148 research outputs found
Stochastic Block Mirror Descent Methods for Nonsmooth and Stochastic Optimization
- Author
- Publication venue
- Publication date
- 09/09/2013
- Field of study
In this paper, we present a new stochastic algorithm, namely the stochastic
block mirror descent (SBMD) method for solving large-scale nonsmooth and
stochastic optimization problems. The basic idea of this algorithm is to
incorporate the block-coordinate decomposition and an incremental block
averaging scheme into the classic (stochastic) mirror-descent method, in order
to significantly reduce the cost per iteration of the latter algorithm. We
establish the rate of convergence of the SBMD method along with its associated
large-deviation results for solving general nonsmooth and stochastic
optimization problems. We also introduce different variants of this method and
establish their rate of convergence for solving strongly convex, smooth, and
composite optimization problems, as well as certain nonconvex optimization
problems. To the best of our knowledge, all these developments related to the
SBMD methods are new in the stochastic optimization literature. Moreover, some
of our results also seem to be new for block coordinate descent methods for
deterministic optimization
Linearly Convergent First-Order Algorithms for Semi-definite Programming
- Author
- Publication venue
- Publication date
- 09/09/2013
- Field of study
In this paper, we consider two formulations for Linear Matrix Inequalities
(LMIs) under Slater type constraint qualification assumption, namely, SDP
smooth and non-smooth formulations. We also propose two first-order linearly
convergent algorithms for solving these formulations. Moreover, we introduce a
bundle-level method which converges linearly uniformly for both smooth and
non-smooth problems and does not require any smoothness information. The
convergence properties of these algorithms are also discussed. Finally, we
consider a special case of LMIs, linear system of inequalities, and show that a
linearly convergent algorithm can be obtained under a weaker assumption
On Pre-Commitment Aspects of a Time-Consistent Strategy for a Mean-Variance Investor
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
Logging intensity drives variability in carbon stocks in lowland forests in Vietnam
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Forest degradation in the tropics is generating large carbon (C) emissions. In tropical Asia, logging is the main driver of forest degradation. For effective implementation of REDD+ projects in logged forests in Southeast Asia, the impacts of logging on forest C stocks need to be assessed. Here, we assess C stocks in logged lowland forests in central Vietnam and explore correlations between logging intensity, soil, topography and living aboveground carbon (AGC) stocks. We present an approach to estimate historical logging intensities for the prevalent situation when complete records on logging history are unavailable. Landsat analysis and participatory mapping were used to quantify the density of historical disturbances, used as a proxy of logging intensities in the area. Carbon in AGC, dead wood, belowground carbon (BGC) and soil (SOC) was measured in twenty-four 0.25 ha plots that vary in logging intensity, and data on recent logging, soil properties, elevation and slope were also collected. Heavily logged forests stored only half the amount of AGC of stems ≥10 cm dbh as lightly logged forests, mainly due to a reduction in the number of large (≥60 cm dbh) trees. Carbon in AGC of small trees (5–10 cm dbh), dead wood and BGC comprised only small fractions of total C stocks, while SOC in the topsoil of 0–30 cm depth stored ~50% of total C stocks. Combining logging intensities with soil and topographic data showed that logging intensity was the main factor explaining the variability in AGC. Our research shows large reductions in AGC in medium and heavily logged forests. It highlights the critical importance of conserving big trees to maintain high forest C stocks and accounting for SOC in total C stock estimates
