Archives et enjeux mémoriels

Mémoire du Master archives numériques portant sur l\u27affaire Maurras, une polémique mémorielle

Perancangan Identitas Sentul International Circuit

Indonesia sedang mendunia setelah sukses menggelar event balap dunia World Superbike (WSBK) dan Moto Gran Pix (MotoGP) di Mandalika, Lombok. Kesuksesan ini membuat nama Sentul International Circuit tersorot. Sentul International Circuit merupakan sejarah, pelopor dunia balap di Indonesia tersorot dan dibandingkan dengan kesuksesan yang diraih Pertamina Mandalika International Circuit yang baru memulai debutnya dengan menggelar WSBK dan MotoGP. Karena relevan, penulis tertarik untuk meneliti lebih lanjut untuk menjadikannya sebagai judul tugas akhir karena identitas yang dimiliki Sentul International ini sangat minim dan cenderung tidak memiliki identitas secara visual, hanya berupa logo. Setelah diteliti lebih dalam melalui wawancara bersama direktur niaga Sentul International Circuit, didapati bahwa Sentul International Circuit sedang menarget positioning baru. Namun sayang, keinginan itu tidak tercapai karena tidak mendapat support dari pemerintah dan mengakibatkan alokasi dana untuk identitas visual tidak ada hingga akhirnya menjadi tidak terurus. Setelah masalah dan urgensi didapatkan, maka dari itu penyelesaian masalah akan dilakuikan dengan rebranding

Microstructural evolution of a delta containing nickel-base superalloy during heat treatment and isothermal forging

The next generation of aerospace gas turbine engines need to operate at higher temperatures and stresses to improve their efficiency and reduce emissions. These operating conditions are beyond the capability of existing nickel-base superalloys, requiring the development of new high temperature materials. Controlling the microstructures of these new materials is key to obtaining the required properties and, therefore, it is critical to understand how these alloys respond to processing and heat treatment. Here, the microstructural evolution of V207M, a new δ containing, nickel-base superalloy, has been investigated following heat treatment and forging. The solvus temperatures of the γ′ and δ phases, determined by differential scanning calorimetry and microscopy, were found to be ~985 and ~1060 °C respectively. Isothermal forging of the alloy was conducted at 1000, 1050 and 1100 °C, corresponding to different volume fractions of retained δ. Considerable softening was observed prior to steady state flow when forging at 1000 °C, whilst only steady state flow occurred at 1050 and 1100 °C. The steady state flow process was believed to be dominated by dynamic recovery in the γ phase, with an activation energy of 407 kJmol−1. Samples that exhibited flow softening also showed a significant change in the orientation of the δ precipitates, preferentially aligning normal to the forging axis, and this reorientation was thought to be the cause of the observed flow softening

Exploring Technology-Aided Education in Dementia Care

Background: Healthcare and allied professionals (HAP) play an important role in providing quality care for persons living with Alzheimer\u27s and related dementias (ADRD) and their families. With over 6.9 million Americans aged 65 and older living with ADRD, it is imperative that HAP students are properly educated in dementia care prior to graduating from their programs. Examples, registered nurses play an essential role in providing quality care to persons living with dementia, which is why it is important for nursing students to be given an education on ADRD-related care. Objective: To explore the experience of HAP students in learning about dementia care and their use of educational technology in developing related competence. Methods: This research used secondary analysis of qualitative and quantitative data from a larger study to explore the targeted populations’ experience and analyze the use of gamified virtual reality applications in dementia care education. Participants eligible for this study are enrolled in undergraduate healthcare or allied programs, aged 18 or older and have completed coursework focused on dementia care. Recruitment was then conducted through advertisements in student organizations using flyers and email correspondence with student groups. Three focus group sessions were conducted, lasting between 60-90 minutes and analyzed using a thematic approach. Socio-demographic data were collected. Preliminary findings: 18 final-year HAP students from diverse programs participated in the study, aged over 18 years old. Two main themes were revealed: (1) Limited dementia educational apps available for students and (2) Lack of dementia care experiential learning opportunities. Conclusions: This study identified the limitations of the current pedagogical methodologies and the availability of technologies-aided teaching/learning apps about dementia care for HAP students

Glutathione peroxidase 3 is a potential biomarker for konzo.

