Propuesta en Supply Chain Management y Logística en la Empresa Colchones El Dorado

En el presente trabajo se aplican los conocimientos basados en Ingeniería Industrial aplicándolos en la empresa Colchones El Dorado el cual se identifican los niveles de los proveedores que viene sentido aguas arriba y los niveles de los clientes sentido aguas debajo de los miembros del Supply Chain. Conjuntamente se adquiere conocimiento de los procesos de cada actividad de la cadena de suministro relacionados en la empresa como son la materia prima, la producción, el transporte y logística como también la gestión del almacenamiento y su distribución hasta llegar al cliente final. El objetivo es proponer herramientas y estrategias que puedan mejorar con eficiencia cada uno de los procesos de cada dependencia como la gestión aprovisionamiento, gestión de inventarios, la gestión de distribución y logística y así lograr una buena comunicación de cada uno de los miembros. La empresa debe de ir renovando su tecnología utilizando software que facilite llegar a los objetivos propuestos y de acuerdo a su capacidad económica, esto con el fin de que tenga una ventaja competitiva en el mercado.In the present work, the knowledge based on Industrial Engineering is applied by applying it in the company Colchones El Dorado, which identifies the levels of the suppliers coming upstream and the levels of the customers downstream of the members of the Supply Chain. Together, knowledge of the processes of each activity of the supply chain related to the company is acquired, such as raw materials, production, transport and logistics, as well as storage and distribution management until reaching the final customer. The objective is to propose tools and strategies that can efficiently improve each of the processes of each agency, such as supply management, inventory management, distribution and logistics management, and thus achieve good communication from each of the members. The company must be renewing its technology using software that facilitates reaching the proposed objectives and according to its economic capacity, this in order to have a competitive advantage in the market

Potentially toxic concentrations of synthetic pyrethroids associated with low density residential land use

Trace organic compounds associated with human activity are now ubiquitous in the environment. As the population becomes more urbanised and the use of pesticides and person care products continues to increase, urban waterways are likely to receive higher loads of trace organic contaminants with unknown ecological consequences. To establish the extent of trace organic contamination in urban runoff, concentrations of emerging chemicals of concern were determined in sediments from 99 urban wetlands in and around Melbourne, Australia between February and April, 2015. As a preliminary estimation of potential risks to aquatic biota, we compared measured concentrations with thresholds for acute and chronic toxicity, and modelled toxic units as a function of demographic and land use trends. The synthetic pyrethroid insecticide bifenthrin was common and widespread, and frequently occurred at concentrations likely to cause toxicity to aquatic life. Personal care products DEET and triclosan were common and widely distributed, while the herbicides diuron and prometryn, and the fungicides pyrimethanil and trifloxystrobin occurred less frequently. Toxic unit modelling using random forests found complex and unexpected associations between urban land uses and trace organic concentrations. Synthetic pyrethroid insecticides were identified as emerging compounds of concern, particularly bifenthrin. In contrast with previous surveys, the highest bifenthrin concentrations were associated with lower housing and population density, implicating low-density residential land use in bifenthrin contamination. We discuss the implications for pesticide regulation and urban wetland management in a global context

Metabolomic Profiles of a Midge (Procladius villosimanus, Kieffer) Are Associated with Sediment Contamination in Urban Wetlands

Metabolomic techniques are powerful tools for investigating organism-environment interactions. Metabolite profiles have the potential to identify exposure or toxicity before populations are disrupted and can provide useful information for environmental assessment. However, under complex environmental scenarios, metabolomic responses to exposure can be distorted by background and/or organismal variation. In the current study, we use LC-MS (liquid chromatography-mass spectrometry) and GC-MS (gas chromatography-mass spectrometry) to measure metabolites of the midge Procladius villosimanus inhabiting 21 urban wetlands. These metabolites were tested against common sediment contaminants using random forest models and metabolite enrichment analysis. Sediment contaminant concentrations in the field correlated with several P. villosimanus metabolites despite natural environmental and organismal variation. Furthermore, enrichment analysis indicated that metabolite sets implicated in stress responses were enriched, pointing to specific cellular functions affected by exposure. Methionine metabolism, sugar metabolism and glycerolipid metabolism associated with total petroleum hydrocarbon and metal concentrations, while mitochondrial electron transport and urea cycle sets associated only with bifenthrin. These results demonstrate the potential for metabolomics approaches to provide useful information in field-based environmental assessments

Genomic characterization of SARS-CoV-2 from Uganda using MinION nanopore sequencing