Immunological properties of Oxygen-Transport Proteins: Hemoglobin, Hemocyanin and Hemerythrin
- Author
- A Dhainaut
- A Dolashki
- A Machado
- A Meyer
- A Pallavicini
- AC Fogaca
- AF Riggs
- AI Alayash
- AJ Gow
- AJ Ullal
- AJ Ullal
- AM Swartz
- AN Schechter
- B Lieb
- B Moltedo
- B Salzet-Raveillon
- B Vanhollebeke
- B Xu
- C Dang
- C Gatsogiannis
- C Gatsogiannis
- C Hellio
- C Liepke
- C Lisk
- C Manwell
- C Qiu
- CA Parish
- CE French
- Christopher J. Coates
- CJ Coates
- CJ Coates
- CJ Coates
- CJ Coates
- CJ Coates
- D Destoumieux-Garzon
- D Guo
- D Hobson
- D Miles
- D Morera
- D Morera
- D Vergote
- D Yang
- DA Newton
- DB Allen
- DC Pimenta
- DJ Autelitano
- DJ Schaer
- DJ Schaer
- DL Zhang
- DM Lorenzini
- E Beutler
- E Jaenicke
- E Schwarzer
- E Schwarzer
- E Solem
- EF Pettersen
- G Galvez-Romero
- G Terova
- GJ Kato
- H Choi
- H Decker
- H Decker
- H Decker
- H Decker
- H Decker
- H Yang
- Heinz Decker
- HR Ibrahim
- J Bechsgaard
- J Hu
- J Jandaruang
- J Kommanee
- J Markl
- J Ruggiero Bachega
- J Wright
- J Zhuang
- JB Wittenberg
- JH Ner
- JK Seo
- JL Gifford
- JMO Fernandes
- K Adachi
- K Adachi
- K Conceição
- K Jonsson
- K Suzuki
- KCT Riciluca
- KE Van-Holde
- KW Sanggaard
- L Cerenius
- L Cerenius
- L Coutte
- L Deloffre
- L Deng
- L Fan
- L Guo
- L Liu
- L Zheng
- LAC Carvalho
- M Goldfeder
- M Guncheva
- M Guncheva
- M Kanteev
- M Kokkinopoulou
- M Kokkinopoulou
- M Meloni
- M Rolff
- MA Menze
- ME Ricci-Silva
- ML Sforca
- MP Soares
- N Bahl
- N Bahl
- N Hellmann
- N Jiang
- N Nedjar-Arroume
- N Nedjar-Arroume
- NB Terwilliger
- NI Siddiqui
- O Antonova
- O Bochenska
- P Ascenzi
- P Dolashka
- P Dolashka
- P Dolashka
- P Dolashka-Angelova
- P Mak
- P Mak
- P Mak
- P Mak
- P Mak
- P Mak
- P Mak
- P Munoz
- PJ Sabbatini
- Q Zhang
- R Belmonte
- R Daoud
- R Du
- R Du
- R Froidevaux
- R Hristova
- R Paul
- R Perdomo-Morales
- RA Friesner
- RE Stenkamp
- RL Auten
- S Akira
- S Arancibia
- S Arancibia
- S Arya
- S Baird
- S Demuynck
- S Demuynck
- S Itoh
- S Maijaroen
- S Preecharram
- S Schenk
- S Schreml
- S Singh
- S Srihongthong
- S Vanin
- S-J Cho
- SH Atkinson
- SK Lee
- SK Lee
- SL James
- SN Vinogradov
- ST Ong
- SY Lee
- SY Lee
- T Bashir
- T Burmester
- T Fan
- T Lin
- T Nagai
- TN Zanjani
- UK Hahn
- V Gesheva
- V Gesheva
- V Moeller
- VT Ivanov
- VW Petit
- W Bellamy
- WE Royer
- X Bailly
- X Lu
- X Zhao
- Y Bao
- Y Bao
- Y Bao
- Y Bao
- Y Cong
- Y Liu
- Y Nakajima
- Y Okamoto
- Y Qin
- Y Yuan
- Z Gai
- Á Sánchez-Ferrer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
- Alberto Ramirez Reyes H.
- Albuquerque A.
- Alcaravela J.
- Alcocer Gamba M.
- Alegret Colomer J. M.
- Alegria Ezquerra E.
- Alekseenko V.
- Alekseeva T.
- Alexanderson E.
- Alexopoulos I.
- Alford K.
- Alitto F.
- Alizon F.
- Allcock A.
- Almeida Fernandez C. A.
- Altevogt B. -M.
- Altmann U.
- Alvarenga Recalde N.
- Alvarez Aunon A.
- Alvarez Garcia P.
- Alvarez Gil J.
- Alvarez Ramires F. J.
- Alves Costa M.
- Alves C.
- Amiel Oster Sauvinet G.
- Amini R.
- Amlaiky A.
- Amo Fernandez C.
- Amor R.
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- Amoros Galito C.
- Anastasiou E.
- Ancin Viguiristi R.
- Ancliff H.
- Andersen L. K.
- Andreev E.
- Andreicheva E.
- Andrews M.
- Ang C. C.
- Angela R.
- Anghel M.
- Ansalone G.
- Antia V.