Konzo is a neglected paralytic neurological disease associated with food (cassava) poisoning that affects the worlds poorest children and women of childbearing ages across regions of sub-Saharan Africa. Despite understanding the dietary factors that lead to konzo, the molecular markers and mechanisms that trigger this disease remain unknown. To identify potential protein biomarkers associated with a disease status, plasma was collected from two independent Congolese cohorts, a discovery cohort (n = 60) and validation cohort (n = 204), sampled 10 years apart and subjected to multiple high-throughput assays. We identified that Glutathione Peroxidase 3 (GPx3), a critical plasma-based antioxidant enzyme, was the sole protein examined that was both significantly and differentially abundant between affected and non-affected participants in both cohorts, with large reductions observed in those affected with konzo. Our findings raise the notion that reductions in key antioxidant mechanisms may be the biological risk factor for the development of konzo, particularly those mediated through pathways involving the glutathione peroxidase family

3,3′Diindolylmethane Suppresses Vascular Smooth Muscle Cell Phenotypic Modulation and Inhibits Neointima Formation after Carotid Injury

3,3'Diindolylmethane (DIM), a natural phytochemical, has shown inhibitory effects on the growth and migration of a variety of cancer cells; however, whether DIM has similar effects on vascular smooth muscle cells (VSMCs) remains unknown. The purpose of this study was to assess the effects of DIM on the proliferation and migration of cultured VSMCs and neointima formation in a carotid injury model, as well as the related cell signaling mechanisms.DIM dose-dependently inhibited the platelet-derived growth factor (PDGF)-BB-induced proliferation of VSMCs without cell cytotoxicity. This inhibition was caused by a G0/G1 phase cell cycle arrest demonstrated by fluorescence-activated cell-sorting analysis. We also showed that DIM-induced growth inhibition was associated with the inhibition of the expression of cyclin D1 and cyclin-dependent kinase (CDK) 4/6 as well as an increase in p27(Kip1) levels in PDGF-stimulated VSMCs. Moreover, DIM was also found to modulate migration of VSMCs and smooth muscle-specific contractile marker expression. Mechanistically, DIM negatively modulated PDGF-BB-induced phosphorylation of PDGF-recptorβ (PDGF-Rβ) and the activities of downstream signaling molecules including Akt/glycogen synthase kinase(GSK)3β, extracellular signal-regulated kinase1/2 (ERK1/2), and signal transducers and activators of transcription 3 (STAT3). Our in vivo studies using a mouse carotid arterial injury model revealed that treatment with 150 mg/kg DIM resulted in significant reduction of the neointima/media ratio and proliferating cell nuclear antigen (PCNA)-positive cells, without affecting apoptosis of vascular cells and reendothelialization. Infiltration of inflammatory cells was also inhibited by DIM administration.These results demonstrate that DIM can suppress the phenotypic modulation of VSMCs and neointima hyperplasia after vascular injury. These beneficial effects on VSMCs were at least partly mediated by the inhibition of PDGF-Rβ and the activities of downstream signaling pathways. The results suggest that DIM has the potential to be a candidate for the prevention of restenosis

PDGF-Rα gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts

<p>Abstract</p> <p>Background</p> <p>Platelet-derived growth factor A (PDGF-A) signals solely through PDGF-Rα, and is required for fibroblast proliferation and transdifferentiation (fibroblast to myofibroblast conversion) during alveolar development, because <it>pdgfa</it>-null mice lack both myofibroblasts and alveoli. However, these PDGF-A-mediated mechanisms remain incompletely defined. At postnatal days 4 and 12 (P4 and P12), using mouse lung fibroblasts, we examined (a) how PDGF-Rα correlates with ki67 (proliferation marker) or alpha-smooth muscle actin (αSMA, myofibroblast marker) expression, and (b) whether PDGF-A directly affects αSMA or modifies stimulation by transforming growth factor beta (TGFβ).</p> <p>Methods</p> <p>Using flow cytometry we examined PDGF-Rα, αSMA and Ki67 in mice which express green fluorescent protein (GFP) as a marker for PDGF-Rα expression. Using real-time RT-PCR we quantified αSMA mRNA in cultured Mlg neonatal mouse lung fibroblasts after treatment with PDGF-A, and/or TGFβ.</p> <p>Results</p> <p>The intensity of GFP-fluorescence enabled us to distinguish three groups of fibroblasts which exhibited absent, lower, or higher levels of PDGF-Rα. At P4, more of the higher than lower PDGF-Rα + fibroblasts contained Ki67 (Ki67+), and Ki67+ fibroblasts predominated in the αSMA + but not the αSMA- population. By P12, Ki67+ fibroblasts comprised a minority in both the PDGF-Rα + and αSMA+ populations. At P4, most Ki67+ fibroblasts were PDGF-Rα + and αSMA- whereas at P12, most Ki67+ fibroblasts were PDGF-Rα- and αSMA-. More of the PDGF-Rα + than - fibroblasts contained αSMA at both P4 and P12. In the lung, proximate αSMA was more abundant around nuclei in cells expressing high than low levels of PDGF-Rα at both P4 and P12. Nuclear SMAD 2/3 declined from P4 to P12 in PDGF-Rα-, but not in PDGF-Rα + cells. In Mlg fibroblasts, αSMA mRNA increased after exposure to TGFβ, but declined after treatment with PDGF-A.</p> <p>Conclusion</p> <p>During both septal eruption (P4) and elongation (P12), alveolar PDGF-Rα may enhance the propensity of fibroblasts to transdifferentiate rather than directly stimulate αSMA, which preferentially localizes to non-proliferating fibroblasts. In accordance, PDGF-Rα more dominantly influences fibroblast proliferation at P4 than at P12. In the lung, TGFβ may overshadow the antagonistic effects of PDGF-A/PDGF-Rα signaling, enhancing αSMA-abundance in PDGF-Rα-expressing fibroblasts.</p

