Elaborar banco probador de cajas mecánicas para el taller de auto mecatrónica de la Universidad Los Libertadores

Este proyecto es una muestra tangible de lo que puede realizarse cuando se reúnen ciertas fortalezas como la capacidad de aprender, la aplicación de conocimientos y una situación en la cual hay que resolver; que para este caso es el proyecto de grado. El cual está compuesto de ciertas características que se verán a continuación, porque en los últimos dos años se han adquirido conocimientos prácticos y teóricos para ser aplicados en el campo de acción. Utilizando la relación entre las actividades de aprendizaje y práctica generando la base técnica del proyecto

Phenotypic characterization of X-linked hypophosphatemia in pediatric Spanish population

BACKGROUND: X-linked hypophosphatemia (XLH) is a hereditary rare disease caused by loss-of-function mutations in PHEX gene leading tohypophosphatemia and high renal loss of phosphate. Rickets and growth retardation are the major manifestations of XLH in children, but there is a broad phenotypic variability. Few publications have reported large series of patients. Current data on the clinical spectrum of the disease, the correlation with the underlying gene mutations, and the long-term outcome of patients on conventional treatment are needed, particularly because of the recent availability of new specific medications to treat XLH. RESULTS: The RenalTube database was used to retrospectively analyze 48 Spanish patients (15 men) from 39 different families, ranging from 3months to 8years and 2months of age at the time of diagnosis (median age of 2.0years), and with XLH confirmed by genetic analysis. Bone deformities, radiological signs of active rickets and growth retardation were the most common findings at diagnosis. Mean (±SEM) height was - 1.89±0.19 SDS and 55% (22/40) of patients had height SDS below-2. All cases had hypophosphatemia, serum phosphate being - 2.81±0.11 SDS. Clinical manifestations and severity of the disease were similar in both genders. No genotype-phenotype correlation was found. Conventional treatment did not attenuate growth retardation after a median follow up of 7.42years (IQR=11.26; n=26 patients) and failed to normalize serum concentrations of phosphate. Eleven patients had mild hyperparathyroidism and 8 patients nephrocalcinosis. CONCLUSIONS: This study shows that growth retardation and rickets were the most prevalent clinical manifestations at diagnosis in a large series of Spanish pediatric patients with XLH confirmed by mutations in the PHEX gene. Traditional treatment with phosphate and vitamin D supplements did not improve height or corrected hypophosphatemia and was associated with a risk of hyperparathyroidism and nephrocalcinosis. The severity of the disease was similar in males and females

La Comarca: un instrumento lúdico para el aprendizaje y un proyecto transversal multiescuela en la Universitat Politècnica de València (UPV)

[ES] Esta comunicación es el resultado de un Proyecto de Innovación y Mejora Educativa (PIME), financiado por el Vicerrectorado de Estudios, Calidad y Acreditación de la Universitat Politècnica de València, y por la Escuela Técnica Superior de Ingeniería de Caminos, Canales y Puertos. El objetivo del PIME que se presenta en esta comunicación es encontrar un nuevo recurso educativo para resolver problemas de motivación y aprendizaje en la enseñanza universitaria relacionada con la disciplina del Urbanismo y la Ordenación del Territorio. El uso del juego permite motivar y enseñar, y bajo esta premisa, se propone la creación de un juego de estrategia de cooperación-oposición, La Comarca, diseñado como un sencillo tablero representando el territorio, dividido en cuatro municipios, en el que cuatro alcaldías interactúan y trabajan para conseguir un territorio bien organizado. En esta comunicación se describe el proceso de construcción del juego, desde su idea hasta su producción, pasando por el proceso de diseño, fruto de un proyecto transversal entre dos escuelas de la Universitat Politècnica de València (Escuela Técnica Superior de Ingeniería de Caminos, Canales y Puertos y la Facultad de Bellas Artes) y los principales resultados obtenidos tras dicha experiencia.[EN] This communication is the result of an Educational Innovation and Improvement Project (PIME), financed by the Vicerrectorado de Estudios, Calidad y Acreditación of Universitat Politècnica de València, and by the School of Civil Engineering. The objective of the PIME presented in this communication is to find a new educational resource to solve motivation and learning problems in university education related to the discipline of Urbanism and Territorial Planning.The use of the game allows to motivate and teach, and under this premise, it is proposed the creation of a strategy game of cooperation-opposition, La Comarca, designed as a simple board representing the territory, divided into four municipalities, in which four mayors interact and work to achieve a well-organized territory. This communication describes the construction process of the game, from its idea to its production, including the design process, which is the result of a transversal project between two schools of the Universitat Politècnica de València (Escuela Técnica Superior de Ingeniería de Caminos, Canales y Puertos and the Facultad de Bellas Artes) and the main results obtained from this experience. The first results show that the game created constitutes a useful didactic resource, allowing to present in a simple way many of the basic concepts of the discipline, so that the students work and assimilate complex concepts successfully, in a different and motivating teacher-student context.Gielen, E.; Sosa Espinosa, A.; Palencia Jiménez, JS.; Pérez Alonso, Y.; Moreno Navarro, MS.; Temes Córdovez, RR.; Miralles García, JL.... (2021). La Comarca: un instrumento lúdico para el aprendizaje y un proyecto transversal multiescuela en la Universitat Politècnica de València (UPV). En IN-RED 2020: VI Congreso de Innovación Educativa y Docencia en Red. Editorial Universitat Politècnica de València. 421-437. https://doi.org/10.4995/INRED2020.2020.12031OCS42143

Adherence and Toxicity during the Treatment of Latent Tuberculous Infection in a Referral Center in Spain

Latent tuberculosis infection; Toxicity; Tuberculosis screeningInfecció tuberculosa latent; Toxicitat; Cribratge de tuberculosiInfección tuberculosa latente; Toxicidad; Cribado de tuberculosisThe screening and treatment of latent tuberculosis infection (LTBI) in countries with a low incidence of TB is a key strategy for the elimination of tuberculosis (TB). However, treatment can result in adverse events (AEs) and have poor adherence. This study aimed to describe treatment outcomes and AEs for LTBI patients at two departments in Vall d'Hebron University Hospital in Barcelona, Spain. A retrospective study was conducted on all persons treated for LTBI between January 2018 and December 2020. Variables collected included demographics, the reason for LTBI screening and treatment initiation, AEs related to treatment, and treatment outcome. Out of 261 persons who initiated LTBI treatment, 145 (55.6%) were men, with a median age of 42.1 years. The indications for LTBI screening were household contact of a TB case in 96 (36.8%) persons, immunosuppressive treatment in 84 (32.2%), and recently arrived migrants from a country with high TB incidence in 81 (31.0%). Sixty-three (24.1%) persons presented at least one AE during treatment, and seven (2.7%) required definitive discontinuation of treatment. In the multivariate analysis, AE development was more frequent in those who started LTBI treatment due to immunosuppression. Overall, 226 (86.6%) completed treatment successfully. We concluded that LTBI screening and treatment groups had different risks for adverse events and treatment outcomes. Persons receiving immunosuppressive treatment were at higher risk of developing AEs, and recently arrived immigrants from countries with a high incidence of TB had greater LTFU. A person-centered adherence and AE management plan is recommended.A.M.L. was supported by a postdoctoral grant “Juan Rodés” (JE21/00027) from the Instituto de Salud Carlos through the Ministry of Economy and Competitiveness, Spain

Multi-Omics Integration Highlights the Role of Ubiquitination in CCl4-Induced Liver Fibrosis

Liver fibrosis is the excessive accumulation of extracellular matrix proteins that occurs in chronic liver disease. Ubiquitination is a post-translational modification that is crucial for a plethora of physiological processes. Even though the ubiquitin system has been implicated in several human diseases, the role of ubiquitination in liver fibrosis remains poorly understood. Here, multi-omics approaches were used to address this. Untargeted metabolomics showed that carbon tetrachloride (CCl4)-induced liver fibrosis promotes changes in the hepatic metabolome, specifically in glycerophospholipids and sphingolipids. Gene ontology analysis of public deposited gene array-based data and validation in our mouse model showed that the biological process “protein polyubiquitination” is enriched after CCl4-induced liver fibrosis. Finally, by using transgenic mice expressing biotinylated ubiquitin (bioUb mice), the ubiquitinated proteome was isolated and characterized by mass spectrometry in order to unravel the hepatic ubiquitinated proteome fingerprint in CCl4-induced liver fibrosis. Under these conditions, ubiquitination appears to be involved in the regulation of cell death and survival, cell function, lipid metabolism, and DNA repair. Finally, ubiquitination of proliferating cell nuclear antigen (PCNA) is induced during CCl4-induced liver fibrosis and associated with the DNA damage response (DDR). Overall, hepatic ubiquitome profiling can highlight new therapeutic targets for the clinical management of liver fibrosis.This work was supported by grants from Gobierno Vasco-Departamento de Salud 2013111114 (to M.L.M.-C.), ELKARTEK 2016, Departamento de Industria del Gobierno Vasco (to M.L.M.-C.), Ministerio de Ciencia, Innovación y Universidades MICINN: SAF2017-87301-R, SAF2017-88041-R, RTI2018-096759-A-100 and SAF2016-76898-P integrado en el Plan Estatal de Investigación Cientifica y Técnica y Innovación, cofinanciado con Fondos FEDER (to M.L.M.-C., J.M.M., T.C.D. and U.M. respectively); AECC Bizkaia (M.S.-M.); Asociación Española contra el Cáncer (T.C.D.), Fundación Científica de la Asociación Española Contra el Cancer (AECC Scientific Foundation) Rare Tumor Calls 2017 (to M.L.M., J.M.B., M.A.A., J.J.G.M.), La Caixa Foundation Program (to M.L.M.), 2018 BBVA Foundation Grants for Scientific Research Teams (to M.L.M.-C.). This research was also funded by the CIBERehd (EHD15PI05/2016) and “Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III”, Spain (PI16/00598 and PI19/00819, co-funded by European Regional Development Fund/European Social Fund, “Investing in your future”); Spanish Ministry of Economy, Industry and Competitiveness (SAF2016-75197-R); “Junta de Castilla y Leon” (SA063P17); AECC Scientific Foundation (2017/2020), Spain; “Centro Internacional sobre el Envejecimiento” (OLD-HEPAMARKER, 0348_CIE_6_E), Spain; University of Salamanca Foundation, Spain (PC-TCUE18-20_051), and Fundació Marato TV3 (Ref. 201916-31), Spain (to J.J.G.M.). The UPV/EHU Lab and the Proteomics Platform are members of Proteored, PRB3 and is supported by grant PT17/0019, of the PE I + D + i 2013-2016, funded by ISCIII and ERDF. Ciberehd_ISCIII_MINECO is funded by the Instituto de Salud Carlos III. We thank MINECO for the Severo Ochoa Excellence Accreditation to CIC bioGUNE (SEV-2016-0644)

