Інформаційна культура й професійно-особистісний розвиток майбутнього вчителя історії

(uk) У статті розглядається ціннісно-мотиваційний компонент та прояв індивідуальності в структурі інформаційної культури майбутнього вчителя історії.(ru) В статье рассматривается ценностно-мотивационный компонент и проявление индивидуальности в структуре информационной культуры будущего учителя истории

CONSERVATION OF THE IRISH POPULATIONS OF THE POLLAN COREGONUS AUTUMNALIS

ABSTRACT The Irish lake populations of pollan Coregonus autumnalis Pallas are detached from other Arctic populations and exist at the southern extreme of the range of the species. They are landlocked relics of postglacial colonisation by anadromous forms. In Ireland, pollan exist in atypical habitats and temperature ranges for the species as a whole and are threatened with extinction by a range of potentially detrimental factors, including eutrophication and competition with introduced nonindigenous species. All but one of the four populations is critically endangered. This paper summarises current knowledge of pollan, the status of the four populations and actions proposed to protect and enhance the remaining stocks

The building stone of the Roman city of Lixus (NW Morocco) : provenance, petrography and petrophysical characterization

Characterization of building material is a key tool to assess deterioration processes and improve potential restoration works of archaeological sites. The aim of this paper is to identify and characterize the building stone used in the construction of the Phoenician-Roman city of Lixus (Larache, Morocco) by means of petrographic and petrophysical technics. Based on the visual analysis of the monuments, three major building stones (i.e., lithotypes) have been identified: (1) Oligocene sandstones, (2) Quaternary sandstones, and (3) Quaternary conglomerates. Based on the analysis of the regional geology and exploitation marks, these three lithotypes have been identified to crop out in the surroundings of Lixus and the quarries, presumably Roman in origin, recognized. The Oligocene sandstone is the primary building stone in Lixus as form and crop out extensively in the Tchemmis hill, at top of which the city is settled. The Quaternary sandstones and conglomerates, which represent nearshore deposits and eolianites, are less abundant as building rocks in Lixus and crop out along the Atlantic coast where form part pf the cliffs close to Larache. Petrographic results indicate that lithotypes differ notably in grain size, ratio of detrital to allochemical components, and the configuration of their porous system. Mechanical analysis show that the Oligocene sandstones are more resistant to compression than the Quaternary sandstones and conglomerates, the latter exhibiting low compressive strength. The Oligocene sandstones, which display scarce porosity and permeability, show a hydric behaviour characterized by a very low degree of absorbing and desorbing water, likely resulting from a poor connectivity of the pore network. Contrary to later lithotype, the Quaternary sandstones and conglomerates, which exhibit very high porosity and permeability, display a hydric behaviour characterized by high degree of both absorbing and desorbing water. This behaviour is attributed to both the low degree of cementation and excellent connectivity of the porous network of the lithotype typical of coastal deposists. Finally, the accelerated artificial aging test they do not show a significant weight loss after twelve cycles of salt crystallization, indicating that the three lithotypes are not vulnerable to sodium sulphate attacks. Results of this study indicate that the good state of conservation of the building rocks of Lixus is linked to intrinsic factors as mineralogy and petrophysical characteristics together with the favourable effect of the climatic condition of the study area

Evidence for Color Dichotomy in the Primordial Neptunian Trojan Population

In the current model of early Solar System evolution, the stable members of the Jovian and Neptunian Trojan populations were captured into resonance from the leftover reservoir of planetesimals during the outward migration of the giant planets. As a result, both Jovian and Neptunian Trojans share a common origin with the primordial disk population, whose other surviving members constitute today's trans-Neptunian object (TNO) populations. The cold classical TNOs are ultra-red, while the dynamically excited "hot" population of TNOs contains a mixture of ultra-red and blue objects. In contrast, Jovian and Neptunian Trojans are observed to be blue. While the absence of ultra-red Jovian Trojans can be readily explained by the sublimation of volatile material from their surfaces due to the high flux of solar radiation at 5AU, the lack of ultra-red Neptunian Trojans presents both a puzzle and a challenge to formation models. In this work we report the discovery by the Dark Energy Survey (DES) of two new dynamically stable L4 Neptunian Trojans,2013 VX30 and 2014 UU240, both with inclinations i >30 degrees, making them the highest-inclination known stable Neptunian Trojans. We have measured the colors of these and three other dynamically stable Neptunian Trojans previously observed by DES, and find that 2013 VX30 is ultra-red, the first such Neptunian Trojan in its class. As such, 2013 VX30 may be a "missing link" between the Trojan and TNO populations. Using a simulation of the DES TNO detection efficiency, we find that there are 162 +/- 73 Trojans with Hr < 10 at the L4 Lagrange point of Neptune. Moreover, the blue-to-red Neptunian Trojan population ratio should be higher than 17:1. Based on this result, we discuss the possible origin of the ultra-red Neptunian Trojan population and its implications for the formation history of Neptunian Trojans

Novel therapeutic strategies for patients with NSCLC that do not respond to treatment with EGFR inhibitors

