Mobile Phone as an Everyday Life Style Object – The Move from »Plain old Mobile« to »Electronic Brain in your Pocket«

Seit der Einführung des Mobiltelefons hat sich seine Nutzung sehr stark verändert. Mittlerweile sind sie zu wichtigen Hilfsmitteln im täglichen Leben geworden, z. B. als Organizer oder Nachschlagewerk. Hier drängt sich nun die entscheidende Frage auf, inwieweit mobile Dienste Zugriff auf die Daten der Nutzer bekommen. Um dies, aber auch die Akzeptanz von verschiedenen mobilen Diensten zu erforschen, wurden im Rahmen dieses Papiers Umfragen in Berlin und Brandenburg durchgeführt. Ein weiterer Gegenstand der Umfrage war es, herauszufinden, ob die Nutzer bereit sind, private Daten Diensten zur Verfügung zu stellen, damit diese die Daten zu einer großen Menge vereinen, um so Vorschläge zu den Interessen der Nutzer machen zu können.Since the mobile phone was introduced to the market, its way of using changed rapidly. Nowadays it is an important tool, e.g. as organizer or knowledge base in people’s every days life. The important question is now: In which way mobile services will gain influence on private data. For this purpose surveys were conducted in Berlin-Brandenburg to get a serious database and to figure out customer‘s wishes and expectations regarding these services. Another reason for this survey was to find out, whether people are willing to provide their private data to programs or services that combine different kinds of those data, to connect these independent data to a huge database, to make suggestions of people’s interests

RELATIONSHIP BETWEEN MUSCLE VOLUME AND STRENGTH ASYMMETRY IN ELITE ATHLETES: INVESTIGATION OF THE QUADRICEPS FEMORIS AND HAMSTRING MUSCLES

The purpose of this study was to examine the relationship between muscle volume asymmetries and strength asymmetries of the lower extremity. 26 highly trained athletes underwent isometric and isokinetic strength tests at different speeds (60, 180, 0 °/s) and magnetic resonance imaging (MRI) to analyse quadriceps femoris and hamstring muscle volume. Pearson’s correlation coefficients revealed significant correlations between both the quadriceps volume asymmetries and the maximum knee extension asymmetries (r = .60 to r = .72) as well as the hamstring volume asymmetries and the maximum knee flexion asymmetries (r = .39 to r = .52). It is assumed that bilateral differences in muscle volume in part explain the existence of strength asymmetries and that unilateral resistance training of the lower extremity could reduce strength asymmetries by increasing muscle siz

Spectral Energy Distributions of a set of HII regions in M33 (HerM33es)

Within the framework of the HerM33es Key Project for Herschel and in combination with multi-wavelength data, we study the Spectral Energy Distribution (SED) of a set of HII regions in the Local Group Galaxy M33. Using the Halpha emission, we perform a classification of a selected HII region sample in terms of morphology, separating the objects in filled, mixed, shell and clear shell objects. We obtain the SED for each HII region as well as a representative SED for each class of objects. We also study the emission distribution of each band within the regions. We find different trends in the SEDs for each morphological type that are related to properties of the dust and their associated stellar cluster. The emission distribution of each band within the region is different for each morphological type of object.Comment: 3pages, 4 figures. To appear in 'The Spectral Energy Distribution of Galaxies' Proceedings IAU Symposium No 284, 201

Obtención de azúcares fermentables a partir de aserrín de pino pretratado secuencialmente con ácido-base

