, 1.02 +/- 0.22, 1.02 +/- 0.16, 1.16 +/- 0.28, 1.75 +/- 0.37, 1.40 +/- 0.26 and 1.01 +/- 0.39, respectively. After renormalizing the galaxy luminosity functions we find a mean local \bj luminosity density of j_{b_J} = (1.986 +/- 0.031) x 10^8 h L_{\odot} Mpc^-3.Comment: 20 pages, LaTeX, 20 Postscript figures (some low resolution), MNRAS, in press; considerably revised versio