- Antona Makoshi J.
- Antonelli G.
- Antoniadis G. A.
- Antonicelli R.
- Antunes J.
- Aparici Feal M.
- Apinyasawat S.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Consistent patterns of common species across tropical tree communities
- Author
- Adu-Bredu Stephen
- Affum-Baffoe Kofi
- Ahuite Reategui Manuel Augusto
- Aiba Shin-Ichiro
- Albuquerque Bianca Weiss
- Alonso Alfonso
- Amani Christian A.
- Andrade Ana
- Angoboy Ilondea B.
- Araujo-Murakami Alejandro
- Arboleda Nicolás Castaño
- Arroyo Luzmila
- Ashton Peter
- Aymard C Gerardo A.
- Baider Cláudia
- Baker Timothy R.
- Balinga Michael Philippe Bessike
- Balslev Henrik
- Banin Lindsay F.
- Baraloto Chris
- Barbier Nicolas
- Barbosa Edelcilio Marques
- Barbosa Flávia Rodrigues
- Barlow Jos
- Bastin Jean-Francois
- Beeckman Hans
- Begne Serge
- Bengone Natacha Nssi
- Berenguer Erika
- Berry Nicholas
- Bitariho Robert
- Boeckx Pascal
- Bogaert Jan
- Bonyoma Bernard
- Boundja Patrick
- Bourland Nils
- Boyemba Bosela Faustin
- Brambach Fabian
- Brienen Roel
- Burslem David F. R. P.
- Bánki Olaf S.
- Camargo José Luís
- Campelo Wegliane
- Cano Angela
- Carrero Márquez Yrma Andreina
- Carvalho Fernanda Antunes
- Casas Luisa Fernanda
- Castellanos Hernán
- Castilho Carolina V.
- Cerón Carlos
- Chapman Colin A.
- Chave Jerome
- Chhang Phourin
- Chutipong Wanlop
- Chuyong George B.
- Cintra Bruno Barçante Ladvocat
- Clark Connie J.
- Coelho de Souza Fernanda
- Comiskey James A.
- Coomes David A.
- Cooper Declan L. M.
- Cornejo Valverde Fernando
- Correa Diego F.
- Costa Flávia R. C.
- Costa Janaina Barbosa Pedrosa
- Couteron Pierre
- Culmsee Heike
- Cuni-Sanchez Aida
- Cárdenas López Dairon
- Cárdenas Sasha
- da Silva Guimarães José Renan
- Dallmeier Francisco
- Damasco Gabriel
- Dauby Gilles
- de Aguiar Daniel P. P.
- De Alban Jose Don T.
- de Almeida Matos Francisca Dionízia
- de Andrade Miranda Ires Paula
- de Assis Rafael L.
- De Canniere Charles
- De Haulleville Thales
- de Jesus Veiga Carim Marcelo
- de Medeiros Marcelo Brilhante
- de Oliveira Edmar Almeida
- de Queiroz Helder Lima
- de Sousa Farias Emanuelle
- de Souza Coelho Luiz
- de Sá Carpanedo Rainiellen
- de Toledo José Julio
- Demarchi Layon O.
- Dexter Kyle G.
- Di Fiore Anthony
- Din Hazimah Haji Mohammad
- Disney Mathias I.
- Djiofack Brice Yannick
- Djuikouo Marie-Noël K.
- do Amaral Dário Dantas
- do Amaral Iêda Leão
- Do Tran Van
- Doucet Jean-Louis
- Draper Freddie C.
- Droissart Vincent
- Duivenvoorden Joost F.
- Dávila Doza Hilda Paulette
- Dávila Nállarett
- Engel Julien
- Estienne Vittoria
- Ewango Corneille E. N.
- Farfan-Rios William
- Fauset Sophie
- Feeley Kenneth J.
- Feitosa Yuri Oliveira
- Feldpausch Ted R.
- Ferreira Cid
- Ferreira Joice
- Ferreira Leandro Valle
- Fletcher Christine D.
- Flores Bernardo Monteiro
- Fofanah Alusine
- Foli Ernest G.
- Fonty Émile
- Fredriksson Gabriella M.
- Fuentes Alfredo
- Galbraith David
- Gallardo Gonzales George Pepe
- Garcia-Cabrera Karina
- García-Villacorta Roosevelt
- Gomes Vitor H. F.