Introduction: Treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) yields tumour responses in non-small cell lung cancer (NSCLC) patients harbouring activating EGFR mutations. However, even in long-lasting responses, resistance to EGFR TKIs invariably occurs. Areas covered: This review examines resistance mechanisms to EGFR TKI treatment, which mainly arise from secondary EGFR mutations. Other resistance-inducing processes include mesenchymal\u2013epithelial transition factor (MET) amplification, epithelial\u2013mesenchymal transformation, phenotypic change from NSCLC to small-cell lung carcinoma, and modifications in parallel signalling pathways. Current therapeutic strategies to overcome these EGFR TKI resistance mechanisms focus on the inhibition or blocking of multiple members of the ErbB family. Several molecules which target multiple ErbB receptors are being investigated in NSCLC and other indications including afatinib, an ErbB Family Blocker, as well as dacomitinib and lapatinib. Novel, non-quinazoline, EGFR inhibitors, that also target EGFR activating and resistance (T790M) mutations, are currently under clinical development. Other therapeutic strategies include inhibition of parallel and downstream pathways, using agents which target heat shock protein (HSP)90 orpoly (ADP-ribose) polymerase in addition to mammalian target of rapamycin (mTOR), monoclonal antibodies against the insulin-like growth factor-1 receptor, and fulvestrant-mediated oestrogen receptor regulation. Conclusion: Improved understanding of mechanisms underlying resistance to EGFR TKIs emphasises the importance of a genotype-guided approach to therapy. Elucidation of resistance mechanisms is indeed crucial to target innovative therapeutic approaches and to improve the efficacy of anticancer regimes in NSCLC

Evidence of Dopaminergic Processing of Executive Inhibition

Inhibition of unwanted response is an important function of the executive system. Since the inhibitory system is impaired in patients with dysregulated dopamine system, we examined dopamine neurotransmission in the human brain during processing of a task of executive inhibition. The experiment used a recently developed dynamic molecular imaging technique to detect and map dopamine released during performance of a modified Eriksen's flanker task. In this study, young healthy volunteers received an intravenous injection of a dopamine receptor ligand (11C-raclopride) after they were positioned in the PET camera. After the injection, volunteers performed the flanker task under Congruent and Incongruent conditions in a single scan session. They were required to inhibit competing options to select an appropriate response in the Incongruent but not in the Congruent condition. The PET data were dynamically acquired during the experiment and analyzed using two variants of the simplified reference region model. The analysis included estimation of a number of receptor kinetic parameters before and after initiation of the Incongruent condition. We found increase in the rate of ligand displacement (from receptor sites) and decrease in the ligand binding potential in the Incongruent condition, suggesting dopamine release during task performance. These changes were observed in small areas of the putamen and caudate bilaterally but were most significant on the dorsal aspect of the body of left caudate. The results provide evidence of dopaminergic processing of executive inhibition and demonstrate that neurochemical changes associated with cognitive processing can be detected and mapped in a single scan session using dynamic molecular imaging

The Phoenix stream : a cold stream in the southern hemisphere

We report the discovery of a stellar stream in the Dark Energy Survey Year 1 (Y1A1) data. The discovery was made through simple color–magnitude filters and visual inspection of the Y1A1 data. We refer to this new object as the Phoenix stream, after its resident constellation. After subtraction of the background stellar population we detect a clear signal of a simple stellar population. By fitting the ridge line of the stream in color–magnitude space, we find that a stellar population with age τ=11.5±0.5 Gyr and [Fe/H]<−1.6, located 17.5±0.9 kpc from the Sun, gives an adequate description of the stream stellar population. The stream is detected over an extension of 8°.1 (2.5 kpc) and has a width of ∼54 pc assuming a Gaussian profile, indicating that a globular cluster (GC) is a probable progenitor. There is no known GC within 5 kpc that is compatible with being the progenitor of the stream, assuming that the stream traces its orbit. We examined overdensities (ODs) along the stream, however, no obvious counterpart-bound stellar system is visible in the coadded images. We also find ODs along the stream that appear to be symmetrically distributed—consistent with the epicyclic OD scenario for the formation of cold streams—as well as a misalignment between the northern and southern part of stream. Despite the close proximity we find no evidence that this stream and the halo cluster NGC 1261 have a common accretion origin linked to the recently found EriPhe OD

An r -process enhanced star in the dwarf galaxy Tucana III

Chemically peculiar stars in dwarf galaxies provide a window for exploring the birth environment of stars with varying chemical enrichment. We present a chemical abundance analysis of the brightest star in the newly discovered ultra-faint dwarf galaxy candidate Tucana III. Because it is particularly bright for a star in an ultra-faint Milky Way (MW) satellite, we are able to measure the abundance of 28 elements, including 13 neutron-capture species. This star, DES J235532.66−593114.9 (DES J235532), shows a mild enhancement in neutron-capture elements associated with the r-process and can be classified as an r-I star. DES J235532 is the first r-I star to be discovered in an ultra-faint satellite, and Tuc III is the second extremely low-luminosity system found to contain rprocess enriched material, after Reticulum II. Comparison of the abundance pattern of DES J235532 with r-I and r-II stars found in other dwarf galaxies and in the MW halo suggests a common astrophysical origin for the neutron-capture elements seen in all r-process enhanced stars. We explore both internal and external scenarios for the r-process enrichment of Tuc III and show that with abundance patterns for additional stars, it should be possible to distinguish between them