Respirer, digérer : points de vue didactiques

Les articles de ce volume tentent de répondre aux questions : à partir de quels éléments déjà présents dans leur esprit les élèves assimilent-ils? à partir de quels éléments introduits dans l'enseignement

Enseignement de l'énergie. Une recherche pluridisciplinaire de l'INRP

Cette recherche demandée à l'INRP par différents organismes oeuvrant dans le domaine énergétique s'est surtout axée sur une approche pluridisciplinaire cohérente du " savoir-énergie ". Elle a donné lieu à la réalisation, dans plusieurs collèges et lycées, de progressions pluridisciplinaires importantes par leur durée et l'intérêt suscité auprès des élèves. Elle a conduit ses concepteurs à élaborer des dossiers pédagogiques qui devraient aider les enseignants désireux de s'engager dans un travail pluridisciplinaire à propos de l'énergi

Planning familial: regard sur les prestations de la Fondation Profa et de l'Espace Prévention Morges-Aubonne

Ce rapport rend compte d'une étude menée en 2003, à l'instigation de la Direction de la Fondation Profa dans le but de faire le point sur l'évolution des prestations de planning familial. [...] L'étude comporte : - un volet rétrospectif portant sur les prestations de planning familial entre 1972 et 2002, - une analyse quantitative de l'activité actuelle menée en collaboration avec l'Unité de Prévention de l'Institut universitaire de médecine sociale et préventive de Lausanne, - une analyse qualitative menée auprès des médecins et des conseillères en planning familial du Service visant à évaluer le fonctionnement des centres et les pratiques des professionnels en regard des demandes du public, - des propositions d'aménagements ou de développement des prestations adaptés aux besoins actuels en matière de santé sexuelle et reproductive. [Extrait, p. 6]]]> Family Planning Services ; Contraception ; Pregnancy, Unwanted ; Switzerland ; Vaud fre https://serval.unil.ch/resource/serval:BIB_D78ABC28F873.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_D78ABC28F8733 info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_D78ABC28F8733 info:eu-repo/semantics/submittedVersion info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer application/pdf oai:serval.unil.ch:BIB_D78B39FC9AC1 2022-05-07T01:28:00Z <oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd"> https://serval.unil.ch/notice/serval:BIB_D78B39FC9AC1 Physiological ligands of PPARs in inflammation and lipid homeostasis info:doi:10.2217/17460875.1.2.191 info:eu-repo/semantics/altIdentifier/doi/10.2217/17460875.1.2.191 Lathion, C. Michalik, L. Wahli, W. info:eu-repo/semantics/review article 2006 Future Lipidology, vol. 1, no. 2, pp. 191-201 info:eu-repo/semantics/altIdentifier/pissn/1746-0875 <![CDATA[Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that are involved in many physiological processes, such as inflammation and energy homeostasis. In general, PPARs must be activated by ligands to stimulate the expression of their target genes. These agonists can be synthetic molecules, such as drugs used to treat hypertriglyceridemia and insulin resistance, or natural physiological ligands, such as fatty acids and eicosanoids. Although recent work has uncovered a surprisingly broad variety of natural molecules capable of activating PPARs, relatively little is known about their mode of action in an in vivo physiological context. The action of physiological ligands in situations of food deprivation and abundance, especially with respect to their intervention in the inflammatory response, and in both lipid homeostasis and inflammation resolution will be reviewed

Revenue management for airline alliances : passenger origin-destination simulation analysis

Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 2001.Includes bibliographical references (p. 165-166).The increasing importance of airline alliances and codesharing creates new challenges for the revenue management systems currently used by the airlines. In this thesis, these challenges were discussed quantitatively and proposed solutions were tested, using a computer tool called the Passenger-Origin Destination Simulator. The performance of current revenue management methods was assessed in a hypothetical environment, which modeled the hub-and-spoke US domestic market. In this environment, an alliance of two airlines competed against another airline. The performance of origin destination revenue management methods, especially those using bid-price control, was shown to be sensitive to the evaluation of codeshare passengers. The sole use of different evaluation or discount methods for these passengers, by taking into account either the fare of their whole itinerary or the corresponding local fare, did not give an accurate estimate of the value of those passengers for the alliance. This issue limits the revenue gains of the alliance partners using origin-destination methods. Two innovative schemes, bid-price sharing and bid-price inference, were proposed to allow airlines to more accurately assess the value of connecting passengers for the alliance, by allowing each alliance partner to estimate the revenue displacement costs on the other partner's legs. The use of bid-price sharing with an origin-destination revenue management method produced an additional revenue gain on the order of one percent for the alliance. With bid-price sharing, the alliance performed almost as well as if it were a single airline using the same method. The bid-price inference scheme led to similar results, while being easier to implement technically and legally. However, it required preliminary tuning to ensure its revenue performance.by Jérémy F.J. Darot.S.M