- Gonzales Therany
- Gribel Rogerio
- Guedes Marcelino Carneiro
- Guevara Juan Ernesto
- Gómez Ricardo Zárate
- Hakeem Khalid Rehman
- Hall Jefferson S.
- Hamer Keith C.
- Hamilton Alan C.
- Harris David J.
- Harrison Rhett D.
- Hart Terese B.
- Hector Andy
- Henkel Terry W.
- Herbohn John
- Hockemba Mireille B. N.
- Hoffman Bruce
- Holmgren Milena
- Honorio Coronado Euridice N.
- Huamantupa-Chuquimaco Isau
- Hubau Wannes
- Imai Nobuo
- Irume Mariana Victória
- Jansen Patrick A.
- Jeffery Kathryn J.
- Jimenez Eliana M.
- Jucker Tommaso
- Junqueira André Braga
- Kalamandeen Michelle
- Kamdem Narcisse G.
- Kartawinata Kuswata
- Kasongo Yakusu Emmanuel
- Katembo John M.
- Kearsley Elizabeth
- Kenfack David
- Kessler Michael
- Khaing Thiri Toe
- Killeen Timothy J.
- Kitayama Kanehiro
- Klitgaard Bente
- Labrière Nicolas
- Laumonier Yves
- Laurance Susan G. W.
- Laurance William F.
- Laurent Félix
- Le Tinh Cong
- Le Trai Trong
- Leal Miguel E.
- Levesley Aurora
- Lewis Simon L.
- Leão de Moraes Novo Evlyn Márcia
- Libalah Moses B.
- Licona Juan Carlos
- Lima Filho Diógenes de Andrade
- Lindsell Jeremy A.
- Lopes Aline
- Lopes Maria Aparecida
- Lovett Jon C.
- Lowe Richard
- Lozada José Rafael
- Lu Xinghui
- Luambua Nestor K.
- Luize Bruno Garcia
- Maas Paul
- Magalhães José Leonardo Lima
- Magnusson William E.
- Mahayani Ni Putu Diana
- Makana Jean-Remy
- Malhi Yadvinder
- Maniguaje Rincón Lorena
- Mansor Asyraf
- Manzatto Angelo Gilberto
- Marimon Beatriz S.
- Marimon-Junior Ben Hur
- Marshall Andrew R
- Martins Maria Pires
- Mbayu Faustin M.
- Mesones Italo
- Metali Faizah
- Mihindou Vianet
- Millet Jerome
- Milliken William
- Mogollón Hugo F.
- Mohd. Said Mohd. Nizam
- Molino Jean-François
- Monteagudo Mendoza Abel
- Montero Juan Carlos
- Moore Sam
- Mostacedo Bonifacio
- Mozombite Pinto Linder Felipe
- Mukul Sharif Ahmed
- Munishi Pantaleo K. T.
- Nagamasu Hidetoshi
- Nascimento Henrique Eduardo Mendonça
- Nascimento Marcelo Trindade
- Neill David
- Nilus Reuben
- Noronha Janaína Costa
- Nsenga Laurent
- Núñez Vargas Percy
- Ojo Lucas
- Oliveira Alexandre A.
- Ondo Fidèle Evouna
- Palacios Cuenca Walter
- Pansini Susamar
- Pansonato Marcelo Petratti
- Paredes Marcos Ríos
- Paudel Ekananda
- Pauletto Daniela
- Pearson Richard G.
- Pena José Luis Marcelo
- Pennington R. Toby
- Peres Carlos A.
- Permana Andrea
- Petronelli Pascal
- Peñuela Mora Maria Cristina
- Phillips Juan Fernando
- Phillips Oliver L.
- Pickavance Georgia
- Piedade Maria Teresa Fernandez
- Pitman Nigel C. A.
- Ploton Pierre
- Popelier Andreas
- Poulsen John R.
- Prado Paulo I.
- Prieto Adriana
- Primack Richard B.
- Priyadi Hari
- Qie Lan
- Quaresma Adriano Costa
- Ramirez-Angulo Hirma
- Ramos José Ferreira
- Reis Neidiane Farias Costa
- Reitsma Jan
- Revilla Juan David Cardenas
- Riutta Terhi
- Rivas-Torres Gonzalo
- Robiansyah Iyan
- Rocha Maira
- Rodrigues Domingos de Jesus
- Rodriguez-Ronderos M. Elizabeth
- Rovero Francesco
- Rozak Andes H.