Priorities and interactions of Sustainable Development Goals (SDGs) with focus on wetlands

Wetlands are often vital physical and social components of a country's natural capital, as well as providers of ecosystem services to local and national communities. We performed a network analysis to prioritize Sustainable Development Goal (SDG) targets for sustainable development in iconic wetlands and wetlandscapes around the world. The analysis was based on the information and perceptions on 45 wetlandscapes worldwide by 49 wetland researchers of the GlobalWetland Ecohydrological Network (GWEN). We identified three 2030 Agenda targets of high priority across the wetlandscapes needed to achieve sustainable development: Target 6.3-'Improve water quality'; 2.4-'Sustainable food production'; and 12.2-'Sustainable management of resources'. Moreover, we found specific feedback mechanisms and synergies between SDG targets in the context of wetlands. The most consistent reinforcing interactions were the influence of Target 12.2 on 8.4-'Efficient resource consumption'; and that of Target 6.3 on 12.2. The wetlandscapes could be differentiated in four bundles of distinctive priority SDG-targets: 'Basic human needs', 'Sustainable tourism', 'Environmental impact in urban wetlands', and 'Improving and conserving environment'. In general, we find that the SDG groups, targets, and interactions stress that maintaining good water quality and a 'wise use' of wetlandscapes are vital to attaining sustainable development within these sensitive ecosystems. © 2019 by the authors

Хирургическое лечение холециститов и их осложнений

ЖЕЛЧНОКАМЕННАЯ БОЛЕЗНЬЖЕЛЧНЫХ ПУТЕЙ БОЛЕЗНИПЕЧЕНИ БОЛЕЗНИХИРУРГИЯ ЖЕЛЧНЫХ ПУТЕЙХИРУРГИЯ ПЕЧЕНИХОЛЕЦИСТИТКурс лекций включает в себя 8 лекций, посвященных анатомическим сведениям о желчевыводящих путях, этиопатогенезу острого и хронического холецистита. Освещены современные методы диагностики заболевания желчевыводящих путей, приведена клиническая картина различных форм острого холецистита, включая поражения желчевыводящих путей, хирургическая тактика, способы хирургических вмешательств, ошибки в хирургии желчевыводящих путей, постхолецистэктомический синдром

Desafíos en ciencia, tecnología e innovación en tiempo de Coronavirus Covid-19

El objetivo del presente estudio consistió en determinar el impacto de actividad física en la percepción de bienestar y salud en adolescentes, durante el periodo de confinamiento condicionado por la pandemia COVID-19. Se realizó un estudio observacional-longitudinal. N = 50 participantes (28 mujeres, 22 hombres; edad X = 15.12), quienes llevaron a cabo un programa de actividad física diseñado para espacios pequeños, además de realizar un pre y post-test. Los resultados muestran que hubo una mejora en la percepción de bienestar y salud después del periodo de actividad física (p=.05). Se concluye que, en la población de estudio, el programa de actividad física en espacios pequeños fue efectivo en la mejora de la percepción del bienestar y la salud