El uso de residuos lignocelulósicos constituye una fuente abundante y de bajo costo, que genera, además, una solución al problema de su disposición final. El objetivo del trabajo fue evaluar el efecto de distintas condiciones de pretratamiento secuencial ácido-base de aserrín de pino, sobre la liberación de azúcares reductores en la etapa de sacarificación. El material lignocelulósico se pretrató en dos etapas: la primera, se realizó con ácido sulfúrico (PT1) y la segunda con hidróxido de sodio (PT2), ambas con tres niveles: 1, 2 y 3 % mediante un diseño 32 factorial. La hidrólisis enzimática se realizó a 50 ºC y 150 rpm en frascos de 50 mL. Se tomaron muestras a las 0.15, 24, 48, 72 y 96 h. Se determinó el porcentaje de lignina ácido soluble (% ASL) y la concentración de azúcares reductores. El nivel óptimo de cada factor que favoreció la mayor deslignificación correspondió a 3 % de ácido sulfúrico y 3 % de hidróxido de sodio. La producción de azúcares reductores no se vio afectada por el PT2, pero si por el PT1, alcanzando un máximo para el nivel 0 del mismo (2 % de ácido sulfúrico). Se optimizó el pretratamiento secuencial ácido-base y se comprobó además que éste mejora la hidrólisis enzimática con respecto al aserrín de pino sin pretratar. La cantidad de azúcares reductores obtenidos fue comparable a la obtenida por otros autores.The use of lignocellulosic waste constitutes an abundant and inexpensive source; it also offers a solution to the problem of waste disposal. The aim of the study was to evaluate the effect of different conditions of a sequential acid-base pretreatment of pine sawdust, through the release of reducing sugars in the saccharification step. The lignocellulosic material was pretreated in two stages: acid pretreatment (PT1), using sulfuric acid and basic pretreatment (PT2), employing sodium hydroxide at three levels each one: 1, 2 and 3 % in a factorial design. Enzymatic hydrolysis was carried out at 50 ºC and 150 rpm in 50 mL vials. Samples were taken at 0.15, 24, 48, 72 and 96 h. The percentage of acid soluble lignin and the concentration of reducing sugars were determined. The optimum level of each factor favoring the highest delignification corresponded to 3 % sulfuric acid and 3 % sodium hydroxide. The production of reducing sugars was not affected by the PT2, but by the PT1, achieving a maximum for level 0 thereof (2 % of sulfuric acid). The sequential acid-base pretreatment was optimized and it was found that this pretreatment improves enzymatic hydrolysis of pine sawdust respect to unpretreated samples. The amount of reducing sugars obtained was comparable to that obtained by other authors.Fil: Rodríguez, María Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Provincia de Mendoza. Instituto Argentino de Investigaciones de las Zonas Áridas. Universidad Nacional de Cuyo. Instituto Argentino de Investigaciones de las Zonas Áridas; ArgentinaFil: Castrillo, María Lorena. Universidad Nacional de Misiones. Facultad de Cs.exactas Quimicas y Naturales. Departamento de Bioquimica Clinica. Laboratorio de Biotecnologia Molecular; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Velázquez, Juan Ernesto. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Quimicas y Naturales. Departamento de Bioquimica Clinica. Laboratorio de Biotecnologia Molecular; ArgentinaFil: Kramer, Gustavo Raul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Materiales de Misiones. Universidad Nacional de Misiones. Facultad de Ciencias Exactas Químicas y Naturales. Instituto de Materiales de Misiones; ArgentinaFil: Sedler, Cyntia Ingeborg. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Quimicas y Naturales. Departamento de Bioquimica Clinica. Laboratorio de Biotecnologia Molecular; ArgentinaFil: Zapata, Pedro Dario. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Misiones. Facultad de Cs.exactas Quimicas y Naturales. Departamento de Bioquimica Clinica. Laboratorio de Biotecnologia Molecular; ArgentinaFil: Villalba, Laura. Universidad Nacional de Misiones. Facultad de Cs.exactas Quimicas y Naturales. Departamento de Bioquimica Clinica. Laboratorio de Biotecnologia Molecular; Argentin

INCLUSÃO SOCIAL PARA PACIENTE COM DEFICIÊNCIA: UM NOVO MOTIVO PARA SORRIR

Há séculos a sociedade encontra dificuldades em lidar com indivíduos com deficiências. Essas dificuldades são frutos do legado histórico e da falta de informação, gerando preconceito e despreparo da sociedade para atendê-los. As pessoas com deficiências são indivíduos que possuem alterações físicas, intelectuais, sociais e/ou emocionais e que necessitam de educação especial e instruções suplementares temporárias ou definitivas. A inclusão social pressupõe que todo ser humano tenha direito à educação, saúde, cultura, lazer, trabalho, assistência social, além de acesso à informação, comunicação, meios de transporte e locais de convivência. Neste sentido, a assistência odontológica precisa ser incentivada.  O presente trabalho tem como objetivo apresentar um caso clínico de um paciente deficiente com 17 anos, que apresentava dificuldades de acesso ao mercado de trabalho em função de sua condição bucal. Após o tratamento realizado no Projeto de Extensão “Conquistando Saúde: Atendimento de pacientes com deficiências” da ULBRA/RS, o paciente teve sua auto-estima elevada e inclusão social resgatada. For many centuries, society has been having difficulties dealing with disabled individuals. Such difficulties are a result of historical legacy and lack of information, which generates prejudice and makes society unable to provide care to these people. Disabled individuals have physical, intellectual, social and/or emotional alterations and they need to receive special education and temporary and definitive additional instructions. Social inclusion is based on the fact that every human being has the right to education, health, culture, leisure, work, social care, as well as access to information, communication, means of transport, and venues to get together. In that sense, dental care must be promoted. The objective of the present study is to report on a clinical case of a 17-year-old disabled patient who was having difficulties getting a job due to his oral condition. After being treated in the Extracurricular Project "Achieving Health:  Disabled Patients' Care" of ULBRA/RS, the patient's self-esteem was higher and he was socially included. Desde hace siglos la sociedad encuentra dificultades en tratar con individuos con deficiencias. Esas dificultades son frutos del legado histórico y de la falta de información, generando prejuicio y falta de preparación de la sociedad para atenderlos. Las personas con deficiencia son individuos que poseen alteraciones físicas, intelectuales, sociales y/o emocionales y que necesitan de educación especial e instrucciones suplementarias temporales o definitivas. La inclusión social presupone que todo ser humano tenga derecho a la educación, la salud, la cultura, el ocio, el trabajo, la asistencia social, además de acceso a la información, la comunicación, los medios de transporte y los locales de convivencia. En este sentido, la asistencia odontológica necesita ser incentivada.  El presente trabajo tiene por objetivo presentar un caso clínico de un paciente deficiente con 17 años, que presentaba dificultades de acceso al mercado laboral en función de su condición bucal. Después del tratamiento realizado en el Proyecto de Extensión “Conquistando Salud: Atención a pacientes con deficiencias”, de ULBRA/RS, el paciente tuvo su autoestima elevada e inclusión social rescatada.

MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

SummaryThe MDM2 oncoprotein ubiquitinates and antagonizes p53 but may also carry out p53-independent functions. Here we report that MDM2 is required for the efficient generation of induced pluripotent stem cells (iPSCs) from murine embryonic fibroblasts, in the absence of p53. Similarly, MDM2 depletion in the context of p53 deficiency also promoted the differentiation of human mesenchymal stem cells and diminished clonogenic survival of cancer cells. Most of the MDM2-controlled genes also responded to the inactivation of the Polycomb Repressor Complex 2 (PRC2) and its catalytic component EZH2. MDM2 physically associated with EZH2 on chromatin, enhancing the trimethylation of histone 3 at lysine 27 and the ubiquitination of histone 2A at lysine 119 (H2AK119) at its target genes. Removing MDM2 simultaneously with the H2AK119 E3 ligase Ring1B/RNF2 further induced these genes and synthetically arrested cell proliferation. In conclusion, MDM2 supports the Polycomb-mediated repression of lineage-specific genes, independent of p53

Shotgun Lipidomics Discovered Diurnal Regulation of Lipid Metabolism Linked to Insulin Sensitivity in Nondiabetic Men.

CONTEXT: Meal timing affects metabolic homeostasis and body weight, but how composition and timing of meals affect plasma lipidomics in humans is not well studied. OBJECTIVE: We used high throughput shotgun plasma lipidomics to investigate effects of timing of carbohydrate and fat intake on lipid metabolism and its relation to glycemic control. DESIGN: 29 nondiabetic men consumed (1) a high-carb test meal (MTT-HC) at 09.00 and a high-fat meal (MTT-HF) at 15.40; or (2) MTT-HF at 09.00 and MTT-HC at 15.40. Blood was sampled before and 180 minutes after completion of each MTT. Subcutaneous adipose tissue (SAT) was collected after overnight fast and both MTTs. Prior to each investigation day, participants consumed a 4-week isocaloric diet of the same composition: (1) high-carb meals until 13.30 and high-fat meals between 16.30 and 22:00 or (2) the inverse order. RESULTS: 12 hour daily lipid patterns showed a complex regulation by both the time of day (67.8%) and meal composition (55.4%). A third of lipids showed a diurnal variation in postprandial responses to the same meal with mostly higher responses in the morning than in the afternoon. Triacylglycerols containing shorter and more saturated fatty acids were enriched in the morning. SAT transcripts involved in fatty acid synthesis and desaturation showed no diurnal variation. Diurnal changes of 7 lipid classes were negatively associated with insulin sensitivity, but not with glucose and insulin response or insulin secretion. CONCLUSIONS: This study identified postprandial plasma lipid profiles as being strongly affected by meal timing and associated with insulin sensitivity

Heatwave-associated Vibrio infections in Germany, 2018 and 2019

Background: Vibrio spp. are aquatic bacteria that prefer warm seawater with moderate salinity. In humans, they can cause gastroenteritis, wound infections, and ear infections. During the summers of 2018 and 2019, unprecedented high sea surface temperatures were recorded in the German Baltic Sea. Aim: We aimed to describe the clinical course and microbiological characteristics of Vibrio infections in Germany in 2018 and 2019. Methods: We performed an observational retrospective multi-centre cohort study of patients diagnosed with domestically-acquired Vibrio infections in Germany in 2018 and 2019. Demographic, clinical, and microbiological data were assessed, and isolates were subjected to whole genome sequencing and antimicrobial susceptibility testing. Results: Of the 63 patients with Vibrio infections, most contracted the virus between June and September, primarily in the Baltic Sea: 44 (70%) were male and the median age was 65 years (range: 2–93 years). Thirty-eight patients presented with wound infections, 16 with ear infections, six with gastroenteritis, two with pneumonia (after seawater aspiration) and one with primary septicaemia. The majority of infections were attributed to V. cholerae (non–O1/non-O139) (n = 30; 48%) or V. vulnificus (n = 22; 38%). Phylogenetic analyses of 12 available isolates showed clusters of three identical strains of V. vulnificus, which caused wound infections, suggesting that some clonal lines can spread across the Baltic Sea. Conclusions: During the summers of 2018 and 2019, severe heatwaves facilitated increased numbers of Vibrio infections in Germany. Since climate change is likely to favour the proliferation of these bacteria, a further increase in Vibrio-associated diseases is expected.Peer Reviewe