- Rudas Agustín
- Rutishauser Ervan
- Sabatier Daniel
- Sagang Le Bienfaiteur
- Sampaio Adeilza Felipe
- Samsoedin Ismayadi
- Satdichanh Manichanh
- Schietti Juliana
- Schöngart Jochen
- Scudeller Veridiana Vizoni
- Seuaturien Naret
- Sheil Douglas
- Sierra Rodrigo
- Silman Miles R.
- Silva Thiago Sanna Freire
- Simo-Droissart Murielle
- Simon Marcelo Fragomeni
- Sist Plinio
- Slik Ferry
- Sonké Bonaventure
- Sousa Thaiane R.
- Spracklen Dominick V.
- Stas Suzanne M.
- Steinmetz Robert
- Stevenson Pablo R.
- Stropp Juliana
- Sukri Rahayu S.
- Sullivan Martin J. P.
- Sunderland Terry C. H.
- Suzuki Eizi
- Swaine Michael D.
- Tang Jianwei
- Taplin James
- Taylor David M.
- Tello J. Sebastián
- ter Steege Hans
- Terborgh John
- Texier Nicolas
- Theilade Ida
- Thomas Duncan W.
- Thomas Raquel
- Thomas Sean C.
- Tirado Milton
- Toirambe Benjamin
- Tomlinson Kyle W.
- Torres-Lezama Armando
- Tran Hieu Dang
- Tshibamba Mukendi John
- Tumaneng Roven D.
- Umaña Maria Natalia
- Umunay Peter M.
- Urrego Giraldo Ligia Estela
- Valderrama Sandoval Elvis H.
- Valenzuela Gamarra Luis
- Van Andel Tinde R.
- van de Bult Martin
- van de Pol Jaqueline
- van der Heijden Geertje
- Vasquez Rodolfo
- Vela César I. A.
- Venticinque Eduardo Martins
- Verbeeck Hans
- Veridiano Rizza Karen A.
- Vicentini Alberto
- Vieira Ima Célia Guimarães
- Vilanova Torre Emilio
- Villa Zegarra Boris Eduardo
- Villarroel Daniel
- Vleminckx Jason
- von Hildebrand Patricio
- Vos Vincent Antoine
- Vriesendorp Corine
- Webb Edward L.
- White Lee J. T.
- Wich Serge
- Wittmann Florian
- Zagt Roderick
- Zang Runguo
- Zartman Charles Eugene
- Zemagho Lise
- Zent Egleé L.
- Zent Stanford
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Trees structure the Earth’s most biodiverse ecosystem, tropical forests. The vast number of tree species presents a formidable challenge to understanding these forests, including their response to environmental change, as very little is known about most tropical tree species. A focus on the common species may circumvent this challenge. Here we investigate abundance patterns of common tree species using inventory data on 1,003,805 trees with trunk diameters of at least 10 cm across 1,568 locations1,2,3,4,5,6 in closed-canopy, structurally intact old-growth tropical forests in Africa, Amazonia and Southeast Asia. We estimate that 2.2%, 2.2% and 2.3% of species comprise 50% of the tropical trees in these regions, respectively. Extrapolating across all closed-canopy tropical forests, we estimate that just 1,053 species comprise half of Earth’s 800 billion tropical trees with trunk diameters of at least 10 cm. Despite differing biogeographic, climatic and anthropogenic histories7, we find notably consistent patterns of common species and species abundance distributions across the continents. This suggests that fundamental mechanisms of tree community assembly may apply to all tropical forests. Resampling analyses show that the most common species are likely to belong to a manageable list of known species, enabling targeted efforts to understand their ecology. Although they do not detract from the importance of rare species, our results open new opportunities to understand the world’s most diverse forests, including modelling their response to environmental change, by focusing on the common species that constitute the majority of their trees.Publisher PDFPeer reviewe
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
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- Ahmed Shahana
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- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
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- Alleman Jennifer
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- Allen Heather
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- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
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- Amin Amita G.
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- Antonarakis Stylianos E.
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- Arredondo Dilrukshi P.
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- Hamilton Matt
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- Hamlett John
- Hammon Nancy
- Hammond Martin
- Hammond Sha
- Hammond Sian
- Hamza Khalid
- Han Guiqing
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- Hanak Vincent A.