Faith Community Nursing: Ministering to God\u27s People in Ukraine through Lamentation

Non

Synthesis, characterization and shaping of nanoparticles based on SrTiO3 as EHT anode materials for the oxidative coupling of methane

Le titanate de strontium (SrTiO3) est un matériau d'un grand intérêt en raison de ses propriétés électriques, optiques et catalytiques remarquables, ainsi que de sa stabilité chimique. Sa structure cristalline de type pérovskite, qui autorise un certain nombre de dopages permettant d’ajuster facilement ses propriétés, est au coeur de son attrait. Parmi les méthodes de synthèse de SrTiO3 dopé ou non dopé, la voie fluides supercritiques présente une alternative intéressante. En effet, dans le domaine de la science des matériaux, la voie fluides supercritiques a révolutionné la synthèse de nanoparticules, films minces et matériaux poreux. Cette méthode permet, au-delà d’élaborer des matériaux qui ne peuvent être obtenus avec des approches conventionnelles, d’obtenir une distribution uniforme des tailles de particules, une grande pureté et une cristallinité améliorée, des facteurs clés pour optimiser les performances des matériaux. Le titanate de strontium autorise le dopage sur les sites A (strontium) et B (titane). Les dopages les plus courants se font avec des terres rares sur le site du strontium ou des métaux de transition sur le site du titane. Le but du dopage est d'améliorer des propriétés spécifiques pour la photocatalyse, l’optique ou encore les propriétés diélectriques ou électroniques. Différents procédés de synthèse ont permis d’obtenir des compositions dopées de titanate de strontium, allant de la réaction à l’état solide aux méthodes plus avancées comme le sol-gel ou la synthèse hydrothermale. Cependant, la synthèse de titanate de strontium dopé par la voie fluides supercritiques n’a pas été rapportée, à l’exception de la solution solide complète entre le titanate de baryum et de strontium. Au cours de ces travaux de thèse, la synthèse de titanate de strontium par la voie fluides supercritiques en flux continu a été réalisée avec succès à l’aide de précurseurs du type alkoxydes et acétylacétonates. Une fois la synthèse validée, des compositions avec dopants ont été produites en substituant le strontium par des terres rares tel que le praséodyme et le titane par des métaux de transition comme le niobium, démontrant la flexibilité de cette méthode pour obtenir des matériaux dopés n ou p avec des taux atomiques précis allant d’un taux maximum de substitution de 10 at.% à 1 at.%, permettant d’améliorer les propriétés électroniques. De plus, ces propriétés électroniques ont été caractérisées pour évaluer l’impact du dopage. Les propriétés de conduction électronique ont ensuite été déterminées et ont démontré pour certaines compositions une conductivité 1 000 fois supérieure au titanate de strontium de base. Cette conductivité accrue permet au matériau d’être viable pour des applications d’électrodes dans divers dispositifs électrochimiques comme les électrolyseurs. Ces électrodes ont été élaborées par formulation des nanoparticules en encre et déposition sur support par sérigraphie. L’application finale envisagée pour ce matériau est l’utilisation comme anode dans un électrolyseur à haute température. Grâce à ses propriétés de conduction et sa taille nanométrique, ce matériau pourrait favoriser la réaction catalytique de couplage oxydant du méthane et promouvoir la conversion du méthane en éthylène.Strontium titanate (SrTiO3) is a material of great interest due to its remarkable electrical, optical, and catalytic properties, as well as its chemical stability. Its perovskite-type crystal structure, which allows for various dopings to easily adjust its properties, is central to its appeal. Among the synthesis methods for doped and undoped SrTiO3, the supercritical fluid route presents an intriguing alternative. Indeed, in the field of materials science, the supercritical fluid route has revolutionized the synthesis of nanoparticles, thin films, and porous materials. This method not only enables the creation of materials that cannot be obtained through conventional approaches but also achieves a uniform particle size distribution, high purity, and improved crystallinity which is a key factor for optimizing material performance. Strontium titanate allows doping at both A-site (strontium) and B-site (titanium). The most common doping involves rare earth elements at the strontium site or transition metals at the titanium site. The goal of doping is to enhance specific properties for photocatalysis, optics, or dielectric and electronic characteristics. Various synthesis processes have yielded doped strontium titanate compositions, ranging from solid-state reactions to more advanced methods like sol-gel or hydrothermal synthesis. However, the synthesis of doped strontium titanate via the supercritical fluid route has not been reported, except for the complete solid solution between barium titanate and strontium titanate. In this thesis work, the synthesis of strontium titanate via the continuous-flow supercritical solvothermal method has been successfully achieved using alkoxide and acetylacetonate precursors. Once the synthesis was validated, compositions with dopants were produced by substituting strontium with rare earth elements such as praseodymium and titanium with transition metals like niobium, demonstrating the flexibility of this method to obtain n- or p-doped materials with precise atomic doping rates ranging from a maximum substitution rate of 10 at.% down to 1 at.%, thereby improving electronic properties. Additionally, these electronic properties were characterized to assess the impact of doping. The electronic conduction properties were then determined, revealing that for certain compositions, the conductivity was 1,000 times greater than that of the bare strontium titanate. This increased conductivity makes the material viable for electrode applications in various electrochemical devices, such as electrolyser. These electrodes were developed by formulating nanoparticles into ink and depositing them onto a substrate via screen printing. The final envisioned application for this material is as an anode in a high-temperature electrolyser. Due to its conductive properties and nanoscale size, this material could facilitate the catalytic oxidative coupling of methane and promote the conversion of methane to ethylene

