3,336 research outputs found
Surface-confined molecular coolers for cryogenics
An excellent molecule-based cryogenic magnetic refrigerant, gadolinium
acetate tetrahydrate, is here used to decorate selected portions of silicon
substrate. By quantitative magnetic force microscopy for variable applied
magnetic field near liquid-helium temperature, we demonstrate that the
molecules hold intact their magnetic properties, and therefore their cooling
functionality, after their deposition. Our result represents a step forward
towards the realization of a molecule-based microrefrigerating device for very
low temperatures.Comment: 16 pages, 4+1 figures, S.I. available from author
Towards an understanding of the rapid decline of the cosmic star formation rate
We present a first analysis of deep 24 micron observations with the Spitzer
Space Telescope of a sample of nearly 1500 galaxies in a thin redshift slice,
0.65<z<0.75. We combine the infrared data with redshifts, rest-frame
luminosities, and colors from COMBO-17, and with morphologies from Hubble Space
Telescope images collected by the GEMS and GOODS projects. To characterize the
decline in star-formation rate (SFR) since z~0.7, we estimate the total thermal
infrared (IR) luminosities, SFRs, and stellar masses for the galaxies in this
sample. At z~0.7, nearly 40% of intermediate and high-mass galaxies (with
stellar masses >2x10^10 solar masses) are undergoing a period of intense star
formation above their past-averaged SFR. In contrast, less than 1% of
equally-massive galaxies in the local universe have similarly intense star
formation activity. Morphologically-undisturbed galaxies dominate the total
infrared luminosity density and SFR density: at z~0.7, more than half of the
intensely star-forming galaxies have spiral morphologies, whereas less than
\~30% are strongly interacting. Thus, a decline in major-merger rate is not the
underlying cause of the rapid decline in cosmic SFR since z~0.7. Physical
properties that do not strongly affect galaxy morphology - for example, gas
consumption and weak interactions with small satellite galaxies - appear to be
responsible.Comment: To appear in the Astrophysical Journal 1 June 2005. 14 pages with 8
embedded figure
Age Determination of Six Intermediate-age SMC Star Clusters with HST/ACS
We present a photometric analysis of the star clusters Lindsay 1, Kron 3,
NGC339, NGC416, Lindsay 38, and NGC419 in the Small Magellanic Cloud (SMC),
observed with the Hubble Space Telescope Advanced Camera for Surveys (ACS) in
the F555W and F814W filters. Our color magnitude diagrams (CMDs) extend ~3.5
mag deeper than the main-sequence turnoff points, deeper than any previous
data. Cluster ages were derived using three different isochrone models: Padova,
Teramo, and Dartmouth, which are all available in the ACS photometric system.
Fitting observed ridgelines for each cluster, we provide a homogeneous and
unique set of low-metallicity, single-age fiducial isochrones. The cluster CMDs
are best approximated by the Dartmouth isochrones for all clusters, except for
NGC419 where the Padova isochrones provided the best fit. The CMD of NGC419
shows several main-sequence turn-offs, which belong to the cluster and to the
SMC field. We thus derive an age range of 1.2-1.6 Gyr for NGC419.