- Hancock Julie
- Harbes Brandy A.
- Harding Adam
- Harkins C. Richard
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- Hashimoto Wakako
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- Haugen Eric
- Haussler David
- Havlak Paul
- Hawes Alicia C.
- Hawkins Ebere Sylvia Onyirioha
- Hawkins Natalie
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- Heyen Joshua
- Higgs Douglas
- Hildebrand Carl E.
- Hillier LaDeana
- Hillyard Guy
- Hines Sandra
- Hinkins Russell
- Hinrichs Angela S.
- Hitchens Matthew Edward
- Ho Issac
- Ho Sara-Jane
- Hodgson Anne V.
- Hodgson David
- Hoffman Susan M.G.
- Hoffs Michael
- Hogues Marilyn E.
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- Nakato Eriko
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- Nandkeshwar Richard
- Nankervis Colin E.
- Naranjo Cleo M.
- Nash William
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- Nwokenkwo Stanley
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- Okumura Reina
- Okwuonu Geoffrey O.
- Okwuonu Kenneth C.
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- Sheridan Elizabeth
- Sherpa Ngawang
- Shi Guibin
- Shi Hongfang
- Shibuya Kazunori
- Shiino Noriko
- Shimizu Atsushi
- Shimizu Hidetsugu
- Shimizu Nobuyoshi
- Shimizu Yoshiko
- Shin Maria
- Shindoh Nobuaki
- Shintani Ai
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- Shotland Yoram
- Shought Timothy
- Shownkeen Ratna
- Shreve Jeff
- Siddiqui Roman
- Siepel Adam C.
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- Sindelar Linda
- Sinha Prashant
- Sisson Ida
- Sivadasan Shanthi
- Sivadasan Shanthi
- Skowronski Evan
- Skuce Carl
- Skuce Carl
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- Slezak Tom
- Smedley Damian
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- Solovyez Victor
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- Squares Janet
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- Steffen David
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- Tabor Paul E.
- Tacey Kristina
- Tagett Beckie
- Tagney Matthew
- Tahara Takashi
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- Takano Nobuhiro
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- Takayanagi Atsushi
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- Talamas Jessica
- Tam Serena
- Tamerisa Kavitha S.
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- Tan Steven
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- Tang Xiangjun
- Tansey Jennifer
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- Tapia Roxanne
- Taring Elizabeth
- Tatsuyama Miho
- Tatum Owatha I.
- Taudien Stefan
- Taylor Amy
- Taylor Christina C.
- Taylor Gillian
- Taylor Kate
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- Taylor Sam
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- Taylor Tineace R.
- Taylor Todd Duane
- Tchuinga Pierre
- Tee Louise
- Telford Ethan Brett
- Tenzin Pema
- Terada Yoriko
- Terry Astrid
- Tesfaye Senait
- Tesmer Judith G.
- Tester Julieanne
- Thayer Nina
- Theaker Andrew
- Theil James
- Theodore Joumathe
- Thexton David
- Thies Stephanie
- Thomas Craig
- Thomas Daniel
- Thomas Daryl J.
- Thomas Karen
- Thomas Nicole
- Thomas Paulette
- Thomas Ruth
- Thomas Shereen
- Thommai Roselin
- Thompson Linda S.
- Thorne Rachel Diane
- Thorpe Andrea
- Thorpe Karen
- Thoulutsang Yama
- Threadgold Glen
- Thurston Scott
- Tian Chaoguang
- Tian Chaoguang
- Tian Wei
- Tian Yan
- Tian Yong
- Tian Yuqing
- Tice Hope
- Tighe Damon
- Tin-Wollam Aye M.
- Tinsley Emma
- Tochigi Miwako
- Togashi Naoko
- Tomizawa Iori
- Tomlinson Chad
- Tong Jingli
- Topham Kerri
- Torcaso Bill
- Torney David C.
- Totoki Yasushi
- Towey Sarah
- Toyoda Atsushi
- Tracey Alan
- Tran Ly Thanh
- Tran-Gyamfi Mary
- Trani Lee
- Trankiem Margie
- Trask Barbara J.
- Travers Johnathan
- Trejos Zulma Y.