Diversité de genre et d’orientation sexuelle (Digos) : memento à l’usage des intervenant-e-s de l’école

Dans le cadre de son mandat, l’Unité de promotion de la santé et de prévention en milieu scolaire (Unité PSPS) a été chargée par les départements concernés (DFJC et DSAS) de mettre en place un groupe de travail qui a réalisé ce mémento. Objectifs : Ce mémento vise à fournir des bases de connaissances et des ressources à chaque adulte intervenant dans les établissements scolaires et de formation. Ces éléments contribuent de manière interdisciplinaire à prévenir les violences basées sur l’orientation sexuelle et l’identité de genre, réelles ou supposées, et leurs conséquences pour toute-s les jeunes. (glossaire et ressources en pp.17-21). Contexte: Un-e jeune se découvrant une orientation sexuelle minoritaire et / ou une identité de genre atypique se trouve le plus souvent seul-e face à ses questions. Ce sentiment initial d’isolement peut être renforcé par les violences vécues ou anticipées et par l’absence de soutien et de ressource

A re-annotation pipeline for Illumina BeadArrays: improving the interpretation of gene expression data.

Illumina BeadArrays are among the most popular and reliable platforms for gene expression profiling. However, little external scrutiny has been given to the design, selection and annotation of BeadArray probes, which is a fundamental issue in data quality and interpretation. Here we present a pipeline for the complete genomic and transcriptomic re-annotation of Illumina probe sequences, also applicable to other platforms, with its output available through a Web interface and incorporated into Bioconductor packages. We have identified several problems with the design of individual probes and we show the benefits of probe re-annotation on the analysis of BeadArray gene expression data sets. We discuss the importance of aspects such as probe coverage of individual transcripts, alternative messenger RNA splicing, single-nucleotide polymorphisms, repeat sequences, RNA degradation biases and probes targeting genomic regions with no known transcription. We conclude that many of the Illumina probes have unreliable original annotation and that our re-annotation allows analyses to focus on the good quality probes, which form the majority, and also to expand the scope of biological information that can be extracted

Geophysical tests for habitability in ice-covered ocean worlds

Geophysical measurements can reveal the structure of icy ocean worlds and cycling of volatiles. The associated density, temperature, sound speed, and electrical conductivity of such worlds thus characterizes their habitability. To explore the variability and correlation of these parameters, and to provide tools for planning and data analyses, we develop 1-D calculations of internal structure, which use available constraints on the thermodynamics of aqueous MgSO$_4$, NaCl (as seawater), and NH$_3$, water ices, and silicate content. Limits in available thermodynamic data narrow the parameter space that can be explored: insufficient coverage in pressure, temperature, and composition for end-member salinities of MgSO$_4$ and NaCl, and for relevant water ices; and a dearth of suitable data for aqueous mixtures of Na-Mg-Cl-SO$_4$-NH$_3$. For Europa, ocean compositions that are oxidized and dominated by MgSO$_4$, vs reduced (NaCl), illustrate these gaps, but also show the potential for diagnostic and measurable combinations of geophysical parameters. The low-density rocky core of Enceladus may comprise hydrated minerals, or anydrous minerals with high porosity comparable to Earth's upper mantle. Titan's ocean must be dense, but not necessarily saline, as previously noted, and may have little or no high-pressure ice at its base. Ganymede's silicious interior is deepest among all known ocean worlds, and may contain multiple phases of high-pressure ice, which will become buoyant if the ocean is sufficiently salty. Callisto's likely near-eutectic ocean cannot be adequately modeled using available data. Callisto may also lack high-pressure ices, but this cannot be confirmed due to uncertainty in its moment of inertia