Separating the BL Lac and Cluster X-ray Emissions in Abell 689 with Chandra

We present the results of a Chandra observation of the galaxy cluster Abell 689 (z=0.279). Abell 689 is one of the most luminous clusters detected in the ROSAT All Sky Survey (RASS), but was flagged as possibly including significant point source contamination. The small PSF of the Chandra telescope allows us to confirm this and separate the point source from the extended cluster X-ray emission. For the cluster we determine a bolometric luminosity of L_{bol}=(3.3+/-0.3)x10^{44} erg s-1 and a temperature of kT=5.1^{+2.2}_{-1.3} keV when including a physically motivated background model. We compare our measured luminosity for A689 to that quoted in the Rosat All Sky Survey (RASS) and find L_{0.1-2.4,keV}=2.8x10^{44} erg s-1, a value \sim10 times lower than the ROSAT measurement. Our analysis of the point source shows evidence for significant pileup, with a pile-up fraction of ~60%. SDSS spectra and HST images lead us to the conclusion that the point source within Abell 689 is a BL Lac object. Using radio and optical observations from the VLA and HST archives, we determine {\alpha}_{ro}=0.50, {\alpha}_{ox}=0.77 and {\alpha}_{rx}=0.58 for the BL Lac, which would classify it as being of 'High-energy peak BL Lac' (HBL) type. Spectra extracted of A689 show a hard X-ray excess at energies above 6 keV that we interpret as inverse Compton emission from aged electrons that may have been transported into the cluster from the BL Lac.Comment: 11 pages, 15 figures, MNRAS in pres

LoCuSS: Comparison of Observed X-ray and Lensing Galaxy Cluster Scaling Relations with Simulations

The Local Cluster Substructure Survey (LoCuSS, Smith et al.) is a systematic multi-wavelength survey of >100 X-ray luminous galaxy clusters (0.14<z<0.3) selected from the ROSAT all sky survey. We used data on 37 LoCuSS clusters from the XMM-Newton archive to investigate the global scaling relations of galaxy clusters. The scaling relations based solely on the X-ray data obey empirical self-similarity and reveal no additional evolution beyond the LSS growth. Weak lensing mass measurements are also available in the literature for 19 of the clusters with XMM-Newton data. The average of the weak lensing mass to X-ray based mass ratio is 1.09+/-8, setting the limit of the non-thermal pressure support to 9+/-8%. The mean of the weak lensing mass to X-ray based mass ratio of these clusters is ~1 with 31-51% scatter. The scatter in the mass--observable relations (M-Y_X, M-M_{gas} and M-T) is smaller using X-ray based masses than using weak lensing masses by a factor of 2. Using the scaled radius defined by the Y_X profile, we obtain lower scatter in the weak lensing mass based mass--observable relations. The normalization of the M-Y_X relation (also M-M_{gas} and M-T relations) using X-ray (weak lensing) mass estimates is lower than the one from simulations by up to 20% at ~3 sigma (~2 sigma) significance. Despite the large scatter in the X-ray to lensing comparison, the agreement between these two completely independent observational methods is an important step towards controlling astrophysical and measurement systematics in cosmological scaling relations.Comment: 56 pages, 32 figure, 2008A&A...482..451Z, typos corrected in Table A.

Glucose enhancement of human memory: A comprehensive research review of the glucose memory facilitation effect

The brain relies upon glucose as its primary fuel. In recent years, a rich literature has developed from both human and animal studies indicating that increases in circulating blood glucose can facilitate cognitive functioning. This phenomenon has been termed the ‘glucose memory facilitation effect’. The purpose of this review is to discuss a number of salient studies which have investigated the influence of glucose ingestion on neurocognitive performance in individuals with (a) compromised neurocognitive capacity, as well as (b) normally functioning individuals (with a focus on research conducted with human participants). The proposed neurocognitive mechanisms purported to underlie the modulatory effect of glucose on neurocognitive performance will also be considered. Many theories have focussed upon the hippocampus, given that this brain region is heavily implicated in learning and memory. Further, it will be suggested that glucose is a possible mechanism underlying the phenomenon that enhanced memory performance is typically observed for emotionally laden stimuli

