332 research outputs found
Genotipagem de SNPs em genes candidatos a características de interesse comercial em bovinos de corte com sondas de hidrólise.
The MURALES survey. VI. Properties and origin of the extended line emission structures in radio galaxies
Relationship between galactomannan structure and physicochemical properties of films produced thereof
In this work five sources of galactomannans, Adenanthera pavonina, Cyamopsis tetragonolobus, Caesalpinia pulcherrima, Ceratonia siliqua and Sophora japonica, presenting mannose/galactose ratios of 1.3, 1.7, 2.9, 3.4 and 5.6, respectively, were used to produce galactomannan-based films. These films were characterized in terms of: water vapour, oxygen and carbon dioxide permeabilities (WVP, O 2 P and CO 2 P); moisture content, water solubility, contact angle, elongation-at-break (EB), tensile strength (TS) and glass transition temperature (T g ). Results showed that films properties vary according to the galactomannan source (different galactose distribution) and their mannose/galactose ratio. Water affinity of mannan and galactose chains and the intermolecular interactions of mannose backbone should also be considered being factors that affect films properties. This work has shown that knowing mannose/galactose ratio of galactomannans is possible to foresee galactomannan-based edible films properties.The authors thank the fellowship (SFRH/BPD/ 72753/2010) from the Fundação para a Ciência e Tecnologia (FCT, Portugal). The authors also thank the FCT Strategic Project of UID/BIO/ 04469/2013 unit, the project RECI/BBB-EBI/0179/2012 (FCOMP-010124-FEDER-027462) and the project BBioInd - Biotechnology and Bioengineering for improved Industrial and Agro-Food processes, REF. NORTE-07-0124-FEDER-000028 Co-funded by the Programa OperacionalRegionaldoNorte(ON.2–ONovoNorte),QREN,FEDER. Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico – FUNCAP, CE Brazil (CI1-0080-00055.01.00/13)
The MURALES survey. IV. Searching for nuclear outflows in 3C radio galaxies at z < 0.3 with MUSE observations
We analyze VLT/MUSE observations of 37 radio galaxies from the Third
Cambridge catalogue (3C) with redshift 0.3 searching for nuclear outflows of
ionized gas. These observations are part of the MURALES project (a MUse RAdio
Loud Emission line Snapshot survey), whose main goal is to explore the feedback
process in the most powerful radio-loud AGN. We applied a nonparametric
analysis to the [O~III] 5007 emission line, whose asymmetries and
high-velocity wings reveal signatures of outflows. We find evidence of nuclear
outflows in 21 sources, with velocities between 400 - 1000 km s,
outflowing masses of M, and a kinetic energy in the
range erg. In addition, evidence for extended outflows
is found in the 2D gas velocity maps of 13 sources of the subclasses of
high-excitation (HEG) and broad-line (BLO) radio galaxies, with sizes between
0.4 and 20 kpc. We estimate a mass outflow rate in the range 0.4 - 30 M
yr and an energy deposition rate of erg s. Comparing the jet power, the nuclear luminosity of the active
galactic nucleus, and the outflow kinetic energy rate, we find that outflows of
HEGs and BLOs are likely radiatively powered, while jets likely only play a
dominant role in galaxies with low excitation. The low loading factors we
measured suggest that these outflows are driven by momentum and not by energy.
Based on the gas masses, velocities, and energetics involved, we conclude that
the observed ionized outflows have a limited effect on the gas content or the
star formation in the host. In order to obtain a complete view of the feedback
process, observations exploring the complex multiphase structure of outflows
are required.Comment: 40 pages; accepted for publication on A&A
Recovery from Posttraumatic Stress Symptoms: A Qualitative Study of Attributions in Survivors of War
This study was funded by a grant from the European Commission, contract number INCO-CT-2004-50917
Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles
There are very few drug delivery
systems that target key organs
via the oral route, as oral delivery advances normally address gastrointestinal
drug dissolution, permeation, and stability. Here we introduce a nanomedicine
in which nanoparticles, while also protecting the drug from gastric
degradation, are taken up by the gastrointestinal epithelia and transported
to the lung, liver, and spleen, thus selectively enhancing drug bioavailability
in these target organs and diminishing kidney exposure (relevant to
nephrotoxic drugs). Our work demonstrates, for the first time, that
oral particle uptake and translocation to specific organs may be used
to achieve a beneficial therapeutic response. We have illustrated
this using amphotericin B, a nephrotoxic drug encapsulated within <i>N</i>-palmitoyl-<i>N</i>-methyl-<i>N</i>,<i>N</i>-dimethyl-<i>N</i>,<i>N</i>,<i>N</i>-trimethyl-6-<i>O</i>-glycol chitosan
(GCPQ) nanoparticles, and have evidenced our approach in three separate
disease states (visceral leishmaniasis, candidiasis, and aspergillosis)
using industry standard models of the disease in small animals. The
oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease
models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral
liposomal AmB (AmBisome). Our work thus paves the way for others to
use nanoparticles to achieve a specific targeted delivery of drug
to key organs via the oral route. This is especially important for
drugs with a narrow therapeutic index
Predicting Impaired Extinction of Traumatic Memory and Elevated Startle