Interestingly, our intermediate-age star clusters have a metallicity spread of
~0.6 dex, which demonstrates that the SMC does not have a smooth, monotonic
age-metallicity relation. We find an indication for centrally concentrated blue
straggler star candidates in NGC416, while for the other clusters these are not
present. Using the red clump magnitudes, we find that the closest cluster,
NGC419 (~50kpc), and the farthest cluster, Lindsay 38 (~67kpc), have a relative
distance of ~17kpc, which confirms the large depth of the SMC.Comment: 25 pages, 45 Figure
Human adipose-derived mesenchymal stem cell-conditioned medium ameliorates polyneuropathy and foot ulceration in diabetic BKS db/db mice
Background: Diabetic polyneuropathy (DPN) is the most common and early developing complication of diabetes mellitus, and the key contributor for foot ulcers development, with no specific therapies available. Different studies have shown that mesenchymal stem cell (MSC) administration is able to ameliorate DPN; however, limited cell survival and safety reasons hinder its transfer from bench to bedside. MSCs secrete a broad range of antioxidant, neuroprotective, angiogenic, and immunomodulatory factors (known as conditioned medium), which are all decreased in the peripheral nerves of diabetic patients. Furthermore, the abundance of these factors can be boosted in vitro by incubating MSCs with a preconditioning stimulus, enhancing their therapeutic efficacy. We hypothesize that systemic administration of conditioned medium derived from preconditioned MSCs could reverse DPN and prevent foot ulcer formation in a mouse model of type II diabetes mellitus. Methods: Diabetic BKS db/db mice were treated with systemic administration of conditioned medium derived from preconditioned human MSCs; conditioned medium derived from non-preconditioned MSCs or vehicle after behavioral signs of DPN was already present. Conditioned medium or vehicle administration was repeated every 2 weeks for a total of four administrations, and several functional and structural parameters characteristic of DPN were evaluated. Finally, a wound was made in the dorsal surface of both feet, and the kinetics of wound closure, re-epithelialization, angiogenesis, and cell proliferation were evaluated. Results: Our molecular, electrophysiological, and histological analysis demonstrated that the administration of conditioned medium derived from non-preconditioned MSCs or from preconditioned MSCs to diabetic BKS db/db mice strongly reverts the established DPN, improving thermal and mechanical sensitivity, restoring intraepidermal nerve fiber density, reducing neuron and Schwann cell apoptosis, improving angiogenesis, and reducing chronic inflammation of peripheral nerves. Furthermore, DPN reversion induced by conditioned medium administration enhances the wound healing process by accelerating wound closure, improving the re-epithelialization of the injured skin and increasing blood vessels in the wound bed in a skin injury model that mimics a foot ulcer. Conclusions: Studies conducted indicate that MSC-conditioned medium administration could be a novel cell-free therapeutic approach to reverse the initial stages of DPN, avoiding the risk of lower limb amputation triggered by foot ulcer formation and accelerating the wound healing process in case it occurs.Fil: De Gregorio, Cristian. Universidad del Desarrollo; ChileFil: Contador, David. Universidad del Desarrollo; ChileFil: DĂaz, Diego. Universidad del Desarrollo; ChileFil: CĂĄrcamo, Constanza. Universidad del Desarrollo; ChileFil: Santapau, Daniela. Universidad del Desarrollo; ChileFil: Lobos Gonzalez, Lorena. Universidad del Desarrollo; ChileFil: Acosta, Cristian Gabriel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - Mendoza. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias MĂ©dicas. Instituto de HistologĂa y EmbriologĂa de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Campero, Mario. Universidad de Chile; ChileFil: Carpio, Daniel. Universidad Austral de Chile; ChileFil: Gabriele, Caterina. University Of Catanzaro; ItaliaFil: Gaspari, Marco. University Of Catanzaro; ItaliaFil: Aliaga Tobar, Victor. Universidad de Chile; ChileFil: Maracaja Coutinho, Vinicius. Universidad de Chile; ChileFil: Ezquer, Marcelo. Universidad del Desarrollo; ChileFil: Ezquer, Fernando. Universidad del Desarrollo; Chil
European achievements in soil remediation and brownfield redevelopment
With the aim of sharing best practices of soil restoration and management of contaminated sites among European countries and to raise awareness of the enormous efforts made to succeed in such difficult commitment, the experts of the EIONET Soil working group on contaminated sites and brownfields agreed to gather their country's interesting cases and successful stories of recovery of contaminated areas. This second edition of the monograph presents seventeen new cases from eight European countries and its Regions of how polluted sites and brownfields have been remediated like new methodologies of sustainable restoration of the subsoil, development of innovative technologies, and funding mechanisms etc. These stories have been compiled to present what national, regional or local governments are doing to improve the quality of the environment and the living conditions of their population. A second aim is the promotion of best practices among industry, consultancies and business operators.JRC.D.3-Land Resource
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