Halo mass - concentration relation from weak lensing

We perform a statistical weak lensing analysis of dark matter profiles around tracers of halo mass from galactic- to cluster-size halos. In this analysis we use 170,640 isolated ~L* galaxies split into ellipticals and spirals, 38,236 groups traced by isolated spectroscopic Luminous Red Galaxies (LRGs) and 13,823 MaxBCG clusters from the Sloan Digital Sky Survey (SDSS) covering a wide range of richness. Together these three samples allow a determination of the density profiles of dark matter halos over three orders of magnitude in mass, from 10^{12} M_{sun} to 10^{15} M_{sun}. The resulting lensing signal is consistent with an NFW or Einasto profile on scales outside the central region. We find that the NFW concentration parameter c_{200b} decreases with halo mass, from around 10 for galactic halos to 4 for cluster halos. Assuming its dependence on halo mass in the form of c_{200b} = c_0 [M/(10^{14}M_{sun}/h)]^{\beta}, we find c_0=4.6 +/- 0.7 (at z=0.22) and \beta=0.13 +/- 0.07, with very similar results for the Einasto profile. The slope (\beta) is in agreement with theoretical predictions, while the amplitude is about two standard deviations below the predictions for this mass and redshift, but we note that the published values in the literature differ at a level of 10-20% and that for a proper comparison our analysis should be repeated in simulations. We discuss the implications of our results for the baryonic effects on the shear power spectrum: since these are expected to increase the halo concentration, the fact that we see no evidence of high concentrations on scales above 20% of the virial radius suggests that baryonic effects are limited to small scales, and are not a significant source of uncertainty for the current weak lensing measurements of the dark matter power spectrum. [ABRIDGED]Comment: 17 pages, 5 figures, accepted to JCAP pending minor revisions that are included in v2 here on arXi

TEMPLATES: Direct Abundance Constraints for Two Lensed Lyman-Break Galaxies

Using integrated spectra for two gravitationally lensed galaxies from the JWST TEMPLATES Early Release Science program, we analyze faint auroral lines, which provide direct measurements of the gas-phase chemical abundance. For the brighter galaxy, SGAS1723$+$34 ($z = 1.3293$), we detect the [OIII]$\lambda4363$, [SIII]$\lambda6312$, and [OII]$\lambda\lambda$7320,7330 auroral emission lines, and set an upper limit for the [NII]$\lambda5755$ line. For the second galaxy, SGAS1226$+$21 ($z = 2.925$), we do not detect any auroral lines, and report upper limits. With these measurements and upper limits, we constrain the electron temperatures in different ionization zones within both of these galaxies. For SGAS1723$+$34, where auroral lines are detected, we calculate direct oxygen and nitrogen abundances, finding an N/O ratio consistent with observations of nearby ($z\sim 0$) galaxies. These observations highlight the potent combination of JWST and gravitational lensing to measure faint emission lines in individual distant galaxies and to directly study the chemical abundance patterns in those galaxies.Comment: Submitted to the Astrophysical Journal's Focus Issue on the TEMPLATES JWST Early Release Science Program. 15 pages, 6 figures. Comments welcom

Cluster Lenses

Clusters of galaxies are the most recently assembled, massive, bound structures in the Universe. As predicted by General Relativity, given their masses, clusters strongly deform space-time in their vicinity. Clusters act as some of the most powerful gravitational lenses in the Universe. Light rays traversing through clusters from distant sources are hence deflected, and the resulting images of these distant objects therefore appear distorted and magnified. Lensing by clusters occurs in two regimes, each with unique observational signatures. The strong lensing regime is characterized by effects readily seen by eye, namely, the production of giant arcs, multiple-images, and arclets. The weak lensing regime is characterized by small deformations in the shapes of background galaxies only detectable statistically. Cluster lenses have been exploited successfully to address several important current questions in cosmology: (i) the study of the lens(es) - understanding cluster mass distributions and issues pertaining to cluster formation and evolution, as well as constraining the nature of dark matter; (ii) the study of the lensed objects - probing the properties of the background lensed galaxy population - which is statistically at higher redshifts and of lower intrinsic luminosity thus enabling the probing of galaxy formation at the earliest times right up to the Dark Ages; and (iii) the study of the geometry of the Universe - as the strength of lensing depends on the ratios of angular diameter distances between the lens, source and observer, lens deflections are sensitive to the value of cosmological parameters and offer a powerful geometric tool to probe Dark Energy. In this review, we present the basics of cluster lensing and provide a current status report of the field.Comment: About 120 pages - Published in Open Access at: http://www.springerlink.com/content/j183018170485723/ . arXiv admin note: text overlap with arXiv:astro-ph/0504478 and arXiv:1003.3674 by other author