- Treuhaft Marianne
- Trevino Brenda Kaye
- Tromans Anthony
- Trong Stephan
- Trumbower Heather
- Tsai Ming
- Tsamla Tsamla
- Tsolas Jason
- Tsomo Nawang
- Tsujimoto Susan
- Tsukamoto Yumi
- Tsuruoka Hiromi
- Tsuzuki Rina
- Tu Yuefeng
- Tu Yuefeng
- Tubby Ben
- Tufarelli Cristina
- Turner Heidi
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- Tynan Katherine
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- Un Chun
- Ung Quyen
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- Urban Jeremy B.
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- Ureta-Vidal Abel
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- Valle Duane
- Valles Yvonne
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- Vargas Michelle
- Vargo Charles E.
- Vartanian Steffan
- Vasquez Lydia I.
- Vassiliev Helen
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- Wang Huifeng
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- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
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- Wang Jingqiang
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- Wang Jun
- Wang Jun
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- Wang Lijie
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- Wang Suzhen
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- Wang Xiaoning
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- Wang Xuegang
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- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
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- Warren Graham
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- Warry Georgina
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- Wei Shulin
- Wei Xuehong
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- Weinstock Keith
- Weir John
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- Wells Sarah
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- Wen Gaiping
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- Wesley Mary Melissa
- West Paul
- West Tony
- Wetterstrand Kris
- Wheatley Angela
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- Wheeler Gideon
- Wheeler Jeremy
- Whitaker Hayley
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- Williamson Helen
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- Wilmer Tamsin
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- Wilson Margaret
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- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
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- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
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- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
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- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
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- Yao Zhijian
- Yao Zhijian
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- Ye Chen
- Yeager Shane
- Yeh Mimi
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- Yeshitela Rahel Retta
- Yoakum Martin
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- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
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- You Bo
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- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Araújo Ana Margarida
- Aravkin Aleksandr Y
- Aremu Abdulfatai
- Ariffin Hany
- Aripov Timur
- Armocida Benedetta
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azhar Gulrez Shah
- Aziz Shahkaar
- Azzam Ahmed Y
- Babashahi Mina
- Babu Abraham Samuel
- Badar Muhammad
- Badawi Alaa
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bai Jianjun
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balogun Saliu A
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Bansal Hansi
- Barati Shirin
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barr Ronald D
- Barrero Lope H
- Basharat Zarrin
- Bashir Asma'u I J
- Bashiru Hameed Akande
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso João Diogo
- Basu Saurav
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Begum Tahmina
- Behboudi Emad
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belgaumi Uzma Iqbal
- Bell Michelle L
- Bello Aminu K
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berezvai Zombor
- Berman Adam E
- Bermudez Amiel Nazer C
- Bettencourt Paulo J G
- Beyene Habtamu B
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Binmadi Nada
- Bintoro Bagas Suryo
- Biondi Antonio
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
- Biswas Raaj Kishore
- Bitaraf Saeid
- Bjørge Tone
- Bleyer Archie
- Boampong Mary Sefa
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bolarinwa Obasanjo Afolabi
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Bora Kaustubh
- Borodo Safiya Bala
- Borschmann Rohan
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boudalia Sofiane
- Boyko Edward J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brenner Hermann
- Britton Gabrielle
- Browne Annie J
- Brunoni Andre R
- Bulamu Norma B
- Bulto Lemma N
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Burugina Nagaraja Sharath
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Cai Tianji
- Calina Daniela
- Campos Luciana Aparecida
- Campos-Nonato Ismael R
- Cao Chao
- Cardenas Carlos Alberto
- Carr Sinclair
- Carreras Giulia
- Carrero Juan J
- Carugno Andrea
- Carvalho Felix
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catalá-López Ferrán
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cámera Luis Alberto
- Cárdenas Rosario
- Cederroth Christopher R
- Cembranel Francieli
- Cenderadewi Muthia
- Cercy Kelly M
- Cerin Ester
- Cevik Muge
- Chacón-Uscamaita Pamela R Uscamaita
- Chahine Yaacoub
- Chakraborty Chiranjib
- Chan Jeffrey Shi Kai
- Chang Chin-Kuo
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- Nejjari Chakib
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- Nepal Samata
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- Yao Yao
- Ye Pengpeng
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- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yiğit Arzu
- Yiğit Vahit
- Yip Paul
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- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
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- Zanghì Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
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