Emotionally traumatic experiences can lead to debilitating anxiety disorders, such as phobias and Post-Traumatic Stress Disorder (PTSD). Exposure to such experiences, however, is not sufficient to induce pathology, as only up to one quarter of people exposed to such events develop PTSD. These statistics, combined with findings that smaller hippocampal size prior to the trauma is associated with higher risk of developing PTSD, suggest that there are pre-disposing factors for such pathology. Because prospective studies in humans are limited and costly, investigating such pre-dispositions, and thus advancing understanding of the genesis of such pathologies, requires the use of animal models where predispositions are identified before the emotional trauma. Most existing animal models are retrospective: they classify subjects as those with or without a PTSD-like phenotype long after experiencing a traumatic event. Attempts to create prospective animal models have been largely unsuccessful.Here we report that individual predispositions to a PTSD-like phenotype, consisting of impaired rate and magnitude of extinction of an emotionally traumatic event coupled with long-lasting elevation of acoustic startle responses, can be revealed following exposure to a mild stressor, but before experiencing emotional trauma. We compare, in rats, the utility of several classification criteria and report that a combination of criteria based on acoustic startle responses and behavior in an anxiogenic environment is a reliable predictor of a PTSD-like phenotype.There are individual predispositions to developing impaired extinction and elevated acoustic startle that can be identified after exposure to a mildly stressful event, which by itself does not induce such a behavioral phenotype. The model presented here is a valuable tool for studying the etiology and pathophysiology of anxiety disorders and provides a platform for testing behavioral and pharmacological interventions that can reduce the probability of developing pathologic behaviors associated with such disorders
How can we treat vulvar carcinoma in pregnancy? A systematic review of the literature
According to our systematic literature review (PRISMA guidelines), only 37 vulvar squamous cell carcinomas (VSCCs) were diagnosed during pregnancy (age range: 17\u201341 years). The tumor size range was 0.3\u201315 cm. The treatment was performed after (14/37, 38%), before (10/37, 27%), or before\u2010and\u2010after delivery (11/37, 30%). We found that 21/37 (57%) cases were stage I, 2 II (5%), 11 III (30%), and 3 IVB (8%). HPV\u2010related features (condylomas/warts; HPV infection; high\u2010grade squamous intraepithelial lesion) were reported in 11/37 (30%) cases. We also found that 9/37 (24%) patients had inflammatory conditions (lichen sclerosus/planus, psoriasis, chronic dermatitis). The time\u2010to\u2010recurrence/progression (12/37, 32%) ranged from 0 to 36 (mean 9) months. Eight women died of disease (22%) 2.5\u201348 months after diagnosis, 2 (5%) were alive with disease, and 23 (62%) were disease\u2010free at the end of follow\u2010up. Pregnant patients must be followed\u2010up. Even if they are small, newly arising vulvar lesions should be biopsied, especially in women with risk factors (HPV, dermatosis, etc.). The treatment of VSCCs diagnosed in late third trimester might be delayed until postpartum. Elective cesarean section may prevent vulvar wound dehiscence. In the few reported cases, pregnancy/fetal outcomes seemed to not be affected by invasive treatments during pregnancy. However, clinicians must be careful; larger cohorts should define the best treatment. Definite guidelines are lacking, so a multidisciplinary approach and discussion with patients are mandatory
Income redistribution in the European Union
We explore the redistributive effects of taxes and benefits in the 27 member states of the European Union (EU) using EUROMOD, the tax-benefit microsimulation model for the EU. As well as describing redistributive effects in aggregate, we assess and compare the effectiveness of eight individual types of policy in reducing income disparities. We derive results for the 27 members of the EU using policies in effect in 2010 and present them for each country separately as well as for the EU as a whole
Young People and Development: The Role of Global Youth Work in Engagement and Learning
In this chapter I will outline the definitions and principles of what is known as global youth work and relate this to learning and development in the wider youth work sector. 1 will also look at how global youth work has been interpreted and what makes it distinctive, in terms of its approach, agenda and intended outcomes; be it young people’s personal, social and political development or awareness of global development issues. Historically many local government youth services and voluntary and community sector organisations in the UK and Ireland have explored global issues with young people through international work, including youth exchanges, links and intercultural learning as distinct curriculum areas. However this work has always been constrained by the limited funding available and a lack of understanding of the value of this work as a core activity at a strategic level within the youth work and development education (DE) sectors and government departments. This chapter will identify some of the perceived differences between global youth work and school-based development education in regard to aims and methodology, in particular youth work’s principle of ‘Voluntarism’ and a desire to be ‘action focused’ involving the active participation of young people in curriculum design and delivery
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