Gefitinib and <i>EGFR</i> Gene Copy Number Aberrations in Esophageal Cancer

Purpose: The cancer esophagus gefitinib (COG) trial demonstrated improved progression free survival with the Epidermal Growth Factor Receptor (EGFR) tyrosine kinase inhibitor (TKI), gefitinib relative to placebo in advanced esophageal cancer patients with disease progression after chemotherapy. Rapid and durable responses were observed in a minority. We hypothesised that genetic aberration of the EGFR pathway would identify patients benefitting from gefitinib. Patients and Methods: A pre-specified blinded molecular analysis of COG trial tumours was conducted to compare efficacy of gefitinib to placebo according to EGFR copy number gain (CNG) and EGFR, KRAS, BRAF and PIK3CA mutation status. EGFR CNG was determined by fluorescent insitu hybridisation (FISH) using pre-specified criteria and EGFR FISH positive defined as high polysomy or amplification. Results: Biomarker data were available for 340 patients. In EGFR FISH positive tumours (20.2%) overall survival was improved with gefitinib compared to placebo (hazard ratio [HR] for death, 0.59; 95% confidence interval [CI], 0.35, 1.00 p=0.05). In EGFR FISH negative tumours there was no difference in overall survival with gefitinib compared to placebo (HR for death, 0.90, 95% CI 0.69, 1.18 p=0.46). EGFR amplification (7.2%) patients gained greatest benefit from gefitinib (HR for death, 0.21; 95% CI 0.07-0.64; p=0.006). There was no difference in overall survival for gefitinib versus placebo for patients with EGFR, KRAS, BRAF and PIK3CA mutations, or for any mutation versus none. Conclusion: EGFR CNG assessed by FISH appears to identify a subgroup of esophageal cancer patients who may benefit from gefitinib as a second line treatment, and suggests that anti-EGFR 3 therapies should be investigated in prospective clinical trials in different settings in EGFR FI SH positive, and in particular EGFR amplified, esophageal cancer

Gravitational Lensing

Gravitational lensing has developed into one of the most powerful tools for the analysis of the dark universe. This review summarises the theory of gravitational lensing, its main current applications and representative results achieved so far. It has two parts. In the first, starting from the equation of geodesic deviation, the equations of thin and extended gravitational lensing are derived. In the second, gravitational lensing by stars and planets, galaxies, galaxy clusters and large-scale structures is discussed and summarised.Comment: Invited review article to appear in Classical and Quantum Gravity, 85 pages, 15 figure

COOL-LAMPS VI: Lens model and New Constraints on the Properties of COOL J1241+2219, a Bright z = 5 Lyman Break Galaxy and its z = 1 Cluster Lens

We present a strong lensing analysis of COOL J1241+2219, the brightest known gravitationally lensed galaxy at $z \geq 5$, based on new multi-band Hubble Space Telescope (HST) imaging data. The lensed galaxy has a redshift of z=5.043, placing it shortly after the end of the Epoch of Reionization, and an AB magnitude z_AB=20.47 mag (Khullar et al. 2021). As such, it serves as a touchstone for future research of that epoch. The high spatial resolution of HST reveals internal structure in the giant arc, from which we identify 15 constraints and construct a robust lens model. We use the lens model to extract cluster mass and lensing magnification. We find that the mass enclosed within the Einstein radius of the z=1.001 cluster lens is M(<5.77'')=$1.079^{+0.023}_{-0.007}$, significantly lower than other known strong lensing clusters at its redshift. The average magnification of the giant arc is $=76^{+40}_{-20}$, a factor of $2.4^{+1.4}_{-0.7}$ greater than previously estimated from ground-based data; the flux-weighted average magnification is $=92^{+37}_{-31}$ We update the current measurements of the stellar mass and star formation rate (SFR) of the source for the revised magnification, $\log(M_\star/M_{\odot})=9.7\pm0.3$ and ${\rm SFR} = 10.3^{+7.0}_{-4.4}$ $M_{\odot}$yr$^{-1}$. The powerful lensing magnification acting upon COOL J1241+2219 resolves the source and enables future studies of the properties of its star formation on a clump-by-clump basis. The lensing analysis presented here will support upcoming multiwavelength characterization with HST and JWST data of the stellar mass assembly and physical properties of this high-redshift lensed galaxy.Comment: Submitted to Ap

A hypothetico-deductive approach to assessing the social function of chemical signalling in a non-territorial solitary carnivore

The function of chemical signalling in non-territorial solitary carnivores is still relatively unclear. Studies on territorial solitary and social carnivores have highlighted odour capability and utility, however the social function of chemical signalling in wild carnivore populations operating dominance hierarchy social systems has received little attention. We monitored scent marking and investigatory behaviour of wild brown bears Ursus arctos, to test multiple hypotheses relating to the social function of chemical signalling. Camera traps were stationed facing bear ‘marking trees’ to document behaviour by different age sex classes in different seasons. We found evidence to support the hypothesis that adult males utilise chemical signalling to communicate dominance to other males throughout the non-denning period. Adult females did not appear to utilise marking trees to advertise oestrous state during the breeding season. The function of marking by subadult bears is somewhat unclear, but may be related to the behaviour of adult males. Subadults investigated trees more often than they scent marked during the breeding season, which could be a result of an increased risk from adult males. Females with young showed an increase in marking and investigation of trees outside of the breeding season. We propose the hypothesis that females engage their dependent young with marking trees from a young age, at a relatively ‘safe’ time of year. Memory, experience, and learning at a young age, may all contribute towards odour capabilities in adult bears