When Leader-member exchanges make workers happy and innovative: do efforts and rewards act as mediators?

Today innovation is considered to be essential for organizational development, and organizations depend increasingly on employees’ efforts to innovate. Drawing on the eudemonic theory of well-being based on the idea of optimal functioning, we look at whether rewards and efforts act as mediators between leader-member exchange (LMX) and two dependent variables: well-being at work and innovative work behaviors (IWB). We examine how LMX is linked to IWB and well-being at work, and we test the mediating effects of workload and rewards in these links. A sample of 179 French workers responded to an online questionnaire. The results indicated that LMX was significantly linked to IWB and psychological well-being at work. The study also found an indirect effect of work rewards between LMX and psychological well-being at work. This mediating role was not found in the relationship between LMX and IWB.Hoy en día se considera que la innovación es esencial para el desarrollo organizativo, y las organizaciones dependen cada vez más de los esfuerzos de los empleados por innovar. Partiendo de la teoría eudemónica del bienestar basada en la idea del funcionamiento óptimo, examinamos si las recompensas y los esfuerzos actúan como mediadores entre el intercambio líder-miembro (LMX) y dos variables dependientes: el bienestar en el trabajo y los comportamientos laborales innovadores (IWB). Examinamos cómo el LMX está vinculado al IWB y al bienestar en el trabajo, y comprobamos los efectos mediadores de la carga de trabajo y las recompensas en estos vínculos. Una muestra de 179 trabajadores franceses respondió a un cuestionario en línea. Los resultados indicaron que la LMX estaba significativamente vinculada a la IWB y al bienestar psicológico en el trabajo. El estudio también encontró un efecto indirecto de las recompensas laborales entre la LMX y el bienestar psicológico en el trabajo. Este papel mediador no se encontró en la relación entre LMX y IWB

Comparative analysis of metazoan chromatin organization

Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosoph ..

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Publisher's version (útgefin grein).Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity.Alexander von Humboldt-StiftungPeer Reviewe

A meta-analysis of genome-wide association studies identifies multiple longevity genes

Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,262/3484 cases surviving at or beyond the age corresponding to the 90th/99th survival percentile, respectively, and 25,483 controls whose age at death or at last contact was at or below the age corresponding to the 60th survival percentile. Consistent with previous reports, rs429358 (apolipoprotein E (ApoE) ε4) is associated with lower odds of surviving to the 90th and 99th percentile age, while rs7412 (ApoE ε2) shows the opposite. Moreover, rs7676745, located near GPR78, associates with lower odds of surviving to the 90th percentile age. Gene-level association analysis reveals a role for tissue-specific expression of multiple genes in longevity. Finally, genetic correlation of the longevity GWA results with that of several disease-related phenotypes points to a shared genetic architecture between health and longevity

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Quality of life at work : what effects of organizational, psychological and individual factors on well-being and career success ?

En lien avec les théories du bien-être, du succès de carrière, de l'autodétermination et de l'échange social, la thèse s'attache à cerner les déterminants organisationnels, psychosociaux et individuels du bien-être psychologique dans une perspective eudémonique et des succès de carrière objectif et subjectif avec comme mécanisme explicatif central la satisfaction des besoins psychologiques auprès des conseiller-es. En parallèle, cette thèse vise à valider plusieurs échelles (e.g., échelle d'auto-efficacité en conseil de carrière ; échelles de succès de carrière objectif et subjectif, échelle de gestion des carrières organisationnelle perçue...). Une première étape (étude 1) à l'aide d'entretiens exploratoires (N=15) a permis de cerner les concepts en lien avec bien-être et la réussite des conseillers. La deuxième étape, reposant sur un questionnaire, incluait les outils de mesure du bien-être psychologique au travail (BEPT) du succès e carrière, de la qualité es échanges leaders et membres (LMX), du soutien des colègues, du sentiment d'efficacité, de l'estime de soi et de la satisfaction des besoins psychologiques puis une échelle de mesure de la gestion organisationnelle de carrière. Les questionnaires ont été complétés par 1132 conseiller-es de l'accompagnement professionnel en France. La phase 1 (études 2 à6) a permis de tester des modèles avec analyses de médiations (Hayes & Preacher, 2014) auprès de la population totale puis des consiller-es en Cabinet de Conseil (N=287), des conseiller-es Psychologue de l'Education Nationale (N=297) et des conseiller-es de Pôle Emploi (N=224). La phase 2 (études 7,8,9) a testé et validé trois modèles à l'aide de modélisations en équations structurelles 5SEM) pour le bien-être psychologique au travail, les succès de carrière objectif et subjectif. Il en résulte que la satisfaction des besoins joue un rôle primordial dans l'émergence du bien-être psychologique au travail et des deux formes de succès de carrière facilitant les effets du soutien organisationnel et des échanges leader-membres ainsi que du sentiment d'auto-efficacité et de la satisfaction de carrière. Les implications scientifiques et pratiques sont discutées de manière générale et au regard de chaque type de population.Based on theories of well-being, career success, self-determination, and social exchange, this thesis attempts to understand the organizational, psychosocial, and individual inducers of psychological well-being (PWB) and the objective and subjective forms of career success by taking into account need satisfaction as an explanatory mechanism. Another aim is to validate several scales (e.g., a carreer counseling self-efficiency scale, objective and subjective career scales, perceived organizational career scales, etc.). The first part (Study 1) using exploratory interviews (N=15) allowed us to identify some concepts related to the well-being and success of counselors. The second part, based on questionnaires, included scales of well-being at work, career success, leader-member exchange quality 5LMX), colleague support, self-efficacy, self-esteem, psychological needs, and perceived organizational career management. Questionnaires were filled out by 1132 counselors in France. Studies 2 to 6 tested specifically on counselors from counseling agencies (N=287), counselor psychologists working for theFrench Board of Education (N=297), and counselors from publicu unemployment agencies (N=224). Studies 7, 8, et 9 tested and validated three structural equation models (SEM) of well-being at work, and objective and subjective career success. The results showed the need satisfaction played a major role in well-being at work and both kinds of career success, thereby facilitating the effects of organizational support, leader-member exchange, self-efficacy, and career satisfaction. Scientific and practical implications are discussed in general and with regard to each type of participant group

L’addiction au travail : quels effets de la charge de travail, de la dissonance émotionnelle et du surinvestissement ?

International audienceThe present study aimed to assess workaholism in the light of job demands (psychological demands, efforts, emotional dissonance) and job resources (control, social support, rewards). The study was conducted among 342 employment counselors. The results revealed that the employment counselors would have all the more workaholism behaviors that the organizational context expose them to high levels of psychological demands and efforts, high levels of over-commitment and emotional dissonance and low levels of social support and rewards. Multiple regressions highlighted the central role of psychological demands, over-investment and emotional dissonance to reveal workaholism.L’étude avait pour objectif d’évaluer l’addiction au travail au regard des exigences du travail (demande psychologique, effort, surinvestissement, dissonance émotionnelle) et des ressources liées au travail (latitude, soutien, récompense). Cette recherche a été conduite auprès de 342 conseillers en insertion professionnelle. Les résultats révèlent que les conseillers en insertion ont d’autant plus tendance à développer des comportements d’addiction au travail que le contexte de travail les expose à des demandes psychologiques élevées, à des efforts importants, à un surinvestissement et les place en situation de dissonance émotionnelle élevée et de faibles niveaux de soutien ainsi que de récompenses. La régression multiple met en évidence le rôle central des demandes psychologiques, du surinvestissement et de la dissonance émotionnelle pour expliquer l’addiction au travail

Etre prosocial au travail: une question d’empathie, d’affect, d’engagement ou de justice organisationnelle

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ETRE PROSOCIAL AU TRAVAIL :UNE QUESTION D’ENGAGEMENT OU DE JUSTICE ORGANISATIONNELLE ?

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