Abstract SARS-CoV-2 undergoes frequent mutations, affecting COVID-19 diagnostics, transmission and vaccine efficacy. Here, we describe the genetic diversity of 49 SARS-CoV-2 samples from Uganda, collected during the COVID-19 waves of 2020/2021. Overall, the samples were similar to previously reported SARS-CoV-2 from Uganda and the Democratic Republic of Congo (DRC). The main lineages were AY.46 and A.23, which are considered to be Delta SARS-CoV-2 variants. Further, a total of 268 unique single nucleotide variants and 1456 mutations were found, with more than seventy percent mutations in the ORF1ab and S genes. The most common mutations were 2042C>G (83.4%), 14143C>T (79.5%), 245T>C (65%), and 1129G>T (51%), which occurred in the S, ORF1ab, ORF7a and N genes, respectively. As well, 28 structural variants—21 insertions and 7 deletions, occurred in 16 samples. Our findings point to the possibility that most SARS-CoV-2 infections in Uganda at the time arose from local spread and were not newly imported. Moreover, the relatedness of variants from Uganda and the DRC reflects high human mobility and interaction between the two countries, which is peculiar to this region of the world

A multi-country phase 2 study to evaluate the suitcase lab for rapid detection of SARS-CoV-2 in seven Sub-Saharan African countries: Lessons from the field

From Elsevier via Jisc Publications RouterHistory: issued 2023-03-03Article version: AMPaul Kadetz - ORCID: 0000-0002-2824-1856 https://orcid.org/0000-0002-2824-1856Background : The COVID-19 pandemic led to severe health systems collapse, as well as logistics and supply delivery shortages across sectors. Delivery of PCR related healthcare supplies continue to be hindered. There is the need for a rapid and accessible SARS-CoV-2 molecular detection method in low resource settings. Objectives : To validate a novel isothermal amplification method for rapid detection of SARS-CoV-2 across seven sub-Sharan African countries. Study design : In this multi-country phase 2 diagnostic study, 3,231 clinical samples in seven African sites were tested with two reverse transcription Recombinase-Aided Amplification (RT-RAA) assays (based on SARS-CoV-2 Nucleocapsid (N) gene and RNA-dependent RNA polymerase (RdRP) gene). The test was performed in a mobile suitcase laboratory within 15 minutes. All results were compared to a real-time RT-PCR assay. Extraction kits based on silica gel or magnetic beads were applied. Results : Four sites demonstrated good to excellent agreement, while three sites showed fair to moderate results. The RdRP gene assay exhibited an overall PPV of 0.92 and a NPV of 0.88. The N gene assay exhibited an overall PPV of 0.93 and a NPV 0.88. The sensitivity of both RT-RAA assays varied depending on the sample Ct values. When comparing sensitivity between sites, values differed considerably. For high viral load samples, the RT-RAA assay sensitivity ranges were between 60.5 and 100% (RdRP assay) and 25 and 98.6 (N assay). Conclusion : Overall, the RdRP based RT-RAA test showed the best assay accuracy. This study highlights the challenges of implementing rapid molecular assays in field conditions. Factors that are important for successful deployment across countries include the implementation of standardized operation procedures, in-person continuous training for staff, and enhanced quality control measures.inpressinpres

The effect of urban ground covers on arthropods: An experiment.

Changes to the ground layer in urban areas are extensive, but the effects on arthropod fauna are poorly understood. We undertook a manipulative experiment to examine the response of arthropods to small-scale variation in ground covers commonly found in urban parks and gardens in Australia. The ground covers tested were bare ground, leaf litter, woodchips and grass, with plot sizes of 3.6 m2. Epigeic arthropods were sampled with pitfall traps and Tullgren funnels over 12 months following establishment of the treatments. All epigeic arthropods were sorted to order and the ants (Hymenoptera: Formicidae), beetles (Coleoptera), millipedes (Diplopoda) and slaters (Isopoda: Oniscidea) were examined at lower taxonomic levels. Diverse arthropods rapidly colonised previously cleared plots in all four treatments and were most abundant in grass plots. The diversity of ants and beetles was significantly different in different ground covers and tended to be most diverse in grass plots. Despite the treatments providing very different microclimates, the fauna studied did not show strong selection for a particular cover type overall. The abundance of grass cover in the surrounding area may have led to the grass plots having the greatest abundance of arthropods. These results have important implications for developing effective small-scale conservation efforts for arthropods in anthropogenically modified landscapes, especially for species with poor dispersal abilities.This research was conducted while B.N. was a recipient of an Australian Postgraduate Award and a Holsworth Wildlife Research Grant. Additional funding and support were provided by the Baker Foundation