Effect of the Use of Natural Gas-Diesel Fuel Mixture on Performance, Emissions and Combustion Characteristics of a Compression-Ignition Engine

A compression ignition engine with a mechanical fuel system was converted into common rail fuel system by means of a self-developed electronic control unit. The engine was modified to be operated with mixtures of diesel and natural gas fuels in dual-fuel mode. Then, diesel fuel was injected into the cylinder while natural gas was injected into intake manifold with both injectors controlled with the electronic control unit. Energy content of the sprayed gas fuel was varied in the amounts of 0% (only diesel fuel), 15%, 40%, and 75% of total fuel’s energy content. All tests were carried out at constant engine speed of 1500 r/min at full load. In addition to the experiments, the engine was modeled with a one-dimensional commercial software. The experimental and numerical results were compared and found to be in reasonable agreement with each other. Both NO x and soot emissions were dropped with 15% and 40%, respectively, energy content rates in gas–fuel mixture compared to only diesel fuel. However, an increase was observed in carbon monoxide emissions with 15% natural gas fuel addition compared to only diesel fuel. Although smoke emission was reduced with natural gas fuel addition, there was a dramatic increase in NO x emissions with 75% natural gas fuel addition

A Nonlinear Constitutive Theory for Heat Conduction in Lagrangian Description Based on Integrity

If the deforming matter is to be in thermodynamic equilibrium, then all constitutive theories, including those for heat vector, must satisfy conservation and balance laws. It is well known that only the second law of thermodynamics provides possible conditions or mechanisms for deriving constitutive theories, but the constitutive theories so derived also must not violate other conservation and balance laws. In the work presented here constitutive theories for heat vector in Lagrangian description are derived (i) strictly using the conditions resulting from the entropy inequality and (ii) using theory of generators and invariants in conjunction with the conditions resulting from the entropy inequality. Both theories are used in the energy equation to construct a mathematical model in R1 that is utilized to present numerical studies using p-version least squares finite element method based on residual functional in which the local approximations are considered in higher order scalar product spaces that permit higher order global differentiability approximations. The constitutive theory for heat vector resulting from the theory of generators and invariants contains up to cubic powers of temperature gradients and is based on integrity, hence complete. The constitutive theory in approach (i) is linear in temperature gradient, standard Fourier heat conduction law, and shown to be subset of the constitutive theory for heat vector resulting from the theory of generators and invariants

Analysis of AML genes in dysregulated molecular networks

<p>Abstract</p> <p>Background</p> <p>Identifying disease causing genes and understanding their molecular mechanisms are essential to developing effective therapeutics. Thus, several computational methods have been proposed to prioritize candidate disease genes by integrating different data types, including sequence information, biomedical literature, and pathway information. Recently, molecular interaction networks have been incorporated to predict disease genes, but most of those methods do not utilize invaluable disease-specific information available in mRNA expression profiles of patient samples.</p> <p>Results</p> <p>Through the integration of protein-protein interaction networks and gene expression profiles of acute myeloid leukemia (AML) patients, we identified subnetworks of interacting proteins dysregulated in AML and characterized known mutation genes causally implicated to AML embedded in the subnetworks. The analysis shows that the set of extracted subnetworks is a reservoir rich in AML genes reflecting key leukemogenic processes such as myeloid differentiation.</p> <p>Conclusion</p> <p>We showed that the integrative approach both utilizing gene expression profiles and molecular networks could identify AML causing genes most of which were not detectable with gene expression analysis alone due to the minor changes in mRNA level.</p

COST292 experimental framework for TRECVID 2006

In this paper we give an overview of the four TRECVID tasks submitted by COST292, European network of institutions in the area of semantic multimodal analysis and retrieval of digital video media. Initially, we present shot boundary evaluation method based on results merged using a confidence measure. The two SB detectors user here are presented, one of the Technical University of Delft and one of the LaBRI, University of Bordeaux 1, followed by the description of the merging algorithm. The high-level feature extraction task comprises three separate systems. The first system, developed by the National Technical University of Athens (NTUA) utilises a set of MPEG-7 low-level descriptors and Latent Semantic Analysis to detect the features. The second system, developed by Bilkent University, uses a Bayesian classifier trained with a "bag of subregions" for each keyframe. The third system by the Middle East Technical University (METU) exploits textual information in the video using character recognition methodology. The system submitted to the search task is an interactive retrieval application developed by Queen Mary, University of London, University of Zilina and ITI from Thessaloniki, combining basic retrieval functionalities in various modalities (i.e. visual, audio, textual) with a user interface supporting the submission of queries using any combination of the available retrieval tools and the accumulation of relevant retrieval results over all queries submitted by a single user during a specified time interval. Finally, the rushes task submission comprises a video summarisation and browsing system specifically designed to intuitively and efficiently presents rushes material in video production environment. This system is a result of joint work of University of Bristol, Technical University of Delft and LaBRI, University of Bordeaux 1

A systematic review of interventions to improve knowledge and self-management skills concerning contraception, pregnancy and breastfeeding in people with rheumatoid arthritis

This systematic review aimed to determine the effectiveness of interventions for improving knowledge and/or self-management skills concerning contraception, pregnancy and breastfeeding in people with rheumatoid arthritis (RA). We searched four databases (MEDLINE, CINAHL, Cochrane Trials, PsycINFO) using a comprehensive search strategy. Studies were eligible if they were prospective, published in English from 2004 to 2015, included participants with RA and tested an intervention designed to improve knowledge and/or self-management skills relating to family planning, pregnancy or breastfeeding. As no studies met the latter criterion, the search strategy was expanded to include all prospective studies evaluating RA educational and/or self-management interventions. Data on study characteristics, participant characteristics and programme content were extracted to summarise the evidence base for interventions to support people with RA during their reproductive years. Expanded literature searches identified 2290 papers, of which 68 were eligible. Of these, nine papers (13 %) specifically excluded pregnant women/breastfeeding mothers or recruited only older people.Only one study (1 %) explicitly evaluated pregnancy-focused education via a motherhood decision aid, while eight studies (12 %) incorporated relevant (albeit minor) components within broader RA educational or self-management interventions. Of these, three studies provided methotrexate education in relation to conception/pregnancy/breastfeeding; three incorporated discussions on RA and relationships, impact of RA on the family or sexual advice; one provided information regarding contraception and fertility; and one issued a warning regarding use of biologic therapy in pregnancy/breastfeeding. In conclusion, information regarding family planning, pregnancy or breastfeeding represents a negligible part of published RA educational interventions, with scope to develop targeted resources

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus