Strategy for implementing stabilizer-based codes on solid-state qubits

We present a method for implementing stabilizer-based codes with encoding schemes of the operator quantum error correction paradigm, e.g., the "standard" five-qubit and CSS codes, on solid-state qubits with Ising or XY-type interactions. Using pulse sequences, we show how to induce the effective dynamics of the stabilizer Hamiltonian, the sum of an appropriate set of stabilizer operators for a given code. Within this approach, the encoded states (ground states of the stabilizer Hamiltonian) can be prepared without measurements and preserved against both the time evolution governed by the original qubit Hamiltonian, and energy-nonconserving errors caused by the environment.Comment: 5 pages, 1 figur

Preserving universal resources for one-way quantum computing

The common spin Hamiltonians such as the Ising, XY, or Heisenberg model do not have ground states that are the graph states needed in measurement-based quantum computation. Various highly-entangled many-body states have been suggested as a universal resource for this type of computation, however, it is not easy to preserve these states in solid-state systems due to their short coherence times. Here we propose a scheme for generating a Hamiltonian that has a cluster state as ground state. Our approach employs a series of pulse sequences inspired by established NMR techniques and holds promise for applications in many areas of quantum information processing.Comment: 5 pages, 2 figure

Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats

Bartonella spp. are globally distributed bacteria that cause endocarditis in humans and domestic animals. Recent work has suggested bats as zoonotic reservoirs of some human Bartonella infections; however, the ecological and spatiotemporal patterns of infection in bats remain largely unknown. Here we studied the genetic diversity, prevalence of infection across seasons and years, individual risk factors, and possible transmission routes of Bartonella in populations of common vampire bats (Desmodus rotundus) in Peru and Belize, for which high infection prevalence has previously been reported. Phylogenetic analysis of the gltA gene for a subset of PCR-positive blood samples revealed sequences that were related to Bartonella described from vampire bats from Mexico, other Neotropical bat species, and streblid bat flies. Sequences associated with vampire bats clustered significantly by country but commonly spanned Central and South America, implying limited spatial structure. Stable and nonzero Bartonella prevalence between years supported endemic transmission in all sites. The odds of Bartonella infection for individual bats was unrelated to the intensity of bat flies ectoparasitism, but nearly all infected bats were infested, which precluded conclusive assessment of support for vector-borne transmission. While metagenomic sequencing found no strong evidence of Bartonella DNA in pooled bat saliva and fecal samples, we detected PCR positivity in individual saliva and feces, suggesting the potential for bacterial transmission through both direct contact (i.e., biting) and environmental (i.e., fecal) exposures. Further investigating the relative contributions of direct contact, environmental, and vector-borne transmission for bat Bartonella is an important next step to predict infection dynamics within bats and the risks of human and livestock exposures

Localised edge states nucleate turbulence in extended plane Couette cells

We study the turbulence transition of plane Couette flow in large domains where localised perturbations are observed to generate growing turbulent spots. Extending previous studies on the boundary between laminar and turbulent dynamics we determine invariant structures intermediate between laminar and turbulent flow. In wide but short domains we find states that are localised in spanwise direction, and in wide and long domains the states are also localised in downstream direction. These localised states act as critical nuclei for the transition to turbulence in spatially extended domains.Comment: 15 pages, 5 figure

Direct determination of vibrational density of states change on ligand binding to a protein

The change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium

Predictors and immunological correlates of sublethal mercury exposure in vampire bats

Mercury (Hg) is a pervasive heavy metal that often enters the environment from anthropogenic sources such as gold mining and agriculture. Chronic exposure to Hg can impair immune function, reducing the ability of animals to resist or recover from infections. How Hg influences immunity and susceptibility remains unknown for bats, which appear immunologically distinct from other mammals and are reservoir hosts of many pathogens of importance to human and animal health. We here quantify total Hg (THg) in hair collected from common vampire bats (Desmodus rotundus), which feed on blood and are the main reservoir hosts of rabies virus in Latin America. We examine how diet, sampling site and year, and bat demography influence THg and test the consequences of this variation for eight immune measures. In two populations from Belize, THg concentrations in bats were best explained by an interaction between long-term diet inferred from stable isotopes and year. Bats that foraged more consistently on domestic animals exhibited higher THg. However, relationships between diet and THg were evident only in 2015 but not in 2014, which could reflect recent environmental perturbations associated with agriculture. THg concentrations were low relative to values previously observed in other bat species but still correlated with bat immunity. Bats with higher THg had more neutrophils, weaker bacterial killing ability and impaired innate immunity. These patterns suggest that temporal variation in Hg exposure may impair bat innate immunity and increase susceptibility to pathogens such as bacteria. Unexpected associations between low-level Hg exposure and immune function underscore the need to better understand the environmental sources of Hg exposure in bats and the consequences for bat immunity and susceptibility

Palladium(II)-Catalyzed Dicarboxymethylation of Chiral Allylic Alcohols: Chirality Transfer Affording Optically Active Diesters Containing Three Contiguous Chiral Centers

This manuscript describes the extension of Stille’s palladium-catalyzed olefin dicarbonylation reaction to chiral allylic alcohols with chirality transfer to afford the corresponding chiral alcohol functionalized with bis-carbomethoxy esters, containing three contiguous chiral centers, in good to excellent diastereoselectivities (78–98%)

Synthesis of an Ortho-Triazacyclophane: N,N\u27,N\u27\u27-Trimethyltribenzo-1,4,7-triazacyclononatriene

N,N\u27,N\u27\u27-Trimethyltribenzo-1,4,7-triazacyclononatriene has been synthesized via sequential palladium-catalyzed Buchwald-Hartwig N-arylation reactions affording the 9-membered triaza o-cyclophane in 35% overall yield. An X-ray crystal structure shows the new cyclophane to have a C(2)-symmetric saddle conformation, as compared to the crown conformation exhibited by the related carbocyclic cyclotriveratrylene (CTV)

Lysine Biosynthesis in Bacteria: A Metallodesuccinylase as a Potential Antimicrobial Target

In this review, we summarize the recent literature on dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE) enzymes, with an emphasis on structure–function studies that provide insight into the catalytic mechanism. Crystallographic data have also provided insight into residues that might be involved in substrate and hence inhibitor recognition and binding. These data have led to the design and synthesis of several new DapE inhibitors, which are described along with what is known about how inhibitors interact with the active site of DapE enzymes, including the efficacy of a moderately strong DapE inhibitor