Simultaneous growth of self-patterned carbon nanotube forests with dual height scales

In this study, we report on a unique, one-step fabrication technique enabling the simultaneous synthesis of vertically aligned multi-walled carbon nanotubes (VA-MWCNTs) with dual height scales through alcohol catalyzed chemical vapor deposition (ACCVD). Regions of VA-MWCNTs with different heights were well separated from each other leading to a self-patterning on the surface. We devised a unique layer-by-layer process for application of catalyst and inhibitor precursors on oxidized Si (100) surfaces before the ACCVD step to achieve a hierarchical arrangement. Patterning could be controlled by adjusting the molarity and application sequence of precursors. Contact angle measurements on these self-patterned surfaces indicated that manipulation of these hierarchical arrays resulted in a wide range of hydrophobic behavior changing from that of a sticky rose petal to a lotus leaf. © 2013 The Royal Society of Chemistry

Sarcomere Formation Occurs by the Assembly of Multiple Latent Protein Complexes

The stereotyped striation of myofibrils is a conserved feature of muscle organization that is critical to its function. Although most components that constitute the basic myofibrils are well-characterized biochemically and are conserved across the animal kingdom, the mechanisms leading to the precise assembly of sarcomeres, the basic units of myofibrils, are poorly understood. To gain insights into this process, we investigated the functional relationships of sarcomeric protein complexes. Specifically, we systematically analyzed, using either RNAi in primary muscle cells or available genetic mutations, the organization of myofibrils in Drosophila muscles that lack one or more sarcomeric proteins. Our study reveals that the thin and thick filaments are mutually dependent on each other for striation. Further, the tension sensor complex comprised of zipper/Zasp/α-actinin is involved in stabilizing the sarcomere but not in its initial formation. Finally, integrins appear essential for the interdigitation of thin and thick filaments that occurs prior to striation. Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly

Analysis of the common genetic component of large-vessel vasculitides through a meta- Immunochip strategy

Giant cell arteritis (GCA) and Takayasu's arteritis (TAK) are major forms of large-vessel vasculitis (LVV) that share clinical features. To evaluate their genetic similarities, we analysed Immunochip genotyping data from 1,434 LVV patients and 3,814 unaffected controls. Genetic pleiotropy was also estimated. The HLA region harboured the main disease-specific associations. GCA was mostly associated with class II genes (HLA-DRB1/HLA-DQA1) whereas TAK was mostly associated with class I genes (HLA-B/MICA). Both the statistical significance and effect size of the HLA signals were considerably reduced in the cross-disease meta-analysis in comparison with the analysis of GCA and TAK separately. Consequently, no significant genetic correlation between these two diseases was observed when HLA variants were tested. Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P?=?7.54E-07; ORGCA?=?1.19, ORTAK?=?1.50). This marker was confirmed as novel GCA risk factor using four additional cohorts (PGCA?=?5.52E-04, ORGCA?=?1.16). Taken together, our results provide evidence of strong genetic differences between GCA and TAK in the HLA. Outside this region, common susceptibility factors were suggested, especially within the IL12B locus

Impacts of climate change on spatial drought distribution in the Mediterranean Basin (Turkey): different climate models and downscaling methods

The impacts of climate change increasingly show themselves in many forms in our everyday lives such as heatwaves and droughts. Drought is one of the critical events today for increasing drought frequency. This study focuses on meteorological drought because it directly affects other drought types. Hence, this study focuses on how the future drought conditions will vary under climate change effects in the Mediterranean basin (Turkey). In doing so, this study utilizes precipitation data from three General Circulation Models (GCMs) and three Regional Circulation Models (RCMs). The GCMs are CNRM-CM6, GFDL-CM4, and MPI-ESM1, while the RCMs are (RCA4)-CNRM-CM5, (Reg CM4)-GFDL-ESM2M, and (RCA4)-MPI-ESM-MR. Mitigating biases of the climate models, this study utilizes four statistical downscaling methods (SD), linear scaling (LS), local intensity scaling (LOCI), power transformation (PT), and distribution mapping (DM). Here, the study has two purposes. The main aim of the paper here is to compare the performance of SD methods in improving the representation of observed climate variables in climate models. In addition, the study shows how different methods will affect the spatial drought distribution in the area under the SSP2 4.5 and SSP5 8.5 scenarios. Consequently, the study uses the standardized precipitation index (SPI) and Z-score index (ZSI) to quantify future drought conditions and reaches the following results. The study reveals that mild drought conditions are prevalent in the basin for future periods, and drought indices go down to − 0.55. The study also shows that different SD methods affect the results obtained by each climate model diversely. For example, while the LS method causes the most drought conditions on the results based on CNRM-CM5 and CNRM-CM6, the DM method has a similar impact on outcomes based on GFDL-CM4 and GFDL-ESM2M and causes the most drought conditions