Comment Napoléon Bonaparte est-il abordé dans les programmes scolaires et pourquoi est-il de moins en moins présent ?

Général à 26 ans, empereur à 33 ans, mort en exil à 52 ans, après avoir dominé quinze ans l’Europe, Napoléon Bonaparte a eu un destin hors du commun qui fascine encore aujourd’hui. Napoléon reste dans toutes les mémoires : il a notamment remporté quelques-unes des plus grandes batailles de l’histoire de France. Mais il reste également l’un des plus grands hommes de l’histoire grâce à ses qualités d’administrateur et de meneur d’hommes hors pair : il a terminé la Révolution faisant définitivement basculer la France dans la période contemporaine notamment grâce à la création du Code civil qui continue encore aujourd’hui à être la base de notre législation. C’est une des époques les plus importantes de l’histoire et une époque qui laisse, encore aujourd’hui, des traces indélébiles. En effet, Napoléon est un personnage très contrasté qui fait l’objet, encore aujourd’hui, des plus grands débats notamment entre la gauche et la droite du XIXème et XXème siècle. Il est l’homme qui a suscité le plus de livres en France et à l’étranger. Et le nombre de livres et d’ouvrages ne cesse d’augmenter au fil du temps. Napoléon fascine par son héritage qui vit encore aujourd’hui dans notre société mais également par sa personne et ses actes. Chloé Morin* explique que, d’après les enquêtes menées, pour les Français, Napoléon est l’une des figures les plus connues en France, c’est même lui qui est partiellement à l’origine de questions actuelles portant sur le fonctionnement de la démocratie. En effet, il a conforté l’idée de l’homme fort. L’historiographie napoléonienne ne cesse d’évoluer. C’est un personnage qui est très compliqué à aborder pour la communauté éducative, notamment à l’école primaire. En effet, plusieurs débats ont lieu, depuis maintenant quelques années, pour savoir quel volet de l’histoire napoléonienne il faut mettre en avant. À ce propos, après analyse des différents manuels et programmes scolaires, on eut constater que, suivant les années et les réformes, Napoléon n’est pas mis en avant de la même manière et certains aspects de cette époque ne le sont pas non plus